4,133 research outputs found
lp-Recovery of the Most Significant Subspace among Multiple Subspaces with Outliers
We assume data sampled from a mixture of d-dimensional linear subspaces with
spherically symmetric distributions within each subspace and an additional
outlier component with spherically symmetric distribution within the ambient
space (for simplicity we may assume that all distributions are uniform on their
corresponding unit spheres). We also assume mixture weights for the different
components. We say that one of the underlying subspaces of the model is most
significant if its mixture weight is higher than the sum of the mixture weights
of all other subspaces. We study the recovery of the most significant subspace
by minimizing the lp-averaged distances of data points from d-dimensional
subspaces, where p>0. Unlike other lp minimization problems, this minimization
is non-convex for all p>0 and thus requires different methods for its analysis.
We show that if 0<p<=1, then for any fraction of outliers the most significant
subspace can be recovered by lp minimization with overwhelming probability
(which depends on the generating distribution and its parameters). We show that
when adding small noise around the underlying subspaces the most significant
subspace can be nearly recovered by lp minimization for any 0<p<=1 with an
error proportional to the noise level. On the other hand, if p>1 and there is
more than one underlying subspace, then with overwhelming probability the most
significant subspace cannot be recovered or nearly recovered. This last result
does not require spherically symmetric outliers.Comment: This is a revised version of the part of 1002.1994 that deals with
single subspace recovery. V3: Improved estimates (in particular for Lemma 3.1
and for estimates relying on it), asymptotic dependence of probabilities and
constants on D and d and further clarifications; for simplicity it assumes
uniform distributions on spheres. V4: minor revision for the published
versio
COST Action “EuroTelepath”: digital pathology integration in electronic health record, including primary care centres
Exploring the canonical behaviour of long gamma-ray bursts using an intrinsic multiwavelength afterglow correlation
In this paper, we further investigate the relationship, reported by Oates et al., between the optical/UV afterglow luminosity (measured at restframe 200 s) and average afterglow decay rate (measured from restframe 200 s onwards) of long duration gamma-ray bursts (GRBs). We extend the analysis by examining the X-ray light curves, finding a consistent correlation. We therefore explore how the parameters of these correlations relate to the prompt emission phase and, using a Monte Carlo simulation, explore whether these correlations are consistent with predictions of the standard afterglow model. We find significant correlations between: log LO, 200 s and log LX, 200 s; αO, >200 s and αX, >200 s, consistent with simulations. The model also predicts relationships between log Eiso and log L200 s; however, while we find such relationships in the observed sample, the slope of the linear regression is shallower than that simulated and inconsistent at ≳3σ. Simulations also do not agree with correlations observed between log L200 s and α> 200 s, or
logEiso
logEiso
and α> 200 s. Overall, these observed correlations are consistent with a common underlying physical mechanism producing GRBs and their afterglows regardless of their detailed temporal behaviour. However, a basic afterglow model has difficulty explaining all the observed correlations. This leads us to briefly discuss alternative more complex models
Pregnancy success of lactating Holstein cows after a single administration of a sustained-release formulation of recombinant bovine somatotropin
Exploring the canonical behaviour of long gamma-ray bursts with an intrinsic multiwavelength afterglow correlation
In this conference proceeding we examine a correlation between the afterglow luminosity (measured at restframe 200 s; logL200s) and average afterglow decay rate (measured from restframe 200 s onwards; α>200s) found in both the optical/UV and X-ray afterglows of long duration Gamma-ray Bursts (GRBs). Examining the X-ray light curves, we find the correlation does not depend on the presence of specific light curve features. We explore how the parameters in the optical/UV and X-ray bands relate to each other and to the prompt emission phase. We also use a Monte Carlo simulation to explore whether these relationships are consistent with predictions of the standard afterglow model. We conclude that the correlations are consistent with a common underlying physical mechanism producing GRBs and their afterglows regardless of their detailed temporal behaviour. However, a basic afterglow model has difficulty explaining correlations involving α>200s. We therefore briefly discuss alternative more complex models
Electronic Spin Transport in Dual-Gated Bilayer Graphene
The elimination of extrinsic sources of spin relaxation is key in realizing
the exceptional intrinsic spin transport performance of graphene. Towards this,
we study charge and spin transport in bilayer graphene-based spin valve devices
fabricated in a new device architecture which allows us to make a comparative
study by separately investigating the roles of substrate and polymer residues
on spin relaxation. First, the comparison between spin valves fabricated on
SiO2 and BN substrates suggests that substrate-related charged impurities,
phonons and roughness do not limit the spin transport in current devices. Next,
the observation of a 5-fold enhancement in spin relaxation time in the
encapsulated device highlights the significance of polymer residues on spin
relaxation. We observe a spin relaxation length of ~ 10 um in the encapsulated
bilayer with a charge mobility of 24000 cm2/Vs. The carrier density dependence
of spin relaxation time has two distinct regimes; n<4 x 1012 cm-2, where spin
relaxation time decreases monotonically as carrier concentration increases, and
n>4 x 1012 cm-2, where spin relaxation time exhibits a sudden increase. The
sudden increase in the spin relaxation time with no corresponding signature in
the charge transport suggests the presence of a magnetic resonance close to the
charge neutrality point. We also demonstrate, for the first time, spin
transport across bipolar p-n junctions in our dual-gated device architecture
that fully integrates a sequence of encapsulated regions in its design. At low
temperatures, strong suppression of the spin signal was observed while a
transport gap was induced, which is interpreted as a novel manifestation of
impedance mismatch within the spin channel
Diffusion microscopic MRI of the mouse embryo: Protocol and practical implementation in the splotch mouse model
Advanced methodologies for visualizing novel tissue contrast are essential for phenotyping the ever-increasing number of mutant mouse embryos being generated. Although diffusion microscopic MRI (μMRI) has been used to phenotype embryos, widespread routine use is limited by extended scanning times, and there is no established experimental procedure ensuring optimal data acquisition
Simple models of the chemical field around swimming plankton
Background. Cervical cancer is the fourth most common cancer in women, and we recently reported human leukocyte antigen (HLA) alleles showing strong associations with cervical neoplasia risk and protection. HLA ligands are recognized by killer immunoglobulin-like receptors (KIRs) expressed on a range of immune cell subsets, governing their proinflammatory activity. We hypothesized that the inheritance of particular HLA-KIR combinations would increase cervical neoplasia risk. Methods. Here, we used HLA and KIR dosages imputed from single-nucleotide polymorphism genotype data from 2143 cervical neoplasia cases and 13 858 healthy controls of European decent. Results. The following 4 novel HLA alleles were identified in association with cervical neoplasia, owing to their linkage disequilibrium with known cervical neoplasia-associated HLA-DRB1 alleles: HLA-DRB3*9901 (odds ratio [OR], 1.24; P = 2.49 × 10−9), HLA-DRB5*0101 (OR, 1.29; P = 2.26 × 10−8), HLA-DRB5*9901 (OR, 0.77; P = 1.90 × 10−9), and HLA-DRB3*0301 (OR, 0.63; P = 4.06 × 10−5). We also found that homozygosity of HLA-C1 group alleles is a protective factor for human papillomavirus type 16 (HPV16)-related cervical neoplasia (C1/C1; OR, 0.79; P = .005). This protective association was restricted to carriers of either KIR2DL2 (OR, 0.67; P = .00045) or KIR2DS2 (OR, 0.69; P = .0006). Conclusions. Our findings suggest that HLA-C1 group alleles play a role in protecting against HPV16-related cervical neoplasia, mainly through a KIR-mediated mechanism
Entropy of three-dimensional asymptotically flat cosmological solutions
The thermodynamics of three-dimensional asymptotically flat cosmological
solutions that play the same role than the BTZ black holes in the anti-de
Sitter case is derived and explained from holographic properties of flat space.
It is shown to coincide with the flat-space limit of the thermodynamics of the
inner black hole horizon on the one hand and the semi-classical approximation
to the gravitational partition function associated to the entropy of the outer
horizon on the other. This leads to the insight that it is the Massieu function
that is universal in the sense that it can be computed at either horizon.Comment: 16 pages Latex file, v2: references added, cosmetic changes, v3: 1
reference adde
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Investigating the impact of poverty on colonization and infection with drug-resistant organisms in humans: a systematic review
Background
Poverty increases the risk of contracting infectious diseases and therefore exposure to antibiotics. Yet there is lacking evidence on the relationship between income and non-income dimensions of poverty and antimicrobial resistance. Investigating such relationship would strengthen antimicrobial stewardship interventions.
Methods
A systematic review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, Ovid, MEDLINE, EMBASE, Scopus, CINAHL, PsychINFO, EBSCO, HMIC, and Web of Science databases were searched in October 2016. Prospective and retrospective studies reporting on income or non-income dimensions of poverty and their influence on colonisation or infection with antimicrobial-resistant organisms were retrieved. Study quality was assessed with the Integrated quality criteria for review of multiple study designs (ICROMS) tool.
Results
Nineteen articles were reviewed. Crowding and homelessness were associated with antimicrobial resistance in community and hospital patients. In high-income countries, low income was associated with Streptococcus pneumoniae and Acinetobacter baumannii resistance and a seven-fold higher infection rate. In low-income countries the findings on this relation were contradictory. Lack of education was linked to resistant S. pneumoniae and Escherichia coli. Two papers explored the relation between water and sanitation and antimicrobial resistance in low-income settings.
Conclusions
Despite methodological limitations, the results suggest that addressing social determinants of poverty worldwide remains a crucial yet neglected step towards preventing antimicrobial resistance
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