STRATEGIC CONTROLLING IN ROMANIA-SUPPORT OF MANAGERIAL DECISIONS

This paper introduces theoretical matters concerning the strategic controlling procedure as well as economical practice elements up to corporate group branch. Especially by its concurrence to strategically scheduling and its add to strategically feed forward and feedback process, the strategically controlling supports the composition of managerial decisions on strategic level.controlling, decision, management.

Septic processes in colonic surgery

USMF “Carol Davila”, Clinica Chirurgie, Spitalul Clinic de Urgență “Bagdasar-Arseni”, Bucureşti, Serviciul de laborator, Spitalul “Bagdasar Arseni”, București, Catedra Informatică, Facultatea de Medicină, București, Al XI-lea Congres al Asociației Chirurgilor „Nicolae Anestiadi” din Republica Moldova și cea de-a XXXIII-a Reuniune a Chirurgilor din Moldova „Iacomi-Răzeșu” 27-30 septembrie 2011Introducere: În studiul prospectiv a 174 pacienți cu media vârstei de 64,3 ani (limite:19-84 ani) au fost operați pentru afecțiuni chirurgicale ale colonului. Material și metoda: Pentru cancer au fost operați 111(63,79%) pacienți: stadiul clinic II(n = 29;27,3%) și stadiul IV(n = 54;31,03 %). Rezultate: S-a intervenit în urgență la 45(25,86%) pacienți pentru semne clinice ale proceselor septice intraperitoneale (n = 15;13,51%) și pentru sindroame ocluzive (n = 30; 27,02%) dintre care ocluzii intestinale (n = 12;19,04%) în patologia netumorală. Pentru afecțiuni netumorale au fost operați 63(36,21%) pacienți pentru: diverticulita colică (n = = 24;13,79%), polipi colici (n = 20;11,60%), volvulus sigmoid (n = 11;6,32 %), rectocolită ulcerohemoragică și purulentă (n=5;2,29%), boala Crohn (n=3;1,72%). Complicațiile postoperatorii au fost reprezentate de manifestările locale și generale ale proceselor septice intraperitoneale (n = 30;17,24%) și complicațiile septice parietale (n=27%;15,81%). Complicațiile postoperatorii mai frecvente în prima săptămână postoperator: hidroelectrolitice (66,66%), a patra decadă postoperator: septice. Au fost efectuate operații în urgență (n=74;44,2%). Operațiile radicale-11,36%. Prezența preoperatorie a sindromului raspunsului inflamator sistemic și evoluția sa postoperatorie a condus la declansarea sindromului de insuficiență multiplă a organelor, factor de predicție a letalitații postoperatorii (p<0,001). S-au înregistrat 37(21,22%) decese postoperatorii. Dezunirea liniei de anastomoza s-a soldat cu mortalitatea de 100 %. Concluzii: Complicațiile septice în chirurgia colonului au valoare predictivă pozitivă de 60 % în producerea deceselor postoperatorii.Introduction: In a prospective study of 174 patients with mean age of 64.3 years (range:19-84 years) were operated for surgical diseases of the colon.Material and methods: For cancer were operated 111(63.79%) patients: clinical stage II (n = 29,27.3%), IV (n = 54,31.03%).Results: We operated in emergency 45(25.86%) patients for clinical signs of intraperitoneal septic processes (n = 15,13.51%) and occlusive syndromes (n = 30,27.02%) from which intestinal occlusion (n = 12,19.04%) with nontumoral pathology. For nontumoral diseases were operated 63(36.21%) patients for: colic diverticulosis (n = 24, 13.79%), colic polyps (n = 20,11.60%), sigmoid volvulus (n = 11,6.32%), ulcerative ulcerohemorrhagic colitis and purulent (n = 5,2.29%), Crohn’s disease (n = 3,1.72%). Postoperative complications were represented by local and general manifestations of septic processes intraperitoneal (n = 30,17.24%) and parietal septic complications (n = 27%, 15.81%).More frequent postoperative complications in the first week after surgery: electrolytes disorders (66.66% ), the fourth decade after surgery: septic complications. Emergency surgery: n = 74,44.2%;11,36% radical operations. This preoperative systemic inflammatory response syndrome and postoperative evolution led to the outbreak of the syndrome multiple organ failure, a predictor of postoperative lethality (p < 0.001). There were 37(21.22%) postoperative deaths. Dehiscence of anastomosis line resulted in 100% mortality.Conclusions: Septic complications of colon surgery were 60% positive predictive value in producing postoperative deaths

Influence of APOE and RNF219 on Behavioral and Cognitive Features of Female Patients Affected by Mild Cognitive Impairment or Alzheimer's Disease.

The risk for Alzheimer's disease (AD) is associated with the presence of the ?4 allele of Apolipoprotein E (APOE) gene and, recently, with a novel genetic variant of the RNF219 gene. This study aimed at evaluating interactions between APOE-?4 and RNF219/G variants in the modulation of behavioral and cognitive features of two cohorts of patients suffering from mild cognitive impairment (MCI) or AD. We enrolled a total of 173 female MCI or AD patients (83 MCI; 90 AD). Subjects were screened with a comprehensive set of neuropsychological evaluations and genotyped for the APOE and RNF219 polymorphic variants. Analysis of covariance was performed to assess the main and interaction effects of APOE and RNF219 genotypes on the cognitive and behavioral scores. The analysis revealed that the simultaneous presence of APOE-?4 and RNF219/G variants results in significant effects on specific neuropsychiatric scores in MCI and AD patients. In MCI patients, RNF219 and APOE variants worked together to impact the levels of anxiety negatively. Similarly, in AD patients, the RNF219 variants were found to be associated with increased anxiety levels. Our data indicate a novel synergistic activity APOE and RNF219 in the modulation of behavioral traits of female MCI and AD patients

Functionality of special beer processes and potential health benefits

ReviewConsumers’ demand for functional fermented food that can fulfill nutritional needs and help maintain a balanced diet while also having a positive impact on one’s health status is increasing all over the world. Thus, healthy choices could include beverages with nutrients and bioactive compounds which can be used as an effective disease-prevention strategy. Regular beer has certain health benefits which inspire further research with the prospect of obtaining special functional beers with little or no alcohol content. As observed, the special beer market remains highly dynamic and is predicted to expand even further. Therefore, brewers need to keep up with the consumers’ interests and needs while designing special beers, namely nonalcoholic beers (NABs), low-alcohol beers (LABs), and craft beers (CBs). Thus, understanding the potential uses of bioactive compounds in special beer, the wide range of therapeutic effects, and the possible mechanisms of action is essential for developing healthier beverages. This review aimed to evaluate the nutritional features of special beers, and their proven or potential beneficial actions on one’s health status and in preventing certain diseasesinfo:eu-repo/semantics/publishedVersio

A framework for human microbiome research

A variety of microbial communities and their genes (the microbiome) exist throughout the human body, with fundamental roles in human health and disease. The National Institutes of Health (NIH)-funded Human Microbiome Project Consortium has established a population-scale framework to develop metagenomic protocols, resulting in a broad range of quality-controlled resources and data including standardized methods for creating, processing and interpreting distinct types of high-throughput metagenomic data available to the scientific community. Here we present resources from a population of 242 healthy adults sampled at 15 or 18 body sites up to three times, which have generated 5,177 microbial taxonomic profiles from 16S ribosomal RNA genes and over 3.5 terabases of metagenomic sequence so far. In parallel, approximately 800 reference strains isolated from the human body have been sequenced. Collectively, these data represent the largest resource describing the abundance and variety of the human microbiome, while providing a framework for current and future studies