Identifying sources, pathways and risk drivers in ecosystems of Japanese Encephalitis in an epidemic-prone north Indian district

Japanese Encephalitis (JE) has caused repeated outbreaks in endemic pockets of India. This study was conducted in Kushinagar, a highly endemic district, to understand the human-animal-ecosystem interactions, and the drivers that influence disease transmission. Utilizing the ecosystems approach, a cross-sectional, descriptive study, employing mixed methods design was employed. Four villages (two with pig-rearing and two without) were randomly selected from a high, a medium and a low burden (based on case counts) block of Kushinagar. Children, pigs and vectors were sampled from these villages. A qualitative arm was incorporated to explain the findings from the quantitative surveys. All human serum samples were screened for JE-specific IgM using MAC ELISA and negative samples for JE RNA by rRT-PCR in peripheral blood mononuclear cells. In pigs, IgG ELISA and rRT-PCR for viral RNA were used. Of the 242 children tested, 24 tested positive by either rRT-PCR or MAC ELISA; in pigs, 38 out of the 51 pigs were positive. Of the known vectors, Culex vishnui was most commonly isolated across all biotopes. Analysis of 15 blood meals revealed human blood in 10 samples. Univariable analysis showed that gender, religion, lack of indoor residual spraying of insecticides in the past year, indoor vector density (all species), and not being vaccinated against JE in children were significantly associated with JE positivity. In multivariate analysis, only male gender remained as a significant risk factor. Based on previous estimates of symptomatic: asymptomatic cases of JE, we estimate that there should have been 618 cases from Kushinagar, although only 139 were reported. Vaccination of children and vector control measures emerged as major control activities; they had very poor coverage in the studied villages. In addition, lack of awareness about the cause of JE, lack of faith in the conventional medical healthcare system and multiple referral levels causing delay in diagnosis and treatment emerged as factors likely to result in adverse clinical outcomes

Patrolling a path connecting a set of points with unbalanced frequencies of visits

Patrolling consists of scheduling perpetual movements of a collection of mobile robots, so that each point of the environment is regularly revisited by any robot in the collection. In previous research, it was assumed that all points of the environment needed to be revisited with the same minimal frequency. In this paper we study efficient patrolling protocols for points located on a path, where each point may have a different constraint on frequency of visits. The problem of visiting such divergent points was recently posed by Gąsieniec et al. in [14], where the authors study protocols using a single robot patrolling a set of n points located in nodes of a complete graph and in Euclidean spaces. The focus in this paper is on patrolling with two robots. We adopt a scenario in which all points to be patrolled are located on a line. We provide several approximation algorithms concluding with the best currently known 3 -approximation

Petrographic study of silica bearing rocks from Assam, India

338-341Silica bearing rock samples collected from various locations of the rock from Bihubar, Assam, India were studied using XRD, FT-IR and chemical analysis for assessing the durability of these rocks used for different purposes like building and road constructions. XRD patterns of the rock samples-reddish coloured rock variety (2QPR ) and white coloured rock variety (5QRS) showed that the samples contained the amorphous and crystalline materials,  the former being the major one in both the samples. Both the samples contained α-quartz as the major phase with rutile, albite, calcite and illite-2M1 for 2QPR and muscovite-2M1, illite and analcime for 5QRS as the minor phases. Microstrains and crystallite sizes of α-quartz associated in the rock samples were derived by using Fourier and integral methods. FT-IR and chemical analysis are also included to supplement the result obtained from XRD method. The presence of the clay minerals and microstrains in both the samples indicate the possibility of degradation of the rocks in environment and hence ultimately effects its durability in utilization