Lymphocyte population in the granulomatous lesions of wild-boars (Sus scrofa) suspected of tuberculosis

Só está disponível o resumoLymphocyte population in the granulomatous lesions of wild-boars (Sus scrofa) suspected of tuberculosis

Importância dos Saca-Rabos (Herpestes Ichneumon) como Reservatório de Mycobacterium avium subsp. paratuberculosis. Deteção por Técnicas Tradicionais e Moleculares

Poster apresentado nas IV Jornadas de Genética, realizadas na UTAD, Vila Real, nos dias 1,2 e 3 de Março de 2012.Os saca-rabos (Herpestes ichneumon) também conhecidos por mangustos, são carnívoros diurnos selvagens que juntamente com a geneta (Genetta genetta) representam os exemplares da família Viverridae em Portugal. É uma espécie cinegética de caça menor que se alimenta de coelhos, roedores, aves, cobras, insectos e ovos. Neste estudo colheram-se amostras de 8 animais mortos por atropelamento e em ações de controlo de predadores, durante os anos de 2010 e 2011, nos concelhos de Idanha-a-Nova e Penamacor do distrito de Castelo Branco. As amostras colhidas foram fígado, pulmão, baço, intestino, rim, gânglio mesentérico, retrofaríngeo, mediastínico, amígdalas e fezes. As amostras foram submetidas à técnica de PCR e a cultura microbiológica em meios específicos. Em três saca-rabos (37,5%) detectou-se Mycobacterium avium subsp. paratuberculosis (Map) através da técnica de biologia molecular. Dois eram machos e um era fêmea. Map foi confirmado também em cultura nos dois machos. Sete saca-rabos (87,5%) apresentaram bactérias álcool-ácido resistentes compatíveis com Map em esfregaços de diferentes tecidos, quando corados pelo método de Ziehl-Neelsen. Estes resultados preliminares confirmam os saca-rabos como reservatório de Map no nosso país. Atualmente, estão a ser desenvolvidos mais estudos para a avaliação dos saca-rabos na dinâmica da infeção de Map em mamíferos selvagens

Deteção molecular de Mycobacterium avium subsp. paratuberculosis em duas lontras (Lutra lutra, Linnaeus, 1758)

Deteção molecular de Mycobacterium avium subsp. paratuberculosis em duas lontras (Lutra lutra, Linnaeus, 1758)

Granulomatous lesions and Mycobacterium avium subsp. paratuberculosis in portuguese wild boars (Sus scrofa)

Granulomatous lesions and Mycobacterium avium subsp. paratuberculosis in portuguese wild boars (Sus scrofa)

Disease processes identified in road killed wild carnivores

Só está disponível o resumoDisease processes identified in road killed wild carnivores

Renal lesions in deer (Cervus elaphus) - Mycobacterium avium subsp. paratuberculosis involvelment

Renal lesions in deer (Cervus elaphus) - Mycobacterium avium subsp. paratuberculosis involvelment

Reactive phenotypes after acute and chronic NK‐cell activation

J Biol Regul Homeost Agents. 2004 Jul-Dec;18(3-4):331-4. Reactive phenotypes after acute and chronic NK-cell activation. Lima M, Almeida J, Teixeira MA, Santos AH, Queirós ML, Fonseca S, Moura J, Gonçalves M, Orfão A, Pinto Ribeiro AC. Service of Clinical Hematology, Laboratory of Cytometry, Hospital Geral de Santo António, Porto, Portugal. [email protected] Abstract Several phenotypic changes have been shown to occur after NK-cell stimulation, involving molecules that have been proved to regulate NK-cell migration into tissues and NK-cell activation and proliferation as well as target cell recognition and killing. Here, we review the reactive phenotypes observed in vivo after acute and chronic NK-cell activation. PMID: 15786700 [PubMed - indexed for MEDLINE

The Dark Matter Density in the Solar Neighborhood reconsidered

Both the gas flaring and the dip in the rotation curve, which was recently reconfirmed with precise measurements using the VERA VLBI array in Japan, suggest doughnut-like substructure in the dark matter (DM) halo. A global fit to all available data shows that the data are indeed best described by an NFW DM profile complemented by two doughnut-like DM substructures with radii of 4.2 and 12.4 kpc, which coincide with the local dust ring and the Monocerus ring of stars, respectively. Both regions have been suggested as regions with tidal streams from "shredded" satellites. If real, the radial extensions of these nearby ringlike structures enhance the local dark matter density by a factor of four to about 1.3$\pm0.3$ GeV/cm$^3$. It is shown that i) this higher DM density is perfectly consistent with the local gravitational potential determining the surface density and the local matter density (Oort limit), ii) previous determinations of the surface density were biased by the assumption of a smoothly varying DM halo and iii) the s-shaped gas flaring is explained. Such a possible enhancement of the local DM density is of great interest for direct DM searches and would change the directional dependence for indirect DM searches.Comment: 14 pages, 4 figures, extended version, accepted for publication in JCA

Neonatal Apex Resection Triggers Cardiomyocyte Proliferation, Neovascularization and Functional Recovery Despite Local Fibrosis

So far, opposing outcomes have been reported following neonatal apex resection in mice, questioning the validity of this injury model to investigate regenerative mechanisms. We performed a systematic evaluation, up to 180 days after surgery, of the pathophysiological events activated upon apex resection. In response to cardiac injury, we observed increased cardiomyocyte proliferation in remote and apex regions, neovascularization, and local fibrosis. In adulthood, resected hearts remain consistently shorter and display permanent fibrotic tissue deposition in the center of the resection plane, indicating limited apex regrowth. However, thickening of the left ventricle wall, explained by an upsurge in cardiomyocyte proliferation during the initial response to injury, compensated cardiomyocyte loss and supported normal systolic function. Thus, apex resection triggers both regenerative and reparative mechanisms, endorsing this injury model for studies aimed at promoting cardiomyocyte proliferation and/or downplaying fibrosis. In this article, Nascimento and colleagues demonstrate that neonatal apex resection stimulates cardiomyocyte proliferation and permanent scarring in the apex. Newly formed cardiomyocytes compensate muscle loss by resection, and resected hearts recover functional competence in adulthood. These findings endorse this model for studies aiming to block cardiac fibrosis and/or favoring CM proliferation

Assessing chronic wasting disease risk in Portugal

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