132 research outputs found
Pneumonia hospitalisations in Scotland following the introduction of pneumococcal conjugate vaccination in young children
- Author
- A Bottle
- AM Fry
- Arun Thor Watts
- CA Lexau
- Centers for Disease Control and Prevention
- CL Trotter
- Colin R. Simpson
- Comptroller and Auditor General
- CS Roxburgh
- E Koshy
- E Miller
- FT Cutts
- GBD 2013 Mortality and Causes of Death Collaborators
- Harish Nair
- Harry Campbell
- I Blunt
- I Rudan
- J Hansen
- J. Claire Cameron
- JD Mooney
- JG Bartlett
- JJ Oosterheert
- Linda J. Williams
- Lorna J. Willocks
- MR Griffin
- MR Moore
- MR Moore
- PJ Gill
- PK Lindenauer
- Public Health England
- RW Thomsen
- S Flasche
- Saad B. Omer
- SI Pelton
- SK Obaro
- T Pilishvili
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: Scotland introduced PCV7 and PCV13 immunisation in young children in 2006 and 2010 respectively. One recent study from the United States reported a decrease in hospitalisation rates for all-cause pneumonia most notably in adults older than 75Â years of age following PCV7 introduction in the US child population. We aimed to examine the effect of PCV7 and PCV13 on hospitalisation rates for all-cause pneumonia across all age groups in Scotland. METHODS: We linked hospital records and death certification datasets for the entire Scottish population for the period 2000 to 2012. We included all cases where the primary / secondary diagnosis was pneumonia. Differences in hospital admission rates for pneumonia by age group were calculated using the difference in average annual rates for each period. RESULTS: We estimated that all-cause pneumonia hospitalisation rates in children <2Â years decreased by about 30Â % in the post-PCV-13 period compared with the pre-PCV period. However, in adults aged 75â84 years and â„85Â years, all-cause pneumonia hospitalisation rates increased by 63 and 46Â % respectively in the post-PCV 13 period compared to the pre-PCV period. This resulted in an additional 7000 hospitalisations across all age groups in Scotland in 2012 about half of which were in adults >75Â years. At the same time, the median length of hospital stay decreased by a third in children <2Â years and by about 20Â % in adults >75Â years in the post-PCV13 period compared to the pre-PCV period. Additionally, there was an 11Â % reduction in deaths due to all-cause pneumonia, and 30Â % reduction in pneumococcal hospitalisations across all age groups in the post-PCV13 period compared with pre-PCV period. DISCUSSION: The modest and sustained decline in the rates of hospitalisation for all-cause pneumonia in children and the reduction in proportion of pneumonia hospitalisations in children coded as pneumococcal disease in the post-PCV period should alleviate concerns that pneumococcal serotype replacement may have resulted in an increased pneumonia burden in this age group. The indirect impact of child PCV immunisation in those not vaccinated (in terms of reduction in all-cause pneumonia hospitalisations in the elderly) has not been seen in Scotland. Our results are likely to be confounded by changes in clinical coding and healthcare practices over the same period. CONCLUSIONS: Our results illustrate that health care planners cannot, with confidence, predict indirect PCV vaccine impacts on hospitalisations. IPD surveillance across all age groups is needed to assess the indirect effects of PCV in the community. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12879-016-1693-x) contains supplementary material, which is available to authorized users
Different expression of ÎČ subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes
- Author
- A Chan
- A Gibofsky
- AK Ekwall
- AL Meredith
- AN Bukiya
- AN Bukiya
- AN Bukiya
- B Bartok
- B Toro
- B Wang
- BF Haynes
- C Beeton
- C Beeton
- C Beeton
- C Beeton
- Christine Beeton
- D Aletaha
- D Naor
- D StrĂžbaek
- EH Noss
- EJ Tarcha
- F Saleem
- GF Contreras
- Gyorgy Panyi
- H Singh
- H Wulff
- HH Fidder
- HP Kiener
- J Tao
- J Yan
- J Zhang
- JM Kahlenberg
- M Sanchez
- M Sausbier
- M Sausbier
- M Wallner
- Mark R. Tanner
- MM Zarei
- MR Tanner
- N Bottini
- N Comes
- N Quignot
- P Meera
- P Orio
- P Orio
- PK Gregersen
- PS Gulko
- PĂ©rcio S. Gulko
- R Behrens
- R Brenner
- Rajeev B. Tajhya
- Redwan Huq
- S Candia
- S Chhabra
- S Hu
- S Jothy
- S Koshy
- S Shruti
- T Laragione
- T Laragione
- T Laragione
- TC Tolboom
- TCA Tolboom
- Teresina Laragione
- US Lee
- V Chi
- W Knudson
- X Hu
- X Sun
- Y Zhou
- YP Torres
- ZoltĂĄn PethĆ
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses
- Author
- Adele S
- Adeniji K
- Agranoff D
- Agwuh K
- Ahmed KA
- Ail D
- Aldera EL
- Alegria A
- Alex B
- Aley PK
- Allen S
- Amini A
- Andrikopoulos P
- Angus B
- Armstrong JA
- Ashish A
- Ashworth M
- Asiimwe IG
- Assadi S
- Atkinson D
- Avinoam O
- Bach B
- Bahar M
- Baillie JK
- Baillie JK
- Baillie V
- Bakshi S
- Barclay WS
- Bari S
- Barlow G
- Barlow SL
- Barnass S
- Barnes E
- Barrett N
- Bassford C
- Basude S
- Baxter D
- Beadsworth M
- Bellass A
- Bernatoniene J
- Berridge J
- Berry C
- Best N
- Bogaert D
- Booth L
- Bothma P
- Brennan B
- Brittain-Long R
- Bullock K
- Bulteel N
- Burden T
- Burtenshaw A
- Carlucci N
- Carracedo AD
- Carroll MW
- Carson G
- Caruth V
- Cass E
- Catterall BWA
- Chadwick D
- Chadwick D
- Chambler D
- Chand M
- Chechi K
- Chee N
- Child J
- Chukkambotla S
- Clark JJ
- Clark R
- Clark T
- Clarke EA
- Clohisey S
- Cole S
- Cole S
- Collini P
- Conlon C
- Connor M
- Constantinides B
- Cooke GS
- Cooper L
- Cosgrove C
- Costa Clemens SA
- Coutts A
- Cox H
- Crook D
- Cupitt J
- Cutino-Moguel M-T
- da Silva Filipe A
- Da Silva K
- Dalton J
- Dark P
- Davis C
- Dawson C
- de Silva T
- Deeks AS
- Dejnirattisai W
- Dervisevic S
- Dijokaite A
- Dincarslan O
- Docherty AB
- Dold C
- Donegan C
- Donnelly L
- Donnison P
- Donohue C
- dos Santos Correia G
- Douthwaite S
- Drake TM
- Drummond A
- Dumas M-E
- Dunachie SJ
- Dunn C
- Dunning J
- DuRand I
- Dushianthan A
- Duyvesteyn HME
- Dyer P
- Dyer T
- Elliott A
- Evans A
- Evans C
- Eziefula C
- Fairfield CJ
- Fawkes A
- Fegan C
- Fernandes da Costa C
- Finch L
- Finn A
- Fisher LWS
- Flaherty L
- Flaxman A
- Fletcher T
- Foster T
- Frater J
- Frending L
- Fry EE
- Fullerton D
- Gamble C
- Garcia-Dorival I
- Gardiner S
- Garg A
- Garg S
- Garg S
- Gilchrist T
- Ginn HM
- Girvan M
- Gkrania-Klotsas E
- Godden J
- Goldsmith A
- Graham C
- Green CA
- Greenhalf W
- Griffin JL
- Griffiths F
- Gunning P
- Gupta RK
- Hafezi K
- Hall DR
- Halpin S
- Hardwick H
- Hardy E
- Harrison EM
- Harrison J
- Hartley C
- Hartshorn S
- Harvey D
- Havalda P
- Hawcutt DB
- Hendry R
- Hiscox JA
- Hobrok M
- Hodgson L
- Holmes A
- Horby PW
- Hormis A
- Huang K-YA
- Huo J
- Ijaz S
- Jackson C
- Jacobs M
- Jain S
- Jeffery K
- Jenkin D
- Jennings P
- Jensen RL
- Johnson SA
- Jones CB
- Jones TR
- JÀmsén A
- Kaliappan A
- Kasipandian V
- Keating S
- Kegg S
- Kelsey M
- Kendall J
- Kerrison C
- Kerslake I
- Khan S
- Khandaker S
- Khoo S
- King K
- Kiy RT
- Klenerman P
- Klenerman P
- Knight SR
- Koch O
- Koduri G
- Koeckerling D
- Koshy G
- Koukorava C
- Kwatra G
- Laha S
- Laird S
- Lake A
- Lambe T
- Lant S
- Larkin S
- Latawiec D
- Lavelle-Langham L
- Law A
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- Lee J
- Leeming G
- Lefteri D
- Leiner T
- Lett L
- Lewis MR
- Liggi S
- Lillie P
- Lim WS
- Limb J
- Linnett V
- Little J
- Liu C
- Livoti LA
- Lyttle M
- MacGillivray L
- Maclean A
- MacMahon M
- MacNaughton E
- Madhi SA
- Malik T
- Malone T
- Mancini M
- Mankregod R
- Marsh L
- Maslen L
- Mason C
- Massey H
- Masson H
- Matovu E
- Maziere N
- McCafferty S
- McCullough K
- McDonald S
- McDonald SE
- McEvoy L
- McEwen R
- McLauchlan J
- Mclean KA
- Meda M
- Mentzer AJ
- Mentzer AJ
- Merson L
- Metelmann S
- Meynert AM
- Miah NS
- Middleton J
- Mills G
- Minton J
- Mirfenderesky M
- Mitchell J
- Mohandas K
- Mok Q
- Mongkolsapaya J
- Moon J
- Moore E
- Moore SC
- Moore SC
- Morgan P
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- Moses S
- Mpenge M
- Mulla R
- Murphy D
- Murphy EG
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- Nagarajan T
- Nagel M
- Nascimento F
- Nascimento V
- Naveca FG
- Nelson M
- Norman L
- Norris L
- Noursadeghi M
- Nunes MC
- Nutalai R
- Olanipekun M
- Omo-Dare N
- Oosthuyzen W
- Openshaw PJM
- Openshaw PJM
- Osagie A
- Ostermann M
- Otahal I
- OâShea MK
- Pais M
- Palmarini M
- Palmieri C
- Palmieri C
- Pan D
- Panchatsharam S
- Papakonstantinou D
- Papineni P
- Paraiso H
- Patel B
- Paterson NG
- Pattison N
- Pauvolid-Correa A
- Paxton WA
- Penrice-Randal R
- Pepperell J
- Peters M
- Phillips E
- Phull M
- Pilgrim J
- Pintus S
- Pius R
- Planche T
- Plotkin D
- Pollakis G
- Pollard AJ
- Pooni JS
- Post F
- Price D
- Price N
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- Prout R
- Rae N
- Rambaut A
- Ren J
- Reschreiter H
- Resende PC
- Reynolds T
- Reynolds W
- Richardson N
- Ridley PM
- Ritter TG
- Roberts D
- Roberts M
- Roberts S
- Robertson DL
- Rose A
- Rothwell L
- Rousseau G
- Ruge B
- Russell CD
- Ryan B
- Sales D
- Saluja T
- Sancho-Shimizu V
- Sands CJ
- Saviciute E
- Schmid ML
- Schreiber G
- Scott JT
- Scott-Brown J
- Screaton GR
- Semple MG
- Semple MG
- Serafin N
- Shah A
- Shankar-Hari M
- Shanmuga P
- Sharma A
- Shaw CA
- Shaw V
- Shaw VE
- Shawcross A
- Shears RK
- Sigfrid L
- Siqueira MM
- Sizer J
- Skelly D
- Small B
- Smith R
- Snelson C
- Solomon T
- Spencer RG
- Spittle N
- Sriskandan S
- Stafford L
- Staines N
- Stambach T
- Stewart R
- Stuart D
- Stuart DI
- Subramaniam KS
- Subudhi P
- Summers C
- Supasa P
- Swann OV
- Szakmany T
- Szemiel A
- Taggart A
- Takats Z
- Takis P
- Tan TK
- Tanianis-Hughes J
- Tatham K
- Tedder RS
- Thomas J
- Thomas J
- Thompson AAR
- Thompson C
- Thompson R
- Thomson EC
- Thwaites RS
- Townsend AR
- Tridente A
- Trochu E
- Tuekprakhon A
- Tupper-Carey D
- Turtle LCW
- Twagira M
- Vallotton N
- van Tonder L
- Vancheeswaran R
- Vincent-Smith L
- Visuvanathan S
- Voysey M
- Vuylsteke A
- Waddy S
- Wai Ho AY
- Wake R
- Walden A
- Wang B
- Webster H
- Welters I
- Wham M
- Whitehouse T
- Whittaker P
- Whittington A
- Wijesinghe M
- Wilcock E
- Williams M
- Williams MA
- Wilson L
- Winchester S
- Wiselka M
- Wolverson A
- Wootton DG
- Workman A
- Wrobel N
- Yates B
- Young P
- ZahradnĂk J
- Zambon M
- Zhang JE
- Zhou D
- Publication venue
- Elsevier BV
- Publication date
- 22/12/2021
- Field of study
On 24th November 2021, the sequence of a new SARS-CoV-2 viral isolate Omicron-B.1.1.529 was announced, containing far more mutations in Spike (S) than previously reported variants. Neutralization titers of Omicron by sera from vaccinees and convalescent subjects infected with early pandemic Alpha, Beta, Gamma, or Delta are substantially reduced, or the sera failed to neutralize. Titers against Omicron are boosted by third vaccine doses and are high in both vaccinated individuals and those infected by Delta. Mutations in Omicron knock out or substantially reduce neutralization by most of the large panel of potent monoclonal antibodies and antibodies under commercial development. Omicron S has structural changes from earlier viruses and uses mutations that confer tight binding to ACE2 to unleash evolution driven by immune escape. This leads to a large number of mutations in the ACE2 binding site and rebalances receptor affinity to that of earlier pandemic viruses
The SARS-CoV-2 Alpha variant was associated with increased clinical severity of COVID-19 in Scotland: A genomics-based retrospective cohort analysis
- Author
- Aanensen DM
- Abudahab K
- Adams A
- Adams H
- Afifi S
- Aggarwal D
- Ahmad SSY
- Aigrain L
- Alcolea-Medina A
- Alikhan N - F
- Allara E
- Amato R
- Angyal A
- Annett T
- Aplin S
- Ariani CV
- Asad H
- Ash A
- Ashfield P
- Ashford F
- Atkinson L
- Attwood SW
- Auckland C
- Aydin A
- Baker DJ
- Baker P
- Balcazar CE
- Ball PJ
- Barrett JC
- Barrow M
- Barton E
- Bashton M
- Bassett AR
- Batra R
- Baxter C
- Bayzid N
- Beaver C
- Beckett AH
- Beckwith SM
- Bedford L
- Beer R
- Beggs A
- Bellis KL
- Berry L
- Bertolusso B
- Best A
- Betteridge E
- Bibby D
- Bicknell K
- Binns D
- Birchley A
- Bird PW
- Bishop C
- Blacow R
- Blakey V
- Blane B
- Bolt F
- Bonfield J
- Bonner PS
- Bonsall D
- Boswell T
- Bosworth A
- Bourgeois Y
- Bouzidi KE
- Boyd O
- Bradley DT
- Breen C
- Bresner C
- Breuer PJ
- Bridgett S
- Bronner IF
- Brooks E
- Broos A
- Brown JR
- Bucca G
- Buchan SL
- Buck D
- Bull M
- Bulteel N
- Burns PJ
- Burton-Fanning S
- Byaruhanga T
- Byott M
- Callico LD
- Campbell A
- Campbell R
- Campbell S
- Carabelli AM
- Cargill JS
- Carlile M
- Carvalho SF
- Casey A
- Castigador A
- Catalan J
- Chalker V
- Chaloner NJ
- Chand M
- Chappell JG
- Charalampous T
- Chatterton W
- Chaudhry Y
- Churcher CM
- Clark G
- Clarke P
- Clifford S
- Cogger BJ
- Cole K
- Collins J
- Colquhoun R
- Connor TR
- Cook KF
- Coombes J
- Corden S
- Cormie C
- Cortes N
- Cotic M
- Cotton S
- Cottrell S
- Coupland L
- Cox A
- Cox M
- Craine N
- Crawford L
- Cross A
- Crown MR
- Crudgington D
- Cumley N
- Curran MD
- Curran T
- Cutino-Moguel T
- Dabrera G
- Darby AC
- Davidson RK
- Davies A
- Davies RM
- Davis C
- Davis T
- de Angelis PD
- De Lacy E
- de Oliveira Martins L
- de Silva TI
- Debebe J
- Denton-Smith R
- Dervisevic S
- Dewar R
- Dey J
- Dias J
- Dobie D
- Dorman MJ
- Downing F
- Driscoll M
- du Plessis L
- Duckworth N
- Durham J
- Eastick K
- Easton LJ
- Eccles R
- Edgeworth J
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- Eldirdiri S
- Ellaby N
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- Eltringham G
- Ensell L
- Erkiert MJ
- Essex S
- Evans C
- Evans JM
- Everson W
- Fairley DJ
- Fallon K
- Fanaie A
- Farr BW
- Fearn C
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- Filipe ADS
- Fina L
- Fjodorova L
- Flaviani F
- Fleming VM
- Forrest R
- Forrest S
- Foster-Nyarko E
- Foulkes BH
- Foulser L
- Fragakis M
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- Galai K
- Gallagher A
- Gallagher E
- Gallagher MD
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- Gaskin A
- Gatica-Wilcox B
- Geidelberg L
- Gemmell M
- Georgana I
- George RP
- Gifford L
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- Girgis ST
- Glaysher S
- Goldstein EJ
- Golubchik T
- Gomes AN
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- Goodfellow IG
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- Goudarzi S
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- Hsu SN
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- Illingworth CJ
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- Irish-Tavares D
- Iturriza-Gomara M
- Izuagbe R
- Jackson B
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- Kwiatkowski PD
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- Laing KG
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- Langford CF
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- Martincorena I
- Martinez Nunez RT
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- Odedra M
- Ohemeng-Kumi N
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- Onishi Y
- Orton RJ
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- Pacchiarini N
- Padgett D
- Page AJ
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- Park EJ
- Park NR
- Parker MD
- Parmar S
- Partridge DG
- Pascall DJ
- Patel A
- Patel B
- Paterson PS
- Payne BAI
- Peacock SJ
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- Pymont HM
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- Raghwani J
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- Rajatileka S
- Ramadan NA
- Rambaut PA
- Ramble J
- Randell PA
- Ratcliffe L
- Raviprakash V
- Ray S
- Raza M
- Redshaw NM
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- Robson SC
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- Rowe W
- Roy S
- Rudder S
- Ruis C
- Rushton PS
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- Sakka NE
- Samaraweera B
- Sambles CM
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- Silviera S
- Simpson DA
- Singh A
- Singleton D
- Skvortsov T
- Sloan TJ
- Sluga G
- Smith CP
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- Somassa T
- Southgate J
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- Spencer Chapman MH
- Spurgin LG
- Spyer MJ
- Stanley R
- Stanley W
- Stanton TD
- Starinskij I
- Stockton J
- Stonehouse S
- Storey N
- Studholme DJ
- Sudhanva M
- Swindells E
- Taha Y
- Tan NK
- Tang JW
- Tang M
- Taylor BEW
- Taylor JF
- Taylor S
- Temperton B
- Templeton KE
- Thomas C
- Thomas-McEwen PMD
- Thomson EC
- Thomson L
- Thornton A
- Thurston SAJ
- Todd JA
- Tomb R
- Tong L
- Tonkin-Hill G
- Torok ME
- Tovar-Corona JM
- Trebes A
- Trotter AJ
- Tsatsani I
- Turnbull R
- Twohig KA
- Umpleby H
- Underwood AP
- Vamos EE
- Vasylyeva TI
- Vattipally S
- Vernet G
- Vink E
- Vipond BB
- Volz EM
- Walsh S
- Wang D
- Warne B
- Warwick-Dugdale J
- Wastnedge E
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- Waugh S
- Webster HJ
- Weldon D
- Westwick E
- Whalley T
- Wheeler H
- Whitehead M
- Whiteley M
- Whitwham A
- Wierzbicki C
- Wilkie C
- Willford NJ
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- Williams C
- Williams C
- Williams CA
- Williams L - A
- Williams R
- Williams RJ
- Williams T
- Williamson KA
- Wilson-Davies E
- Witele E
- Withell KT
- Witney AA
- Wolverson P
- Wong N
- Workman T
- Wright DW
- Wright V
- Wyatt T
- Wyllie S
- Xu-McCrae L
- Yavus M
- Yaze G
- Yeats CA
- Yebra G
- Yew WC
- Young GR
- Young J
- Zarebski AE
- Zhang P
- Publication venue
- Publication date
- 13/04/2023
- Field of study
Objectives
The SARS-CoV-2 Alpha variant was associated with increased transmission relative to other variants present at the time of its emergence and several studies have shown an association between Alpha variant infection and increased hospitalisation and 28-day mortality. However, none have addressed the impact on maximum severity of illness in the general population classified by the level of respiratory support required, or death. We aimed to do this.
Methods
In this retrospective multi-centre clinical cohort sub-study of the COG-UK consortium, 1475 samples from Scottish hospitalised and community cases collected between 1st November 2020 and 30th January 2021 were sequenced. We matched sequence data to clinical outcomes as the Alpha variant became dominant in Scotland and modelled the association between Alpha variant infection and severe disease using a 4-point scale of maximum severity by 28 days: 1. no respiratory support, 2. supplemental oxygen, 3. ventilation and 4. death.
Results
Our cumulative generalised linear mixed model analyses found evidence (cumulative odds ratio: 1.40, 95% CI: 1.02, 1.93) of a positive association between increased clinical severity and lineage (Alpha variant versus pre-Alpha variants).
Conclusions
The Alpha variant was associated with more severe clinical disease in the Scottish population than co-circulating lineages
Obesity and colorectal cancer: molecular features of adipose tissue
- Author
- A Bergstrom
- A Kaidi
- A Kuchiba
- A Mantovani
- A Mantovani
- A Mrozek
- A OâToole
- A Romero-Corral
- A Russo
- A Sanchez-de-Abajo
- A Tchernof
- AD Kostic
- AG Renehan
- AG Renehan
- AP Thrift
- AR Murray
- AT Dietz
- B Guiu
- B Vogelstein
- BE Lippitz
- BJ Caan
- C Alliot
- C Leung
- C Therkildsen
- CA Gilbert
- CE Bronner
- CL Ogden
- CL Ogden
- CM Yang
- CN Lumeng
- CS Fox
- CS Lee
- D Colussi
- D Leclerc
- D Paola
- D Wang
- DB Liesenfeld
- DK Rex
- DM Parkin
- DS Chan
- DS Chan
- E Giovannucci
- E Parkin
- E Shaulian
- E Volgyi
- E Volkova
- E Volkova
- E Yehuda-Shnaidman
- EK Choe
- ER Cantwell-Dorris
- ER Fearon
- ER Simpson
- EY Lee
- F Bozzetti
- F Luo
- G Brambilla
- G Caro Di
- G Koshy
- G Malietzis
- G Poulogiannis
- GA Kune
- GC Prendergast
- GO Fruhwirth
- GS Patel
- GY Ho
- H Arem
- H Ashktorab
- H Davies
- H Esterbauer
- H Lahm
- H Rajagopalan
- H Yin
- HJ Schneider
- HP Ji
- HT Lynch
- HW Kim
- IA Blair
- IH Sahin
- J Brandstedt
- J Galon
- J Park
- J Park
- J Trojan
- JA Meyerhardt
- JA Satia
- Javier Martinez-Useros
- Jesus Garcia-Foncillas
- JI Fenton
- JL Bos
- JL Halaas
- JM Olefsky
- JP Spano
- JV Tricoli
- K Mima
- K Mima
- K Newton
- K Tandon
- K Taniguchi
- K Uchida
- K Xu
- KA Kwon
- KH Goss
- KH Park-Min
- L Flanagan
- L Marchand Le
- L Santarpia
- L Shu
- LA Cupul-Uicab
- LJ Marnett
- LJ Niedernhofer
- M Ahmadian
- M Ashwell
- M Bjorndahl
- M Karin
- M Koenuma
- M Krzystek-Korpacka
- M Pollak
- M Savio
- M Sekharam
- M Song
- M Wang
- MA Fuchs
- MA Pelleymounter
- MC Amato
- MD Castellone
- MD Schulz
- ME Martinez
- MF Gregor
- MG Verdier de
- MJ Khandekar
- MJ Morgan
- MJ Orlich
- ML Bartoli
- ML Slattery
- ML Slattery
- ML Slattery
- ML Veigl
- MM Remacle-Bonnet
- MP Cleary
- MS Cooke
- MS Shah
- MS Shah
- N Chalhoub
- N Nagata
- N Papadopoulos
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- N Shanmugam
- N Vazzana
- N Zarkovic
- OO Ogunwobi
- PC Lin
- PK Kinnunen
- PT Campbell
- Q Shi
- QB She
- R Pai
- R Rosati
- RA Merendino
- RC Barcelos
- RE Mirza
- RE Schoen
- RE Schoen
- RJ Sram
- RL Siegel
- S Edin
- S Fujioka
- S Graham
- S Miyamoto
- S Ogino
- S Ogino
- S Wu
- SC Garcia
- SC Wong
- SD Hursting
- SJ Baker
- SM Kang
- SS Comstock
- SS Comstock
- SW Park
- T Fujiwara
- T Morikawa
- T Pang
- T Tahara
- T Yamaji
- TK Murphy
- V Fedirko
- VM Chia
- WL Hwang
- X Wang
- X Zhang
- Y Ionov
- Y Samuels
- Y Wu
- Y Xiao
- Y Yin
- YI Cha
- YS Guo
- Z Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Observation of triple J/Ï meson production in proton-proton collisions
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- Alexander J
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- Amendola C
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- Ălvarez CR
- Ăzçelik Ă
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 19/01/2023
- Field of study
Data availability:
Tabulated results are provided in the HEPData record for this analysis71. Release and preservation of data used by the CMS Collaboration as the basis for publications is guided by the CMS policy as stated in CMS data preservation, re-use and open access policy.Code availability:
The CMS core software is publically available at https://github.com/cms-sw/cmssw.Copyright . Protons consist of three valence quarks, two up-quarks and one down-quark, held together by gluons and a sea of quark-antiquark pairs. Collectively, quarks and gluons are referred to as partons. In a proton-proton collision, typically only one parton of each proton undergoes a hard scattering â referred to as single-parton scattering â leaving the remainder of each proton only slightly disturbed. Here, we report the study of double- and triple-parton scatterings through the simultaneous production of three J/Ï mesons, which consist of a charm quark-antiquark pair, in proton-proton collisions recorded with the CMS experiment at the Large Hadron Collider. We observed this process â reconstructed through the decays of J/Ï mesons into pairs of oppositely charged muons â with a statistical significance above five standard deviations. We measured the inclusive fiducial cross-section to be 272+141â104(stat)±17(syst)fb, and compared it to theoretical expectations for triple-J/Ï meson production in single-, double- and triple-parton scattering scenarios. Assuming factorization of multiple hard-scattering probabilities in terms of single-parton scattering cross-sections, double- and triple-parton scattering are the dominant contributions for the measured process.SCOAP3.Change history:
27 February 2023A Correction to this paper has been published: https://doi.org/10.1038/s41567-023-01992-
Search for a heavy resonance decaying into a top quark and a W boson in the lepton+jets final state at â s = 13 TeV
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- Aarup Petersen H
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- Ălvarez FernĂĄndez A
- Ăzçelik Ă
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
A preprint version of the article is available at arXiv 2111.10216: https://arxiv.org/abs/2111.10216.Copyright © CERN, for the benefit of the CMS Collaboration 2022. A search for a heavy resonance decaying into a top quark and a W boson in proton-proton collisions at âs = 13 TeV is presented. The data analyzed were recorded with the CMS detector at the LHC and correspond to an integrated luminosity of 138 fbâ1. The top quark is reconstructed as a single jet and the W boson, from its decay into an electron or muon and the corresponding neutrino. A top quark tagging technique based on jet clustering with a variable distance parameter and simultaneous jet grooming is used to identify jets from the collimated top quark decay. The results are interpreted in the context of two benchmark models, where the heavy resonance is either an excited bottom quark bâ or a vector-like quark B. A statistical combination with an earlier search by the CMS Collaboration in the all-hadronic final state is performed to place upper cross section limits on these two models. The new analysis extends the lower range of resonance mass probed from 1.4 down to 0.7 TeV. For left-handed, right-handed, and vector-like couplings, bâ masses up to 3.0, 3.0, and 3.2 TeV are excluded at 95% confidence level, respectively. The observed upper limits represent the most stringent constraints on the bâ model to date.SCOAP3
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Search for Higgs boson decays to a Z boson and a photon in proton-proton collisions at sâ = 13 TeV
- Author
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- Aarup Petersen H
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- Zorbilmez C
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- Ălvarez FernĂĄndez A
- Ăzçelik Ă
- Publication venue
- Springer Nature on behalf of SISSA
- Publication date
- 01/08/2022
- Field of study
A preprint version of the article is available at arXiv:2204.12945v2 [hep-ex], https://arxiv.org/abs/2204.12945v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/HIG-19-014 (CMS Public Pages). Report number: CMS-HIG-19-014, CERN-EP-2022-019.Results are presented from a search for the Higgs boson decay H â ZÎł, where Z â â+ââ with â = e or ÎŒ. The search is performed using a sample of proton-proton (pp) collision data at a center-of-mass energy of 13 TeV, recorded by the CMS experiment at the LHC, corresponding to an integrated luminosity of 138 fb^{â1}. Events are assigned to mutually exclusive categories, which exploit differences in both event topology and kinematics of distinct Higgs production mechanisms to enhance signal sensitivity. The signal strength ÎŒ, defined as the product of the cross section and the branching fraction [Ï(pp â H)B(H â ZÎł)] relative to the standard model prediction, is extracted from a simultaneous fit to the â+ââÎł invariant mass distributions in all categories and is found to be ÎŒ = 2.4 ± 0.9 for a Higgs boson mass of 125.38 GeV. The statistical significance of the observed excess of events is 2.7 standard deviations. This measurement corresponds to Ï(pp â H)B(H â ZÎł) = 0.21 ± 0.08 pb. The observed (expected) upper limit at 95% confidence level on ÎŒ is 4.1 (1.8). The ratio of branching fractions B(H â ZÎł)/B(H â γγ) is measured to be 1.5 +0.7â0.6, which agrees with the standard model prediction of 0.69 ± 0.04 at the 1.5 standard deviation level.SCOAP3
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Measurements of the Higgs boson production cross section and couplings in the W boson pair decay channel in proton-proton collisions at sâ = 13 TeV
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- Springer Nature on behalf of SISSA
- Publication date
- 09/10/2022
- Field of study
A preprint version of the article is available at arXiv:2206.09466v2 [hep-ex], https://arxiv.org/abs/2206.09466v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at httpS://cms-results.web.cern.ch/cms-results/public-results/publications/HIG-20-013 (CMS Public Pages). Report number: CMS-HIG-20-013, CERN-EP-2022-120.Production cross sections of the standard model Higgs boson decaying to a pair of W bosons are measured in proton-proton collisions at a center-of-mass energy of 13 TeV. The analysis targets Higgs bosons produced via gluon fusion, vector boson fusion, and in association with a W or Z boson. Candidate events are required to have at least two charged leptons and moderate missing transverse momentum, targeting events with at least one leptonically decaying W boson originating from the Higgs boson. Results are presented in the form of inclusive and differential cross sections in the simplified template cross section framework, as well as couplings of the Higgs boson to vector bosons and fermions. The data set collected by the CMS detector during 2016-2018 is used, corresponding to an integrated luminosity of 138 fb^â1. The signal strength modifier ÎŒ, defined as the ratio of the observed production rate in a given decay channel to the standard model expectation, is measured to be ÎŒ = 0.95 +0.10â0.09. All results are found to be compatible with the standard model within the uncertainties.SCOAP3
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- Ăzçelik Ă
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 07/07/2022
- Field of study
A Correction to this paper has been published (18 October 2023) : https://doi.org/10.1038/s41586-023-06164-8.Data availability:
Tabulated results are provided in the HEPData record for this analysis. Release and preservation of data used by the CMS Collaboration as the basis for publications is guided by the CMS data preservation, re-use and open acess policy.Code availability:
The CMS core software is publicly available on GitHub (https://github.com/cms-sw/cmssw).In July 2012, the ATLAS and CMS collaborations at the CERN Large Hadron Collider announced the observation of a Higgs boson at a mass of around 125âgigaelectronvolts. Ten years later, and with the data corresponding to the production of a 30-times larger number of Higgs bosons, we have learnt much more about the properties of the Higgs boson. The CMS experiment has observed the Higgs boson in numerous fermionic and bosonic decay channels, established its spinâparity quantum numbers, determined its mass and measured its production cross-sections in various modes. Here the CMS Collaboration reports the most up-to-date combination of results on the properties of the Higgs boson, including the most stringent limit on the cross-section for the production of a pair of Higgs bosons, on the basis of data from protonâproton collisions at a centre-of-mass energy of 13âteraelectronvolts. Within the uncertainties, all these observations are compatible with the predictions of the standard model of elementary particle physics. Much evidence points to the fact that the standard model is a low-energy approximation of a more comprehensive theory. Several of the standard model issues originate in the sector of Higgs boson physics. An order of magnitude larger number of Higgs bosons, expected to be examined over the next 15 years, will help deepen our understanding of this crucial sector.BMBWF and FWF (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, FAPERGS, and FAPESP (Brazil); MES and BNSF (Bulgaria); CERN; CAS, MoST, and NSFC (China); MINCIENCIAS (Colombia); MSES and CSF (Croatia); RIF (Cyprus); SENESCYT (Ecuador); MoER, ERC PUT and ERDF (Estonia); Academy of Finland, MEC, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF (Germany); GSRI (Greece); NKFIH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); MSIP and NRF (Republic of Korea); MES (Latvia); LAS (Lithuania); MOE and UM (Malaysia); BUAP, CINVESTAV, CONACYT, LNS, SEP, and UASLP-FAI (Mexico); MOS (Montenegro); MBIE (New Zealand); PAEC (Pakistan); MES and NSC (Poland); FCT (Portugal); MESTD (Serbia); MCIN/AEI and PCTI (Spain); MOSTR (Sri Lanka); Swiss Funding Agencies (Switzerland); MST (Taipei); MHESI and NSTDA (Thailand); TUBITAK and TENMAK (Turkey); NASU (Ukraine); STFC (United Kingdom); DOE and NSF (USA). Individuals have received support from the Marie-Curie programme and the European Research Council and Horizon 2020 Grant, contract Nos. 675440, 724704, 752730, 758316, 765710, 824093, 884104, and COST Action CA16108 (European Union); the Leventis Foundation; the Alfred P. Sloan Foundation; the Alexander von Humboldt Foundation; the Belgian Federal Science Policy Office; the Fonds pour la Formation Ă la Recherche dans lâIndustrie et dans lâAgriculture (FRIA-Belgium); the Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium); the F.R.S.-FNRS and FWO (Belgium) under the âExcellence of Science â EOSâ â be.h project n. 30820817; the Beijing Municipal Science & Technology Commission, No. Z191100007219010; the Ministry of Education, Youth and Sports (MEYS) of the Czech Republic; the Stavros Niarchos Foundation (Greece); the Deutsche Forschungsgemeinschaft (DFG), under Germanyâs Excellence Strategy â EXC 2121 âQuantum Universeâ â 390833306, and under project number 400140256 - GRK2497; the Hungarian Academy of Sciences, the New National Excellence Program - ĂNKP, the NKFIH research grants K 124845, K 124850, K 128713, K 128786, K 129058, K 131991, K 133046, K 138136, K 143460, K 143477, 2020-2.2.1-ED-2021-00181, and TKP2021-NKTA-64 (Hungary); the Council of Science and Industrial Research, India; the Latvian Council of Science; the Ministry of Education and Science, project no. 2022/WK/14, and the National Science Center, contracts Opus 2021/41/B/ST2/01369 and 2021/43/B/ST2/01552 (Poland); the Fundação para a CiĂȘncia e a Tecnologia, grant CEECIND/01334/2018 (Portugal); the National Priorities Research Program by Qatar National Research Fund; MCIN/AEI/10.13039/501100011033, ERDF âa way of making Europeâ, and the Programa Estatal de Fomento de la InvestigaciĂłn CientĂfica y TĂ©cnica de Excelencia MarĂa de Maeztu, grant MDM-2017-0765 and Programa Severo Ochoa del Principado de Asturias (Spain); the Chulalongkorn Academic into Its 2nd Century Project Advancement Project, and the National Science, Research and Innovation Fund via the Program Management Unit for Human Resources & Institutional Development, Research and Innovation, grant B05F650021 (Thailand); the Kavli Foundation; the Nvidia Corporation; the SuperMicro Corporation; the Welch Foundation, contract C-1845; and the Weston Havens Foundation (USA)
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