Tourist experiences of individuals with vision impairments

People with visual disabilities Travel Australia. Tourism Research Australia

National Trends Reflected in Changing Ohio Swine Industry

ESO-2344 marked "ESO-2234" on title page.A long term decline in comparative importance of Ohio farm income from livestock compared to crops is part of larger regional and national changes in both the location and organization of livestock production. These developments appear to suggest continuing declines in the comparative importance of animal agriculture (compared to crops) in Ohio, Yet the Northeast census region contains 20 percent of the meat consuming (but non-producing) U.S. population, a market that states like North Carolina hasten to supply. Does this market potential justify collective efforts in Ohio to reverse long term industry trends

Revisiting Educational Policies and Priorities in Commonwealth Small States

The article can be viewed at: http://www.cedol.org/wp-content/uploads/2012/02/Michael-Crossley-article.pd

Revisiting Educational Policies and Priorities in Commonwealth Small States

The article can be viewed at: http://www.cedol.org/wp-content/uploads/2012/02/Michael-Crossley-article.pd

771-3 Direct Characterization of F1ecalnide Binding Rates from Use-Dependent Conduction Delay In Canine Purkinje Fibers

To quantitatively characterize flecainide-induced channel blockade from usedependent conduction delay (CD), 12 canine purkinje fibers were studied using a dual microelectrode technique. During 60 sec of pacing at interstimulus intervals (ISI) of 1.25–0.4 sec with 2μM flecainide (FLEC), incremental CD followed a monoexponential time course, the rates of which were linearly related to the interpulse recovery interval (tr=ISI — action potential duration). Steady state block was an exponential function of the recovery rates. Use-dependent block derived from incremental CD and decremental squared conduction velocity (θ2) was characterized by the forward (k) and reverse (I) rate constants for the activated (a) and resting (r) states:ka (× 106) (mol-1 s-1)la (s-1)kr (× 102) (mol-1 s-1)Ir (s-1)CD7.0±2.612.0±4.40.6±1.74.01±1.63θ210.0±3.414.7±2.52.8±5.73.66±1.40Vmax(prox)6.8±2.315.9±5.05.1±10.34.22±1.11These rates reflect marked open state Na+ channel block and closed channel trapping at resting membrane potentials with FLEC. The addition of 1μM isoproterenol (ISO) to FLEC-superfused fibers reversed the FLEC-induced reduction of θ2 from 1.79±0.7 to 1.89±0.89 (m/s)2 (p=0.017) without changing V˙max. The rate constants for FLEC binding and unbinding were not altered by ISO. Thus FLEC's apparent binding rates can be quantified from its use-{jependent effects on conduction. Both ISO's selective reversal of FLEC effect on θ2 but not V˙max and the absence of changes in the rate constants suggest that the modulation of FLEC effect is due to an alteration in passive membrane properties. These characterizations will facilitate subsequent comparisons of FLEC interactions in pathologic and hyperadrenergic states in vivo