991 research outputs found
The ALTCRISS project on board the International Space Station
The Altcriss project aims to perform a long term survey of the radiation
environment on board the International Space Station. Measurements are being
performed with active and passive devices in different locations and
orientations of the Russian segment of the station. The goal is to perform a
detailed evaluation of the differences in particle fluence and nuclear
composition due to different shielding material and attitude of the station.
The Sileye-3/Alteino detector is used to identify nuclei up to Iron in the
energy range above 60 MeV/n. Several passive dosimeters (TLDs, CR39) are also
placed in the same location of Sileye-3 detector. Polyethylene shielding is
periodically interposed in front of the detectors to evaluate the effectiveness
of shielding on the nuclear component of the cosmic radiation. The project was
submitted to ESA in reply to the AO in the Life and Physical Science of 2004
and data taking began in December 2005. Dosimeters and data cards are rotated
every six months: up to now three launches of dosimeters and data cards have
been performed and have been returned with the end of expedition 12 and 13.Comment: Accepted for publication on Advances in Space Research
http://dx.doi.org/10.1016/j.asr.2007.04.03
Capability of the PAMELA Time-Of-Flight to identify light nuclei: results from a beam test calibration
PAMELA is a space telescope orbiting around the Earth since June 2006. The
scientific objectives addressed by the mission are the measurement of the
antiprotons and positrons spectra in cosmic rays, the hunt for anti-nuclei as
well as the determination of light nuclei fluxes from Hydrogen to Oxygen in a
wide energy range and with very high statistics. In this paper the charge
discrimination capabilities of the PAMELA Time-Of-Flight system for light
nuclei, determined during a beam test calibration, will be presented.Comment: 17 pages, 9 figures, accepted for pubblication in NIM
Antimatter research in Space
Two of the most compelling issues facing astrophysics and cosmology today are
to understand the nature of the dark matter that pervades the universe and to
understand the apparent absence of cosmological antimatter. For both issues,
sensitive measurements of cosmic-ray antiprotons and positrons, in a wide
energy range, are crucial. Many different mechanisms can contribute to
antiprotons and positrons production, ranging from conventional reactions up to
exotic processes like neutralino annihilation. The open problems are so
fundamental (i.e.: is the universe symmetric in matter and antimatter ?) that
experiments in this field will probably be of the greatest interest in the next
years. Here we will summarize the present situation, showing the different
hypothesis and models and the experimental measurements needed to lead to a
more established scenario.Comment: 10 pages, 7 figures, Invited talk at the 18th European Cosmic Ray
Symposium, Moscow, July 2002, submitted to Journal of Physics
Evaluation of the imaging performance of the TECNOMUSE muon tomograph and its feasibility in a real scenario
Muon tomography is a very promising imaging technique for the control of cargo
containers. It takes advantage of cosmic muons and their interaction mechanisms to reconstruct
images of the volume traversed by these particles. In the present work, the imaging
performance of a novelmuon tomography scanner based on resistive plate chambers detectors
is investigated. By means of several Monte Carlo simulations, some imaging parameters are
evaluated. The results in terms of spatial resolution, field-of-view and volume and material
recognition make the presented scanner and its geometry suitable for muon tomograph
The nucleolar protein nucleophosmin is physiologically secreted by endothelial cells in response to stress exerting proangiogenic activity both in vitro and in vivo
Nucleophosmin (NPM), a nucleolar multifunctional phosphoprotein, acts as a stress sensor in different cell types. NPM can be actively secreted by inflammatory cells, however its biology on endothelium remains unexplored. In this study, we show for the first time that NPM is secreted by human vein endothelial cells (HUVEC) in the early response to serum deprivation and that NPM acts as a pro-inflammatory and angiogenic molecule both in vitro and in vivo. Accordingly, 24 h of serum starvation condition induced NPM relocalization from the nucleus to cytoplasm. Interestingly, NPM was increasingly excreted in HUVEC-derived conditioned media in a time dependent fashion upon stress conditions up to 24 h. The secretion of NPM was unrelated to cell necrosis within 24 h. The treatment with exogenous and recombinant NPM (rNPM) enhanced migration as well as the Intercellular Adhesion Molecule 1 (ICAM-1) but not Vascular cell adhesion protein 1 (VCAM-1) expression and it did not affect cell proliferation. Notably, in vitro tube formation by Matrigel assay was significantly increased in HUVEC treated with rNPM compared to controls. This result was confirmed by the in vivo injection of Matrigel plug assay upon stimulation with rNPM, displaying significant enhanced number of functional capillaries in the plugs. The stimulation with rNPM in HUVEC was also associated to the increased expression of master genes regulating angiogenesis and migration, including Vascular Endothelial Growth Factor-A (VEGF-A), Hepatocyte Growth Factor (HGF), Stromal derived factor-1 (SDF-1), Fibroblast growth factor-2 (FGF-2), Platelet Derived Growth Factor-B (PDGF-B), and Matrix metallopeptidase 9 (MMP9). Our study demonstrates for the first time that NPM is physiologically secreted by somatic cells under stress condition and in the absence of cell necrosis. The analysis of the biological effects induced by NPM mainly related to a pro-angiogenic and inflammatory activity might suggest an important autocrine/paracrine role for NPM in the regulation of both phenomena
EBV-specific CD8 T lymphocytes and B cells during glatiramer acetate therapy in patients with MS
OBJECTIVE: Infection with Epstein-Barr virus (EBV) has been associated with clinical activity and risk of developing MS. The purpose of this study is to investigate the impact of glatiramer acetate (GA) therapy on EBV-specific immune responses and disease course. METHODS: We characterized EBV-specific CD8 T lymphocytes and B cells during disease-modifying treatments in 2 groups of patients with MS. We designed a 2-pronged approach consisting of a cross-sectional study (39 untreated patients, 38 patients who had undergone 12 months of GA treatment, and 48 healthy donors compatible for age and sex with the patients with MS) and a 12-month longitudinal study (35 patients treated with GA). CD8 EBV-specific T cells and B lymphocytes were studied using pentamers and multiparametric flow cytometry. RESULTS: We find that treatment with GA enhances viral recognition by inducing an increased number of circulating virus-specific CD8 T cells (p = 0.0043) and by relieving their features of exhaustion (p = 0.0053) and senescence (p < 0.0001, p = 0.0001). B cells, phenotypically and numerically tracked along the 1-year follow-up study, show a steady decrease in memory B-cell frequencies (p = 0.025), paralleled by an increase of the naive B subset. CONCLUSION: GA therapy acts as a disease-modifying therapy restoring homeostasis in the immune system, including anti-EBV responses
The Cosmic-Ray Proton and Helium Spectra measured with the CAPRICE98 balloon experiment
A new measurement of the primary cosmic-ray proton and helium fluxes from 3
to 350 GeV was carried out by the balloon-borne CAPRICE experiment in 1998.
This experimental setup combines different detector techniques and has
excellent particle discrimination capabilities allowing clear particle
identification. Our experiment has the capability to determine accurately
detector selection efficiencies and systematic errors associated with them.
Furthermore, it can check for the first time the energy determined by the
magnet spectrometer by using the Cherenkov angle measured by the RICH detector
well above 20 GeV/n. The analysis of the primary proton and helium components
is described here and the results are compared with other recent measurements
using other magnet spectrometers. The observed energy spectra at the top of the
atmosphere can be represented by (1.27+-0.09)x10^4 E^(-2.75+-0.02) particles
(m^2 GeV sr s)^-1, where E is the kinetic energy, for protons between 20 and
350 GeV and (4.8+-0.8)x10^2 E^(-2.67+-0.06) particles (m^2 GeV nucleon^-1 sr
s)^-1, where E is the kinetic energy per nucleon, for helium nuclei between 15
and 150 GeV nucleon^-1.Comment: To be published on Astroparticle Physics (44 pages, 13 figures, 5
tables
Accelerator Testing of the General Antiparticle Spectrometer, a Novel Approach to Indirect Dark Matter Detection
We report on recent accelerator testing of a prototype general antiparticle
spectrometer (GAPS). GAPS is a novel approach for indirect dark matter searches
that exploits the antideuterons produced in neutralino-neutralino
annihilations. GAPS captures these antideuterons into a target with the
subsequent formation of exotic atoms. These exotic atoms decay with the
emission of X-rays of precisely defined energy and a correlated pion signature
from nuclear annihilation. This signature uniquely characterizes the
antideuterons. Preliminary analysis of data from a prototype GAPS in an
antiproton beam at the KEK accelerator in Japan has confirmed the
multi-X-ray/pion star topology and indicated X-ray yields consistent with prior
expectations. Moreover our success in utilizing solid rather than gas targets
represents a significant simplification over our original approach and offers
potential gains in sensitivity through reduced dead mass in the target area.Comment: 18 pages, 9 figures, submitted to JCA
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