Comparative results of surgical, combined and comprehensive treatment of newly onset medulloblastoma in children

The authors present the outcomes of treatment of 107 patients with histologically verified diagnosis of medulloblastoma. Of these, 22 children were subjected only to surgical treatment, 25 – operative and radiotherapy, and 60 – polychemotherapy as a stage of a comprehensive or combined treatment. It was determined that survival of children with medulloblastoma was influenced by such factors as the presence of polychemotherapy and radiotherapy, a residual tumour following nonradical removal thereof, involvement of the brain stem into the tumour process, as well as tumour cells in the lumbal liquor. Carrying out ventriculoperitoneal by-pass decreases survival of patients with medulloblastoma. © 2002, Fund - Doctors, Innovations,Science for Children. All rights reserved

Evaluating modelled tropospheric columns of CH4, CO, and 03 in the Arctic using ground-based Fourier transform infrared (FTIR) measurements

This study evaluates tropospheric columns of methane, carbon monoxide, and ozone in the Arctic simulated by 11 models. The Arctic is warming at nearly 4 times the global average rate, and with changing emissions in and near the region, it is important to understand Arctic atmospheric composition and how it is changing. Both measurements and modelling of air pollution in the Arctic are difficult, making model validation with local measurements valuable. Evaluations are performed using data from five high-latitude ground-based Fourier transform infrared (FTIR) spectrometers in the Network for the Detection of Atmospheric Composition Change (NDACC). The models were selected as part of the 2021 Arctic Monitoring and Assessment Programme (AMAP) report on short-lived climate forcers. This work augments the model–measurement comparisons presented in that report by including a new data source: column-integrated FTIR measurements, whose spatial and temporal footprint is more representative of the free troposphere than in situ and satellite measurements. Mixing ratios of trace gases are modelled at 3-hourly intervals by CESM, CMAM, DEHM, EMEP MSC-W, GEM-MACH, GEOS-Chem, MATCH, MATCH-SALSA, MRI-ESM2, UKESM1, and WRF-Chem for the years 2008, 2009, 2014, and 2015. The comparisons focus on the troposphere (0–7 km partial columns) at Eureka, Canada; Thule, Greenland; Ny Ålesund, Norway; Kiruna, Sweden; and Harestua, Norway. Overall, the models are biased low in the tropospheric column, on average by −9.7 % for CH4, −21 % for CO, and −18 % for O3. Results for CH4 are relatively consistent across the 4 years, whereas CO has a maximum negative bias in the spring and minimum in the summer and O3 has a maximum difference centered around the summer. The average differences for the models are within the FTIR uncertainties for approximately 15 % of the model–location comparisons