11,067 research outputs found
Quantum Lightning Never Strikes the Same State Twice
Public key quantum money can be seen as a version of the quantum no-cloning
theorem that holds even when the quantum states can be verified by the
adversary. In this work, investigate quantum lightning, a formalization of
"collision-free quantum money" defined by Lutomirski et al. [ICS'10], where
no-cloning holds even when the adversary herself generates the quantum state to
be cloned. We then study quantum money and quantum lightning, showing the
following results:
- We demonstrate the usefulness of quantum lightning by showing several
potential applications, such as generating random strings with a proof of
entropy, to completely decentralized cryptocurrency without a block-chain,
where transactions is instant and local.
- We give win-win results for quantum money/lightning, showing that either
signatures/hash functions/commitment schemes meet very strong recently proposed
notions of security, or they yield quantum money or lightning.
- We construct quantum lightning under the assumed multi-collision resistance
of random degree-2 systems of polynomials.
- We show that instantiating the quantum money scheme of Aaronson and
Christiano [STOC'12] with indistinguishability obfuscation that is secure
against quantum computers yields a secure quantum money schem
VVV High Proper Motion Survey
Here we present survey of proper motion stars towards the Galactic Bulge and an adjacent plane region base on VISTA-VVV data. The searching method based on cross-matching photometric Ks-band CASU catalogs. The most interesting discoveries are shown.Peer reviewe
MicroRNA-24 regulates vascularity after myocardial infarction
BACKGROUND: Myocardial infarction leads to cardiac remodeling and development of heart failure. Insufficient myocardial capillary density after myocardial infarction has been identified as a critical event in this process, although the underlying mechanisms of cardiac angiogenesis are mechanistically not well understood. METHODS AND RESULTS: Here, we show that the small noncoding RNA microRNA-24 (miR-24) is enriched in cardiac endothelial cells and considerably upregulated after cardiac ischemia. MiR-24 induces endothelial cell apoptosis, abolishes endothelial capillary network formation on Matrigel, and inhibits cell sprouting from endothelial spheroids. These effects are mediated through targeting of the endothelium-enriched transcription factor GATA2 and the p21-activated kinase PAK4, which were identified by bioinformatic predictions and validated by luciferase gene reporter assays. Respective downstream signaling cascades involving phosphorylated BAD (Bcl-XL/Bcl-2-associated death promoter) and Sirtuin1 were identified by transcriptome, protein arrays, and chromatin immunoprecipitation analyses. Overexpression of miR-24 or silencing of its targets significantly impaired angiogenesis in zebrafish embryos. Blocking of endothelial miR-24 limited myocardial infarct size of mice via prevention of endothelial apoptosis and enhancement of vascularity, which led to preserved cardiac function and survival. CONCLUSIONS: Our findings indicate that miR-24 acts as a critical regulator of endothelial cell apoptosis and angiogenesis and is suitable for therapeutic intervention in the setting of ischemic heart disease. [KEYWORDS: Animals, Apoptosis/drug effects, Arterioles/pathology, Capillaries/pathology, Cell Hypoxia, Cells, Cultured/drug effects/metabolism, Collagen, Drug Combinations, Drug Evaluation, Preclinical, Endothelial Cells/ metabolism/pathology, GATA2 Transcription Factor/biosynthesis/genetics, Gene Expression Profiling, Heart Failure/etiology, Heme Oxygenase-1/biosynthesis/genetics, Laminin, Male, Mice, Mice, Inbred C57BL, MicroRNAs/antagonists & inhibitors/genetics/ physiology, Myocardial Infarc
Neon and Sulfur Abundances of Planetary Nebulae in the Magellanic Clouds
The chemical abundances of neon and sulfur for 25 planetary nebulae (PNe) in
the Magellanic Clouds are presented. These abundances have been derived using
mainly infrared data from the Spitzer Space Telescope. The implications for the
chemical evolution of these elements are discussed. A comparison with similarly
obtained abundances of Galactic PNe and HII regions and Magellanic Clouds HII
regions is also given. The average neon abundances are 6.0x10(-5) and
2.7x10(-5) for the PNe in the Large and Small Magellanic Clouds respectively.
These are ~1/3 and 1/6 of the average abundances of Galactic planetary nebulae
to which we compare. The average sulfur abundances for the LMC and SMC are
respectively 2.7x10(-6) and 1.0x10(-6). The Ne/S ratio (23.5) is on average
higher than the ratio found in Galactic PNe (16) but the range of values in
both data sets is similar for most of the objects. The neon abundances found in
PNe and HII regions agree with each other. It is possible that a few (3-4) of
the PNe in the sample have experienced some neon enrichment, but for two of
these objects the high Ne/S ratio can be explained by their very low sulfur
abundances. The neon and sulfur abundances derived in this paper are also
compared to previously published abundances using optical data and
photo-ionization models.Comment: 13 pages, 4 tables, 5 figures. Accepted for publication in Ap
A strategy for implementing non-perturbative renormalisation of heavy-light four-quark operators in the static approximation
We discuss the renormalisation properties of the complete set of four-quark operators with the heavy quark treated in the static
approximation. We elucidate the role of heavy quark symmetry and other symmetry
transformations in constraining their mixing under renormalisation. By
employing the Schroedinger functional, a set of non-perturbative
renormalisation conditions can be defined in terms of suitable correlation
functions. As a first step in a fully non-perturbative determination of the
scale-dependent renormalisation factors, we evaluate these conditions in
lattice perturbation theory at one loop. Thereby we verify the expected mixing
patterns and determine the anomalous dimensions of the operators at NLO in the
Schroedinger functional scheme. Finally, by employing twisted-mass QCD it is
shown how finite subtractions arising from explicit chiral symmetry breaking
can be avoided completely.Comment: 41 pages, 6 figure
Quaternary structure change as a mechanism for the regulation of thymidine kinase 1-like enzymes
SummaryThe human cytosolic thymidine kinase (TK) and structurally related TKs in prokaryotes play a crucial role in the synthesis and regulation of the cellular thymidine triphosphate pool. We report the crystal structures of the TK homotetramer from Thermotoga maritima in four different states: its apo-form, a binary complex with thymidine, as well as the ternary structures with the two substrates (thymidine/AppNHp) and the reaction products (TMP/ADP). In combination with fluorescence spectroscopy and mutagenesis experiments, our results demonstrate that ATP binding is linked to a substantial reorganization of the enzyme quaternary structure, leading to a transition from a closed, inactive conformation to an open, catalytic state. We hypothesize that these structural changes are relevant to enzyme function in situ as part of the catalytic cycle and serve an important role in regulating enzyme activity by amplifying the effects of feedback inhibitor binding
Functional evaluation and testing of a newly developed Teleost’s Fish Otolith derived biocomposite coating for healthcare
Polymers such as polycaprolactone (PCL) possess biodegradability, biocompatibility and affinity with other organic media that makes them suitable for biomedical applications. In this work, a novel biocomposite coating was synthesised by mixing PCL with layers of calcium phosphate (hydroxyapatite, brushite and monetite) from a biomineral called otolith extracted from Teleost fish (Plagioscion Squamosissimus) and multiwalled carbon nanotubes in different concentrations (0.5, 1.0 and 1.5 g/L). The biocomposite coating was deposited on an osteosynthesis material Ti6Al4V by spin coating and various tests such as Fourier transformation infrared spectroscopy (FTIR), Raman spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), scratch tests, MTT reduction cytotoxicity, HOS cell bioactivity (human osteosarcoma) by alkaline phosphatase (ALP) and fluorescence microscopy were performed to comprehensively evaluate the newly developed biocoating. It was found that an increase in the concentration of carbon nanotube induced microstructural phase changes of calcium phosphate (CP) leading to the formation of brushite, monetite and hydroxyapatite. While we discovered that an increase in the concentration of carbon nanotube generally improves the adhesion of the coating with the substrate, a certain threshold exists such that the best deposition surfaces were obtained as PCL/CP/CNT 0.0 g/L and PCL/CP/CNT 0.5 g/L
Chemical Abundances of Planetary Nebulae in the Sagittarius Dwarf Elliptical Galaxy
Spectrophotometry and imaging of the two planetary nebulae He2-436 and
Wray16-423, recently discovered to be in the Sagittarius dwarf elliptical
galaxy, are presented. Wray16-423 is a high excitation planetary nebula (PN)
with a hot central star. In contrast He2-436 is a high density PN with a cooler
central star and evidence of local dust, the extinction exceeding that for
Wray16-423 by E(B-V)=0.28. The extinction to Wray16-423, (E(B-V)=0.14), is
consistent with the extinction to the Sagittarius (Sgr) Dwarf. Both PN show
Wolf-Rayet features in their spectra, although the lines are weak in
Wray16-423. Images in [O III] and H-alpha+[N II], although affected by poor
seeing, yield a diameter of 1.2'' for Wray16-423 after deconvolution; He~2-436
was unresolved. He2-436 has a luminosity about twice that of Wray16-423 and its
size and high density suggest a younger PN. In order to reconcile the differing
luminosity and nebular properties of the two PN with similar age progenitor
stars, it is suggested that they are on He burning tracks
The abundance pattern is very similar in both nebulae and shows an oxygen
depletion of -0.4 dex with respect to the mean O abundance of Galactic PN and
[O/H] = -0.6. The Sgr PN progenitor stars are representative of the higher
metallicity tail of the Sgr population. The pattern of abundance depletion is
similar to that in the only other PN in a dwarf galaxy companion of the Milky
Way, that in Fornax, for which new spectra are presented. However the
abundances are larger than for Galactic halo PN suggesting a later formation
age. The O abundance of the Sgr galaxy deduced from its PN, shows similarities
with that of dwarf ellipticals around M31, suggesting that this galaxy was a
dwarf elliptical before its interaction with the Milky Way.Comment: 24 pages, Latex (aas2pp4.sty) including 5 postscript figures. To
appear in Ap
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