1,034 research outputs found
Standardizing Disparate Impact: How Ricci Circumvents Title VII and Why Congress Should Amend it Now
تاثیر آموزش تغذیه مبتنی بر تئوری در دوران بارداری بر بهبود عملکرد تغذیه ای زنان باردار
Delays-induced Phase Transitions in Active Matter
We consider the patterns of collective motion emerging when many aligning,
self-propelling units move in two dimensions while interacting through a
repulsive potential and are also subject to delays and random perturbations. In
this approach, delay plays the role analogous to reaction time so that a given
particle is influenced by the information about the velocity and the position
of the other particles in its vicinity with some time delay. To get insight
into the involved complex flows and the transitions between them we use a
simple model allowing, by fine-tuning of its few parameters, the observation
and analysis of behaviours that are less accessible by experiments or analytic
calculations and at the same time make the reproduction of experimental results
possible. We report for the first time about a transition from an ordered,
polarized collective motion to disorder as a function of the increasing time
delay. For a fixed intermediate value of the delay similar transition (from
order to disorder) is obtained as the repulsion radius is increased. Our
simulations show a transition from total polarization to two kinds of states:
fully disordered and a kind of state which is a mixture of patches of fully
disordered motion in the background of orderly moving other particles. The
transition occurs as the delay time is increased and is sharp, indicating that
the nature of this order-disorder transition is either of first-order or is
described by a sharply decreasing linear function. Our model is a simplified
version of a practical situation of quickly growing interest because time
delays are expected to play an increasingly important role when the traffic of
many, densely distributed autonomous drones will move around in a
quasi-two-dimensional air space
Investigating the presence rate of clinical medicine highly cited scientists of islamic countries in the academic social networks
Recommended from our members
The fear of COVID-19 and its role in preventive behaviors
The economic and psychosocial consequences of the COVID-19 pandemic have been far-reaching and unprecedented around the world. These circumstances appear to have had profound psychological effects on all individuals worldwide. One psychological aspect of the COVID-19 pandemic is fear. This brief paper argues that assessing fear is important and is the key reason we co-developed the 'Fear of COVID-19 Scale' (FCV-19S). It is argued that without knowing the level of fear about COVID-19 among different groups by specific socio-demographic variables (e.g., gender, age, education, ethnicity, religiosity, etc.) and/or different psychological factors (e.g., personality type) it is difficult to know whether education and prevention programs are needed, and if they are needed which groups to target and where. The collation and application of such data could be used to devise targeted education and/or prevention programs to help overcome fear of COVID-19 and help such individuals to engage in preventative behaviors
بررسی میزان Øضور دانشمندان پراستناد Øوزه پزشکی بالینی کشور های اسلامی در شبکه های اجتماعی دانشگاهی
Protein kinase C-dependent signaling controls the midgut epithelial barrier to malaria parasite infection in anopheline mosquitoes.
Anopheline mosquitoes are the primary vectors of parasites in the genus Plasmodium, the causative agents of malaria. Malaria parasites undergo a series of complex transformations upon ingestion by the mosquito host. During this process, the physical barrier of the midgut epithelium, along with innate immune defenses, functionally restrict parasite development. Although these defenses have been studied for some time, the regulatory factors that control them are poorly understood. The protein kinase C (PKC) gene family consists of serine/threonine kinases that serve as central signaling molecules and regulators of a broad spectrum of cellular processes including epithelial barrier function and immunity. Indeed, PKCs are highly conserved, ranging from 7 isoforms in Drosophila to 16 isoforms in mammals, yet none have been identified in mosquitoes. Despite conservation of the PKC gene family and their potential as targets for transmission-blocking strategies for malaria, no direct connections between PKCs, the mosquito immune response or epithelial barrier integrity are known. Here, we identify and characterize six PKC gene family members--PKCδ, PKCε, PKCζ, PKD, PKN, and an indeterminate conventional PKC--in Anopheles gambiae and Anopheles stephensi. Sequence and phylogenetic analyses of the anopheline PKCs support most subfamily assignments. All six PKCs are expressed in the midgut epithelia of A. gambiae and A. stephensi post-blood feeding, indicating availability for signaling in a tissue that is critical for malaria parasite development. Although inhibition of PKC enzymatic activity decreased NF-κB-regulated anti-microbial peptide expression in mosquito cells in vitro, PKC inhibition had no effect on expression of a panel of immune genes in the midgut epithelium in vivo. PKC inhibition did, however, significantly increase midgut barrier integrity and decrease development of P. falciparum oocysts in A. stephensi, suggesting that PKC-dependent signaling is a negative regulator of epithelial barrier function and a potential new target for transmission-blocking strategies
- …