Alkali release from aggregates in long-service concrete structures. Laboratory test evaluation and ASR prediction

Il lavoro propone un semplice modello per la previsione dello sviluppo di espansione deleteria da reazione alcali-silice (ASR) in strutture di calcestruzzo progettate per lunga vita di servizio. Il modello è basato su parametri di composizione e di reattività legati alla ASR, compreso il contributo in alcali a lungo termine da parte degli aggregati. Questo contributo è stato stimato attraverso una prova di estrazione di laboratorio, appositamente sviluppata con lo scopo di massimizzare il rilascio in tempi di prova relativamente brevi e con basso rapporto soluzione lisciviante/aggregato. Il metodo di prova proposto è basato sullo standard italiano riportato nella norma UNI 11417-2 e consiste nel sottoporre l'aggregato a lisciviazione con una soluzione satura di idrossido di calcio a 105°C, in autoclave. Sono stati sottoposti a prova nove aggregati (sette sabbie e due aggregati grossi), il rapporto in peso lisciviante/aggregato era pari a 0,6, il rapporto Ca(OH)2 solida/aggregato era pari a 0,05 ed il tempo di prova 120 ore. I risultati delle prove sono stati utilizzati nel modello di previsione dell'espansione deleteria a lungo termine, ottenendo delle previsioni del tutto congruenti con le informazioni sul comportamento reale dei materiali, nonché con le raccomandazioni riportate nel CEN/TR 16349:2012.This paper proposes a simple model for predicting the development of deleterious expansion from alkali-silica reaction (ASR) in long-service concrete structures. This model is based on some composition and reactivity parameters related to ASR, including the long-term alkali contribution by aggregates to concrete structures. This alkali contribution was estimated by means of a laboratory extraction test, appositely developed in this study in order to maximize the alkali extraction within relatively short testing times and with low leaching solution/aggregate ratios. The proposed test is a modification of the Italian Standard test method UNI 11417-2 (Ente Nazionale Italiano di Normazione) and it consists of subjecting an aggregate sample to leaching with saturated calcium hydroxide solution in a laboratory autoclave at 105 degrees C. Nine natural ASR-susceptible aggregates (seven sands and two coarse aggregates) were tested and the following optimized test conditions were found: leaching solution/aggregate weight ratio = 0.6; solid calcium hydroxide/aggregate weight ratio = 0.05; test duration = 120 h. The results of the optimized alkali extraction tests were used in the proposed model for predicting the potential development of long-term ASR expansion in concrete dams. ASR predictions congruent with both the field experience and the ASR prevention criteria recommended by European Committee for Standardization Technical Report CEN/TR 16349: 2012 were found, thus indicating the suitability of the proposed model

Residual capability of alkali binding by hydrated pozzolanic cements in long-service concrete structures

An experimental procedure was developed and applied to cement pastes made with two different pozzolanic cements (CEM IV/B (P) and CEM IV/B (V)) in order to ascertain the existence of a residual capability of alkali binding by long-term hydrated pozzolanic cements and, at the same time, to evaluate the alkali retention capability and the concentration of OH- ions in the pore solution of such cementitious matrices. The developed procedure consisted of accelerated curing of cement paste specimens (150 days at 60°C and 100% RH), subsequent leaching tests at 60°C for 30 days by using deionized water or basic solutions (NaOH or KOH at different concentrations) as leaching media, and correlation of the leaching test results with a simple mass balance equation for sodium and potassium ions. The developed procedure was found to be appropriate for evaluating both the pore liquid alkalinity and the alkali retention capability by long-term hydrated pozzolanic cement pastes. A residual capability of alkali binding was also identified for both tested pozzolanic cements, thus indicating their potential ability to prevent (CEM IV/B (V)) or minimize (CEM IV/B (P)) the risk of deleterious expansion associated to alkali-aggregate reaction in long-service concrete structures, like concrete dams

Correlation of Impedance and Effective Electrode Area of Iridium Oxide Neural Electrodes

Iridium oxide is routinely used for bionic applications owing to its high charge injection capacity. The electrode impedance at 1 kHz is typically reported to predict neural recording performance. In this article, the impedance of activated iridium oxide films (AIROFs) has been examined. The impedance of unactivated iridium electrodes was half that of platinum electrodes of similar geometry, indicating some iridium oxide was present on the electrode surface. A two time constant equivalent circuit was used to model the impedance of activated iridium. The impedance at low and intermediate frequencies decreased with increasing number of activation pulses and total activation charge. The impedance at 12 Hz correlated with the steady-state diffusion electroactive area. The impedance at 12 Hz also correlated with the charge density of the electrode. The high charge density and low impedance of AIROFs may provide improved neural stimulation and recording properties compared with typically used platinum electrodes

Predicting neural recording performance of implantable electrodes

Recordings of neural activity can be used to aid communication, control prosthetic devices or alleviatedisease symptoms. Chronic recordings require a high signal-to-noise ratio that is stable for years. Currentcortical devices generally fail within months to years after implantation. Development of novel devices toincrease lifetime requires valid testing protocols and a knowledge of the critical parameters controllingelectrophysiological performance. Here we present electrochemical and electrophysiological protocolsfor assessing implantable electrodes. Biological noise from neural recording has significant impact on signal-to-noise ratio. A recently developed surgical approach was utilised to reduce biological noise. This allowed correlation of electrochemical and electrophysiological behaviour. The impedance versus frequency of modified electrodes was non-linear. It was found that impedance at low frequencies was astronger predictor of electrophysiological performance than the typically reported impedance at 1 kHz.Low frequency impedance is a function of electrode area, and a strong correlation of electrode area with electrophysiological response was also seen. Use of these standardised testing protocols will allow future devices to be compared before transfer to preclinical and clinical trials

From ”Sapienza” to “Sapienza, State Archives in Rome”. A looping effect bringing back to the original source communication and culture by innovative and low cost 3D surveying, imaging systems and GIS applications

Applicazione di tecnologie mensorie integrate Low Cost,web GIS,applicazione di tecniche di Computational photography per la comunicazione e condivisione dei dati, sistemi di Cloud computing.Archiviazione Grandi DatiHigh Quality survey models, realized by multiple Low Cost methods and technologies, as a container to sharing Cultural and Archival Heritage, this is the aim guiding our research, here described in its primary applications. The SAPIENZA building, a XVI century masterpiece that represented the first unified headquarters of University in Rome, plays since year 1936, when the University moved to its newly edified campus, the role of the main venue for the State Archives. By the collaboration of a group of students of the Architecture Faculty, some integrated survey methods were applied on the monument with success. The beginning was the topographic survey, creating a reference on ground and along the monument for the upcoming applications, a GNNS RTK survey followed georeferencing points on the internal courtyard. Dense stereo matching photogrammetry is nowadays an accepted method for generating 3D survey models, accurate and scalable; it often substitutes 3D laser scanning for its low cost, so that it became our choice. Some 360°shots were planned for creating panoramic views of the double portico from the courtyard, plus additional single shots of some lateral spans and of pillars facing the court, as a single operation with a double finality: to create linked panotours with hotspots to web-linked databases, and 3D textured and georeferenced surface models, allowing to study the harmonic proportions of the classical architectural order. The use of free web Gis platforms, to load the work in Google Earth and the realization of low cost 3D prototypes of some representative parts, has been even performed

Detección de deslizamientos de ladera mediante imágenes Landsat TM: el impacto de estos disturbios sobre los bosques subtropicales del noroeste de Argentina

La teledetección aplicada a estudios medioambientales ha demostrado ser de gran utilidad para identificar, cartografiar y analizar la dinámica espacial y temporal de los ecosistemas. En el caso particular de los disturbios naturales como incendios y deslizamientos de ladera, la teledetección ayudará a evaluar su impacto a escala temporal y espacial amplias. Utilizando imágenes Landsat TM de los años 1986 y 2001 detectamos deslizamientos de ladera ocurridos en los bosques subtropicales del noroeste de Argentina, y evaluamos su impacto sobre las comunidades naturales. Mediante clasificaciones supervisadas se diferenciaron los deslizamientos de ladera del resto de las unidades del terreno, con una precisión general de 91% en la imagen de 1986 y 89% en la imagen de 2001. En base a estas clasificaciones determinamos el cambio en el tiempo del área de bosque afectada por los deslizamientos de ladera en el año 1986 y en el año 2001. Los estudios sobre deslizamientos de ladera basados en teledetección pueden aportar nuevos conocimientos en cuanto a la dinámica de este tipo de disturbio, su impacto en los bosques del noroeste argentino y su relación con los cambios climáticos (principalmente aumento de precipitaciones) registrados para la zona.Remote sensing technics applied to environmental studies has been used succesfully to identified, mapping and analizyng the spatial and temporal ecosystem dinamics. In studies of natural disturbances, such fires and landslides, the remote sensing approach can be used to asses the impact of these disturbances at broad spatial and temporal scale. Using 1986 and 2001 Landsat TM images we detected landslides accured on norwest Argentina subtropical forests, and we evaluated their impact on natural communities. Using supervised classifications, we diferenciated landslides from others land cover units with an overall accuracy of 91% in the 1986 image and 89% in the 2001 image. Landslides studies based on remote sensing technics can help to a better understanding of this kind of disturbance, in terms of their impact on the subtropical forests and their relationship with the climate change (specially precipitation) registered in the zone.Fil: Paolini, Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Laboratorio de Investigaciones Ecológicas de las Yungas; ArgentinaFil: Sobrino, Jose Antonio. Universidad de Valencia; EspañaFil: Jimenez Muños, Juan Carlos. Universidad de Valencia; Españ

Cycling training effects on fat metabolism blood parameters

BACKGROUND: Study the acute and middle term (4 weeks training) effect of cycling training on fat blood hematological parameters, urine, fatigue, and general health in recreational well-trained cyclists. METHODS: Nineteen cyclists underwent five blood sample collections: before and after an incremental maximal ramp test 7 days before day 0 (D-0); before and after 1 hour exhaustion trial test at baseline (D-0); and after 28 days of training (D-28). Age 34.5 years (\ub19.5); weight 74.87 kg (\ub16.6); height 177.3 cm (\ub15.2); BMI 26.3 (\ub14.9); VO2max 53.75 mL/kg/ min (\ub16.01); distance cycled 314.7 km/week (\ub1137.1). RESULTS: Acute effect was strong elevating WBC from 6.27\ub12.34 to 9.01\ub13.63 7103/\ub5L, an increase in LDL and total CHOL, in this respect, existing literature is controversial. No changes in body weight or blood pressure was observed after 1 month of regular training albeit lipid profile significantly improved, as well as GOT. CONCLUSIONS: Effect of a short incremental bout of exercise was to temporary elevated all the blood parameters except MCH and MCHC. A month of intensive training (distance cycled: 314.7\ub1137.1 km/week) significantly improved blood lipids profile with no permanent effect on WBC, blood pressure or body weight, but improved post effort lactate concentration and fatigue perception. Hematuria is confirmed to be a rare occurrence in recreational cyclists. Data can be useful for training monitoring and comparisons with similar groups of athletes, where there is a lack of information in literature and for comparing exercise effects

First-line treatment of chronic myeloid leukemia with nilotinib: critical evaluation.

The therapeutic landscape of chronic myeloid leukemia (CML) has changed dramatically in the last decade. In particular, the availability of imatinib mesylate, a tyrosine kinase inhibitor targeting BCR-ABL, has led to profound and durable remissions in the majority of patients. However, a couple of issues have emerged and partially obscured this scenario. First, it has become clear that a significant proportion of patients either present with primary resistance to imatinib or develop secondary resistance sooner or later during treatment. Second, although the drug is generally well tolerated, a percentage of patients eventually cease treatment because of toxicity. Bearing this in mind, second-generation tyrosine kinase inhibitors have been introduced, including nilotinib. Phase I and II studies indicate remarkable activity for this compound in CML cases resistant to imatinib, including some of those carrying BCR-ABL1 mutants. More recently, two Phase II studies and a III randomized Phase clinical trial demonstrated the superiority of nilotinib compared with imatinib in terms of complete cytogenetic and major molecular responses, which are two relevant surrogate measures of long-term survival in CML. In this paper, we review the most relevant data on nilotinib as first-line treatment for CML, and discuss the rationale for its routine use, as well as some possible future perspectives for CML patients