Solid state microelectronics tolerant to radiation and high temperature

The 300 C electronics technology based on JFET thick film hybrids was tested up to 10 to the 9th power rad gamma (Si) and 10 to the 15th power neutrons/sq cm. Circuits and individual components from this technology all survived this total dose although some devices required 1 hour of annealing at 200 or 300 C to regain functionality. This technology used with real time annealing should function to levels greater than 10 to the 10th power rad gamma and 10 to the 16th power n/sq cm

6D Muon Ionization Cooling with an Inverse Cyclotron

A large admittance sector cyclotron filled with LiH wedges surrounded by helium or hydrogen gas is explored. Muons are cooled as they spiral adiabatically into a central swarm. As momentum approaches zero, the momentum spread also approaches zero. Long bunch trains coalesce. Energy loss is used to inject the muons into the outer rim of the cyclotron. The density of material in the cyclotron decreases adiabatically with radius. The sector cyclotron magnetic fields are transformed into an azimuthally symmetric magnetic bottle in the center. Helium gas is used to inhibit muonium formation by positive muons. Deuterium gas is used to allow captured negative muons to escape via the muon catalyzed fusion process. The presence of ionized gas in the center may automatically neutralize space charge. When a bunch train has coalesced into a central swarm, it is ejected axially with an electric kicker pulse.Comment: Five pages. LaTeX, three postscript figure files. To appear in the AIP Conference Proceedings for COOL05: International Workshop on Beam Cooling, Galena, IL, 18-23 Sept. 200

A Pulsed Synchrotron for Muon Acceleration at a Neutrino Factory

A 4600 Hz pulsed synchrotron is considered as a means of accelerating cool muons with superconducting RF cavities from 4 to 20 GeV/c for a neutrino factory. Eddy current losses are held to less than a megawatt by the low machine duty cycle plus 100 micron thick grain oriented silicon steel laminations and 250 micron diameter copper wires. Combined function magnets with 20 T/m gradients alternating within single magnets form the lattice. Muon survival is 83%.Comment: 4 pages, 1 figures, LaTeX, 5th International Workshop on Neutrino Factories and Superbeams (NuFact 03), 5-11 Jun 2003, New Yor

MONTE CARLO SIMULATIONS OF MUON PRODUCTION

Muon production requirements for a muon collider are presented. Production of muons from pion decay is studied. Lithium lenses and solenoids are considered for focussing pions from a target, and for matching the pions into a decay channel. Pion decay channels of alternating quadrupoles and long solenoids are compared. Monte Carlo simulations are presented for production of $\pi \rightarrow \mu$ by protons over a wide energy range, and criteria for choosing the best proton energy are discussed.Comment: Latex uses mu95.sty, 19 pages, 5 postscript figures. A postscript file can be seen at URL http://www.cap.bnl.gov/~cap/mumu/important.html Search for Publication

Relative salinity tolerance of freshwater macroinvertebrates from the south-east Eastern Cape, South Africa compared with the Barwon Catchment, Victoria, Australia

Salinity is rising in many southern African and Australian rivers with unknown effects on aquatic organisms. The extent of spatial variation, at any scale, in salt tolerances of aquatic organisms is unknown, so whether data from one location is applicable elsewhere is also unknown. The acute tolerances (72-h median lethal concentration (LC50)) to sea salt of 49 macroinvertebrate taxa from the south-east Eastern Cape (SEEC), South Africa were compared with those of 57 species from the Barwon Catchment, Victoria, Australia. The mean LC50 values from both locations were similar (Barwon: 31 and SEEC: 32 mS cm(-1)) and less abundant (rare) taxa tended to be more tolerant than more abundant (common) taxa. There was, however, a greater range of LC50 values (5.5-76 mS cm(-1)) in the Barwon Catchment than in the SEEC (11-47 mS cm(-1)). The species sensitivity distribution (SSD) for SEEC taxa was bimodal whereas the Barwon Catchment's SSD had a single peak. With few exceptions, members of an order had similar tolerances in both locations. The differences in SSD between locations were related to crustacean, odonate and non-arthropod relative richness. Although it is not ideal to extrapolate SSDs from one location to another, it may be reasonable to assume similar salinity tolerances among related taxa

Haplotype analysis of the PPARgamma Pro12Ala and C1431T variants reveals opposing associations with body weight.

BACKGROUND: Variation at the PPARG locus may influence susceptibility to type 2 diabetes and related traits. The Pro12Ala polymorphism may modulate receptor activity and is associated with protection from type 2 diabetes. However, there have been inconsistent reports of its association with obesity. The silent C1431T polymorphism has not been as extensively studied, but the rare T allele has also been inconsistently linked to increases in weight. Both rare alleles are in linkage disequilibrium and the independent associations of these two polymorphisms have not been addressed. RESULTS: We have genotyped a large population with type 2 diabetes (n = 1107), two populations of non-diabetics from Glasgow (n = 186) and Dundee (n = 254) and also a healthy group undergoing physical training (n = 148) and investigated the association of genotype with body mass index. This analysis has demonstrated that the Ala12 and T1431 alleles are present together in approximately 70% of the carriers. By considering the other 30% of individuals with haplotypes that only carry one of these polymorphisms, we have demonstrated that the Ala12 allele is consistently associated with a lower BMI, whilst the T1431 allele is consistently associated with higher BMI. CONCLUSION: This study has therefore revealed an opposing interaction of these polymorphisms, which may help to explain previous inconsistencies in the association of PPARG polymorphisms and body weight