Follow-Up to Case Study: Neurofeedback as a First Choice Treatment in an ADHD and Comorbidities

The purpose of this case study is to present the evolution in the neurofeedback treatment of a 7-years-old boy with ADHD and comorbidities – OCD, Anxiety and Aggression. The main complaint of parents and school was the lack of control of his impulses, beating his classmates, not sitting quietly in the classroom, disrupting classmates, biting fingernails and toes compulsively – getting hurt. He was asked to withdraw from the previous school and, the parents saw neurofeedback as an alternative non-drug treatment, since the psychiatrist suggested an antidepressant. Brain training by neurofeedback occurred twice a week, in a total of 70 sessions,where the brain areas with the greatest impairment were trained. With only two months of treatment, the boy’s aggressiveness was no longer a problem. At the end of the treatment, the functional impairments were better, validated by mean evolution evaluations. The patient was released, with a high approval rating from parents and school, since their symptoms disappeared. After 1 year and 9 months of the end of treatment at the age of 9, a new assessment was performed to see if the gains remained. The results showed that through Neurofeedback training the brain had the ability to normalize his electrical activity and maintain the gain over time. Keywords: ADHD, neurofeedback, rehabilitatio

Intramuscular Immunisation with Chlamydial Proteins Induces Chlamydia trachomatis Specific Ocular Antibodies.

BACKGROUND: Ocular infection with Chlamydia trachomatis can cause trachoma, which is the leading cause of blindness due to infection worldwide. Despite the large-scale implementation of trachoma control programmes in the majority of countries where trachoma is endemic, there remains a need for a vaccine. Since C. trachomatis infects the conjunctival epithelium and stimulates an immune response in the associated lymphoid tissue, vaccine regimens that enhance local antibody responses could be advantageous. In experimental infections of non-human primates (NHPs), antibody specificity to C. trachomatis antigens was found to change over the course of ocular infection. The appearance of major outer membrane protein (MOMP) specific antibodies correlated with a reduction in ocular chlamydial burden, while subsequent generation of antibodies specific for PmpD and Pgp3 correlated with C. trachomatis eradication. METHODS: We used a range of heterologous prime-boost vaccinations with DNA, Adenovirus, modified vaccinia Ankara (MVA) and protein vaccines based on the major outer membrane protein (MOMP) as an antigen, and investigated the effect of vaccine route, antigen and regimen on the induction of anti-chlamydial antibodies detectable in the ocular lavage fluid of mice. RESULTS: Three intramuscular vaccinations with recombinant protein adjuvanted with MF59 induced significantly greater levels of anti-MOMP ocular antibodies than the other regimens tested. Intranasal delivery of vaccines induced less IgG antibody in the eye than intramuscular delivery. The inclusion of the antigens PmpD and Pgp3, singly or in combination, induced ocular antigen-specific IgG antibodies, although the anti-PmpD antibody response was consistently lower and attenuated by combination with other antigens. CONCLUSIONS: If translatable to NHPs and/or humans, this investigation of the murine C. trachomatis specific ocular antibody response following vaccination provides a potential mouse model for the rapid and high throughput evaluation of future trachoma vaccines

Milho doce: origem de mutações naturais.

Esta publicação tem como objetivo revisar as principais mutações espontâneas que provocam alterações no conteúdo de açúcares na semente do milho. Estas mutações dão origem ao que conhecemos hoje como milho-doce. Este tipo de milho vem ganhando espaço no Brasil e seu consumo tende a aumentar, à medida que um maior número de híbridos com diferentes combinações de mutações e dosagens alélicas apareçam no mercado, atendendo às diferentes necessidades do consumidor e das indústrias alimentícias.bitstream/item/70062/1/doc-144.pd