Social Media and Prosumerism: Implications for Sport Marketing Research

Social media arid the techniques and processes related to marketing using social media are changing at an incredible rate and will require continual monitoring for those involved in-social media research. As such, we identified the need for sport marketing researchers who are abductive thinkers who can design, combine and use innovative research methodologies as stimulated by the continually evolving technology. Ultimately, however, research prospects related to social media and sport marketing are vast for scholars and marketing professionals alike, and are replete with opportunities for designing new research methodologies

Database Dependency

We defined the phenomenon of database dependency as the behavior of a library user to immediately select computerized information resources without considering (1) the appropriateness of the electronic gesource to the immediate information need, (2) the quality and accuracy of the information found, and (3) the amount of time it may take to find the information in a database compared to finding a print resource in that library. The librarians at the Talk Table agreed that patrons seem to accept whatever information they find in an electronic resource even if it takes longer to get the answer, the answer is incomplete, or if the information would have been more easily found in a print reference source. The academic librarians said that they have been seeing this behavior in their libraries for the last several years. The public librarians agreed that this behavior is increasing in their libraries as people are becoming more comfortable with computers

An Analysis of the Initial Contact Characteristics and Recidivism of Offenders with a Serious Mental Illness

This thesis addresses the growing number of inmates with a mental illness in correctional facilities in Canada which continues to attract public attention and concern. Several explanations have been put forward to explain the rise in the number of inmates with a mental illness. These include: the deinstitutionalization of the mentally ill that began in the 1970’s, lack of treatment availability for those released into the community, and criminalization of persons with a mental illness by the justice system. The increasing numbers of persons with a mental illness in the correctional system has led to serious concerns about the capacity of this system to manage, treat, and rehabilitate individuals with a mental illness. Lack of proper treatment, management, rehabilitation and monitored discharge means that inmates with serious mental illness are more likely to come into contact with the criminal justice system more frequently. This thesis examines the incidence seriously mentally ill offenders and their propensity to recontact. Three hundred and ninety eight face-to-face assessments were conducted using the Resident Assessment Instrument-Mental Health 2.0 (RAI-MH) and from total scores from the Level of Service Inventory Ontario Revision (LSI-OR). These assessments were conducted in 14 Ontario Provincial Correctional facilities during the years 2005-2008. Bivariate and multivariate regression analysis was conducted to assess recontact rates for serious mentally disordered and non-mentally disordered offenders. With regards to recontact, no differences were revealed between the seriously mentally ill offender and non-mentally ill offender. This null finding on recontact is very surprising given the current literature on the seriously mentally ill. An additional finding revealed that for offenders with or without a serious mental illness, having a higher score on the scale of criminogenic tendencies (LSI-OR) increased rates for recontact. Another surprising finding is that seriously mentally ill offenders were more likely to commit minor crimes upon release, rather than violent crimes as current literature suggests. A more accurate research tool, as well as a larger sample size, will be required to assess the validity of these results. The implications of the negative outcome with respect to recontact and issues of identifiable risk factors for recidivism for both seriously mentally ill and non-mentally ill inmate populations are discussed in relation to outcomes in terms of both improvements to Corrections policy and theories of criminology. It is important to continue research in this area, to determine the true gravity of the incidence and recontact rates of mentally ill offenders.

Nonstandard Radiographic Techniques for the Equine Practitioner

The diagnostic capabilities of the equine practitioner can be greatly increased with the use of nonstandard radiographic projections that are designed to enhance specific locations within a designated anatomical region. These techniques can easily be performed by using standard portable radiographic equipment. Author's address: New Jersey Equine Clinic, 384 Millstone Rd., Clarksburg, NJ 08510. 1997 AAEP

Effects of cardiotrophin on adipocytes

Cardiotrophin (CT-1) is a naturally occurring protein member of the interleukin (IL)-6 cytokine family and signals through the gp130/leukemia inhibitory factor receptor (LIFR) heterodimer. The formation of gp130/ LIFR complex triggers the auto/trans-phosphorylation of associated Janus kinases, leading to the activation of Janus kinase/STAT and MAPK (ERK1 and -2) signaling pathways. Since adipocytes express both gp130 and LIFR proteins and are responsive to other IL-6 family cytokines, we examined the effects of CT-1 on 3T3-L1 adipocytes. Our studies have shown that CT-1 administration results in a dose- and time-dependent activation and nuclear translocation of STAT1, -3, -5A, and -5B as well as ERK1 and -2. We also confirmed the ability of CT-1 to induce signaling in fat cells in vivo. Our studies revealed that neither CT-1 nor ciliary neurotrophic factor treatment affected adipocyte differentiation. However, acute CT-1 treatment caused an increase in SOCS-3 mRNA in adipocytes and a transient decrease in peroxisome proliferator-activated receptor γ (PPARγ) mRNA that was regulated by the binding of STAT1 to the PPARγ2 promoter. The effects of CT-1 on SOCS-3 and PPARγ mRNA were independent of MAPK activation. Chronic administration of CT-1 to 3T3-L1 adipocytes resulted in a decrease of both fatty acid synthase and insulin receptor substrate-1 protein expression yet did not effect the expression of a variety of other adipocyte proteins. Moreover, chronic CT-1 treatment resulted in the development of insulin resistance as judged by a decrease in insulin-stimulated glucose uptake. In summary, CT-1 is a potent regulator of signaling in adipocytes in vitro and in vivo, and our current efforts are focused on determining the role of this cardioprotective cytokine on adipocyte physiology

Biomarkers of aging associated with past treatments in breast cancer survivors.

Radiation and chemotherapy are effective treatments for cancer, but are also toxic to healthy cells. Little is known about whether prior exposure to these treatments is related to markers of cellular aging years later in breast cancer survivors. We examined whether past exposure to chemotherapy and/or radiation treatment was associated with DNA damage, telomerase activity, and telomere length 3-6 years after completion of primary treatments in breast cancer survivors (stage 0-IIIA breast cancer at diagnosis). We also examined the relationship of these cellular aging markers with plasma levels of Interleukin (IL)-6, soluble TNF-receptor-II (sTNF-RII), and C-reactive protein (CRP). Ninety-four women (36.4-69.5 years; 80% white) were evaluated. Analyses adjusting for age, race, BMI, and years from last treatment found that women who had prior exposure to chemotherapy and/or radiation compared to women who had previously received surgery alone were more likely to have higher levels of DNA damage (P = .02) and lower telomerase activity (P = .02), but did not have differences in telomere length. More DNA damage and lower telomerase were each associated with higher levels of sTNF-RII (P's < .05). We found that exposure to chemotherapy and/or radiation 3-6 years prior was associated with markers of cellular aging, including higher DNA damage and lower telomerase activity, in post-treatment breast cancer survivors. Furthermore, these measures were associated with elevated inflammatory activation, as indexed by sTNF-RII. Given that these differences were observed many years after the treatment, the findings suggest a long lasting effect of chemotherapy and/or radiation exposure

Examining the patient and caregiver experience with diazepam nasal spray for seizure clusters: Results from an exit survey of a phase 3, open-label, repeat-dose safety study

BACKGROUND: Ideal rescue treatments for acute treatment of seizure clusters should be easy to administer, so it is important to assess user perceptions of these treatments. Diazepam nasal spray is designed to have a rapid, noninvasive, and socially acceptable route of administration. Patient and caregiver (including care partner) responses to surveys from a phase 3 safety study of diazepam nasal spray are reported. METHODS: The study enrolled patients aged 6-65 years with seizure clusters. Surveys distributed to patients and caregivers at study end, completion, or discontinuation collected data on comfort using diazepam nasal spray outside the home, timing of administration and return to their usual selves, and comfort of use compared with rectal diazepam. Safety was assessed. RESULTS: Of 175 patients enrolled at the October 31, 2019, interim cutoff, 158 received diazepam nasal spray. Sixty-seven (42.4%) patients and 84 (53.2%) caregivers responded to the surveys (including 35 matched pairs). Most patients (78.8%, 52/66) responded that they were very comfortable doing activities outside the home with diazepam nasal spray available; 59.4% of patients returned to their usual selves within an hour of administration. Twenty-seven (40.3%) of these patients reported self-administration, 48% doing so at the first sign of a seizure. Administration of diazepam nasal spray was rated extremely or very easy by 93.8% of caregivers. Safety profile was consistent with diazepam rectal gel; no patient discontinued owing to treatment-emergent adverse events. Nasal discomfort was typically mild and transient. Among patients who had used diazepam rectal gel, most were not at all comfortable using it outside the home (86.7%) or at home (64.5%) compared with diazepam nasal spray, whereas caregivers reported that diazepam rectal gel was not at all easy to use compared with diazepam nasal spray. CONCLUSIONS: This survey from the phase 3 safety study of diazepam nasal spray shows that patients and caregivers were satisfied with, and more comfortable using, diazepam nasal spray than rectal diazepam in public. NCT02721069