Prolactin delays hair regrowth in mice

Mammalian hair growth is cyclic, with hair-producing follicles alternating between active (anagen) and quiescent (telogen) phases. The timing of hair cycles is advanced in prolactin receptor (PRLR) knockout mice, suggesting that prolactin has a role in regulating follicle cycling. In this study, the relationship between profiles of circulating prolactin and the first post-natal hair growth cycle was examined in female Balb/c mice. Prolactin was found to increase at 3 weeks of age, prior to the onset of anagen 1 week later. Expression of PRLR mRNA in skin increased fourfold during early anagen. This was followed by upregulation of prolactin mRNA, also expressed in the skin. Pharmacological suppression of pituitary prolactin advanced dorsal hair growth by 3.5 days. Normal hair cycling was restored by replacement with exogenous prolactin for 3 days. Increasing the duration of prolactin treatment further retarded entry into anagen. However, prolactin treatments, which began after follicles had entered anagen at 26 days of age, did not alter the subsequent progression of the hair cycle. Skin from PRLR-deficient mice grafted onto endocrine-normal hosts underwent more rapid hair cycling than comparable wild-type grafts, with reduced duration of the telogen phase. These experiments demonstrate that prolactin regulates the timing of hair growth cycles in mice via a direct effect on the skin, rather than solely via the modulation of other endocrine factors

Differentially Private Exponential Random Graphs

We propose methods to release and analyze synthetic graphs in order to protect privacy of individual relationships captured by the social network. Proposed techniques aim at fitting and estimating a wide class of exponential random graph models (ERGMs) in a differentially private manner, and thus offer rigorous privacy guarantees. More specifically, we use the randomized response mechanism to release networks under $\epsilon$-edge differential privacy. To maintain utility for statistical inference, treating the original graph as missing, we propose a way to use likelihood based inference and Markov chain Monte Carlo (MCMC) techniques to fit ERGMs to the produced synthetic networks. We demonstrate the usefulness of the proposed techniques on a real data example.Comment: minor edit

Weakly-Interacting Bosons in a Trap within Approximate Second Quantization Approach

The theory of Bogoliubov is generalized for the case of a weakly-interacting Bose-gas in harmonic trap. A set of nonlinear matrix equations is obtained to make the diagonalization of Hamiltonian possible. Its perturbative solution is used for the calculation of the energy and the condensate fraction of the model system to show the applicability of the method.Comment: 6 pages, two figures .Presented at the International Symposium on Quantum Fluids and Solids QFS2006 (Kyoto, Japan

An Automated System for Hydroxide Catalysis Bonding of Precision-Aligned Optical Systems

Precision-aligned, robust, ultra-stable optical assemblies are required in an increasing number of space-based applications such as fundamental science, metrology and geodesy. Hydroxide catalysis bonding is a proven, glue-free, technology for building such optical systems from materials such as ULE, Zerodur and fused silica. Hydroxide catalysis bonded optical systems have flown in missions such as GP-B and LISA Pathfinder achieving picometer path-length stability and microradian component stability over full mission lifetime. Component alignment and bonding was previously a largely manual process that required skilled operators and significant time. We have recently automated most of the alignment and bonding steps with the goals of improving overall precision, speed and reliability. Positioning and bonding of an optical component to within 4 microns and 10 microradians of a target position and alignment can now be reliably completed within half an hour, compared to the many hours typically taken previously. The key new features of this system are an interferometer that monitors the parallelism and separation of the surfaces to be bonded and a precision multi-axis manipulator that can optimise component alignment as it brings it down to the point of bonding. We present a description of the system and a summary of the alignment results obtained in a series of 9 test bonds. We also show how this system is being developed for integration into a precision optical manufacturing facility for assembly of large optical systems

Predicting Broccoli Development: I. Development Is Predominantly Determined By Temperature Rather Than Photoperiod

Predictive models of broccoli (Brassica oleracea L. var. italica Plenck) ontogeny will aid farmers who need to forecast changes in crop maturity arising from variable climatic conditions so that their forward marketing arrangements can match their anticipated supply. The objective of this study was to quantify the temperature and photoperiod responses of development in a sub-tropical environment from emergence to floral initiation (EFI), and from floral initiation to harvest maturity (FIHM). Three cultivars, ('Fiesta', 'Greenbelt' and 'Marathon') were sown on eight dates from 11 March to 22 May 1997 and grown under natural and extended (16 h) photoperiods at Gatton College, south-east Queensland, under non-limiting conditions of water and nutrient supply. Climatic data, dates of emergence, floral initiation and harvest maturity were obtained. The estimated base (Tbase) and optimum (Topt) temperatures of 0 and 20 degrees C, respectively were consistent across cultivars, but thermal time requirements were cultivar specific. Differences in thermal time between cultivars during FIHM were small and of little practical importance, but differences in thermal time during EFI were large. Sensitivity to photoperiod and solar radiation was low in the three cultivars used. When the thermal time models were tested on independent data for five cultivars ('Fiesta', 'Greenbelt', 'Marathon', 'CMS Liberty' and 'Triathlon') grown as commercial crops over two years, they adequately predicted floral initiation and harvest maturity

Comparative analysis of c-kit gene expression and c-Kit immunoreactivity in horses with and without obstructive intestinal disease

Previous immunohistochemical studies targeting the receptor tyrosine kinase (c-Kit) have demonstrated an apparent reduction in the number of gastrointestinal pacemaker cells--the interstitial cells of Cajal (ICC)--in horses with intestinal motility disorders. This study compared the level of transcription of the c-kit gene encoding this receptor in horses with and without such motility disorders. Transcription levels of this gene were also compared to the density of ICC immunohistochemically positive for the c-Kit antigen. Intestinal samples were collected from 18 horses with intestinal disease and from 15 control animals. Following gene extraction and identification, real-time quantitative analysis of c-kit and a control gene, ACTB (β-actin), was carried out on all samples and the density of the c-Kit-positive ICC compared. There was a significant reduction in c-Kit immunoreactivity in the ICC of horses with large intestinal obstructive disorders relative to controls but no significant difference in the transcription of the c-kit gene between normal and affected animals. Further studies will be required to elucidate the mechanisms regulating c-Kit expression and to assess the pathophysiological significance of these findings

Surface Incompressibility from Semiclassical Relativistic Mean Field Calculations

By using the scaling method and the Thomas-Fermi and Extended Thomas-Fermi approaches to Relativistic Mean Field Theory the surface contribution to the leptodermous expansion of the finite nuclei incompressibility has been self-consistently computed. The validity of the simplest expansion, which contains volume, volume-symmetry, surface and Coulomb terms, is examined by comparing it with self-consistent results of the finite nuclei incompressibility for some currently used non-linear sigma-omega parameter sets. A numerical estimate of higher-order contributions to the leptodermous expansion, namely the curvature and surface-symmetry terms, is made.Comment: 18 pages, REVTeX, 3 eps figures, changed conten

Insights into Nuclear Clusters in 28^{28}Si via Resonant Radiative Capture Measurements

International audienceThe heavyion radiative capture reaction 12C(16O,$\gamma$)28Si has been studied at three energies on( ELab = 20.0 and 21.2 MeV) and off( ELab = 20.7 MeV) resonance at Triumf (Vancouver) using the stateoftheart Dragon 0° spectrometer and its very efficient associated BGO $\gamma$ array. Intermediate states around Ex = 11.5 MeV, carrying a large part of the resonant flux have been observed for the first time in this system. The nature of those doorway states is discussed in terms of recently calculated cluster bands in 28Si. The results are compared to a recent similar investigation of the 12C(12C,$\gamma$)24Mg reaction

Editorial: Addressing community priorities in autism research

Autism is a form of neurodiversity, currently characterized by differences compared to the neurotypical population across multiple domains including sensory processing (Proff et al., 2021), social communication style (Crompton et al., 2021), attentional processing (Murray et al., 2005), and movement and motor processing (Miller et al., 2021). Historically, autism (and thus autistic people) has been studied through a medical lens (Chapman and Carel, 2022), owing primarily to the characterization of autism as a disorder of childhood development. These conceptualizations led to dehumanizing narratives about autistic people (Botha) and have impacted on who we consider to be knowledgeable about what it is like to be autistic (Kourti). In recent years, there has been a shift toward recognition of autism as a form of neurodivergence; a naturally occurring variation in the human population that may lead to a differential profile of strengths and challenges in comparison to the non-autistic population (Den Houting, 2019). This shift has been primarily driven by the autistic self-advocacy and neurodiversity movements (Kapp et al., 2013; Walker, 2021), which have campaigned for better understanding of autistic people

Decay Modes of Narrow Molecular Resonances

présenté par Sandrine Courtin (DRS-IPHC)The heavy-ion radiative capture reactions $^{12}C(^{12}C,\gamma)^{24}Mg$ and $^{12}C(^{16}O,\gamma)^{28}Si$ have been performed on and off resonance at TRIUMF using the Dragon separator and its associated BGO array. The decay of the studied narrow resonances has been shown to proceed predominantly through quasi-bound doorway states which cluster and deformed configurations would have a large overlap with the entry resonance states