Notes on the anatomy and phylogenetic position of Eremias ercolinii Lanza & Poggesi 1975 (Reptilia Lacertidae)

Detailed examination of the only known specimen of Eremias ercolinii Lanza & Poggesi 1975 shows that it has affinities within the Ophisops-Mesalina clade and, on present evidence, is best regarded as a member of Mesalina Gray 1838. However, its exact phylogenetic position will only be confirmed when more material becomes available. Limb proportions and scale form suggest that Mesalina ercolinii probably spends time in low, dense vegetation

Bayesian population approaches to the analysis of dose escalation studies

In dose escalation studies cohorts of subjects are given increasing doses of a candidate drug to assess safety and tolerability, pharmacokinetics and pharmacological response. The escalation is carried on until a predefined stopping limit is achieved, often identified by a pharmacokinetic endpoint such as peak plasma concentration or area under the plasma concentration-time profile. In the present work, the application of Bayesian methodologies to Phase I dose escalation studies is explored. A Bayesian population model is devised, which provides predictions of dose-response and dose-risk curves, both for individuals already enrolled in the trial and for a new, previously untested subject. Empirical and fully Bayesian estimation algorithms are worked out. Such methods provide equivalent performances on both experimental and simulated datasets. With respect to previous work, it is quantitatively proven not only that a more general and flexible model is identifiable, but also that such flexibility is needed in real scenarios

Grosseto. Città etrusca di Roselle: indagini non invasive e saggi di scavo nel settore orientale

Il contributo illustra in dettaglio il resoconto dell'attività condotta sull'area del Parco Archeologico di Roselle nell'anno 201