Precision determination of the dpi -> NN transition strength at threshold

An unusual but effective way to determine at threshold the dpi -> NN transition strength is to exploit the hadronic ground-state broadening in pionic deuterium, accessible by x-ray spectroscopy. The broadening is dominated by the true absorption channel dpi- -> nn, which is related to s-wave pion production pp -> dpi+ by charge symmetry and detailed balance. Using the exotic atom circumvents the problem of Coulomb corrections to the cross section as necessary in the production experiments. Our dedicated measurement finds (1171+23/-49) meV for the broadening yielding (252+5/-11) \mub.Comment: 4 pages, 2 figures, 1 tabl

Line shape of the muH(3p - 1s) hyperfine transitions

The (3p - 1s) X-ray transition to the muonic hydrogen ground state was measured with a high resolution crystal spectrometer. A Doppler effect broadening of the X-ray line was established which could be attributed to different Coulomb de-excitation steps preceding the measured transition. The assumption of a statistical population of the hyperfine levels of the muonic hydrogen ground state was directly confirmed by the experiment and measured values for the hyperfine splitting can be reported. The results allow a decisive test of advanced cascade model calculations and establish a method to extract fundamental strong-interaction parameters from pionic hydrogen experiments.Comment: Submitted to Physical Review Letter

Pionic Deuterium

The strong interaction shift and broadening in pionic deuterium have been remeasured with high statistics by means of the (3p-1s) X-ray transition using the cyclotron trap and a high-resolution crystal spectrometer. Preliminary results are (-2325+/-31) meV (repulsive) for the shift and (1171+23/-49} meV for the width, which yields precise values for the pion-deuteron scattering length and the threshold parameter for pion production.Comment: Conf. Proc. Few Body 19 (FB19), August 31 - September 5, 2009, Bonn, Germany 9 pages, 13 figure

Line shape analysis of the Kβ\beta transition in muonic hydrogen

The K$\beta$ transition in muonic hydrogen was measured with a high-resolution crystal spectrometer. The spectrum is shown to be sensitive to the ground-state hyperfine splitting, the corresponding triplet-to-singlet ratio, and the kinetic energy distribution in the $3p$ state. The hyperfine splitting and triplet-to-singlet ratio are found to be consistent with the values expected from theoretical and experimental investigations and, therefore, were fixed accordingly in order to reduce the uncertainties in the further reconstruction of the kinetic energy distribution. The presence of high-energetic components was established and quantified in both a phenomenological, i.e. cascade-model-free fit, and in a direct deconvolution of the Doppler broadening based on the Bayesian approach.Comment: 22 pages, 21 figure

Measuring the Lyapunov exponent using quantum mechanics

We study the time evolution of two wave packets prepared at the same initial state, but evolving under slightly different Hamiltonians. For chaotic systems, we determine the circumstances that lead to an exponential decay with time of the wave packet overlap function. We show that for sufficiently weak perturbations, the exponential decay follows a Fermi golden rule, while by making the difference between the two Hamiltonians larger, the characteristic exponential decay time becomes the Lyapunov exponent of the classical system. We illustrate our theoretical findings by investigating numerically the overlap decay function of a two-dimensional dynamical system.Comment: 9 pages, 6 figure

A Solvable Regime of Disorder and Interactions in Ballistic Nanostructures, Part I: Consequences for Coulomb Blockade

We provide a framework for analyzing the problem of interacting electrons in a ballistic quantum dot with chaotic boundary conditions within an energy $E_T$ (the Thouless energy) of the Fermi energy. Within this window we show that the interactions can be characterized by Landau Fermi liquid parameters. When $g$, the dimensionless conductance of the dot, is large, we find that the disordered interacting problem can be solved in a saddle-point approximation which becomes exact as $g\to\infty$ (as in a large-N theory). The infinite $g$ theory shows a transition to a strong-coupling phase characterized by the same order parameter as in the Pomeranchuk transition in clean systems (a spontaneous interaction-induced Fermi surface distortion), but smeared and pinned by disorder. At finite $g$, the two phases and critical point evolve into three regimes in the $u_m-1/g$ plane -- weak- and strong-coupling regimes separated by crossover lines from a quantum-critical regime controlled by the quantum critical point. In the strong-coupling and quantum-critical regions, the quasiparticle acquires a width of the same order as the level spacing $\Delta$ within a few $\Delta$'s of the Fermi energy due to coupling to collective excitations. In the strong coupling regime if $m$ is odd, the dot will (if isolated) cross over from the orthogonal to unitary ensemble for an exponentially small external flux, or will (if strongly coupled to leads) break time-reversal symmetry spontaneously.Comment: 33 pages, 14 figures. Very minor changes. We have clarified that we are treating charge-channel instabilities in spinful systems, leaving spin-channel instabilities for future work. No substantive results are change

THE INTERACTION OF WAVES AND A TURBULENT CURRENT - WAVES PROPAGATING AGAINST THE CURRENT

The results of an experimental study of the interaction between waves and a current propagating in the same direction, have been reported by Kemp & Simons (1982). This paper describes the second part of the study, and considers the case of waves propagating against the current. Tests were performed in a laboratory flume with smooth and rough beds, and velocity measurements were made with a directionally sensitive laser anemometer as described in the previous paper. Analysis, including ensemble averaging of velocities and surface elevation, was performed by an on-line computer. Results indicate that the rate of wave attenuation is greatly increased by the addition of an opposing current, and reduced by a following current. Wave profiles remain closely described by Stokes second-order theory; orbital velocities are also found to be in agreement with a second-order wave theory modified to take account of the presence of the current. Certain results described occur regardless of the relative directions of current and wave. Mean velocities in the upper flow increase in the direction of the wave generator for increasing wave height. This suggests that the current is enhancing the wave-induced mass transport. Near the bed the velocity profiles so change that above the rough bed the current is retarded by the wave motion. In the logarithmic layer over the smooth bed velocities are increased with increasing wave height. However, all changes to velocity profiles have to be carefully interpreted, as the sidewall boundary layer decreases in thickness with even the smallest wave superimposed on the current. Turbulence intensities and Reynolds stresses near the rough bed are increased by the presence of the waves, most strongly in a layer two roughness heights above bed level, where fluctuations are periodic and effected by vortices ejected from the roughness troughs. Above this level, and over the smooth bed, turbulence levels are similar to those for the currents alone

THE INTERACTION BETWEEN WAVES AND A TURBULENT CURRENT - WAVES PROPAGATING WITH THE CURRENT

This paper describes an experimental programme carried out in a laboratory channel with rough and smooth beds, to investigate the interaction between gravity waves and a turbulent current. In particular, changes induced in the mean-velocity profiles, turbulent fluctuations, bed shear stresses and wave attenuation rates are considered for a range of wave heights, keeping the wave period constant. The smooth-boundary tests were carried out as a necessary preliminary to the more-realistic rough-boundary condition. A directionally sensitive laser anemometer was used to measure horizontal, vertical, and 45° velocity components in the oscillating fluid, and an on-line minicomputer was programmed to produce ensemble averages of velocities, Reynolds stresses and wave-elevation data. The cycle was sampled at 200 separate phase positions, with 180 observations at each position. Measurements were made at up to 30 points in the vertical. Preliminary tests were carried out on the unidirectional current and on the waves alone. These show that mean-velocity profiles and turbulence parameters of the current agree satisfactorily with previous experiments, and that the waves are approximated closely by Stokes’ second-order theory. For combined wave and current tests, mean-velocity profiles are generally found to differ from those suggested by a linear superposition of wave and current velocities, a change in boundary-layer thickness being indicated. However, shear stresses at the smooth boundary are found to be described by such a linear addition

Intraperitoneal delivery of paclitaxel by poly(ether-anhydride) microspheres effectively suppresses tumor growth in a murine metastatic ovarian cancer model

Intraperitoneal (IP) chemotherapy is more effective than systemic chemotherapy for treating advanced ovarian cancer, but is typically associated with severe complications due to high dose, frequent administration schedule, and use of non-biocompatible excipients/delivery vehicles. Here, we developed paclitaxel (PTX)-loaded microspheres composed of di-block copolymers of poly(ethylene glycol) and poly(sebacic acid) (PEG-PSA) for safe and sustained IP chemotherapy. PEG-PSA microspheres provided efficient loading (∼13 % w/w) and prolonged release (∼13 days) of PTX. In a murine ovarian cancer model, a single dose of IP PTX/PEG-PSA particles effectively suppressed tumor growth for more than 40 days and extended the median survival time to 75 days compared to treatments with Taxol® (47 days) or IP placebo particles (34 days). IP PTX/PEG-PSA was well tolerated with only minimal to mild inflammation. Our findings support PTX/PEG-PSA microspheres as a promising drug delivery platform for IP therapy of ovarian cancer and potentially other metastatic peritoneal cancers

Line shape of the μ H(3 p - 1 s ) transition

The line shape of the (3p − 1s) X-ray transition in muonic hydrogen was measured for the first time with a high-resolution crystal spectrometer. The assumption of a statistical population of the hyperfine levels was directly confirmed by experiment, and a measured value for the hyperfine splitting is reported. An X-ray line broadening due to Doppler effect could be clearly identified and attributed to different Coulomb de-excitation transitions which precede the measured radiative transition. The results allow a decisive test of advanced cascade model calculations and establish an alternative and "model free” method to extract the strong-interaction parameters from pionic hydrogen dat