New findings on the dynamics of HIV and TB coinfection models

In this paper we study a model for HIV and TB coinfection. We consider the integer order and the fractional order versions of the model. Let α∈[0.78,1.0] be the order of the fractional derivative, then the integer order model is obtained for α=1.0. The model includes vertical transmission for HIV and treatment for both diseases. We compute the reproduction number of the integer order model and HIV and TB submodels, and the stability of the disease free equilibrium. We sketch the bifurcation diagrams of the integer order model, for variation of the average number of sexual partners per person and per unit time, and the tuberculosis transmission rate. We analyze numerical results of the fractional order model for different values of α, including α=1. The results show distinct types of transients, for variation of α. Moreover, we speculate, from observation of the numerical results, that the order of the fractional derivative may behave as a bifurcation parameter for the model. We conclude that the dynamics of the integer and the fractional order versions of the model are very rich and that together these versions may provide a better understanding of the dynamics of HIV and TB coinfection

A coinfection model for HIV and HCV

We study a mathematical model for the human immunodeficiency virus (HIV) and hepatites C virus (HCV) coinfection. The model predicts four distinct equilibria: the disease free, the HIV endemic, the HCV endemic, and the full endemic equilibria. The local and global stability of the disease free equilibrium was calculated for the full model and the HIV and HCV submodels. We present numerical simulations of the full model where the distinct equilibria can be observed. We show simulations of the qualitative changes of the dynamical behavior of the full model for variation of relevant parameters. From the results of the model, we infer possible measures that could be implemented in order to reduce the number of infected individuals

A Novel Approach to Optimize the Design of Parts for Additive Manufacturing

Additive Manufacturing (AM) is a term used to group the different manufacturing processes that use various techniques, each of which is capable of producing parts made from a wide variety of materials, such as polymers, ceramics, metals, wood, among others. All these technologies allow parts manufacturing by adding successive layers of material which can be liquid, powder or wire. In order to take advantages of the geometric freedom offered by AM, Topological Optimization (TO) is usually used. TO provides the optimal distribution of material for a given request. The main objective is weight reduction, without compromising the original resistance of an existing part produced by traditional processes. Taking advantage of the freedom allowed by the AM process and conciliating it with the CAE features, which allow to simulate the parts behavior when subjected to the expected loads, a new approach methodology was drawn in order to shorten the time needed to optimize parts design for AM. A case study was developed in order to validate the methodology established. The combination of AM and TO revealed promising results, attending to the component efficiency achieved.info:eu-repo/semantics/publishedVersio

Improving the Cut Surface Quality by Optimizing Parameters in the Fibre Laser Cutting Process

One of the main problems with laser cutting equipment is related to the wrong setting of cutting parameters. The mismatching of these parameters leads to a loss of cut surface quality, which is hardly re-established. This loss of quality is usually related to a burr problem. Thus, this study is aimed to improve and optimize this process using a fibre laser equipment. Three important laser cutting parameters were studied in order to investigate their importance in the cut surface quality: radiation power, cutting speed and gas pressure. The different values were performed cutting a stainless steel AISI 316L and a cold rolled steel St12. Metallographic and cut surface analysis, burr and roughness measurements were carried out, supported by a Scanning Electron Microscopy and profilometry. Through the Taguchi statistical analysis model, it is possible to indicate the best set of laser cutting parameters. It was verified that the values recommended by the equipment manufacturer can be optimized, being possible to use less radiation power in the laser beam with greater speed of cut, providing a better cut surface quality, improving and optimizing the entire process.info:eu-repo/semantics/publishedVersio

Improving manual assembly lines devoted to complex electronic devices by applying Lean tools

Manual assembly lines are usually deeply studied before implementation. Nevertheless, several problems upsurge when the product needs to be slightly changed. This is very common in complex electric and electronic devices usually produced in small batches, where the customers are demanding more and more features and the product needs to be continuously updated. However, these updates sometimes create huge difficulties for the previously installed assembly line, generating as well, line unbalancing and wastes of time regarding the initial situation. In this paper, a deep study of an adjusted assembly line of electronic devices was carried out using Value Stream Mapping (VSM) method to fully understand and document the different tasks and operations. The Lean Line Balancing (LLB) was also applied in order to reduce the line bottleneck by balancing the Task Time (TT) of each workstation so that there are no delays, and nobody is overburden with their task. Standardized processes and standardized work were also applied. During the line layout development stage, assembly fixtures, wastes reductions and visual management techniques were applied as well, different concepts were generated and, finally, the best solutions were selected. Throughout the study, many benefits for the studied manual assembly line were found, which can be considered as a strong motivation to apply Lean Manufacturing (LM) tools for better line efficiency and production rate.info:eu-repo/semantics/publishedVersio

Effects of treatment, awareness and condom use in a coinfection model for HIV and HCV in MSM

We develop a new a coinfection model for hepatitis C virus (HCV) and the human immunodeficiency virus (HIV). We consider treatment for both diseases, screening, unawareness and awareness of HIV infection, and the use of condoms. We study the local stability of the disease-free equilibria for the full model and for the two submodels (HCV only and HIV only submodels). We sketch bifurcation diagrams for different parameters, such as the probabilities that a contact will result in a HIV or an HCV infection. We present numerical simulations of the full model where the HIV, HCV and double endemic equilibria can be observed. We also show numerically the qualitative changes of the dynamical behavior of the full model for variation of relevant parameters. We extrapolate the results from the model for actual measures that could be implemented in order to reduce the number of infected individuals

The Improvement of an APEX Machine involved in the Tire Manufacturing Process

Over the years, there has been a huge expansion in the automotive component industry and its consequent innovation, which has evolved along with automation and robotics. Therefore, in order to ensure component quality, as well as the quality of the entire production process, it is crucial to enhance competitiveness in the sector. Since quality is a key feature in this industry, all manufacturers and suppliers are scrutinized by systematic audits to ensure constant improvements. This work was developed at a multinational industry and focuses on tire production for the automotive sector. Tires present a complex production process, which covers a wide range of activities from mixing, preparation, construction and vulcanization to the inspection departments, all of which are greatly predisposed to process improvement. In one of these departments (Preparation - APEX machines, responsible for the tire bead production), one of the main problems detected was directly related to a large number of failures in the pneumatic systems. These were found to be difficult to control, both in terms of speed and positioning. Some of the failures in automation were generating delays in certain processes, leading to lengthy setup times and culminating in higher production costs. In order to achieve greater quality, reliability and accuracy, a higher level of automation was applied to these kinds of machines by resorting to 5S methodology. A safety upgrade of the equipment was also undertaken, which will allow for the improvement of workplace safety.The performance improvement of the APEX machines was reached by implementing the following strategies: the automation of conveyor and tray movements between the cutting and application subprocesses; the implementation of 5S methodology; the automation of the cutting process; the updating of safety devices; and the automated control of the separation subprocess. A strong decrease in the breakdown time was recorded (-62%) resulting of the project implementation. The APEXmachine performance was also improved in 9%.info:eu-repo/semantics/publishedVersio

Radiative corrections to the Casimir effect for the massive scalar field

We compute the $O(\lambda)$ correction to the Casimir energy for the massive $\lambda\phi^4$ model confined between a pair of parallel plates. The calculations are made with Dirichlet and Neumann boundary conditions. The correction is shown to be sensitive to the boundary conditions, except in the zero mass limit, in which case our results agree with those found in the literature.Comment: 6 pages. Work presented at the XXIII Brazilian National Meeting on Particles and Fields (Aguas de Lindoia, Brazil, 15-19 Oct 2002). Also available at http://www.sbf1.if.usp.br/eventos/enfpc/xxiii/procs/RES142.pd

MAXIMUM NUMBER OF REPETITIONS, TOTAL WEIGHT LIFTED AND NEUROMUSCULAR FATIGUE IN INDIVIDUALS WITH DIFFERENT TRAINING BACKGROUNDS

The aim of this study was to evaluate the performance, as well as neuromuscular activity, in a strength task in subjects with different training backgrounds. Participants (n = 26) were divided into three groups according to their training backgrounds (aerobic, strength or mixed) and submitted to three sessions: (1) determination of the maximum oxygen uptake during the incremental treadmill test to exhaustion and familiarization of the evaluation of maximum strength (1RM) for the half squat; (2) 1RM determination; and (3) strength exercise, four sets at 80�0of the 1RM, in which the maximum number of repetitions (MNR), the total weight lifted (TWL), the root mean square (RMS) and median frequency (MF) of the electromyographic (EMG) activity for the second and last repetition were computed. There was an effect of group for MNR, with the aerobic group performing a higher MNR compared to the strength group (P = 0.045), and an effect on MF with a higher value in the second repetition than in the last repetition (P = 0.016). These results demonstrated that individuals with better aerobic fitness were more fatigue resistant than strength trained individuals. The absence of differences in EMG signals indicates that individuals with different training backgrounds have a similar pattern of motor unit recruitment during a resistance exercise performed until failure, and that the greater capacity to perform the MNR probably can be explained by peripheral adaptations

Hematopoietic stem cell transplantation is effective curative treatment in pediatric refractory/aggressive Langerhans cell histiocytosis

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