Annual Report FY 2018, Office Of Scholarly Communications, University of Nebraska–Lincoln Libraries

Highlights include hosting the ACRL Scholarly Communications Roadshow, joining the National Library of Medicine’s PubMed Link-out program, the Gerald Hodges Intellectual Freedom Chapter Relations Award from the American Library Association, institutional repository deposits and traffic, journals published, Zea Books published, conferences, presentations, publications, staffing notes, and student workers

University of Nebraska-Lincoln DigitalCommons: Statistical Report, August 2018

To: Deeann Allison, Director, Media & Repository Services, UNL Libraries I am pleased to transmit the following statistics report on the UNL DigitalCommons, http://digitalcommons.unl.edu The DigitalCommons is the “institutional repository” for UNL. It’s function is to gather the intellectual output of the university for online public access. It was established in 2005, and now holds 99,000 papers, making it the 3rd largest in the United States, trailing only the University of California system (190,000) and the University of Michigan (120,000). It recently surpassed 50 million downloads, and is the nation’s current leader in that category. Alexa.com reports that the repository is the most visited subdomain of unl.edu, representing 15% to 18% of all internet traffic. The following schedules are attached: I. History of growth (13 years) Growth of contents has been steady at around 6,000 annually. Contents and downloads shown here are UNL free public access only; i.e. they do not include ProQuest’s collection of 14,000 UNL dissertations (which are free to this campus & subscribing institutions only). Download numbers reflect changing interactions with search engines. II. Distribution of contents and usage across series (50) : This schedule lists the 50 most popular series, July 2015 – June 2018, by downloads, and then by number of papers and annualized average per paper. These 50 series represent 36% of the contents and 63% of the downloads. There were approximately 950 series overall, with 19,583,432 downloads over the period. III. Downloads by other educational institutions (115) We are able to trace about 25% of downloads to a network. The following are the most frequently downloading networks and their types. IV. Downloads by continent: July 2016‐‐June 2018 V. Downloads by country (28) Between July 1, 2015, and June 30, 2018, these 28 countries each received \u3e0.5% of geolocated downloads. Note that 59% of downloads are international. VI. Most popular paper by country (10) The DigitalCommons platform is hosted and maintained by bepress in Berkeley, California; they were purchased last year by Elsevier. The repository is operated and administered locally by UNL Libraries faculty and staff: Paul Royster, Sue Gardner, Margaret Mering, and Linnea Fredrickson

University of Nebraska-Lincoln DigitalCommons: Statistical Report, August 2018

To: Deeann Allison, Director, Media & Repository Services, UNL Libraries I am pleased to transmit the following statistics report on the UNL DigitalCommons, http://digitalcommons.unl.edu The DigitalCommons is the “institutional repository” for UNL. It’s function is to gather the intellectual output of the university for online public access. It was established in 2005, and now holds 99,000 papers, making it the 3rd largest in the United States, trailing only the University of California system (190,000) and the University of Michigan (120,000). It recently surpassed 50 million downloads, and is the nation’s current leader in that category. Alexa.com reports that the repository is the most visited subdomain of unl.edu, representing 15% to 18% of all internet traffic. The following schedules are attached: I. History of growth (13 years) Growth of contents has been steady at around 6,000 annually. Contents and downloads shown here are UNL free public access only; i.e. they do not include ProQuest’s collection of 14,000 UNL dissertations (which are free to this campus & subscribing institutions only). Download numbers reflect changing interactions with search engines. II. Distribution of contents and usage across series (50) : This schedule lists the 50 most popular series, July 2015 – June 2018, by downloads, and then by number of papers and annualized average per paper. These 50 series represent 36% of the contents and 63% of the downloads. There were approximately 950 series overall, with 19,583,432 downloads over the period. III. Downloads by other educational institutions (115) We are able to trace about 25% of downloads to a network. The following are the most frequently downloading networks and their types. IV. Downloads by continent: July 2016‐‐June 2018 V. Downloads by country (28) Between July 1, 2015, and June 30, 2018, these 28 countries each received \u3e0.5% of geolocated downloads. Note that 59% of downloads are international. VI. Most popular paper by country (10) The DigitalCommons platform is hosted and maintained by bepress in Berkeley, California; they were purchased last year by Elsevier. The repository is operated and administered locally by UNL Libraries faculty and staff: Paul Royster, Sue Gardner, Margaret Mering, and Linnea Fredrickson

Collection Development Policy, Digital Commons Institutional Repository, University of Nebraska–Lincoln Libraries

Purpose of the University of Nebraska-Lincoln Digital Commons Institutional Repository Collection Development Policy This collection development policy is intended to provide guidance for content selection that anticipates and meets the needs of the communities of the University of Nebraska–Lincoln (UNL). It directly relates to the library\u27s vision statement and defines the scope and standards that guide the services that generate the collection. Purpose of the UNL Digital Commons Institutional Repository The UNL institutional repository (IR) comprises services that result in the stewardship and global online dissemination of content created and selected by UNL authors and affiliates. With the aim of contributing to the broader world of scholarship and facilitating discovery, the repository reflects the intellectual life of the institution. The IR drives a significant level of Web traffic to UNL. As such, the IR may serve as a promotional and marketing tool for authors, programs, and the university as a whole

Reactions at polymer interfaces: A Monte Carlo Simulation

Reactions at a strongly segregated interface of a symmetric binary polymer blend are investigated via Monte Carlo simulations. End functionalized homopolymers of different species interact at the interface instantaneously and irreversibly to form diblock copolymers. The simulations, in the framework of the bond fluctuation model, determine the time dependence of the copolymer production in the initial and intermediate time regime for small reactant concentration $\rho_0 R_g^3=0.163 ... 0.0406$. The results are compared to recent theories and simulation data of a simple reaction diffusion model. For the reactant concentration accessible in the simulation, no linear growth of the copolymer density is found in the initial regime, and a $\sqrt{t}$-law is observed in the intermediate stage.Comment: to appear in Macromolecule

Media and Repository Support Unit, University of Nebraska–Lincoln Libraries, Annual Report July 2018–June 2019

Increasingly, libraries are recognizing the importance of providing access to the research output of their universities. In a June 10, 2019, news release from the provosts of the Big Ten Academic Alliance (BTAA) titled “Sustaining Values and Scholarship” (available at https://tinyurl.com/yyu94aa9), they state, “The Big Ten Academic Alliance will continue its advocacy for a sustainable and open ecosystem of publication. . . . Collectively, our institutions’ more than 50,000 faculty are supported by over $10 billion (2017) in research funding, and our institutions have similarly invested significantly in our capacity to further our missions to advance knowledge. Together, we produce roughly 15% of the research publications in the United States.” This commitment to open information is reflected in the mission of the Media and Repository Support (MARS) unit of the UNL Libraries. We support the creation and preservation of the scholarly accomplishments of the University of Nebraska–Lincoln by providing an infrastructure for disseminating information and scholarship through Digital Commons (articles, reports, journals, books, and more), Luna (multimedia projects), and Rosetta (data) as well as by providing equipment that students and faculty can check out to capture video and digital images. Through our efforts, the intellectual contributions of UNL are provided, when possible, as open access to disseminate information to as wide a community as possible. We provide advice and consult with researchers and students on scholarly communication issues surrounding open education resources, copyright, options for rights management, publication, and preservation of information in coordination with other faculty and staff in the Libraries. We maintain close contact with staff from Archives & Special Collections to ensure that nondigital information is not overlooked in preservation plans. Faculty within the unit have developed close relationships with the UNL Office of Research, faculty across our campus, and colleagues at the other University of Nebraska campuses (through the University of Nebraska Consortium of Libraries, UNCL)

Characterization of an electron conduit between bacteria and the extracellular environment

A number of species of Gram-negative bacteria can use insoluble minerals of Fe(III) and Mn(IV) as extracellular respiratory electron acceptors. In some species of Shewanella, deca-heme electron transfer proteins lie at the extracellular face of the outer membrane (OM), where they can interact with insoluble substrates. To reduce extracellular substrates, these redox proteins must be charged by the inner membrane/periplasmic electron transfer system. Here, we present a spectro-potentiometric characterization of a trans-OM icosa-heme complex, MtrCAB, and demonstrate its capacity to move electrons across a lipid bilayer after incorporation into proteoliposomes. We also show that a stable MtrAB subcomplex can assemble in the absence of MtrC; an MtrBC subcomplex is not assembled in the absence of MtrA; and MtrA is only associated to the membrane in cells when MtrB is present. We propose a model for the modular organization of the MtrCAB complex in which MtrC is an extracellular element that mediates electron transfer to extracellular substrates and MtrB is a trans-OM spanning ß-barrel protein that serves as a sheath, within which MtrA and MtrC exchange electrons. We have identified the MtrAB module in a range of bacterial phyla, suggesting that it is widely used in electron exchange with the extracellular environment

UNL Libraries Deposit Programs

The University of Nebraska–Lincoln Libraries offers several avenues for preserving and providing access to digital and physical research materials. This document outlines the four main avenues for depositing materials with UNL Libraries. Although there are separate repositories with specific missions—Archives & Special Collections, DigitalCommons@University of Nebraska–Lincoln, UNL Data Repository, and UNL Image & Multimedia Collections—all work together toward the goal of preserving the intellectual and creative output of the university and to make our contributions discoverable to state, national, and international communities. This document describes the operations of each repository. The Libraries policy is to publish, or provide online access to, materials (1) when the Libraries holds copyright, (2) when the copyright holder has granted the Libraries permission for online publication, or (3) when the Libraries do not hold copyright but may manage access behind a firewall. The University Libraries is committed to preserving and providing access to the full range of in-tellectual contributions of the faculty and staff at UNL for the benefit of current and future gen-erations. All members of the University of Nebraska–Lincoln are encouraged to deposit content with UNL Libraries. Materials deposited in our institutional repositories are historical and not all historical events confirm to current standards of civility. As such, they may contain racial or sexual stereotypes that are inappropriate by today’s standards. They have been retained in order to fully represent the materials in their original context. All members of the University of Nebraska–Lincoln are encouraged to deposit content with UNL Libraries. Content can be nondigital items supplied to Archives & Special Collections or digital content deposited in the Data, Image & Multimedia Collections, Digital Commons repositories, or University Archives

Microphase Separation Induced by Differential Interactions in Diblock Copolymer/Homopolymer Blends

Phase behavior of diblock copolymer/homopolymer blends (AB/C) is investigated theoretically. The study focuses on a special case where all three binary pairs, A/B, B/C and C/A, are miscible. Despite the miscibility of the binary pairs, a closed-loop immiscible region exists in the AB/C blends when the A/C and B/C pair interactions are sufficiently different. Inside the closed-loop, the system undergoes microphase separation, exhibiting different ordered structures. This phenomenon is enhanced when the homopolymer (C) interacts more strongly to one of the blocks (A or B).Comment: 19 pages, 7 figures, submitted to J. Chem. Phy

First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in patients with advanced solid tumors.

PURPOSE: This first-in-human dose-escalation trial evaluated the safety, tolerability, maximal-tolerated dose (MTD), dose-limiting toxicities (DLT), pharmacokinetics, pharmacodynamics, and preliminary clinical activity of pictilisib (GDC-0941), an oral, potent, and selective inhibitor of the class I phosphatidylinositol-3-kinases (PI3K). PATIENTS AND METHODS: Sixty patients with solid tumors received pictilisib at 14 dose levels from 15 to 450 mg once-daily, initially on days 1 to 21 every 28 days and later, using continuous dosing for selected dose levels. Pharmacodynamic studies incorporated (18)F-FDG-PET, and assessment of phosphorylated AKT and S6 ribosomal protein in platelet-rich plasma (PRP) and tumor tissue. RESULTS: Pictilisib was well tolerated. The most common toxicities were grade 1-2 nausea, rash, and fatigue, whereas the DLT was grade 3 maculopapular rash (450 mg, 2 of 3 patients; 330 mg, 1 of 7 patients). The pharmacokinetic profile was dose-proportional and supported once-daily dosing. Levels of phosphorylated serine-473 AKT were suppressed >90% in PRP at 3 hours after dose at the MTD and in tumor at pictilisib doses associated with AUC >20 h·μmol/L. Significant increase in plasma insulin and glucose levels, and >25% decrease in (18)F-FDG uptake by PET in 7 of 32 evaluable patients confirmed target modulation. A patient with V600E BRAF-mutant melanoma and another with platinum-refractory epithelial ovarian cancer exhibiting PTEN loss and PIK3CA amplification demonstrated partial response by RECIST and GCIG-CA125 criteria, respectively. CONCLUSION: Pictilisib was safely administered with a dose-proportional pharmacokinetic profile, on-target pharmacodynamic activity at dose levels ≥100 mg and signs of antitumor activity. The recommended phase II dose was continuous dosing at 330 mg once-daily.This study was supported by Genentech Inc. The Drug Development Unit, The Royal Marsden NHS Foundation Trust, and The Institute of Cancer Research (London) is supported in part by programme grants from Cancer Research UK. Support was also provided by Experimental Cancer Medicine Center grants (to The Institute of Cancer Research and the Cancer Research UK Center), the National Institute for Health Research Biomedical Research Center (jointly to The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research) and the Wellcome Trust (grant 090952/Z/09/Z to Dr. Ang). Paul Workman is a Cancer Research UK Life Fellow.Originally published by the American Association for Cancer Research in Clinical Cancer Research January 1, 2015 21; 77 http://dx.doi.org/10.1158/1078-0432.CCR-14-094