Water enclosure and world-literature: new perspectives on hydro-power and world-ecology

This editorial introduces the special issue, ‘World Literature and the Blue Humanities’. The authors articulate the commonalities and tensions between world literature, world-ecology, blue humanities, and hydrocultural approaches. Taking megadams, water pollution, and the blue revolution as baselines, we offer short analyses of works by Namwali Serpell, Craig Santos Perez, Jean Arasanayagam, Paul Greengrass, Wyl Menmuir, and Emily St. John Mandel in order to articulate how culture can both contest and normalize water enclosure. The piece ends with a brief summary of the contributions to the special issue

MT-MMPS as Regulators of Vessel Stability Associated with Angiogenesis

The development of vascular system depends on the coordinated activity of a number of distinct families of molecules including growth factors and their receptors, cell adhesion molecules, extracellular matrix (ECM) molecules, and proteolytic enzymes. Matrix metalloproteases (MMPs) are a family of ECM degrading enzymes required for both physiological and pathological angiogenesis. Increasing evidence, point to a direct role of membrane type-MMPs (MT-MMPs) in vascular system stabilization, maturation, and leakage. Our understanding of the nature of MT-MMP interaction with extracellular and cell surface molecules and their multiple roles in vessel walls and perivascular stroma may provide new insights into mechanisms underlying vascular cell–ECM interactions and cell fate decisions in pathological conditions. Regulation of vascular leakage by MT-MMP interactions with the ECM could also lead to novel targeting opportunities for drug delivery in tumor. This review will shed lights on the emerging roles of MT1-MMP and MT4-MMP in vascular system alterations associated with cancer progression

Self-Compassion-Based Interventions in Oncology: A Review of Current Practices

peer reviewe

Solvencia y rentabilidad patrimonial en una empresa minera, periodo 2017-2021

La investigación tiene como finalidad determinar la relación entre la solvencia con la rentabilidad patrimonial en una empresa minera, periodo 2017-2021. Para ello, la metodología empleada fue tipo aplicada, diseño no experimental y enfoque cuantitativo, el instrumento empleado fue la ficha de investigación. Se obtuvo que la solvencia, en el año 2017, se financió en un 14.4% de su actividad comercial con recursos ajenos y 85.6% con recursos propios. 2018 se financió en un 14.9% de su actividad comercial con recursos ajenos y un 85.1% con recursos propios. 2019 la empresa financió en un 15.4% de su actividad comercial con recursos ajenos y un 84.6% con recursos propios. 2020 se financió en un 18.3% de su actividad comercial con recursos ajenos y un 81.7% con recursos propios y por último en 2021, la empresa financió en un 22.97% de su actividad comercial con recursos ajenos y un 77.03% con recursos propios. Se concluyó un Rho Spearman de R=0,900; evidencia que existe una correlación positiva y fuerte entre solvencia y la rentabilidad patrimonial. Demostrando de esta forma que es fundamental mantener una buena solvencia para tener a su vez una buena rentabilidad en el patrimonio

Dynamics of Internalization and Recycling of the Pro-Metastatic Membrane Type 4-Matrix Metalloproteinase (MT4-MMP) in Breast Cancer Cells

MT4-MMP (MMP17) is a glycosylphosphatidyl inositol (GPI)-anchored membrane-type MMP expressed on the cell surface of human breast cancer cells. In triple negative breast cancer cells, MT4-MMP promotes primary tumor growth and lung metastases. Although trafficking and internalization of the transmembrane MT1-MMP have been extensively investigated, little is known about the regulatory mechanisms of the GPI-anchored MT4-MMP. Here, we investigated the fate and cellular trafficking of MT4-MMP by analyzing its homophilic complex interactions, internalization and recycling dynamics compared to an inert form, MT4-MMP-E249A. Oligomeric and dimeric complexes were analyzed by co-transfection of cells with FLAG- or Myc-tagged MT4-MMP by reducing and non-reducing immunoblots and co-immunoprecipitation experiments. The trafficking of MT4-MMP was studied using an antibody feeding assay and confocal microscopy analysis or cell surface protein biotinylation and Western blot analysis. We demonstrate that MT4-MMP forms homophilic complexes at the cell surface, internalizes in early endosomes, and some of the enzyme is either auto-degraded or recycled to the cell surface. Our data indicate that MT4-MMP is internalized by the CLIC/GEEC pathway, a mechanism that differs from other MT-MMP members. Although MT4-MMP localizes with caveolin-1, MT4-MMP internalization was not affected by inhibitors of caveolin-1 or clathrin endocytosis pathways but was reduced by cdc42 or RhoA silencing with siRNA. We provide a new mechanistic insight into the regulatory mechanisms of MT4-MMP, which may have implications in the design of novel therapeutic strategies for metastatic breast cancer. This article is protected by copyright. All rights reserved

Editor's Note: EGFR Activation and Signaling in Cancer Cells Are Enhanced by the Membrane-Bound Metalloprotease MT4-MMP.

peer reviewedThe editors are publishing this note to alert readers to concerns about this article (1). In Fig. 2, the actin loading control bands for cyclin D1 and cyclin D2 are identical-the authors clarified that the Western blots for cyclin D1 and cyclin D2 were performed on the same samples, however, this was not indicated in the figure legend. Additionally, in Fig. 6C, the p-EGFR bands in MDA-MB-231 cells showing stimulation by TGFa treatment are identical to the p-EGFR bands showing stimulation by EGF treatment. In the original submission of this manuscript, a correct version of this figure was used to show both TGFa and EGF could stimulate p-EGFR in control vector (CTR)- and MT4-MMP-expressing (MT4) MDA-MB-231 cells, but these panels were mistakenly duplicated in the revised and final versions of the manuscript

Erratum to: Methods for evaluating medical tests and biomarkers

[This corrects the article DOI: 10.1186/s41512-016-0001-y.]

Evidence synthesis to inform model-based cost-effectiveness evaluations of diagnostic tests: a methodological systematic review of health technology assessments

Background: Evaluations of diagnostic tests are challenging because of the indirect nature of their impact on patient outcomes. Model-based health economic evaluations of tests allow different types of evidence from various sources to be incorporated and enable cost-effectiveness estimates to be made beyond the duration of available study data. To parameterize a health-economic model fully, all the ways a test impacts on patient health must be quantified, including but not limited to diagnostic test accuracy. Methods: We assessed all UK NIHR HTA reports published May 2009-July 2015. Reports were included if they evaluated a diagnostic test, included a model-based health economic evaluation and included a systematic review and meta-analysis of test accuracy. From each eligible report we extracted information on the following topics: 1) what evidence aside from test accuracy was searched for and synthesised, 2) which methods were used to synthesise test accuracy evidence and how did the results inform the economic model, 3) how/whether threshold effects were explored, 4) how the potential dependency between multiple tests in a pathway was accounted for, and 5) for evaluations of tests targeted at the primary care setting, how evidence from differing healthcare settings was incorporated. Results: The bivariate or HSROC model was implemented in 20/22 reports that met all inclusion criteria. Test accuracy data for health economic modelling was obtained from meta-analyses completely in four reports, partially in fourteen reports and not at all in four reports. Only 2/7 reports that used a quantitative test gave clear threshold recommendations. All 22 reports explored the effect of uncertainty in accuracy parameters but most of those that used multiple tests did not allow for dependence between test results. 7/22 tests were potentially suitable for primary care but the majority found limited evidence on test accuracy in primary care settings. Conclusions: The uptake of appropriate meta-analysis methods for synthesising evidence on diagnostic test accuracy in UK NIHR HTAs has improved in recent years. Future research should focus on other evidence requirements for cost-effectiveness assessment, threshold effects for quantitative tests and the impact of multiple diagnostic tests

Erratum to: Methods for evaluating medical tests and biomarkers

[This corrects the article DOI: 10.1186/s41512-016-0001-y.]

Well-being center in CHU of Liege : interest for oncological patients and their families

Bien que la médecine conventionnelle ait réalisé des progrès considérables dans la prise en charge du cancer, cette maladie reste une épreuve difficile pour les patients qui peuvent éprouver un sentiment de perte de contrôle sur leur vie. En réponse à ce besoin d’autonomie vis-à-vis de leurs choix thérapeutiques, certains patients se tournent vers les médecines complémentaires et alternatives . Certains centres de soins oncologiques mettent ainsi à disposition des patients un centre de bien-être où sont proposés différents types d’activités centrées sur le bien-être et le confort de la personne. Afin de rencontrer au mieux les besoins des utilisateurs, une enquête a été réalisée auprès de 82 patients fréquentant l’hôpital de jour oncologique ou le service de radiothérapie. Les résultats nous ont permis d’établir un plan d’action en phase avec les souhaits des patients, dans l’optique de créer un centre de bien-être situé au cœur de l’Institut de Cancérologie Arsène Burny au CHU de Liège et baptisé centre OASIS. Les différentes activités organisées autour d’axes psychocorporel et corporel/psychologique sont présentées dans cet article