Üniversite Hazırlık Sınıfı Öğrencilerinin Dil Öğrenme Stratejileri Kullanımlarının Çeşitli Değişkenlere Göre İncelenmesi

Bu araştırmanın amacı, üniversite hazırlık sınıfı öğrencilerinin dil öğrenme stratejileri kullanımlarını cinsiyet ve LYS puan türü değişkenlerine göre incelemektir. Araştırmaya Düzce Üniversitesi hazırlık biriminde öğrenim göre toplam 461 öğrenci katılmıştır. Üniversite öğrencilerinin dil öğrenme stratejileri kullanımlarını belirlemek üzere, Oxford (1990) tarafından geliştirilen ve Cesur ve Fer (2007) tarafından Türkçe’ye uyarlanan “Dil Öğrenme Stratejileri Envanteri” uygulanmıştır. Araştırma verilerinin analizinde SPSS 16.0 (Statistical Package for Social Sciences) veri analiz programından faydalanılmıştır. Öğrencilerin genel strateji kullanımları ile cinsiyetleri arasındaki fark Independent Sample t-test (Bağımsız Örneklemler İçin t-testi), LYS puan türleri ile genel strateji kullanımları arasındaki fark ise One Way ANOVA tekniği ile analiz edilmiştir. Araştırma sonuçlarına göre, öğrencilerin genel strateji kullanımları ile cinsiyet faktörü arasında anlamlı bir farka rastlanamazken, bellek stratejileri kullanımında kadınlar lehine, telafi stratejileri tercihinde erkekler lehine anlamlı fark olduğu görülmüştür. LYS puan türü ile öğrencilerin kullandıkları dil öğrenme stratejileri arasındaki farka bakıldığında, gerek öğrencilerin genel strateji kullanımı gerekse alt ölçeklerdeki stratejileri kullanımlarıyla LYS puan türleri arasında anlamlı farka rastlanılmamıştır. Anahtar kelimeler: Yabancı Dil Öğrenimi, Dil Öğrenme Stratejileri, Cinsiyet, LYS Puan Tür

Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis

FOXN1 is the master regulatory gene of thymic epithelium development. FOXN1 deficiency leads to thymic aplasia, alopecia, and nail dystrophy, accounting for the nude/severe combined immunodeficiency (nu/SCID) phenotype in humans and mice. We identified several newborns with low levels of T cell receptor excision circles (TRECs) and T cell lymphopenia at birth, who carried heterozygous loss-of-function FOXN1 variants. Longitudinal analysis showed persistent T cell lymphopenia during infancy, often associated with nail dystrophy. Adult individuals with heterozygous FOXN1 variants had in most cases normal CD4+ but lower than normal CD8+ cell counts. We hypothesized a FOXN1 gene dosage effect on the function of thymic epithelial cells (TECs) and thymopoiesis and postulated that these effects would be more prominent early in life. To test this hypothesis, we analyzed TEC subset frequency and phenotype, early thymic progenitor (ETP) cell count, and expression of FOXN1 target genes (Ccl25, Cxcl12, Dll4, Scf, Psmb11, Prss16, and Cd83) in Foxn1nu/+ (nu/+) mice and age-matched wild-type (+/+) littermate controls. Both the frequency and the absolute count of ETP were significantly reduced in nu/+ mice up to 3 weeks of age. Analysis of the TEC compartment showed reduced expression of FOXN1 target genes and delayed maturation of the medullary TEC compartment in nu/+ mice. These observations establish a FOXN1 gene dosage effect on thymic function and identify FOXN1 haploinsufficiency as an important genetic determinant of T cell lymphopenia at birth

Long-term outcome of LRBA deficiency in 76 patients after various treatment modalities as evaluated by the immune deficiency and dysregulation activity (IDDA) score

Background: Recent findings strongly support hematopoietic stem cell transplantation (HSCT) in patients with severe presentation of LPS-responsive beige-like anchor protein (LRBA) deficiency, but long-term follow-up and survival data beyond previous patient reports or meta-reviews are scarce for those patients who do not receive a transplant.Objective: This international retrospective study was conducted to elucidate the longitudinal clinical course of patients with LRBA deficiency who do and do not receive a transplant.Method: We assessed disease burden and treatment responses with a specially developed immune deficiency and dysregulation activity score, reflecting the sum and severity of organ involvement and infections, days of hospitalization, supportive care requirements, and performance indices.Results: Of 76 patients with LRBA deficiency from 29 centers (median follow-up, 10 years; range, 1-52), 24 underwent HSCT from 2005 to 2019. The overall survival rate after HSCT (median follow-up, 20 months) was 70.8% (17 of 24 patients); all deaths were due to nonspecific, early, transplant-related mortality. Currently, 82.7% of patients who did not receive a transplant (43 of 52; age range, 3-69 years) are alive. Of 17 HSCT survivors, 7 are in complete remission and 5 are in good partial remission without treatment (together, 12 of 17 [70.6%]). In contrast, only 5 of 43 patients who did not receive a transplant (11.6%) are without immunosuppression. Immune deficiency and dysregulation activity scores were significantly lower in patients who survived HSCT than in those receiving conventional treatment (P = .005) or in patients who received abatacept or sirolimus as compared with other therapies, and in patients with residual LRBA expression. Higher disease burden, longer duration before HSCT, and lung involvement were associated with poor outcome.Conclusion: The lifelong disease activity, implying a need for immunosuppression and risk of malignancy, must be weighed against the risks of HSCT.Transplantation and immunomodulatio

The examination of the language learning strategies of university preparatory class students with respect to various variables

YÖK Tez No: 331743Bu araştırmanın amacı, üniversite hazırlık sınıfı öğrencilerinin dil öğrenme stratejileri kullanımlarını cinsiyet, LYS puan türü ve anadil değişkenlerine göre incelemektir. Araştırmaya Düzce Üniversitesi hazırlık biriminde öğrenim göre toplam 461 öğrenci katılmıştır. Üniversite öğrencilerinin dil öğrenme stratejileri kullanımlarını belirlemek üzere, Oxford (1990) tarafından geliştirilen ve Cesur ve Fer (2007) tarafından Türkçe'ye uyarlanan ?Dil Öğrenme Stratejileri Envanteri? uygulanmıştır. Araştırma verilerinin analizinde SPSS 16.0 (Statistical Package for Social Sciences) veri analiz programından faydalanılmıştır. Öğrencilerin genel strateji kullanımları ile cinsiyetleri arasındaki fark Independent Sample t-test tekniğiyle, LYS puan türleri ve anadilleri ile genel strateji kullanımları arasındaki fark ise One Way ANOVA tekniği ile analiz edilmiştir. Araştırmada ayrıca anadili Türkçe'den farklı olan öğrencilerle görüşmeler yapılarak nitel veriler elde edilmiştir.Araştırma sonuçlarına göre, öğrencilerin genel strateji kullanım ortalaması, orta düzey strateji kullanım aralığına karşılık gelen 3,06 olarak bulunmuştur. Öğrencilerin, en fazla sosyal stratejileri, en az ise duyuşsal stratejileri tercih ettikleri belirlenmiştir. Öğrencilerin genel strateji kullanımları ile cinsiyet faktörü arasında anlamlı bir farka rastlanamazken, bellek stratejileri kullanımında bayanlar lehine, telafi stratejileri tercihinde ise baylar lehine anlamlı fark gözlemlenmiştir. LYS puan türü ile öğrencilerin kullandıkları dil öğrenme stratejileri arasındaki farka bakıldığında, gerek öğrencilerin genel strateji kullanımı gerekse alt ölçeklerdeki stratejileri kullanımlarıyla LYS puantürleri arasında anlamlı farka rastlanılmamıştır. Araştırmaya katılan anadili Türkçe olan öğrencilerle anadili Türkçe'den farklı olan öğrencilerin dil öğrenme stratejileri karşılaştırıldığında, genel ve alt ölçeklerdeki strateji kullanımları ve anadil faktörü arasında anlamlı bir farka rastlanılmamıştır. Ancak, envanterin bilişsel stratejiler alt boyutunda anadili Kürtçe olan öğrenciler lehine anlamlı farka rastlanılmıştır. Araştırmada ayrıca anadili Türkçeden farklı olan öğrencilerin en yoğun kullandıkları strateji grubunun bilişsel stratejiler olduğu sonucuna ulaşılmıştır.The aim of this study is to examine the use of language learning strategies of university preparatory class students with respect to their gender, sort of LYS (Undergraduate Placement Exam) point and native language. The attendants of the study were 461 students who study at Düzce University preparatory unit. ?Language Learning Strategies Inventory?, which was developed by Oxford (1990) and adapted to Turkish by Cesur and Fer (2007), was used to identify the use of language strategies of the attendants. SPSS 16.0 (Statistical Package for Social Sciences) was benefited to analyze the data obtained from the attendants. The difference between students? general use of strategies and gender was analyzed through Independent Sample t-test technique. The difference between students? sorts of LYS (Undergraduate Placement Exam) point and native language and their students? general use of strategies was analyzed through One Way ANOVA technique. Some qualitative data were also obtained from the students whose native languages are different from Turkish.According to the findings of the study, the mean of the scores of general strategy used was found to be 3,06, which means a medium level of strategy use. It was identified that the mostly preferred strategy type was ?social strategies? and the strategies that were used the least were ?affective strategies?. Although a meaningful difference was not been identified between students? general strategy use and gender; there was a meaningful difference between memory strategies and gender, favoring females, and between compensation strategies and gender, favoring males. As to the difference between strategy use and sort of LYS point, there were not any meaningful differences between sort of LYS point and both general and sub-group strategy uses. There were not any differences between the general and sub-group strategy uses of Turkish speaking and students whose native language is different from Turkish. However; there was a meaningful difference in cognitive strategy use, favoring Kurdish speaking students. Additionally, it was found that the strategy group used by students whose native language is different from Turkish mostly was the group of cognitive strategies

Określenie chemicznych i sensorycznych cech niektórych odmian marchwi uprawianej w Turcji

This study was conducted in Konya region where 60% of the carrot production of Turkey is realized. Eight different-colored carrot varieties were used in the study and their sensory and chemical quality characteristics were determined. It was determined that the orange-colored root varieties were preferred more than those with other colored root varieties in terms of outer and inner color, juiciness, taste and bitterness. A correlation between some sensory and chemical quality characteristics was determined. The most phenolic matter content was determined in Purple carrot (163.52 mg 10-2 g -1 GAE) and Bolero (orange) (155.90 mg 10-2 g -1 GAE) varieties. The most antioxidant activity (45.91% inhibition), dry matter content (16.77%), total sugar content (8.27 g 10-2 g -1) and β carotene (183.01 µg g-1) content were determined in the Maestro (orange) variety. It was determined that the orange colored was preferred more than the other colored varieties in terms of sensory features.Badanie przeprowadzono w rejonie Konya, gdzie produkuje się 60% tureckiej marchwi. W badaniu zastosowano osiem odmian marchwi o różnej barwie, określając ich cechy chemiczne i sensoryczne. Stwierdzono, że odmiany o pomarańczowym korzeniu są preferowane w porównaniu z odmianami o innej barwie jeśli chodzi o barwę, soczystość, smak i gorzkawy posmak. Określono korelację między niektórymi cechami chemicznymi i sensorycznymi. Największą zawartość fenoli stwierdzono w marchwi Purple (163,52 mg 10-2 g-1 GAE) i Bolero (pomarańczowa) (155,90 mg 10-2 g-1 GAE). W odmianie Maestro (pomarańczowa) stwierdzono największe działanie antyoksydacyjne (45,91% inhibicji), zawartość suchej masy (16,77%), całkowitą zawartość cukrów (8,27 g 10-2 g-1) i β karotenu (183,01µg g-1). Stwierdzono, że w kategoriach cech sensorycznych odmiany pomarańczowe były lepiej oceniane od odmian o innej barwie

Üniversite hazırlık sınıfı ö?rencilerinin dil ö?renme stratejileri kullanımlarının çeşitli de?işkenlere göre İncelenmesi

The aim of this study is to examine the use of language learning strategies of university preparatory class students with respect to their gender and sort of LYS (Undergraduate Placement Exam) point. The participants of the study were 461 students who study at Düzce University preparatory unit. "Language Learning Strategies Inventory", developed by Oxford (1990) and adapted to Turkish by Cesur and Fer (2007), was used to identify the use of language strategies of the attendants. The difference between students' general use of strategies and gender was analyzed through Independent Sample t-test technique. The difference between students' sorts of LYS (Undergraduate Placement Exam) point and native language and their general use of strategies was analyzed through One Way ANOVA technique. Although a significant difference was not identified between students' general strategy use and gender; there was a significant difference between memory strategies and gender, favoring females, and between compensation strategies and gender, favoring males. As to the difference between strategy use and sort of LYS point, there were not any significant differences between sort of LYS point and both general and sub-group strategy uses

Linie purpurowej marchwi mające lepsze cechy technologiczne w Turcji

The purple carrot population, which is cultivated commonly in Konya region in Turkey for industrial purposes, was used. Different types of purple carrots were collected in order to have a gene pool, and they were subjected to selection according to the charac-ters studied. The experiment was carried out in a Randomized Blocks Trial Design in a 3-recurrent using 22 inbred lines of purple carrot during 2009–2012. As for average yield, Eregli 1 was the highest (11.54 t·ha-1) whereas Eregli 14 was the lowest (9.27 t·ha-1). A correlation between some physical and chemical quality characteristics was determined. In carrot samples, the amount of dry matter was 12.63–16.30%, total sugar content was 7.13–9.67 g·100 g-1, the amount of β-carotene was 117.17–249.55 μg·g-1, the amount of an-thocyanin was 272.0–596.2 μg·g-1, the amount of total phenolic 155.83–206.67 mg·10-2 g-1GAE, and antioxidant activity ranged from 31.85 to 44.20%. At the end of the study, the Eregli 9 and Eregli 10 lines were determined as hopeful lines, and Eregli 4 and Eregli 16 lines were determined as being cultivar candidate lines.Użyto populacji marchwi purpurowej, która jest powszechnie uprawiana w rejonie Konya w Turcji dla celów przemysłowych. Zebrano różne typy marchwi czerwonej dla puli genów. Poddano je selekcji ze względu na badane cechy. Doświadczenie przeprowadzono w latach 2009–2012 w układzie prób losowanych bloków w 3 powtórze-niach przy użyciu spokrewnionych linii marchwi purpurowej. Eregli 1 miał najwyższy (11,54 t·ha-1), a Eregli 14 najniższy plon (9,27 t·ha-1). Określono korelację między niektórymi cechami fizycznymi i chemicznymi. W próbkach marchwi ilość suchej masy wynosiła 12,3–16,30%, całkowita zwartość cukrów 7,13–9,67 g·100 g-1, ilość β-karotenu 117,17–249,55 μg·g-1, ilość antocyjaniny 272,0–596,2 μg·g-1, całkowita ilość fenoli 155,83–206,67 mg·10-2g-1 GAE, natomiast działanie antyoksydacyjne wynosiło od 31,85 do 44,20%. Przy końcu badania linie Eregli 9 i Eregli 10 określono jako linie dające nadzieję, natomiast Eregli 4 i Eregli 16 jako linie kandydujące na odmiany

Üstün Verim ve Teknolojik Özelliklere Sahip Bazı Salçalık Domates Çeşitlerinin Isparta Koşullarına Uygunluğunun Belirlenmesi

Bu arastırma, 1997 yılında Isparta kosullarına uygun üstün verim ve teknolojik özelliklere sahip domates çesitlerinin belirlenmesi amacı ile yürütülmüstür. Arastırmada, çesitli tohum sirketlerinden temin edilen 38 farklı salçalık domates çesidi (Rio Grande, Shasta, Amico, H 3302, Star F1, Nema 1401, APT 127 (XPH 12047), Amico-C, APTX 390, Chibli I-123, Sixtina, Keban F1, Round Firm, Peto-86, Amico-B, Alta, Rio Fuego, Urbana, RS 6515, SC 2121, T2 Improved, Brixy, AG 2206, Coudoulet, T2, VF 6203, AG 2247, H 2274, Arizona, Mandur 1995, APTX 403, Campell-37, E 6203, Cigalou, Petomesch, Hypeel 235, XPH 12066 ve Indiana) kullanılmıstır. Çesitler verim, erkencilik, briks, salça verimi, ortalama meyve agırlıgı, pH, renk, Vitamin C ve meyve sertligi gibi kalite ve kantite faktörleri bakımından sınıflandırılmıstır. En yüksek verim (7403 kg/da) ve salça verimi (1842 kg/da) XPH 12066 çesidinde tespit edilmistir. Ortalama meyve agırlıgında 110 g ile SC 2121; pH degerinde 4.40 ile Coudoulet; briks (% 10.33) ve askorbik asit (23.67 mg/100 g) içerigi açısından Sixtina çesitleri digerlerinden daha üstün bulunmustur. Renk (2.52 a/b) degeri açısından en iyi çesit T2 olurken, en yüksek meyve delinme direnci (1.826 kg/cm2) Keban F1 çesidinde belirlenmistir