Roving Reference: Getting out in the Wild

[no abstract

Roving Reference: Getting out in the Wild

[no abstract

Caltech: Using our IR with Campus Research Groups

We have expanded the IR into a service that meets the needs of groups and centers on campus. As research dollars become scarce, research support often comes with a requirement to demonstrate a return on investment (ROI). The IR can help groups and centers meet this requirement by assisting with publications lists

ORCID iD Handout

A quick handout with information about ORCID iD

ORCID iD Handout

A quick handout with information about ORCID iD

Evolving library services in the ever-​changing world of chemical information: From printed to electronic to networked

Access to chem. information has evolved dramatically over the past 50 years, from printed to electronic to networked. Channeling and focusing this torrent of information to meet the specific needs of researchers has increased exponentially over time, and has required librarians to become beta testers, instructors, and negotiators. Dana Roth's contributions to chem. information, and to the field of librarianship as a whole, cannot be overestimated. This talk will highlight key contributions that Roth has made to the relationships between the Caltech Library and publishers, and between the Library and the campus research community. These relationships continue to flourish and expand, and examples of past efforts and current projects from across the Caltech Library will be discussed

Supportive use of digital technologies during transition to adult healthcare for young people with long-term conditions, focusing on Type 1 diabetes mellitus: A scoping review.

Type 1 diabetes mellitus (T1DM) is the second most common chronic or long-term condition (LTC) affecting young people (YP); when transitioning from paediatric to adult healthcare, young people with LTCs such as T1DM are expected to self-manage medication, diet and clinical appointments. This scoping review aimed to analyse research examining ways digital health technologies were used to support YP with LTCs during transition from paediatric to adult healthcare and to establish YP's needs, experiences and challenges when transitioning. We aimed to identify knowledge gaps and inform development of a novel chatbot with components such as avatars and linked videos to help YP with T1DM gain self-management confidence and competence during transition. Nineteen studies identified through searching five electronic databases were included in this review. A combination of digital health technologies was used to support transition of YP with LTCs to adult healthcare. Barriers to successful transition were reported and YP described the importance of social relationships and transition readiness and expressed the need for individualised interventions that acknowledge social factors such as work and college. No supportive chatbots with components to help YP with T1DM were identified. This contribution will inform future development and evaluation of such a chatbot

Strategy and the Contested Politics of Scale: Air Transportation in Australia

This article explores the ways in which the contested reconfiguration of air transportation infrastructures following deregulation in Australia resulted in the rescaling of air transportation services and their disassociation from the scales of political jurisdictions. In tracing the complex interactions between the state’s and firms’ strategies and their impacts at different scales, the article contends that it is not sufficient to view scale as an arena and outcome of political struggle. Rather, it argues for an activated understanding of scale as strategy. The reconfigurations of the scales of transportation networks in Australia reveal their profound implications for the production of space: for social equity, the fortunes of cities, and the manner of Australia’s insertion in the international division of labor

Plasmodium chabaudi chabaudi malaria parasites can develop stable resistance to atovaquone with a mutation in the cytochrome b gene

<p>Abstract</p> <p>Background</p> <p><it>Plasmodium falciparum</it>, has developed resistance to many of the drugs in use. The recommended treatment policy is now to use drug combinations. The atovaquone-proguanil (AP) drug combination, is one of the treatment and prophylaxis options. Atovaquone (ATQ) exerts its action by inhibiting plasmodial mitochondria electron transport at the level of the cytochrome bc1 complex. <it>Plasmodium falciparum in vitro </it>resistance to ATQ has been associated with specific point mutations in the region spanning codons 271-284 of the <it>cytochrome b </it>gene. ATQ -resistant <it>Plasmodium yoelii </it>and <it>Plasmodium berghei </it>lines have been obtained and resistant lines have amino acid mutations in their CYT <it>b </it>protein sequences. <it>Plasmodium chabaudi </it>model for studying drug-responses and drug-resistance selection is a very useful rodent malaria model but no ATQ resistant parasites have been reported so far. The aim of this study was to determine the ATQ sensitivity of the <it>P. chabaudi </it>clones, to select a resistant parasite line and to perform genotypic characterization of the <it>cytb </it>gene of these clones.</p> <p>Methods</p> <p>To select for ATQ resistance, <it>Plasmodium. chabaudi chabaudi </it>clones were exposed to gradually increasing concentrations of ATQ during several consecutive passages in mice. <it>Plasmodium chabaudi cytb </it>gene was amplified and sequenced.</p> <p>Results</p> <p>ATQ resistance was selected from the clone AS-3CQ. In order to confirm whether an heritable genetic mutation underlies the response of AS-ATQ to ATQ, the stability of the drug resistance phenotype in this clone was evaluated by measuring drug responses after (i) multiple blood passages in the absence of the drug, (ii) freeze/thawing of parasites in liquid nitrogen and (iii) transmission through a mosquito host, <it>Anopheles stephensi</it>. ATQ resistance phenotype of the drug-selected parasite clone kept unaltered. Therefore, ATQ resistance in clone AS-ATQ is genetically encoded. The Minimum Curative Dose of AS-ATQ showed a six-fold increase in MCD to ATQ relative to AS-3CQ.</p> <p>Conclusions</p> <p>A mutation was found on the <it>P. chabaudi cytb </it>gene from the AS-ATQ sample a substitution at the residue Tyr268 for an Asn, this mutation is homologous to the one found in <it>P. falciparum </it>isolates resistant to ATQ.</p