Potencial frutífero de algumas espécies frutíferas nativas dos cerrados.

A presença de espécies com potencial econômico frutífero na região dos Cerrados e de relevante destaque. Alguns autores inclusive já mostraram a relativa importância e o grande potencial para uso no melhoramento genético de espécies comerciais. Este trabalho aborda descrições botânicas, nomes vulgares, distribuição ecológica e geográfica, de 12 espécies nativas de Cerrado que possuem potencial frutífero. Também são discutidas outras possibilidades de uso e problemas para um aproveitamento comercial. Entre estas espécies destacam-se Anacardium humile, A. nanum, A. othonianum (caju) Annona crassiflora (araticum), Annas ananasoides, (abacaxi do cerrado), Caryocar brasilienses, (pequi), Eugenia dysenterica (cagaita), Hancornia pubescens (mangaba), Mauritia vinifera (buriti) entre outras

A case-control study of CYP2E1 (PstI) and CYP1A1 (MspI) polymorphisms in colorectal cancer

ABSTRACT. Polymorphisms in genes encoding P450 cytochrome enzymes may increase the risk of sporadic colorectal cancer (SCRC). Here we investigated the association between SCRC and CYP2E1 (PstI) and CYP1A1 (MspI) polymorphisms in a case-control study. Moreover, we sought to determine any possible associations between this disease and the sociodemographic factors. We included 273 individuals (74 patients and 199 controls); the gender, age, tobacco usage, and alcohol consumption of the included subjects, and the clinico-histopathological parameters of the tumors, were analyzed. Molecular analyses were performed using PCR-RFLP. The effect of polymorphisms on SCRC development, and the association between this disease and sociodemographic factors were determined by multiple-logistic regression analyses. The combined genotype was also evaluated. Statistically significant differences between the patients and controls regarding the male gender (odds ratio, OR = 0.19, 95% confidence interval, CI = 0.08-0.46; P ≤ 0.05) and age ≥44 years (median = 44; OR = 96.84, 95%CI = 21.78-430.49; P ≤ 0.05) were observed. The evaluated polymorphisms were not associated with SCRC (PstI-CYP2E1: OR = 0.93, 95%CI = 0.30-2.85; P = 0.897; MspI-CYP1A1: OR = 0.75, 95%CI = 0.35-1.61; P = 0.463); the combined genotypes were not associated with the risk of disease. Thus, individuals aged ≥44 years are more sensitive to SCRC, while men are less susceptible. Additionally, polymorphisms in CYP2E1 (PstI) and CYP1A1 (MspI) were not associated with SCRC in the evaluated Brazilian population

HIV-1-Transmitted Drug Resistance and Transmission Clusters in Newly Diagnosed Patients in Portugal Between 2014 and 2019

Objective: To describe and analyze transmitted drug resistance (TDR) between 2014 and 2019 in newly infected patients with HIV-1 in Portugal and to characterize its transmission networks. Methods: Clinical, socioepidemiological, and risk behavior data were collected from 820 newly diagnosed patients in Portugal between September 2014 and December 2019. The sequences obtained from drug resistance testing were used for subtyping, TDR determination, and transmission cluster (TC) analyses. Results: In Portugal, the overall prevalence of TDR between 2014 and 2019 was 11.0%. TDR presented a decreasing trend from 16.7% in 2014 to 9.2% in 2016 (p for-trend = 0.114). Multivariate analysis indicated that TDR was significantly associated with transmission route (MSM presented a lower probability of presenting TDR when compared to heterosexual contact) and with subtype (subtype C presented significantly more TDR when compared to subtype B). TC analysis corroborated that the heterosexual risk group presented a higher proportion of TDR in TCs when compared to MSMs. Among subtype A1, TDR reached 16.6% in heterosexuals, followed by 14.2% in patients infected with subtype B and 9.4% in patients infected with subtype G. Conclusion: Our molecular epidemiology approach indicates that the HIV-1 epidemic in Portugal is changing among risk group populations, with heterosexuals showing increasing levels of HIV-1 transmission and TDR. Prevention measures for this subpopulation should be reinforced.info:eu-repo/semantics/publishedVersio

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.

Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 nondiabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identified 16 loci associated with fasting glucose and HOMA-B and two loci associated with fasting insulin and HOMA-IR. These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1). We also demonstrated association of ADCY5, PROX1, GCK, GCKR and DGKB-TMEM195 with type 2 diabetes. Within these loci, likely biological candidate genes influence signal transduction, cell proliferation, development, glucose-sensing and circadian regulation. Our results demonstrate that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes

Labor, trabalho e ação: elementos pertinentes aos conceitos arendtianos em relatos autobiográficos de trabalhadores do setor de transportes

A reflexão, junto à classe trabalhadora, sobre questões relacionadas à saúde no ambiente de trabalho, visando à criticidade e às ações que resultem no enfrentamento de seus problemas é um importante instrumento de mudança da realidade. O objetivo desta pesquisa exploratória é identificar elementos pertinentes aos conceitos arendtianos (labor, trabalho e ação) presentes no discurso de trabalhadores do setor de transportes participantes de um projeto de extensão universitária. A abordagem é qualitativa e a metodologia consiste em relato autobiográfico. As histórias dos trabalhadores foram gravadas em DVD e posteriormente transcritas. Para a análise, optou-se pela definição de categorias a priori (labor, trabalho e ação), uma vez que o marco teórico era a obra de Hannah Arendt. Como resultado, foram encontrados: insegurança alimentar, doenças crônicas não transmissíveis relacionadas ao conceito de labor; riscos ergonômicos e distúrbios psíquicos relacionados ao trabalho; e participação coletiva e inclusão digital como elementos da ação. Concluiu-se que conhecer, compreender e discutir essas três categorias para o incremento da reflexão acerca da saúde do trabalhador pode ser importante, uma vez que todas elas foram expressas nos relatos de vida, mostrando sua permanência e relevância na história de todos e de cada um

The national inventory of geological heritage: methodological approach and results

A existência de um inventário nacional de património geológico é fundamental para se poderem implementar estratégias de geoconservação. Este trabalho apresenta a metodologia usada no desenvolvimento do mais completo inventário de geossítios, realizado até ao momento em Portugal, assim como os principais resultados obtidos. O inventário vai integrar o Sistema de Informação do Património Natural e o Cadastro Nacional dos Valores Naturais Classificados, ambos geridos pelo Instituto de Conservação da Natureza e da Biodiversidade.The existence of a national inventory of the geological heritage is of paramount importance for the implementation of a geoconservation strategy. This paper presents the methodological approach used to produce the most complete geosites inventory in Portugal, so far, and the obtained results. This inventory will be uploaded into the National Database of Natural Heritage managed by the Portuguese authority for nature conservation.Este trabalho é apoiado pela Fundação para a Ciência e a Tecnologia, através do financiamento plurianual do CGUP e do projecto de investigação “Identificação, caracterização e conservação do património geológico: uma estratégia de geoconservação para Portugal” (PTDC/CTE-GEX/64966/2006).info:eu-repo/semantics/publishedVersio

Biomassa sustentável de juvenis de pirarucu em tanques-rede de pequeno volume

The objective of this work was to estimate the sustainable biomass of pirarucu Arapaima gigas (Cuvier, 1829) juveniles kept in small volume net cages. During 200 days four 1-m3 net cages were stocked with 21 fish/cage and had an initial total biomass of 0.84±0.14 kg (21 fish/cage). The net cages were placed in a 50-m2 pond with constant water flow. Conditioning factor, feed conversion, specific growth rate and gain showed that the sustainable biomass of pirarucu juveniles for intensive rearing in 1-m 3 net cages was approximately 29 kg. Fish length at the end of the trial, in relation to the reduced net cage space, was a limiting factor to obtain good biological indices