DRUMMING AUSPICIOUSNESS THE PAKHĀVAJ OF NATHDWARA AND THE CULT OF THE KING-GOD

The pakhāvaj occupies a unique position in the classical music scene of contemporary India. Identified with the ancient mṛdaṅga and associated with kings and gods, played in the Hindustani tradition of the court dhrupad and in the temple music of various sects, it is the most respected of the Indian drums by musicians as well as the most authoritative, according to textual sources; it is an auspicious drum and multiple origin myths explain its creation; its repertoire includes compositions which musicians connect to literature in Sanskrit or vernacular languages and to prayer. Notwithstanding its relevance in Indian music, there are no specific studies on the pakhāvaj and above all about its language, repertoire, and its unique position connecting sacred and secular music. This dissertation fills the gap with a study of the pakhāvaj of Nathdwara, its history, aesthetics and repertoire. Furthermore, joining ethnographic, historical, religious and iconographic perspectives, it provides a multifaceted interpretation of the role and function of the pakhāvaj in royal courts, temples and contemporary stages, and the first analysis of the visual and narrative contents of its repertoire. It also contributes to the understanding of the language, idea and role of drums and drumming in Indian court and temple music, and their relationship over the last two millennia

Bodies of Silence, Floods of Nectar: Ritual Music in Contemporary Brahmanical Tantric Temples of Kerala

The Tantric concept of sound (nāda) as universal life-force has seen worldwide diffusion over the last few decades but such a fame does not reflect academic interest in the impact of Tantra on music. Indeed, while a number of essays have been written to demonstrate the contribution of Tantrism to the evolution of Indian religions and culture, its contribution to music has been left largely unexplored. The word Tantra refers to a pan-Asian religious phenomenon spread over numerous centuries and including a wide number of sects having different and even opposite philosophical and theological approaches which may be addressed from the perspective of the concept of the body. In fact, the divinization of the body or the understanding of the human body as the major Tantric metaphor of the cosmos and its processes is the most important uniting factor of such diversity. The tradition of Brahmanical temple Tantrism practiced in contemporary Kerala, with its own map of the body, interior practices and rituals including music, helps an understanding of the concepts and ideas embedded in Tantric ritual practices and musical forms. It adopts the human body as the model for temple architecture and also for musical forms and intends the ritual activity as a re-enactment of the process of enlightenment. By adopting a multidimensional approach including ethnography, musical analysis and textual sources, this article studies how ritual music is structured and attributed meaning in the Brahmanical temple Tantric tradition of contemporary Kerala. It reconstructs a narration behind the contemporary ritual procedure associated with the pouring of water and other substances (abhiṣeka) on the icon of the deity and argues that the ideas embedded in compositional forms mirror and complement such narration

Tight temporal coupling between synaptic rewiring of olfactory glomeruli and the emergence of odor-guided behavior in Xenopus tadpoles

Olfactory sensory neurons (OSNs) are chemoreceptors that establish excitatory synapses within glomeruli of the olfactory bulb. OSNs undergo continuous turnover throughout life, causing the constant replacement of their synaptic contacts. Using Xenopus tadpoles as an experimental system to investigate rewiring of glomerular connectivity, we show that novel OSN synapses can transfer information immediately after formation, mediating olfactory-guided behavior. Tadpoles recover the ability to detect amino acids 4 days after bilateral olfactory nerve transection. Restoration of olfactory-guided behavior depends on the efficient reinsertion of OSNs to the olfactory bulb. Presynaptic terminals of incipient synaptic contacts generate calcium transients in response to odors, triggering long lasting depolarization of olfactory glomeruli. The functionality of reconnected terminals relies on well-defined readily releasable and cytoplasmic vesicle pools. The continuous growth of non-compartmentalized axonal processes provides a vesicle reservoir to nascent release sites, which contrasts to the gradual development of cytoplasmic vesicle pools in conventional excitatory synapses. The immediate availability of fully functional synapses upon formation supports an age-independent contribution of OSNs to the generation of odor maps

Analytical Approaches to Music of South Asia, Volume 1 (2023)

Contents: 1. Editors’ Introduction to the AAMSA journal 2. A Novel Generative Paradigm for Carnatic Rhythmic Composition Jagdish A. Krishnaswamy and Robert Wells 3. The Musical Journeys of a Goddess Paolo Pacciolla 4. Suḷādi Songs of Haridāsa Composers Arati Ra

Functional Evaluation of Olfactory Pathways in Living Xenopus Tadpoles

Xenopus tadpoles offer a unique platform to investigate the function of the nervous system. They provide multiple experimental advantages, such as accessibility to numerous imaging approaches, electrophysiological techniques and behavioral assays. The Xenopus tadpole olfactory system is particularly well suited to investigate the function of synapses established during normal development or reformed after injury. Here, we describe methodologies to evaluate the processing of olfactory information in living Xenopus larvae. We outline a combination of in vivo measurements of presynaptic calcium responses in glomeruli of the olfactory bulb with olfactory-guided behavior assays. Methods can be combined with the transection of olfactory nerves to study the rewiring of synaptic connectivity. Experiments are presented using both wild-type and genetically modified animals expressing GFP reporters in central nervous system cells. Application of the approaches described to genetically modified tadpoles can be useful for unraveling the molecular bases that define vertebrate behavior

Tight temporal coupling between synaptic rewiring of olfactory glomeruli and the emergence of odor-guided behavior in Xenopus tadpoles

Olfactory sensory neurons (OSNs) are chemoreceptors that establish excitatory synapses within glomeruli of the olfactory bulb. OSNs undergo continuous turnover throughout life, causing the constant replacement of their synaptic contacts. Using Xenopus tadpoles as an experimental system to investigate rewiring of glomerular connectivity, we show that novel OSN synapses can transfer information immediately after formation, mediating olfactory-guided behavior. Tadpoles recover the ability to detect amino acids 4 days after bilateral olfactory nerve transection. Restoration of olfactory-guided behavior depends on the efficient reinsertion of OSNs to the olfactory bulb. Presynaptic terminals of incipient synaptic contacts generate calcium transients in response to odors, triggering long lasting depolarization of olfactory glomeruli. The functionality of reconnected terminals relies on well-defined readily releasable and cytoplasmic vesicle pools. The continuous growth of non-compartmentalized axonal processes provides a vesicle reservoir to nascent release sites, which contrasts to the gradual development of cytoplasmic vesicle pools in conventional excitatory synapses. The immediate availability of fully functional synapses upon formation supports an age-independent contribution of OSNs to the generation of odor maps

Tight temporal coupling between synaptic rewiring of olfactory glomeruli and the emergence of odor-guided behavior in Xenopus tadpoles

Olfactory sensory neurons (OSNs) are chemoreceptors that establish excitatory synapses within glomeruli of the olfactory bulb. OSNs undergo continuous turnover throughout life, causing the constant replacement of their synaptic contacts. Using Xenopus tadpoles as an experimental system to investigate rewiring of glomerular connectivity, we show that novel OSN synapses can transfer information immediately after formation, mediating olfactory-guided behavior. Tadpoles recover the ability to detect amino acids 4 days after bilateral olfactory nerve transection. Restoration of olfactory-guided behavior depends on the efficient reinsertion of OSNs to the olfactory bulb. Presynaptic terminals of incipient synaptic contacts generate calcium transients in response to odors, triggering long lasting depolarization of olfactory glomeruli. The functionality of reconnected terminals relies on well-defined readily releasable and cytoplasmic vesicle pools. The continuous growth of non-compartmentalized axonal processes provides a vesicle reservoir to nascent release sites, which contrasts to the gradual development of cytoplasmic vesicle pools in conventional excitatory synapses. The immediate availability of fully functional synapses upon formation supports an age-independent contribution of OSNs to the generation of odor maps

The combination of high-sensitivity cardiac troponin T (hs-cTnT) at presentation and changes in N-terminal natriuretic peptide type B (NT-proBNP) after chemotherapy best predicts survival in AL amyloidosis

In light-chain (AL) amyloidosis, prognosis is dictated by cardiac dysfunction. N-terminal natriuretic peptide type B (NT-proBNP) and cardiac troponins (cTn) are used to assess the severity of cardiac damage. We evaluated the prognostic relevance of a high-sensitivity (hs) cTnT assay, NT-proBNP, and cardiac troponin I in 171 consecutive patients with AL amyloidosis at presentation and 6 months after treatment. Response and progression of NT-proBNP were defined as more than 30% and more than 300 ng/L changes. All 3 markers predicted survival, but the best multivariable model included hs-cTnT. The hs-cTnT prognostic cutoff was 77 ng/L (median survival 10.6 months for patients with hs-cTnT above the cutoff). After treatment, response and progression of NT-proBNP and a more than 75% increase of hs-cTnT were independent prognostic determinant. In AL amyloidosis, hs-cTnT is the best baseline prognostic marker. Therapy should be aimed at preventing progression of cardiac biomarkers, whereas NT-proBNP response confers an additional survival benefit

A multi-element psychosocial intervention for early psychosis (GET UP PIANO TRIAL) conducted in a catchment area of 10 million inhabitants: study protocol for a pragmatic cluster randomized controlled trial

Multi-element interventions for first-episode psychosis (FEP) are promising, but have mostly been conducted in non-epidemiologically representative samples, thereby raising the risk of underestimating the complexities involved in treating FEP in 'real-world' services