Retraction Note: An apoptosis-enhancing drug overcomes platinum resistance in a tumour-initiating subpopulation of ovarian cancer.

This Article has been retracted; see accompanying Retraction Note

Poor survival outcomes in HER2 positive breast cancer patients with low grade, node negative tumours

We present a retrospective analysis on a cohort of low-grade, node-negative patients showing that human epidermal growth factor receptor 2 (HER2) status significantly affects the survival in this otherwise very good prognostic group. Our results provide support for the use of adjuvant trastuzumab in patients who are typically classified as having very good prognosis, not routinely offered standard chemotherapy, and who as such do not fit current UK prescribing guidelines for trastuzumab

Polarization rotation via a monoclinic phase in the piezoelectric 92%PbZn1/3Nb2/3O3-8%PbTiO3

The origin of ultrahigh piezoelectricity in the relaxor ferroelectric PbZn1/3Nb2/3O3-PbTiO3 was studied with an electric field applied along the [001] direction. The zero-field rhombohedral R phase starts to follow the direct polarization path to tetragonal symmetry via an intermediate monoclinic M phase, but then jumps irreversibly to an alternate path involving a different type of monoclinic distortion. Details of the structure and domain configuration of this novel phase are described. This result suggests that there is a nearby R-M phase boundary as found in the Pb(Ti,Zr)O3 system.Comment: REVTeX file. 4 pages. New version after referees' comment

CAD Model and Visual Assisted Control System for NIF Target Area Positioners

The National Ignition Facility (NIF) target chamber contains precision motion control systems that reach up to 6 meters into the target chamber for handling targets and diagnostics. Systems include the target positioner, an alignment sensor, and diagnostic manipulators (collectively called positioners). Target chamber shot experiments require a variety of positioner arrangements near the chamber center to be aligned to an accuracy of 10 micrometers. Positioners are some of the largest devices in NIF, and they require careful monitoring and control in 3 dimensions to prevent interferences. The Integrated Computer Control System provides efficient and flexible multi-positioner controls. This is accomplished through advanced video-control integration incorporating remote position sensing and realtime analysis of a CAD model of target chamber devices. The control system design, the method used to integrate existing mechanical CAD models, and the offline test laboratory used to verify proper operation of the control system are described

Expression of hMLH1 is inactivated in the gastric adenomas with enhanced microsatellite instability

Microsatellite instability (MSI) and frameshift mutations in the genes containing coding nucleotide repeats have been reported in a subset of gastric adenomas, however the inactivation profiles of DNA mismatch repair genes in MSI-positive gastric adenomas have not been characterized. To address the origin of MSI in gastric adenomas, expressions of hMLH1 and hMSH2 were explored in 86 gastric adenomas. Gastric carcinomas, of which 16 were MSI-positive and 22 MSI-negative, were used as controls. MSI was found in 15 (17%) of gastric adenomas. Absent or decreased hMLH1 expression by immunohistochemistry was noted in most of the MSI-positive adenomas (13/15, 87%) and carcinomas (14/16, 88%), and all of these tumours showed methylation of the hMLH1 gene promoter. In contrast, rare inactivation of hMLH1 expression was found in MSI-negative adenomas (3/71, 4%) and carcinomas (2/22, 9%). Intense expression of hMSH2 gene product was observed in most of the gastric adenomas and carcinomas regardless of MSI status. These findings indicate that the inactivation of hMLH1 gene expression by promoter methylation is an early event and might be the origin of MSI-positive gastric adenomas. © 2001 Cancer Research Campaign  http://www.bjcancer.co

SCDAP/RELAP5 Modeling of Heat Transfer and Flow Losses in Lower Head Porous Debris

Designs are described for implementing models for calculating the heat transfer and flow losses in porous debris in the lower head of a reactor vessel. The COUPLE model in SCDAP/RELAP5 represents both the porous and nonporous debris that results from core material slumping into the lower head. Currently, the COUPLE model has the capability to model convective and radiative heat transfer from the surfaces of nonporous debris in a detailed manner and to model only in a simplistic manner the heat transfer from porous debris. In order to advance beyond the simplistic modeling for porous debris, designs are developed for detailed calculations of heat transfer and flow losses in porous debris. Correlations are identified for convective heat transfer in porous debris for the following modes of heat transfer; (1) forced convection to liquid, (2) forced convection to gas, (3) nucleate boiling, (4) transition boiling, and (5) film boiling. Interphase heat transfer is modeled in an approximate manner. A design is also described for implementing a model of heat transfer by radiation from debris to the interstitial fluid. A design is described for implementation of models for flow losses and interphase drag in porous debris. Since the models for heat transfer and flow losses in porous debris in the lower head are designed for general application, a design is also described for implementation of these models to the analysis of porous debris in the core region. A test matrix is proposed for assessing the capability of the implemented models to calculate the heat transfer and flow losses in porous debris. The implementation of the models described in this report is expected to improve the COUPLE code calculation of the temperature distribution in porous debris and in the lower head that supports the debris. The implementation of these models is also expected to improve the calculation of the temperature and flow distribution in porous debris in the core region

Detectability of gravitational wave events by spherical resonant-mass antennas

We have calculated signal-to-noise ratios for eight spherical resonant-mass antennas interacting with gravitational radiation from inspiralling and coalescing binary neutron stars and from the dynamical and secular bar-mode instability of a rapidly rotating star. We find that by using technology that could be available in the next several years, spherical antennas can detect neutron star inspiral and coalescence at a distance of 15 Mpc and the dynamical bar-mode instability at a distance of 2 Mpc.Comment: 39 pages, 4 EPS Figures, some additional SNRs for secular instabilities, some changes to LIGO SNRs, Appendix added on the asymptotic expansion of energy sensitivity, corrected supernova rates. Results available at http://www.physics.umd.edu/rgroups/gen_rel_exp/snr.html Submitted to Phys. Rev.

Verification of the Parallel Pin-Wise Core Simulator pCTF/PARCSv3.2 in Operational Control Rod Drop Transient Scenarios

This is an Accepted Manuscript of an article published by Taylor & Francis in Nuclear Science and Engineering on 2017, available online: https://www.tandfonline.com/doi/full/10.1080/00295639.2017.1320892[EN] Thanks to advances in computer technology, it is feasible to obtain detailed reactor core descriptions for safety analysis of the light water reactor (LWR), in order to represent realistically the fuel elements design, as is the case for three-dimensional coupled simulations for local neutron kinetics and thermal hydraulics. This scenario requires an efficient thermal-hydraulic code that can produce a response in a reasonable time for large-scale, detailed models. In two-fluid codes, such as the thermal-hydraulic subchannel code COBRA-TF, the time restriction is even more important, since the set of equations to be solved is more complex. We have developed a message passing interface parallel version of COBRA-TF, called pCTF. The parallel code is based on a cell-oriented domain decomposition approach, and performs well in models that consist of many cells. The Jacobian matrix is computed in parallel, with each processor in charge of calculating the coefficients related to a subset of the cells. Furthermore, the resulting system of linear equations is also solved in parallel, by exploiting solvers and preconditioners from PETSc. The goal of this study is to demonstrate the capability of the recently developed pCTF/PARCS coupled code to simulate large cores with a pin-by-pin level of detail in an acceptable computational time, using for this purpose two control rod drop operational transients that took place in the core of a three-loop pressurized water reactor. As a result, the main safety parameters of the core hot channel have been calculated by the coupled code in a pin level of detail, obtaining best estimate results for this transient.This work has been partially supported by the Universitat Politecnica de Valencia under Projects COBRA_PAR (PAID-05-11-2810) and OpenNUC (PAID-05-12), and by the Spanish Ministerio de Economia y Competitividad under Projects SLEPc-HS (TIN2016-75985-P) and NUC-MULTPHYS (ENE2012-34585).Ramos Peinado, E.; Roman Moltó, JE.; Abarca Giménez, A.; Miró Herrero, R.; Bermejo, JA.; Ortego, A.; Posada-Barral, JM. (2017). Verification of the Parallel Pin-Wise Core Simulator pCTF/PARCSv3.2 in Operational Control Rod Drop Transient Scenarios. Nuclear Science and Engineering. 187(3):254-267. https://doi.org/10.1080/00295639.2017.1320892S2542671873Cuervo, D., Avramova, M., Ivanov, K., & Miró, R. (2006). Evaluation and enhancement of COBRA-TF efficiency for LWR calculations. Annals of Nuclear Energy, 33(9), 837-847. doi:10.1016/j.anucene.2006.03.011Ramos, E., Roman, J. E., Abarca, A., Miró, R., & Bermejo, J. A. (2016). Control rod drop transient analysis with the coupled parallel code pCTF-PARCSv2.7. Annals of Nuclear Energy, 87, 308-317. doi:10.1016/j.anucene.2015.09.016T. DOWNAR et al. “PARCS v2.7 U.S. NRC Core Neutronics Simulator: User Manual” (2006).T. DOWNAR et al. “PARCS v2.7 U.S. NRC Core Neutronics Simulator: Theory Manual” (2006)

Why do we love the Lion King? Perception of animation among young adults

Our lives are easily driven or transformed by technologies, different forms of communication and information available, creating (new) realities or representations of reality. But how can these virtual worlds transform our social world, and our sense of reality? The present study is focused on the way how animation films are percept by young adults, and the importance they have for them. So, we aim to contribute to the understanding of possible connections between a social or practical reality, and the fantasy of virtual worlds. In this paper, we will analyze the answers of some young adults (N=210), men and women with an average age of 30 years, to three open questions concerning the films that marked them the most, the importance of animation on their life and how is animation present on their everyday life. The data gathered from their answers were classified in categories and analyzed with an automatic content analysis software – Leximancer – that permits advanced text analytics visualization. Results showed that animation films are really important in our participants’ lives, as part of the social life and well-being of the individuals, even if an adaptation of reality is not conscious, thus building the virtual worlds that connect us with what we know as reality.info:eu-repo/semantics/acceptedVersio