91 research outputs found
The impact of internal and external influences upon management practice adoption and strategic decision-making in growth oriented firms:an empirical investigation
Investigating the motivation for undertaking, entrepreneurship education using uncertain reasoning
The Evolution of an āIntellectual Property Pipelineā Engaging Business Angels in the commercialisation of University IP
Angels with Dirty Faces! The Potential Role of Business Angel Networks in exploiting University-Generated Intellectual Property
The Piloting of an āIntellectual Property Pipelineā engaging Business Angels in the commercialisation of University IP
Co-Occurrence and Characteristics of Patients With Axial Spondyloarthritis Who Meet Criteria for Fibromyalgia : Results From a UK National Register
The British Society for Rheumatology (BSR) Biologics Register in Ankylosing Spondylitis is funded by the BSR and they have receive funds for this from Pfizer, AbbVie and UCB. These companies receive advance copies of manuscripts and can provide comments but have no input into determining the topics for analysis, publication and no input into the work involved in this analysis. This analysis is part-funded by Arthritis Research UK (Grant No: 21378)Peer reviewedPublisher PD
A NCaRBS analysis of SME intended innovation: Learning about the Donāt Knows
This study demonstrates a novel form of business analytics, respecting the quality of the data available (allowing incompleteness in the data set), as well as engaging with the uncertainty in the considered outcome variable (inclusive of Donāt Know (DK) responses). The analysis employs the NCaRBS technique, based on the DempsterāShafer theory of evidence, to investigate the relationship between Small and Medium-sized Enterprise (SME) characteristics and whether they intended to undertake future innovation. The allowed outcome response for intended innovation was either, Yes, No and DK, all of which are considered pertinent responses in this analysis. An additional consequence of the use of the NCaRBS technique is the ability to analyse an incomplete data set, with missing values in the characteristic variables considered, without the need to manage their presence. From a soft computing perspective, this study demonstrates just how exciting the business analytics field of study can be in terms of pushing the bounds of the ability to handle real āincompleteā business data which has real, and sometimes uncertain, outcomes. Further, the findings also inform how different notions of ignorance in evidence are accounted for in such analysis
AxSpA patients who also meet criteria for fibromyalgia:Identifying distinct patient clusters using data from a UK national register (BSRBR-AS)
Background: Around 1 in 8 patients with axial spondyloarthritis (axSpA) also meet criteria for fibromyalgia and such patients have considerable unmet need. Identifying effective therapy is important but to what extent fibromyalgia-like symptoms relate to axSpA disease severity has not been established. The aim of the current analysis was to determine whether distinct clusters of axSpA patients exist and if so to determine a) whether they differ in terms of prevalence of fibromyalgia and b) the features of patients in clusters with high prevalence. Methods: The British Society for Rheumatology Biologics Register (BSRBR-AS) recruited axSpA patients from 83 centres 2012-2017. Clinical data, and information from patients was collected (including research criteria for fibromyalgia). Cluster analysis was undertaken using split samples for development and validation both in the whole population and the sub-group which met fibromyalgia criteria. Results: One thousand three hundred thirty-eight participants were included of whom 23% met research criteria for fibromyalgia. Four clusters were identified. Two exhibited very high disease activity, one which was primarily axial (n =ā347) and a smaller cluster (n =ā32) with axial and peripheral disease, and in both groups more than half of members met criteria for fibromyalgia. The remaining two clusters (n =ā437, n =ā462) had overall less severe disease however the one which showed greater disease activity and poorer quality of life had a higher proportion meeting fibromyalgia criteria (16% v. 4%). Within those meeting fibromyalgia criteria there were three clusters. The two main groups were defined by level of symptom severity with a smaller third cluster noted to have high average swollen and tender joint counts and high levels of comorbidity. Conclusions: The major feature defining clusters with a high proportion of persons meeting criteria for fibromyalgia is high axSpA disease activity although clusters with features of fibromyalgia in the absence of high disease activity also show moderately high prevalence. Management may be most successful with pharmacologic therapy to target inflammation but enhanced by the concurrent use of non-pharmacologic therapy in such patients
Cost-effectiveness of cognitive behavioural and personalised exercise interventions for reducing fatigue in inflammatory rheumatic diseases
Acknowledgements The authors would like to thank all the participants who supported this trial. We acknowledge the contribution of the Trial Steering Committee and Data Monitoring Committee, and Brian Taylor and Mark Forrest (Centre for Healthcare Randomised Trials [CHaRT], University of Aberdeen, Aberdeen, UK) for their technical assistance. Funding: This work was supported by Versus Arthritis (formerly Arthritis Research UK) grant number 21175.Peer reviewe
Training of Instrumentalists and Development of New Technologies on SOFIA
This white paper is submitted to the Astronomy and Astrophysics 2010 Decadal
Survey (Astro2010)1 Committee on the State of the Profession to emphasize the
potential of the Stratospheric Observatory for Infrared Astronomy (SOFIA) to
contribute to the training of instrumentalists and observers, and to related
technology developments. This potential goes beyond the primary mission of
SOFIA, which is to carry out unique, high priority astronomical research.
SOFIA is a Boeing 747SP aircraft with a 2.5 meter telescope. It will enable
astronomical observations anywhere, any time, and at most wavelengths between
0.3 microns and 1.6 mm not accessible from ground-based observatories. These
attributes, accruing from the mobility and flight altitude of SOFIA, guarantee
a wealth of scientific return. Its instrument teams (nine in the first
generation) and guest investigators will do suborbital astronomy in a
shirt-sleeve environment. The project will invest $10M per year in science
instrument development over a lifetime of 20 years. This, frequent flight
opportunities, and operation that enables rapid changes of science instruments
and hands-on in-flight access to the instruments, assure a unique and extensive
potential - both for training young instrumentalists and for encouraging and
deploying nascent technologies. Novel instruments covering optical, infrared,
and submillimeter bands can be developed for and tested on SOFIA by their
developers (including apprentices) for their own observations and for those of
guest observers, to validate technologies and maximize observational
effectiveness.Comment: 10 pages, no figures, White Paper for Astro 2010 Survey Committee on
State of the Professio
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