I Was Roofied At Work

I used to sling drinks at a notoriously sketchy bar in Campustown. In the six months I spent working there, I knew five people who were roofied—including myself. One dead winter weekend, I let two lady coworkers off early and made them drinks. At the end of the bar were a few of the older creepy skeezeball-types you find prowling the college bars in search of impressionable (read: drunk) tail. The girls went to dance and I almost always set any untended drinks behind the bar as good practice. ‘Almost’ being this night

CHARACTERISTICS OF MANGROVE DIAMONDBACK TERRAPINS (MALACLEMYS TERRAPIN RHIZOPHORARUM) INHABITING ALTERED AND NATURAL MANGROVE ISLANDS

The Mangrove Diamondback Terrapin, (Malaclemys terrapin rhizophorarum) is dependent on a very broad array of the services provided by the mangrove ecosystem. We sought to evaluate both the turtles and their habitat by an integrated assessment of physical, chemical, and physiological parameters. Extreme site fidelity of the turtles to mangrove habitat was evident along with a strong female biased sex ratio. We provide blood serum values and microbial cultures as baselines from these turtles in the wild. Salmonella sp., a potentially zoonotic pathogen, was isolated from one female. Ultimately, the health of these turtle populations may be reflective of the integrity of the mangrove system on which they depend

Modeling of lithium granule injection in NSTX using M3D-C1

In this paper, we present simulations of pedestal control by lithium granule injection (LGI) in NSTX. A model for small granule ablation has been implemented in the M3D-C1 code (Jardin et al 2012 Comput. Sci. Discovery 5 014002), allowing the simulation of realistic lithium granule injections. 2D and 3D simulations of Li injections in NSTX H-mode plasmas are performed and the effect of granule size, injection angle and velocity on the pedestal gradient increase is studied. The amplitude of the local pressure perturbation caused by the granules is found to be highly dependent on the solid granule size. Adjusting the granule injection velocity allows one to inject more particles at the pedestal top. 3D simulations show the destabilization of high order MHD modes whose amplitude is directly linked to the localized pressure perturbation, which is found to depend on the toroidal localization of the granule density source

Stable Integration of Transgenes Delivered by a Retrotransposon–Adenovirus Hybrid Vector

Helper-dependent adenoviruses show great promise as gene delivery vectors. However, because they do not integrate into the host chromosome, transgene expression cannot be maintained indefinitely. To overcome these limitations, we have inserted an L1 retrotransposon/transgene element into a helper-dependent adenovirus to create a novel chimeric gene delivery vector. Efficient adenovirus-mediated delivery of the L1 element into cultured human cells results in subsequent retrotransposition and stable integration of the transgene. L1 retrotransposition frequency was found to correlate with increasing multiplicity of infection by the chimeric vector, and further retrotransposition from newly integrated elements was not observed on prolonged culture. Therefore, this vector, which utilizes components of low immunogenic potential, represents a novel two-stage gene delivery system capable of achieving high titers via the initial helper-dependent adenovirus stage and permanent transgene integration via the retrotransposition stage.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/63154/1/104303401750298571.pd

On the fraction of dark matter in charged massive particles (CHAMPs)

From various cosmological, astrophysical and terrestrial requirements, we derive conservative upper bounds on the present-day fraction of the mass of the Galactic dark matter (DM) halo in charged massive particles (CHAMPs). If dark matter particles are neutral but decay lately into CHAMPs, the lack of detection of heavy hydrogen in sea water and the vertical pressure equilibrium in the Galactic disc turn out to put the most stringent bounds. Adopting very conservative assumptions about the recoiling velocity of CHAMPs in the decay and on the decay energy deposited in baryonic gas, we find that the lifetime for decaying neutral DM must be > (0.9-3.4)x 10^3 Gyr. Even assuming the gyroradii of CHAMPs in the Galactic magnetic field are too small for halo CHAMPs to reach Earth, the present-day fraction of the mass of the Galactic halo in CHAMPs should be < (0.4-1.4)x 10^{-2}. We show that redistributing the DM through the coupling between CHAMPs and the ubiquitous magnetic fields cannot be a solution to the cuspy halo problem in dwarf galaxies.Comment: 21 pages, 2 figures. To appear in JCA

Eureka and beyond: mining's impact on African urbanisation

This collection brings separate literatures on mining and urbanisation together at a time when both artisanal and large-scale mining are expanding in many African economies. While much has been written about contestation over land and mineral rights, the impact of mining on settlement, notably its catalytic and fluctuating effects on migration and urban growth, has been largely ignored. African nation-states’ urbanisation trends have shown considerable variation over the past half century. The current surge in ‘new’ mining countries and the slow-down in ‘old’ mining countries are generating some remarkable settlement patterns and welfare outcomes. Presently, the African continent is a laboratory of national mining experiences. This special issue on African mining and urbanisation encompasses a wide cross-section of country case studies: beginning with the historical experiences of mining in Southern Africa (South Africa, Zambia, Zimbabwe), followed by more recent mineralizing trends in comparatively new mineral-producing countries (Tanzania) and an established West African gold producer (Ghana), before turning to the influence of conflict minerals (Angola, the Democratic Republic of Congo and Sierra Leone)

Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons

The efficiency of first-generation adenoviral vectors as gene delivery tools is often limited by the short duration of transgene expression, which can be related to immune responses and to toxic effects of viral proteins. In addition, readministration is usually ineffective unless the animals are immunocompromised or a different adenovirus serotype is used. Recently, adenoviral vectors devoid of all viral coding sequences (helper-dependent or gutless vectors) have been developed to avoid expression of viral proteins. In mice, liver-directed gene transfer with AdSTK109, a helper-dependent adenoviral (Ad) vector containing the human α1-antitrypsin (hAAT) gene, resulted in sustained expression for longer than 10 months with negligible toxicity to the liver. In the present report, we have examined the duration of expression of AdSTK109 in the liver of baboons and compared it to first- generation vectors expressing hAAT. Transgene expression was limited to approximately 3-5 months with the first-generation vectors. In contrast, administration of AdSTK109 resulted in transgene expression for longer than a year in two of three baboons. We have also investigated the feasibility of circumventing the humoral response to the virus by sequential administration of vectors of different serotypes. We found that the ineffectiveness of readministration due to the humoral response to an Ad5 first-generation vector was overcome by use of an Ad2-based vector expressing hAAT. These data suggest that long-term expression of transgenes should be possible by combining the reduced immunogenicity and toxicity of helper-dependent vectors with sequential delivery of vectors of different serotypes

Recent Advances in Understanding Particle Acceleration Processes in Solar Flares

We review basic theoretical concepts in particle acceleration, with particular emphasis on processes likely to occur in regions of magnetic reconnection. Several new developments are discussed, including detailed studies of reconnection in three-dimensional magnetic field configurations (e.g., current sheets, collapsing traps, separatrix regions) and stochastic acceleration in a turbulent environment. Fluid, test-particle, and particle-in-cell approaches are used and results compared. While these studies show considerable promise in accounting for the various observational manifestations of solar flares, they are limited by a number of factors, mostly relating to available computational power. Not the least of these issues is the need to explicitly incorporate the electrodynamic feedback of the accelerated particles themselves on the environment in which they are accelerated. A brief prognosis for future advancement is offered.Comment: This is a chapter in a monograph on the physics of solar flares, inspired by RHESSI observations. The individual articles are to appear in Space Science Reviews (2011

Particles-vortex interactions and flow visualization in He4

Recent experiments have demonstrated a remarkable progress in implementing and use of the Particle Image Velocimetry (PIV) and particle tracking techniques for the study of turbulence in He4. However, an interpretation of the experimental data in the superfluid phase requires understanding how the motion of tracer particles is affected by the two components, the viscous normal fluid and the inviscid superfluid. Of a particular importance is the problem of particle interactions with quantized vortex lines which may not only strongly affect the particle motion, but, under certain conditions, may even trap particles on quantized vortex cores. The article reviews recent theoretical, numerical, and experimental results in this rapidly developing area of research, putting critically together recent results, and solving apparent inconsistencies. Also discussed is a closely related technique of detection of quantized vortices negative ion bubbles in He4.Comment: To appear in the J Low Temperature Physic