499 research outputs found
Flux Discharge Cascades in Various Dimensions
We study the dynamics of electric flux discharge by charged particle pair or
spherical string or membrane production in various dimensions. When electric
flux wraps at least one compact cycle, we find that a single "pair" production
event can initiate a cascading decay in real time that "shorts out" the flux
and discharges many units of it. This process arises from local dynamics in the
compact space, and so is invisible in the dimensionally-reduced truncation. It
occurs in theories as simple as the Schwinger model on a circle, and has
implications for any theory with compact dimensions and electric flux,
including string theories and the string landscape.Comment: 19+8 pages, 3 figures, 3 appendice
Multifield Dynamics in Higgs-otic Inflation
In Higgs-otic inflation a complex neutral scalar combination of the and
MSSM Higgs fields plays the role of inflaton in a chaotic fashion. The
potential is protected from large trans-Planckian corrections at large inflaton
if the system is embedded in string theory so that the Higgs fields parametrize
a D-brane position. The inflaton potential is then given by a DBI+CS D-brane
action yielding an approximate linear behaviour at large field. The inflaton
scalar potential is a 2-field model with specific non-canonical kinetic terms.
Previous computations of the cosmological parameters (i.e. scalar and tensor
perturbations) did not take into account the full 2-field character of the
model, ignoring in particular the presence of isocurvature perturbations and
their coupling to the adiabatic modes. It is well known that for generic
2-field potentials such effects may significantly alter the observational
signatures of a given model. We perform a full analysis of adiabatic and
isocurvature perturbations in the Higgs-otic 2-field model. We show that the
predictivity of the model is increased compared to the adiabatic approximation.
Isocurvature perturbations moderately feed back into adiabatic fluctuations.
However, the isocurvature component is exponentially damped by the end of
inflation. The tensor to scalar ratio varies in a region ,
consistent with combined Planck/BICEP results.Comment: 35 pages, 11 figure
Soft branes in supersymmetry-breaking backgrounds
We revisit the analysis of effective field theories resulting from
non-supersymmetric perturbations to supersymmetric flux compactifications of
the type-IIB superstring with an eye towards those resulting from the
backreaction of a small number of anti-D3-branes. Independently of the
background, we show that the low-energy Lagrangian describing the fluctuations
of a stack of probe D3-branes exhibits soft supersymmetry breaking, despite
perturbations to marginal operators that were not fully considered in some
previous treatments. We take this as an indication that the breaking of
supersymmetry by anti-D3-branes or other sources may be spontaneous rather than
explicit. In support of this, we consider the action of an anti-D3-brane
probing an otherwise supersymmetric configuration and identify a candidate for
the corresponding goldstino.Comment: 36+5 pages. References added, minor typos correcte
D3-brane Potentials from Fluxes in AdS/CFT
We give a comprehensive treatment of the scalar potential for a D3-brane in a
warped conifold region of a compactification with stabilized moduli. By
studying general ultraviolet perturbations in supergravity, we systematically
incorporate `compactification effects' sourced by supersymmetry breaking in the
compact space. Significant contributions to the D3-brane potential, including
the leading term in the infrared, arise from imaginary anti-self-dual (IASD)
fluxes. For an arbitrary Calabi-Yau cone, we determine the most general IASD
fluxes in terms of scalar harmonics, then compute the resulting D3-brane
potential. Specializing to the conifold, we identify the operator dual to each
mode of flux, and for chiral operators we confirm that the potential computed
in the gauge theory matches the gravity result. The effects of four-dimensional
curvature, including the leading D3-brane mass term, arise directly from the
ten-dimensional equations of motion. Furthermore, we show that gaugino
condensation on D7-branes provides a local source for IASD flux. This flux
precisely encodes the nonperturbative contributions to the D3-brane potential,
yielding a promising ten-dimensional representation of four-dimensional
nonperturbative effects. Our result encompasses all significant contributions
to the D3-brane potential discussed in the literature, and does so in the
single coherent framework of ten-dimensional supergravity. Moreover, we
identify new terms with irrational scaling dimensions that were inaccessible in
prior works. By decoupling gravity in a noncompact configuration, then
systematically reincorporating compactification effects as ultraviolet
perturbations, we have provided an approach in which Planck-suppressed
contributions to the D3-brane effective action can be computed.Comment: 70 page
The Cosmological Constant
This is a review of the physics and cosmology of the cosmological constant.
Focusing on recent developments, I present a pedagogical overview of cosmology
in the presence of a cosmological constant, observational constraints on its
magnitude, and the physics of a small (and potentially nonzero) vacuum energy.Comment: 50 pages. Submitted to Living Reviews in Relativity
(http://www.livingreviews.org/), December 199
Nonlinear phononics: A new ultrafast route to lattice control
To date, two types of coupling between electromagnetic radiation and a
crystal lattice have been identified experimentally. One is direct, for
infrared (IR)-active vibrations that carry an electric dipole. The second is
indirect, it occurs through intermediate excitation of the electronic system
via electron-phonon coupling, as in stimulated Raman scattering. Nearly 40
years ago, proposals were made of a third path, referred to as ionic Raman
scattering (IRS). It was posited that excitation of an IR-active phonon could
serve as the intermediate state for a Raman scattering process relying on
lattice anharmonicity as opposed to electron phonon interaction. In this paper,
we report an experimental demonstration of ionic Raman scattering and show that
this mechanism is relevant to optical control in solids. The key insight is
that a rectified phonon field can exert a directional force onto the crystal,
inducing an abrupt displacement of the atoms from the equilibrium positions
that could not be achieved through excitation of an IR-active vibration alone,
for which the force is oscillatory. IRS opens up a new direction for the
coherent control of solids in their electronic ground state, different from
approaches that rely on electronic excitations.Comment: 10 manuscript pages, 3 figure
f(R) theories
Over the past decade, f(R) theories have been extensively studied as one of
the simplest modifications to General Relativity. In this article we review
various applications of f(R) theories to cosmology and gravity - such as
inflation, dark energy, local gravity constraints, cosmological perturbations,
and spherically symmetric solutions in weak and strong gravitational
backgrounds. We present a number of ways to distinguish those theories from
General Relativity observationally and experimentally. We also discuss the
extension to other modified gravity theories such as Brans-Dicke theory and
Gauss-Bonnet gravity, and address models that can satisfy both cosmological and
local gravity constraints.Comment: 156 pages, 14 figures, Invited review article in Living Reviews in
Relativity, Published version, Comments are welcom
Endometriosis and Headache
Headache and endometriosis show some similarities in their clinical and epidemiological features that are probably due to the influence of female sexual hormones on both disorders. Epidemiological studies indicate that they are comorbid disorders. However, the nature of the comorbidity is not known with certainty, but a likely explanation may be common susceptibility genes. Another possibility is that, because they both are related to pain, increased pain sensitivity induced by one of the disorders may lead to a higher likelihood of developing the other, possibly mediated by nitrogen oxide or prostaglandins. A common link to the widespread use of estroprogestins may seem less probable. For physicians dealing with women with either of these disorders, awareness of the comorbidity may be helpful in the treatment of the patient
Search for Charged Higgs Bosons in e+e- Collisions at \sqrt{s} = 189 GeV
A search for pair-produced charged Higgs bosons is performed with the L3
detector at LEP using data collected at a centre-of-mass energy of 188.6 GeV,
corresponding to an integrated luminosity of 176.4 pb^-1. Higgs decays into a
charm and a strange quark or into a tau lepton and its associated neutrino are
considered. The observed events are consistent with the expectations from
Standard Model background processes. A lower limit of 65.5 GeV on the charged
Higgs mass is derived at 95 % confidence level, independent of the decay
branching ratio Br(H^{+/-} -> tau nu)
A Phase 3 Trial of Luspatercept in Patients with Transfusion-Dependent ÎČ-Thalassemia
BACKGROUND: Patients with transfusion-dependent ÎČ-thalassemia need regular red-cell transfusions. Luspatercept, a recombinant fusion protein that binds to select transforming growth factor ÎČ superfamily ligands, may enhance erythroid maturation and reduce the transfusion burden (the total number of red-cell units transfused) in such patients. METHODS: In this randomized, double-blind, phase 3 trial, we assigned, in a 2:1 ratio, adults with transfusion-dependent ÎČ-thalassemia to receive best supportive care plus luspatercept (at a dose of 1.00 to 1.25 mg per kilogram of body weight) or placebo for at least 48 weeks. The primary end point was the percentage of patients who had a reduction in the transfusion burden of at least 33% from baseline during weeks 13 through 24 plus a reduction of at least 2 red-cell units over this 12-week interval. Other efficacy end points included reductions in the transfusion burden during any 12-week interval and results of iron studies. RESULTS: A total of 224 patients were assigned to the luspatercept group and 112 to the placebo group. Luspatercept or placebo was administered for a median of approximately 64 weeks in both groups. The percentage of patients who had a reduction in the transfusion burden of at least 33% from baseline during weeks 13 through 24 plus a reduction of at least 2 red-cell units over this 12-week interval was significantly greater in the luspatercept group than in the placebo group (21.4% vs. 4.5%, P<0.001). During any 12-week interval, the percentage of patients who had a reduction in transfusion burden of at least 33% was greater in the luspatercept group than in the placebo group (70.5% vs. 29.5%), as was the percentage of those who had a reduction of at least 50% (40.2% vs. 6.3%). The least-squares mean difference between the groups in serum ferritin levels at week 48 was -348 ÎŒg per liter (95% confidence interval, -517 to -179) in favor of luspatercept. Adverse events of transient bone pain, arthralgia, dizziness, hypertension, and hyperuricemia were more common with luspatercept than placebo. CONCLUSIONS: The percentage of patients with transfusion-dependent ÎČ-thalassemia who had a reduction in transfusion burden was significantly greater in the luspatercept group than in the placebo group, and few adverse events led to the discontinuation of treatment. (Funded by Celgene and Acceleron Pharma; BELIEVE ClinicalTrials.gov number, NCT02604433; EudraCT number, 2015-003224-31.)
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