New insight into cataract formation -- enhanced stability through mutual attraction

Small-angle neutron scattering experiments and molecular dynamics simulations combined with an application of concepts from soft matter physics to complex protein mixtures provide new insight into the stability of eye lens protein mixtures. Exploring this colloid-protein analogy we demonstrate that weak attractions between unlike proteins help to maintain lens transparency in an extremely sensitive and non-monotonic manner. These results not only represent an important step towards a better understanding of protein condensation diseases such as cataract formation, but provide general guidelines for tuning the stability of colloid mixtures, a topic relevant for soft matter physics and industrial applications.Comment: 4 pages, 4 figures. Accepted for publication on Phys. Rev. Let

Impact of classical forces and decoherence in multi-terminal Aharonov-Bohm networks

Multi-terminal Aharonov-Bohm (AB) rings are ideal building blocks for quantum networks (QNs) thanks to their ability to map input states into controlled coherent superpositions of output states. We report on experiments performed on three-terminal GaAs/Al_(x)Ga_(1-x)As AB devices and compare our results with a scattering-matrix model including Lorentz forces and decoherence. Our devices were studied as a function of external magnetic field (B) and gate voltage at temperatures down to 350 mK. The total output current from two terminals while applying a small bias to the third lead was found to be symmetric with respect to B with AB oscillations showing abrupt phase jumps between 0 and pi at different values of gate voltage and at low magnetic fields, reminiscent of the phase-rigidity constraint due to Onsager-Casimir relations. Individual outputs show quasi-linear dependence of the oscillation phase on the external electric field. We emphasize that a simple scattering-matrix approach can not model the observed behavior and propose an improved description that can fully describe the observed phenomena. Furthermore, we shall show that our model can be successfully exploited to determine the range of experimental parameters that guarantee a minimum oscillation visibility, given the geometry and coherence length of a QN.Comment: 7 pages, 8 figure

Modelling a Particle Detector in Field Theory

Particle detector models allow to give an operational definition to the particle content of a given quantum state of a field theory. The commonly adopted Unruh-DeWitt type of detector is known to undergo temporary transitions to excited states even when at rest and in the Minkowski vacuum. We argue that real detectors do not feature this property, as the configuration "detector in its ground state + vacuum of the field" is generally a stable bound state of the underlying fundamental theory (e.g. the ground state-hydrogen atom in a suitable QED with electrons and protons) in the non-accelerated case. As a concrete example, we study a local relativistic field theory where a stable particle can capture a light quantum and form a quasi-stable state. As expected, to such a stable particle correspond energy eigenstates of the full theory, as is shown explicitly by using a dressed particle formalism at first order in perturbation theory. We derive an effective model of detector (at rest) where the stable particle and the quasi-stable configurations correspond to the two internal levels, "ground" and "excited", of the detector.Comment: 13 pages, references added, final versio

Highly nonlinear dynamics in a slowly sedimenting colloidal gel

We use a combination of original light scattering techniques and particles with unique optical properties to investigate the behavior of suspensions of attractive colloids under gravitational stress, following over time the concentration profile, the velocity profile, and the microscopic dynamics. During the compression regime, the sedimentation velocity grows nearly linearly with height, implying that the gel settling may be fully described by a (time-dependent) strain rate. We find that the microscopic dynamics exhibit remarkable scaling properties when time is normalized by strain rate, showing that the gel microscopic restructuring is dominated by its macroscopic deformation.Comment: Physical Review Letters (2011) xxx

Current-Phase Relation of a Bose-Einstein Condensate Flowing Through a Weak Link

We study the current-phase relation of a Bose-Einstein condensate flowing through a repulsive square barrier by solving analytically the one dimensional Gross-Pitaevskii equation. The barrier height and width fix the current-phase relation $j(\delta\phi)$, which tends to $j\sim\cos(\delta\phi/2)$ for weak barriers and to the Josephson sinusoidal relation $j\sim\sin(\delta\phi)$ for strong barriers. Between these two limits, the current-phase relation depends on the barrier width. In particular, for wide enough barriers, we observe two families of multivalued current-phase relations. Diagrams belonging to the first family, already known in the literature, can have two different positive values of the current at the same phase difference. The second family, new to our knowledge, can instead allow for three different positive currents still corresponding to the same phase difference. Finally, we show that the multivalued behavior arises from the competition between hydrodynamic and nonlinear-dispersive components of the flow, the latter due to the presence of a soliton inside the barrier region.Comment: 6 pages, 5 figure

Analytical spectrum of nonlinear Thomson scattering including radiation reaction

Accelerated charges emit electromagnetic radiation and the consequent energy-momentum loss alters their trajectory. This phenomenon is known as radiation reaction and the Landau-Lifshitz (LL) equation is the classical equation of motion of the electron, which takes into account radiation-reaction effects in the electron trajectory. By using the analytical solution of the LL equation in an arbitrary plane wave, we compute the analytical expression of the classical emission spectrum via nonlinear Thomson scattering including radiation-reaction effects. Both the angularly-resolved and the angularly-integrated spectra are reported, which are valid in an arbitrary plane wave. Also, we have obtained a phase-dependent expression of the electron dressed mass, which includes radiation-reaction effects. Finally, the corresponding spectra within the locally constant field approximation have been derived.Comment: 18 pages, no figure

Institutional oversight of the graduate medical education enterprise: development of an annual institutional review

Background: The Accreditation Council for Graduate Medical Education (ACGME) fully implemented all aspects of the Next Accreditation System (NAS) on July 1, 2014. In lieu of periodic accreditation site visits of programs and institutions, the NAS requires active, ongoing oversight by the sponsoring institutions (SIs) to maintain accreditation readiness and program quality. Methods: The Ochsner Health System Graduate Medical Education Committee (GMEC) has instituted a process that provides a structured, process-driven improvement approach at the program level, using a Program Evaluation Committee to review key performance data and construct an annual program evaluation for each accredited residency. The Ochsner GMEC evaluates the aggregate program data and creates an Annual Institutional Review (AIR) document that provides direction and focus for ongoing program improvement. This descriptive article reviews the 2014 process and various metrics collected and analyzed to demonstrate the program review and institutional oversight provided by the Ochsner graduate medical education (GME) enterprise. Results: The 2014 AIR provided an overview of performance and quality of the Ochsner GME program for the 2013-2014 academic year with particular attention to program outcomes; resident supervision, responsibilities, evaluation, and compliance with duty-hour standards; results of the ACGME survey of residents and core faculty; and resident participation in patient safety and quality activities and curriculum. The GMEC identified other relevant institutional performance indicators that are incorporated into the AIR and reflect SI engagement in and contribution to program performance at the individual program and institutional levels. Conclusion: The Ochsner GME office and its program directors are faced with the ever-increasing challenges of today’s healthcare environment as well as escalating institutional and program accreditation requirements. The overall commitment of this SI to advancing our GME enterprise is clearly evident, and the opportunity for continued improvement resulting from institutional oversight is being realized