823 research outputs found
Charge Symmetry Breaking in 500 MeV Nucleon-Trinucleon Scattering
Elastic nucleon scattering from the 3He and 3H mirror nuclei is examined as a
test of charge symmetry violation. The differential cross-sections are
calculated at 500 MeV using a microsopic, momentum-space optical potential
including the full coupling of two spin 1/2 particles and an exact treatment of
the Coulomb force. The charge-symmetry-breaking effects investigated arise from
a violation within the nuclear structure, from the p-nucleus Coulomb force, and
from the mass-differences of the charge symmetric states. Measurements likely
to reveal reliable information are noted.Comment: 5 page
Atomic Properties of Lu
Singly ionised Lutetium has recently been suggested as a potential clock
candidate. Here we report a joint experimental and theoretical investigation of
\ce{Lu^+}. Measurements relevant to practical clock operation are made and
compared to atomic structure calculations. Calculations of scalar and tensor
polarizabilities for clock states over a range of wavelengths are also given.
These results will be useful for future work with this clock candidate.Comment: 12 pages, 5 figure
Peripheral venous blood gases and pulse-oximetry in acute cardiogenic pulmonary oedema
Background: The role of venous blood gases as an alternative to arterial blood gases in patients with severe acute heart failure has not been established. Objective: To assess the correlation between arterial and peripheral venous blood gases together with pulse-oximetry (SpO2), as well as to estimate arterial values from venous samples in the first hours upon admission of patients with acute cardiogenic pulmonary oedema. Methods: Simultaneous venous and arterial blood samples were extracted on admission and over the next 1, 2, 3, 4, and 10 hours. SpO2 was also registered at the same intervals. Results: A total of 178 pairs of samples were obtained from 34 consecutive patients with acute cardiogenic pulmonary oedema. Arterial and venous blood gases followed a parallel course in the first hours, showing high correlation rates at all time intervals. Venous samples underestimated pH (mean difference −0.028) and overestimated CO2 (+5.1 mmHg) and bicarbonate (+1 mEq/l). Conversely, SpO2 tended to underestimate SaO2 (mean±SD: 93.1±9.1 vs. 94.2±8.4). Applying simple mathematical formulae based on these differences, arterial values were empirically calculated from venous samples, showing acceptable agreement in the Bland−Altman test. Likewise, a venous pH 51.3 mmHg, and bicarbonate <22.8 mEq/l could fairly identify arterial acidosis, either respiratory or metabolic, with a test accuracy of 92, 68, and 91%, respectively. Conclusions: In patients with cardiogenic pulmonary oedema, arterial blood gas disturbances may be estimated from peripheral venous samples. By monitoring SpO2 simultaneously, arterial punctures could often be avoide
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Bifunctional hydrogels containing the laminin motif IKVAV promote neurogenesis
Engineering of biomaterials with specific biological properties has gained momentum as a means to control stem cell behavior. Here, we address the effect of bifunctionalized hydrogels comprising polylysine (PL) and a 19-mer peptide containing the laminin motif IKVAV (IKVAV) on embryonic and adult neuronal progenitor cells under different stiffness regimes. Neuronal differentiation of embryonic and adult neural progenitors was accelerated by adjusting the gel stiffness to 2 kPa and 20 kPa, respectively.While gels containing IKVAV or PL alone failed to support long-term cell adhesion, in bifunctional gels, IKVAV synergized with PL to promote differentiation and formation of focal adhesions containing b1-integrin in embryonic cortical neurons. Furthermore, in adult neural stem cell culture, bifunctionalized gels promoted neurogenesis via the expansion of neurogenic clones. These data highlight the potential of synthetic matrices to steer stem and progenitor cell behavior via defined mechano-adhesive properties
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Spatial econometrics models for congestion prediction with in-vehicle route guidance
This study explores the congestion dependence relationship among links using microsimulation, based on data from a real road network. The work is motivated by recent innovations to improve the reliability of Dynamic Route Guidance (DRG) systems. The reliability of DRG systems can be significantly enhanced by adding a function to predict the congestion in the road network. This paper also talks about the application of spatial econometrics modelling to congestion prediction, by using historical Traffic Message Channel (TMC) data stored in the vehicle navigation unit. The nature of TMC data is in the form of a time series of geo-referenced congestion warning messages which is generally collected from various traffic sources. The prediction of future congestion could be based on the previous year of TMC data. Synthetic TMC data generated by microscopic traffic simulation for the network of Coventry are used in this study. The feasibility of using spatial econometrics modelling techniques to predict congestion is explored. Results are presented at the end
Interplay between telecommunications and face-to-face interactions - a study using mobile phone data
In this study we analyze one year of anonymized telecommunications data for
over one million customers from a large European cellphone operator, and we
investigate the relationship between people's calls and their physical
location. We discover that more than 90% of users who have called each other
have also shared the same space (cell tower), even if they live far apart.
Moreover, we find that close to 70% of users who call each other frequently (at
least once per month on average) have shared the same space at the same time -
an instance that we call co-location. Co-locations appear indicative of
coordination calls, which occur just before face-to-face meetings. Their number
is highly predictable based on the amount of calls between two users and the
distance between their home locations - suggesting a new way to quantify the
interplay between telecommunications and face-to-face interactions
Un simulador de un modelo poblacional y su caja previsional
By building a system dynamics simulation platform from a demo-graphic model, this document analyzes the behavior of the population over time, as well as the population of the social security system. Simulation results show that there will be different types of problems in the future and will allow the Government to anticipate them. Due to the simplicity of its construction, it is very easy to implement in different regions with different precepts.Sociedad Argentina de Informática e Investigación Operativ
A first--order irreversible thermodynamic approach to a simple energy converter
Several authors have shown that dissipative thermal cycle models based on
Finite-Time Thermodynamics exhibit loop-shaped curves of power output versus
efficiency, such as it occurs with actual dissipative thermal engines. Within
the context of First-Order Irreversible Thermodynamics (FOIT), in this work we
show that for an energy converter consisting of two coupled fluxes it is also
possible to find loop-shaped curves of both power output and the so-called
ecological function against efficiency. In a previous work Stucki [J.W. Stucki,
Eur. J. Biochem. vol. 109, 269 (1980)] used a FOIT-approach to describe the
modes of thermodynamic performance of oxidative phosphorylation involved in
ATP-synthesis within mithochondrias. In that work the author did not use the
mentioned loop-shaped curves and he proposed that oxidative phosphorylation
operates in a steady state simultaneously at minimum entropy production and
maximum efficiency, by means of a conductance matching condition between
extreme states of zero and infinite conductances respectively. In the present
work we show that all Stucki's results about the oxidative phosphorylation
energetics can be obtained without the so-called conductance matching
condition. On the other hand, we also show that the minimum entropy production
state implies both null power output and efficiency and therefore this state is
not fulfilled by the oxidative phosphorylation performance. Our results suggest
that actual efficiency values of oxidative phosphorylation performance are
better described by a mode of operation consisting in the simultaneous
maximization of the so-called ecological function and the efficiency.Comment: 20 pages, 7 figures, submitted to Phys. Rev.
Cytotoxicity of ZnO Nanoparticles Can Be Tailored by Modifying Their Surface Structure: A Green Chemistry Approach for Safer Nanomaterials
ZnO nanoparticles (NP) are extensively used in numerous nanotechnology applications; however, they also happen to be one of the most toxic nanomaterials. This raises significant environmental and health concerns and calls for the need to develop new synthetic approaches to produce safer ZnO NP, while preserving their attractive optical, electronic, and structural properties. In this work, we demonstrate that the cytotoxicity of ZnO NP can be tailored by modifying their surface-bound chemical groups, while maintaining the core ZnO structure and related properties. Two equally sized (9.26 ± 0.11 nm) ZnO NP samples were synthesized from the same zinc acetate precursor using a forced hydrolysis process, and their surface chemical structures were modified by using different reaction solvents. X-ray diffraction and optical studies showed that the lattice parameters, optical properties, and band gap (3.44 eV) of the two ZnO NP samples were similar. However, FTIR spectroscopy showed significant differences in the surface structures and surface-bound chemical groups. This led to major differences in the zeta potential, hydrodynamic size, photocatalytic rate constant, and more importantly, their cytotoxic effects on Hut-78 cancer cells. The ZnO NP sample with the higher zeta potential and catalytic activity displayed a 1.5-fold stronger cytotoxic effect on cancer cells. These results suggest that by modifying the synthesis parameters/conditions and the surface chemical structures of the nanocrystals, their surface charge density, catalytic activity, and cytotoxicity can be tailored. This provides a green chemistry approach to produce safer ZnO NP
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