Compressive Fracture Behavior and Acoustic Emission Characteristics of Sandstone under Constant Crack Water Pressure

Engineering rock containing flaws or defects under a large water source is frequently subject to the couple influence of constant crack water pressure and geostress. To investigate the fracture behavior of precracked rock under hydromechanical coupling with constant crack water pressure, compression tests were conducted on red sandstone specimens containing a single crack of different angles using a device to realize the constant crack water pressure during loading, and the failure process of rock specimens was monitored by acoustic emission (AE) technique. The results show that the presence of constant crack water pressure has a significant promotion effect on the development of shear wing cracks, and the promotion effect is influenced by the prefabricated crack angle and water pressure. As the constant crack water pressure increases, the failure mode of the 0° precrack specimen changes from “X”- shear failure to the single oblique shear failure along the shear wing crack direction, the main failure crack of the inclined precracked specimens (precrack angles of 15°, 45°, and 60°) changes from a small acute angle with the prefabricated crack to a direction along the shear wing crack, and irregular cracks occur at the chipped prefabricated crack in the 90° precracked specimen. With an increase in the constant crack water pressure, the average energy for a single hit, cumulative AE energy, and cumulative AE hits decrease, and the proportion of the tensile cracks increases and that of the shear cracks decreases

Prediction of Stope Stability Using Variable Weight and Unascertained Measurement Technique

A new model is established to analyze mining stope stability, using variable weight theory to calculate the index weight for each factor in different stopes and unascertained measure evaluation technique to predict the risk grade of stope stability. In this model, an evaluation index system by virtue of the 7 most important factors is established, including rock saturated uniaxial compressive strength, rock quality designation, rock joint and fissure, stope span, condition of pillar, groundwater seepage volume, and rate of supporting pit roof. And each index is divided into 5 grades by assignment value and the classification method of standardization. Accordingly, the analysis result is also classified into 5 risk grades. This model is used for the 6 main stopes from the -270 m section in Xin-Qiao Mine, China. The results, giving risk grade for each stope and guiding the use of corresponding measures, avoided the problem of state out of balance caused by conventional invariable weight theory models and have ensured no accident occurred in mining production in recent years. This model can be used in other mines widely, by assigning values for the 7 factors on basis of current in situ cases

Rechallenge of immune checkpoint inhibitors in advanced non‐small cell lung cancer

Abstract Immune checkpoint inhibitor (ICI) rechallenge in non‐small cell lung cancer (NSCLC) is a promising therapeutic strategy. The situation for ICI rechallenge can be divided into three categories: adverse events (AEs); resistance to ICIs, and rechallenge becomes compulsive because of tumor relapse while the patients had completed a 2 year course of immunotherapy. However, these categories are still controversial and should be explored further. Through voting at the 6th Straits Summit Forum on Lung Cancer, in this study we summarize the consensus of 147 experts in ICI rechallenges. A total of 97.74% experts agreed to rechallenge; 48.87% experts rechallenge with the original drug, and the others rechallenge with a different drug; 40.3% agreed to rechallenge directly after progression; 88.06% experts agreed to ICI rechallenge with a combination regimen; and factors such as previous performance status score, PD‐1 expression, and age should also be considered. Understanding the the clinical studies in ICI rechallenge could bring us one step closer to understanding the consensus. In patients with advanced NSCLC who have suffered recurrent or distant metastasis after immunotherapy, the option of rechallenge with ICIs is a promising treatment option

Expert consensus on the diagnosis and treatment of RET gene fusion non‐small cell lung cancer in China

Abstract The rearranged during transfection (RET) gene is one of the receptor tyrosine kinases and cell‐surface molecules responsible for transmitting signals that regulate cell growth and differentiation. In non‐small cell lung cancer (NSCLC), RET fusion is a rare driver gene alteration associated with a poor prognosis. Fortunately, two selective RET inhibitors (sRETi), namely pralsetinib and selpercatinib, have been approved for treating RET fusion NSCLC due to their remarkable efficacy and safety profiles. These inhibitors have shown the ability to overcome resistance to multikinase inhibitors (MKIs). Furthermore, ongoing clinical trials are investigating several second‐generation sRETis that are specifically designed to target solvent front mutations, which pose a challenge for first‐generation sRETis. The effective screening of patients is the first crucial step in the clinical application of RET‐targeted therapy. Currently, four methods are widely used for detecting gene rearrangements: next‐generation sequencing (NGS), reverse transcription‐polymerase chain reaction (RT‐PCR), fluorescence in situ hybridization (FISH), and immunohistochemistry (IHC). Each of these methods has its advantages and limitations. To streamline the clinical workflow and improve diagnostic and treatment strategies for RET fusion NSCLC, our expert group has reached a consensus. Our objective is to maximize the clinical benefit for patients and promote standardized approaches to RET fusion screening and therapy