An Investigation into the Measurement and Prediction of Mechanical Stiffness of Lower-limb Prostheses used for Running

Two energy return prosthesis are subjected to three different statically applied loading methods. This initial study proposes that statically applied loading to a sport prosthesis using several controlled methods were statistically robust enough to derive a mechanical stiffness value. However, any predicted stiffness is drawn into question when allowing any movement of the distal end. This uncertainty will make any evaluation or prescription of lower-limb prosthesis technology based upon their stiffness incorrect. In addition, the peak calculated stiffness at the expected bodyweight induced ground impact load of a runner is judged the most representative assessment method. This study attempts to build on previous research advocating the need to monitor the performance of prosthesis lower-limb technology in disability sport. Practitioner Summary: This paper extends previous research regarding the fairness of prosthetics technology used in running with a lower-limb amputation. It pilots a quantitative assessment of high activity prosthetics technology and ultimately demonstrates how incorrect assessment can lead to incorrect specification of running prosthesis for elite level spor

Repetibilidade da idade ao primeiro parto, intervalo de partos e peso ao parto em bovinos da Rraça Nelore.

Utilizaram-se 407 observações de idade ao primeiro parto, 971 de intervalo de partos e 587 de peso ao parto de vacas da raça Nelore, para avaliar os efeitos de alguns fatores sobre essas características e estimar seus coeficientes de repetibilidade

Influence of Fluorination on the Solubilities of Carbon Dioxide, Ethane, and Nitrogen in 1‑n‑Fluoro-alkyl-3-methylimidazolium Bis(n‑fluoroalkylsulfonyl)amide Ionic Liquids

International audienceThe effect on gas solubilities of adding partially fluorinated alkyl side chains either on imidazolium-based cations or on bis(perfluoroalkylsulfonyl)amide anions was studied. The aim was to gain knowledge of the mechanisms of dissolution of gases in fluorinated ionic liquids and, if possible, to improve physical absorption of carbon dioxide in ionic liquids. We have determined experimentally, in the temperature range of 298–343 K and at pressures close to atmospheric pressure, the solubility and thermodynamics of solvation of carbon dioxide, ethane, and nitrogen in the ionic liquids 1-octyl-3-methylimidazolium bis[trifluoromethylsulfonyl]amide ([C8mim][NTf2]), 1-octyl-3-methylimidazolium bis[pentafluoroethylsulfonyl]amide ([C8mim][BETI]), 1-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)-3-methylimidazolium bis[trifluoromethylsulfonyl]amide ([C8H4F13mim][NTf2]), and 1-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)-3-methylimidazolium bis[pentafluoroethylsulfonyl]amide ([C8H4F13mim][BETI]). Ionic liquids with partial fluorination on the cation were found to exhibit higher carbon dioxide and nitrogen mole fraction solubilities but lower ethane solubilities, compared to those of their hydrogenated counterparts. Molecular simulation provided insights about the mechanisms of solvation of the different gases in the ionic liquids

Transforming growth factor-beta and mutant p53 conspire to induce metastasis by antagonizing p63: a (ternary) complex affair

How and when a tumor acquires metastatic properties remain largely unknown. Recent work has uncovered an intricate new mechanism through which transforming growth factor-beta (TGFβ) acts in concert with oncogenic Ras to antagonize p63-metastasis protective function. p63 inhibition requires the combined action of Ras-activated mutant p53 and TGFβ-induced Smads. Mechanistically, it involves the formation of a p63-Smads-mutant p53 ternary complex. Remarkably, just two of the key downstream targets of p63 turn out to be sufficient as a prognostic tool for breast cancer metastasis. Moreover, the molecular mechanism of this inhibition points to novel therapeutic possibilities

Contribution of ULF Wave Activity to the Global Recovery of the Outer Radiation Belt During the Passage of a HighSpeed Solar Wind Stream Observed in September 2014

Energy coupling between the solar wind and the Earth's magnetosphere can affect the electron population in the outer radiation belt. However, the precise role of different internal and external mechanisms that leads to changes of the relativistic electron population is not entirely known. This paper describes how ultralow frequency (ULF) wave activity during the passage of Alfvenic solar wind streams contributes to the global recovery of the relativistic electron population in the outer radiation belt. To investigate the contribution of the ULF waves, we searched the Van Allen Probes data for a period in which we can clearly distinguish the enhancement of electron uxes from the background. We found that the global recovery that started on 22 September 2014, which coincides with the corotating interaction region preceding a highspeed stream and the occurrence of persistent substorm activity, provides an excellent scenario to explore the contribution of ULF waves. To support our analyses, we employed ground and spacebased observational data and global magnetohydrodynamic simulations and calculated the ULF wave radial diffusion coefcients employing an empirical model. Observations show a gradual increase of electron uxes in the outer radiation belt and a concomitant enhancement of ULF activity that spreads from higher to lower Lshells. Magnetohydrodynamic simulation results agree with observed ULF wave activity in the magnetotail, which leads to both fast and Alfven modes in the magnetospheric nightside sector. The observations agree with the empirical model and are conrmed by phase space density calculations for this global recovery period

Contribution of ULF Wave Activity to the Global Recovery of the Outer Radiation Belt During the Passage of a High-Speed Solar Wind Stream Observed in September 2014

Energy coupling between the solar wind and the Earth's magnetosphere can affect the electron population in the outer radiation belt. However, the precise role of different internal and external mechanisms that leads to changes of the relativistic electron population is not entirely known. This paper describes how ultralow frequency (ULF) wave activity during the passage of Alfvénic solar wind streams contributes to the global recovery of the relativistic electron population in the outer radiation belt. To investigate the contribution of the ULF waves, we searched the Van Allen Probes data for a period in which we can clearly distinguish the enhancement of electron fluxes from the background. We found that the global recovery that started on 22 September 2014, which coincides with the corotating interaction region preceding a high-speed stream and the occurrence of persistent substorm activity, provides an excellent scenario to explore the contribution of ULF waves. To support our analyses, we employed ground- and space-based observational data and global magnetohydrodynamic simulations and calculated the ULF wave radial diffusion coefficients employing an empirical model. Observations show a gradual increase of electron fluxes in the outer radiation belt and a concomitant enhancement of ULF activity that spreads from higher to lower L-shells. Magnetohydrodynamic simulation results agree with observed ULF wave activity in the magnetotail, which leads to both fast and Alfvén modes in the magnetospheric nightside sector. The observations agree with the empirical model and are confirmed by phase space density calculations for this global recovery period

Eficiência de fungicidas para controle de manchas foliares do trigo: resultados da Rede de Ensaios Cooperativos do Trigo, safras 2020 e 2021.

Resumo – Este trabalho é o resultado da avaliação dos dados de 2 anos da rede de ensaios, realizados no Rio Grande do Sul e Paraná, com o objetivo de avaliar a efi ciência de fungicidas para o controle de manchas foliares do trigo. Foram realizados sete ensaios em 2020 e oito em 2021. Foi feita análise estatística para o conjunto de dados de cada ano. Avaliaram o controle da doença, medido por meio da quantifi cação da severidade de sintomas; o rendimento de grãos por hectare e o peso do hectolitro. Nos 2 anos do estudo, os fungicidas utilizados foram efi cientes em reduzir os sintomas da doença, chegando a uma redução de 76% em 2020 e 56,7% em 2021. Na avaliação do rendimento de grãos, em 2020 chegou-se a uma diferença de 627 kg ha-1 a mais que a testemunha sem fungicida. Em 2021 a maior diferença de rendimento de grãos foi de 590 kg ha-1. Pode-se inferir, por esses valores, que o uso de fungicidas para essas doenças pode levar a uma diferença aproximada de 10 sacos de trigo por hectare, sendo economicamente viável, considerando-se os preços de mercado do trigo atualmente