The Grizzly, February 12, 2015

UC Partners With Community College • Fongs to Receive Honorary Degrees • Merit Scholarships Increase Because of Higher Tuition • Changes to Title IX Brought Changes to Sexual Assault Documentation • Being an International Student is Difficult but Gratifying for Zhu • Getting to Know Mr. Wismer • Aux./Vox. Prints • Novelist Shares Her Story • Opinion: Main Street is a Growing Concern for Students; Are Ursinus\u27 Policies Against Weed Practical? • Junior Swimmer Stepping Up for the Men • Freshman Swimmin\u27 Women Playing Key Role in Championship Defensehttps://digitalcommons.ursinus.edu/grizzlynews/1923/thumbnail.jp

The Grizzly, March 5, 2015

Student Senate Discusses Diversity on Campus • Sprinklers in Lower Cause Damage • Ursinus Continues to Globalize in Hong Kong • UC Relay for Life Makes Strides • Dawleys Follow Darwin • Poet Reads Her Work on Campus • Goldsmith Wins Fellowship • Opinion: Take Revenge Porn More Seriously; Marijuana Laws Should be Changed Nationwide • Rugby Teams Set to Tackle Spring • Leading Offhttps://digitalcommons.ursinus.edu/grizzlynews/1926/thumbnail.jp

The Grizzly, February 19, 2015

College Hopes to Expand • Ursinus Celebrates Black History Month • Tensions in North Hall Grow • Influenza Poses its Yearly Threat to Ursinus Students • Art Department Will Sojourn to D.C. • Sing-Along Hits Home • Pre-Med UC Alum Joins Montco Police Force • Opinion: Stress Management Should be Required; Pinnacle of the Booty in Today\u27s Society • Richie Schulz Leading Men\u27s Track • Taking the Plungehttps://digitalcommons.ursinus.edu/grizzlynews/1924/thumbnail.jp

The Grizzly, April 16, 2015

Greeks Collect Clothes for Prom • Tree Campus USA Honors UC • Ursinus to Continue Re-branding • Student Senate Announces 2015-2016 Executive Board • UC Welcomes New Director of Facilities • New Issue of the Lantern Released • UCDC Concert to Have Eclectic Themes and Dances • Guest Author Speaks on Middle Eastern Politics • Opinion: Campus Safety Needs More Resources; Sexual Assault Deserves Coverage • Local Athlete Hyman Steps Up for Bears • Midfielder from the Midwesthttps://digitalcommons.ursinus.edu/grizzlynews/1931/thumbnail.jp

The Grizzly, April 9, 2015

Students Expose Racism on Yik Yak • English Honor Society Hosting Gatsby Party • Goss, Fulbright Winner, Plans to Travel to Turkey • HEART Lab Offers Unique Research • Annual Edible Book Festival Continues for Eleventh Year • New Minors Created for Fall • Opinion: A Fourth CIE Question That Breaks the Silence; Fourth Question Not True to Liberal Arts • Stick it to \u27em • On the Right Trackhttps://digitalcommons.ursinus.edu/grizzlynews/1930/thumbnail.jp

The Grizzly, November 20, 2014

Instruments Stolen From Bomberger • Memorial Honors Ambassador Melrose • Senate Calls Emergency Meeting • Religious Realizations • Compost Company Shut Down • Transitioning from Undergrad to Corson • YAL Spreads Philosophy of Freedom Around UC Campus • Sycamore Tree Remembered in New Logo Shield Designs • Opinion: People Aren\u27t Listening to Victims of Rape; UC Website Emphasizes Students Too Much • Sans Seniors, Women\u27s Basketball Hopes to Improve • An Ocean Away • Stellar Hockey Season Endshttps://digitalcommons.ursinus.edu/grizzlynews/1917/thumbnail.jp

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Host factors are associated with vaginal microbiome structure in pregnancy in the ECHO Cohort Consortium

Using pooled vaginal microbiota data from pregnancy cohorts (N = 683 participants) in the Environmental influences on Child Health Outcomes (ECHO) Program, we analyzed 16S rRNA gene amplicon sequences to identify clinical and demographic host factors that associate with vaginal microbiota structure in pregnancy both within and across diverse cohorts. Using PERMANOVA models, we assessed factors associated with vaginal community structure in pregnancy, examined whether host factors were conserved across populations, and tested the independent and combined effects of host factors on vaginal community state types (CSTs) using multinomial logistic regression models. Demographic and social factors explained a larger amount of variation in the vaginal microbiome in pregnancy than clinical factors. After adjustment, lower education, rather than self-identified race, remained a robust predictor of L. iners dominant (CST III) and diverse (CST IV) (OR = 8.44, 95% CI = 4.06-17.6 and OR = 4.18, 95% CI = 1.88-9.26, respectively). In random forest models, we identified specific taxonomic features of host factors, particularly urogenital pathogens associated with pregnancy complications (Aerococcus christensenii and Gardnerella spp.) among other facultative anaerobes and key markers of community instability (L. iners). Sociodemographic factors were robustly associated with vaginal microbiota structure in pregnancy and should be considered as sources of variation in human microbiome studies