283 research outputs found
Some remarks on the hyperelliptic moduli of genus 3
In 1967, Shioda \cite{Shi1} determined the ring of invariants of binary
octavics and their syzygies using the symbolic method. We discover that the
syzygies determined in \cite{Shi1} are incorrect. In this paper, we compute the
correct equations among the invariants of the binary octavics and give
necessary and sufficient conditions for two genus 3 hyperelliptic curves to be
isomorphic over an algebraically closed field , . For
the first time, an explicit equation of the hyperelliptic moduli for genus 3 is
computed in terms of absolute invariants.Comment: arXiv admin note: text overlap with arXiv:1209.044
Herpes zoster vaccination in the elderly subjects: improving awareness and uptake
Armando Stefanati, Nicoletta Valente, Silvia Lupi, Sara Previato, Matilde Giordani, Giovanni Gabutti Department of Medical Sciences, University of Ferrara, Ferrara, Italy Abstract: Herpes zoster (HZ) is a common disease in adults and older subjects solely related to the reactivation of latent varicella zoster virus in ganglia. The incidence of the disease increases with aging and the decline of varicella zoster virus-specific cell-mediated immunity. HZ has a significant impact on the quality of life of subjects during the acute phase. Besides, pain can persist even for a long time becoming chronic. The chronic pain following HZ is called postherpetic neuralgia, and it is a debilitating long-lasting condition, characterized by metameric pain, allodynia, and hyperalgesia. Therapeutic options against HZ and postherpetic neuralgia are often suboptimal and the impact of the disease and its complications on daily living activities is significant, especially in older subjects. Nowadays, a preventive approach to the disease is possible; as a matter of fact, a high-antigen content live vaccine is available. This vaccine has a good profile in terms of immunogenicity, efficacy, effectiveness, and safety and its use may prevent both HZ and postherpetic neuralgia. Nevertheless, the evaluation of the issues raised in countries that introduced this immunization show that both provider and patient barriers could have prevented a more robust uptake of HZ vaccination. In the USA, HZ immunization storage was expensive, reimbursement was cumbersome, and supply shortages may have limited promotion by the interests of the manufacturer and provider. The doctors did not actively recommend HZ vaccination; on the other hand, subjects were mostly unaware of the HZ vaccine. Several demographic factors, including sex and educational level, could have negatively affected the coverage rates; besides, the clinicians who treat adults focus less on vaccination than those taking care of children. On the other hand, when health care professionals undertook every effort to maximize the uptake of the shingles vaccine (eg, in the UK), the vaccine coverage rate increased very quickly. Keywords: herpes zoster, postherpetic neuralgia, vaccin
Avaliação de diferentes métodos de colheita de embriões bovinos.
Edição dos resumos da 20. Reunião Anual da Sociedade Brasileira de Tecnologia de Embriões, Araxá, MG, agosto 2006
Trypanosoma cruzi Adjuvants Potentiate T Cell-Mediated Immunity Induced by a NY-ESO-1 Based Antitumor Vaccine
Immunological adjuvants that induce T cell-mediate immunity (TCMI) with the least side effects are needed for the development of human vaccines. Glycoinositolphospholipids (GIPL) and CpGs oligodeoxynucleotides (CpG ODNs) derived from the protozoa parasite Trypanosoma cruzi induce potent pro-inflammatory reaction through activation of Toll-Like Receptor (TLR)4 and TLR9, respectively. Here, using mouse models, we tested the T. cruzi derived TLR agonists as immunological adjuvants in an antitumor vaccine. For comparison, we used well-established TLR agonists, such as the bacterial derived monophosphoryl lipid A (MPL), lipopeptide (Pam3Cys), and CpG ODN. All tested TLR agonists were comparable to induce antibody responses, whereas significant differences were noticed in their ability to elicit CD4+ T and CD8+ T cell responses. In particular, both GIPLs (GTH, and GY) and CpG ODNs (B344, B297 and B128) derived from T. cruzi elicited interferon-gamma (IFN-γ) production by CD4+ T cells. On the other hand, the parasite derived CpG ODNs, but not GIPLs, elicited a potent IFN-γ response by CD8+ T lymphocytes. The side effects were also evaluated by local pain (hypernociception). The intensity of hypernociception induced by vaccination was alleviated by administration of an analgesic drug without affecting protective immunity. Finally, the level of protective immunity against the NY-ESO-1 expressing melanoma was associated with the magnitude of both CD4+ T and CD8+ T cell responses elicited by a specific immunological adjuvant
Akns Hierarchy, Self-Similarity, String Equations and the Grassmannian
In this paper the Galilean, scaling and translational self--similarity
conditions for the AKNS hierarchy are analysed geometrically in terms of the
infinite dimensional Grassmannian. The string equations found recently by
non--scaling limit analysis of the one--matrix model are shown to correspond to
the Galilean self--similarity condition for this hierarchy. We describe, in
terms of the initial data for the zero--curvature 1--form of the AKNS
hierarchy, the moduli space of these self--similar solutions in the Sato
Grassmannian. As a byproduct we characterize the points in the Segal--Wilson
Grassmannian corresponding to the Sachs rational solutions of the AKNS equation
and to the Nakamura--Hirota rational solutions of the NLS equation. An explicit
1--parameter family of Galilean self--similar solutions of the AKNS equation
and the associated solution to the NLS equation is determined.Comment: 25 pages in AMS-LaTe
On Separation of Variables for Integrable Equations of Soliton Type
We propose a general scheme for separation of variables in the integrable
Hamiltonian systems on orbits of the loop algebra
. In
particular, we illustrate the scheme by application to modified Korteweg--de
Vries (MKdV), sin(sinh)-Gordon, nonlinear Schr\"odinger, and Heisenberg
magnetic equations.Comment: 22 page
Closed geodesics and billiards on quadrics related to elliptic KdV solutions
We consider algebraic geometrical properties of the integrable billiard on a
quadric Q with elastic impacts along another quadric confocal to Q. These
properties are in sharp contrast with those of the ellipsoidal Birkhoff
billiards. Namely, generic complex invariant manifolds are not Abelian
varieties, and the billiard map is no more algebraic. A Poncelet-like theorem
for such system is known. We give explicit sufficient conditions both for
closed geodesics and periodic billiard orbits on Q and discuss their relation
with the elliptic KdV solutions and elliptic Calogero systemComment: 23 pages, Latex, 1 figure Postscrip
Wave Solutions of Evolution Equations and Hamiltonian Flows on Nonlinear Subvarieties of Generalized Jacobians
The algebraic-geometric approach is extended to study solutions of
N-component systems associated with the energy dependent Schrodinger operators
having potentials with poles in the spectral parameter, in connection with
Hamiltonian flows on nonlinear subvariaties of Jacobi varieties. The systems
under study include the shallow water equation and Dym type equation. The
classes of solutions are described in terms of theta-functions and their
singular limits by using new parameterizations. A qualitative description of
real valued solutions is provided
Expanding the knowledge of the chemical structure of glycoconjugates from Trypanosoma cruzi TcI genotype. Contribution to taxonomic studies
The resultant on compact Riemann surfaces
We introduce a notion of resultant of two meromorphic functions on a compact
Riemann surface and demonstrate its usefulness in several respects. For
example, we exhibit several integral formulas for the resultant, relate it to
potential theory and give explicit formulas for the algebraic dependence
between two meromorphic functions on a compact Riemann surface. As a particular
application, the exponential transform of a quadrature domain in the complex
plane is expressed in terms of the resultant of two meromorphic functions on
the Schottky double of the domain.Comment: 44 page
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