Rotation and activity of pre-main-sequence stars

We present a study of rotation (vsini) and chromospheric activity (Halpha EW) based on an extensive set of high-resolution optical spectra obtained with MIKE on the 6.5m Magellan Clay telescope. Our targets are 74 F-M dwarfs in the young stellar associations Eta Cha, TW Hydrae, Beta Pic, and Tuc-Hor, spanning ages from 6 to 30 Myr. While the Halpha EW for most F and G stars are consistent with pure photospheric absorption, most K and M stars show chromospheric emission. By comparing Halpha EW in our sample to results in the literature, we see a clear evolutionary sequence: Chromospheric activity declines steadily from the T Tauri phase to the main sequence. Using activity as an age indicator, we find a plausible age range for the Tuc-Hor association of 10-40 Myr. Between 5 and 30 Myr, we do not see evidence for rotational braking in the total sample, thus angular momentum is conserved, in contrast to younger stars. This difference indicates a change in the rotational regulation at 5-10 Myr, possibly because disk braking cannot operate longer than typical disk lifetimes, allowing the objects to spin up. The rotation-activity relation is flat in our sample; in contrast to main-sequence stars, there is no linear correlation for slow rotators. We argue that this is because young stars generate their magnetic fields in a fundamentally different way from main-sequence stars, and not just the result of a saturated solar-type dynamo. By comparing our rotational velocities with published rotation periods for a subset of stars, we determine ages of 13 (7-20) Myr and 9 (7-17} Myr for the Eta Cha and TWA associations, respectively, consistent with previous estimates. Thus we conclude that stellar radii from evolutionary models by Baraffe et al. (1998) are in agreement with the observed radii within +-15%. (abridged)Comment: 40 pages, 8 figures, ApJ, in pres

Reflections on retrofits: Overcoming barriers to energy efficiency among the fuel poor in the United Kingdom

To meet targets on fuel poverty, energy efficiency and carbon emissions existing homes need to be more energy efficient. We report the results of a participatory action research project to explore the challenges associated with energy efficiency retrofit programmes and ways to better implement future schemes. Six focus groups were held with 48 participants from a range of energy efficiency roles. Data were analysed thematically using the research question “What are the challenges presented by implementing energy efficiency retrofit programmes”. We identified four themes in the data: Funding mechanisms; Predicting performance; Installation; and People. Challenges include funding mechanisms for retrofit programmes resulting in insufficient time to plan, publicise, implement and evaluate a scheme and insufficient flexibility to specify the most appropriate intervention for individual homes. Site workers sometimes need to adapt retrofit designs because of insufficient detail from the designer and can equate quality of installation with quality of finish. Landlords and occupier behaviour can impact on the programme's success and there is a need for greater information on benefits for landlords and for energy behaviour change interventions run alongside retrofit programmes for occupiers. There is a need for outcome evaluations of retrofit schemes with the results shared with stakeholders

Core cities Green Deal monitoring project – Leeds

Leeds was designated a core city for trialling the Government’s Green Deal domestic energy efficiency policy. Leeds Beckett University undertook a monitoring and testing program on 65 dwellings to investigate the effectiveness of the insulation measures installed and to understand any underperformance. This report outlines the findings from a series of investigations including; surveys, air tightness tests, co heating tests, in situ U-value tests, hygrothermal and thermal bridging modelling, in use monitoring and occupant interviews. The surveys revealed that the ‘whole house approach’ to retrofit was, more often, missing, and quality assurance around insulation detailing was regularly absent, leading to avoidable errors and potentially embedding problems in the installations. Furthermore, moisture issues were, in the majority of instances, over-looked or made worse despite over half the sample having some form of damp. Despite this, energy savings were observed and the appearance of the dwellings were improved, thus apparent satisfaction was generally high, even though the installs were imperfect and moisture problems were introduced. Hygrothermal modelling of IWI cases suggests that thermal bridging at party walls can increase by more than 60% and that there could be potential for rot to embedded timbers. Insulation was recorded to reduce background ventilation of the dwellings by around 25% (a factor unaccounted for in government energy models), although some dwellings were still left with air tightness levels worse than modern day UK Building Regulations limits and replacing wet plaster with IWI was seen to undermine the performance of the insulation. The heat loss coefficient of three homes were tested and showed improvements of 25% and 56% for full retrofits with IWI, and 8% for a party wall retrofit; ¾ of these savings were achieved by fabric improvements and the final quarter from incidentally making dwellings more air tight. The before and after in use monitoring suggested the average savings in energy consumption from all retrofit types (EWI, IWI or other) were between 20% and 29%, although small sampling periods limits the certainty of the results. More reliably it was observed that comfort conditions improved; before the retrofit, 14 of the homes were experiencing discomfort from cold; the retrofit brought on average 2 /3 of uncomfortable homes into more reasonable comfort bands. Nearly all of the occupants had positive experiences, although no householders had to pay for the retrofit, reporting being warmer, bringing unused rooms back into operation and feeling more pride in their homes and communities. A variety of perceptions and behaviours were observed around set point temperatures, use of heating controls and motivations for using energy, all of which contribute to make a complex policy landscape. There is huge potential for domestic retrofit and although this research suggests the curren

The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma.

Blocking the bioactivity of allergens is conceptually attractive as a small-molecule therapy for allergic diseases but has not been attempted previously. Group 1 allergens of house dust mites (HDM) are meaningful targets in this quest because they are globally prevalent and clinically important triggers of allergic asthma. Group 1 HDM allergens are cysteine peptidases whose proteolytic activity triggers essential steps in the allergy cascade. Using the HDM allergen Der p 1 as an archetype for structure-based drug discovery, we have identified a series of novel, reversible inhibitors. Potency and selectivity were manipulated by optimizing drug interactions with enzyme binding pockets, while variation of terminal groups conferred the physicochemical and pharmacokinetic attributes required for inhaled delivery. Studies in animals challenged with the gamut of HDM allergens showed an attenuation of allergic responses by targeting just a single component, namely, Der p 1. Our findings suggest that these inhibitors may be used as novel therapies for allergic asthma

Thin Internal Wall Insulation, Measuring Energy Performance Improvements in Dwellings using Thin Internal Wall Insulation. Summary Report - BEIS

The benefits and risks associated with installing internal wall insulation (IWI) and thin internal wall insulation (TIWI) retrofits into solid wall homes are researched and evaluated for BEIS. In order to deliver this, a holistic approach was adopted and the project was split into four main sections, each of which has an accompanying Annex to this summary report: Annex A: Review of existing literature as well as primary investigations using house surveys, householder questionnaires and installer focus groups into the sociotechnical barriers to IWI and TIWI. Annex B: Technical evaluation of the performance of IWI and six novel TIWI retrofits installed in field trial solid wall Test Houses using before and after building performance evaluations. Annex C: Modelling of the impact on annual energy consumption, EPC rating, overheating risk, condensation risk and moisture accumulation made by IWI and TIWI retrofits in a range of UK house archetypes. Annex D: Laboratory testing of test walls using hygrothermal chambers to quantify the change in moisture and thermal performance of solid brick walls when they are insulated with IWI and TIWI to determine how weathe

The Knee Clinical Assessment Study – CAS(K). A prospective study of knee pain and knee osteoarthritis in the general population

BACKGROUND: Knee pain affects an estimated 25% of the adult population aged 50 years and over. Osteoarthritis is the most common diagnosis made in older adults consulting with knee pain in primary care. However, the relationship between this diagnosis and both the current disease-based definition of osteoarthritis and the regional pain syndrome of knee pain and disability is unclear. Expert consensus, based on current evidence, views the disease and the syndrome as distinct entities but the clinical usefulness of these two approaches to classifying knee pain in older adults has not been established. We plan to conduct a prospective, population-based, observational cohort study to investigate the relative merits of disease-based and regional pain syndrome-based approaches to classification and prognosis of knee pain in older adults. METHODS: All patients aged 50 years and over registered with three general practices in North Staffordshire will be invited to take part in a two-stage postal survey. Respondents to this survey phase who indicate that they have experienced knee pain within the previous 12 months will be invited to attend a research clinic for a detailed assessment. This will consist of clinical interview, physical examination, digital photography, plain x-rays, anthropometric measurement and a brief self-complete questionnaire. All consenting clinic attenders will be followed up by (i) general practice medical record review, (ii) repeat postal questionnaire at 18-months

The DINGO dataset: a comprehensive set of data for the SAMPL challenge

Part of the latest SAMPL challenge was to predict how a small fragment library of 500 commercially available compounds would bind to a protein target. In order to assess the modellers’ work, a reasonably comprehensive set of data was collected using a number of techniques. These included surface plasmon resonance, isothermal titration calorimetry, protein crystallization and protein crystallography. Using these techniques we could determine the kinetics of fragment binding, the energy of binding, how this affects the ability of the target to crystallize, and when the fragment did bind, the pose or orientation of binding. Both the final data set and all of the raw images have been made available to the community for scrutiny and further work. This overview sets out to give the parameters of the experiments done and what might be done differently for future studies

Risk prediction model for knee pain in the Nottingham Community: a Bayesian modeling approach

Background: 25% of the British population over the age of 50 experience knee pain. It can limit physical ability, cause distress and bears significant socioeconomic costs. Knee pain, not knee osteoarthritis (KOA) is the all to common malady. The objectives of this study were to develop and validate the first risk prediction model for incident knee pain in the Nottingham community and validate this internally within the Nottingham cohort and externally within the Osteoarthritis Initiaitve (OAI) Cohort. Methods: 1822 participants at risk for knee pain from the Nottingham community were followed up for 12 years. Of this cohort, 2/3 (n=1203) were used to develop the risk prediction model and 1/3 (n=619) were used to validate the model. Incident knee pain was defined as pain on most days for at least one month in the past 12 months. Predictors were age, gender, body mass index (BMI), pain elsewhere, prior knee injury and knee alignment. Bayesian logistic regression model was used to determine the probability of an odds ratio >1. The Hosmer-Lemeshow x2 statistic (HLS) was used for calibration and receiver operator characteristics (ROC) was used for discrimination. The OAI cohort was used to examine the performance of the model in a secondary care population. Results: A risk prediction model for knee pain incidence was developed using a Bayesian approach. The model had good calibration with HLS of 7.17 (p=0.52) and moderate discriminative abilities (ROC 0.70) in the community. Individual scenarios are given using the model. However, the model had poor calibration (HLS 5866.28, p<0.01) and poor discriminative ability (ROC 0.54) in the OAI secondary care dataset. Conclusion: This is the first risk prediction model for knee pain, irrespective of underlying structural changes of KOA, in the community using a Bayesian modelling approach. The model appears to work well in a community-based population but not in a hospital derived cohort and may provide a convenient tool for primary care to predict the risk of knee pain in the general population