Composition and Determinants of Fiscal Adjustment’S success in the EU27 Contex

Current context brings new challenges posed by the decrease of public revenues,through lowering the tax base and the capacity to collect taxes, and by the inability to adjust the public expenditures. All countries face the challenges of fiscal adjustment. The aim of this paper is to identify the determinant factors of success for fiscal adjustment episodesin UE 27 context. The considered factors are the need, the size and the composition of the fiscal adjustment. The result of the logit models concluded that significant fiscal adjustments lead to sustainable deficit reduction, while the composition of fiscal adjustments through policies based on public expenditure or revenues does not significantly influence the probability of success.

Accountability and Intervening Agency: An Asymmetry between Upstream and Downstream Actors

Suppose someone (P1) does something that is wrongful only in virtue of the risk that it will enable another person (P2) to commit a wrongdoing. Suppose further that P1’s conduct does indeed turn out to enable P2’s wrongdoing. The resulting wrong is agentially mediated: P1 is an enabling agent and P2 is an intervening agent. Whereas the literature on intervening agency focuses on whether P2’s status as an intervening agent makes P1’s conduct less bad, I turn this issue on its head by investigating whether P1’s status as an enabling agent makes P2’s conduct more bad. I argue that it does: P2 wrongs not just the victims of ϕ but P1 as well, by acting in a way that wrongfully makes P1 accountable for ϕ. This has serious implications for compensatory and defensive liability in cases of agentially mediated wrongs

Triangulating the Real Projective Plane

We consider the problem of computing a triangulation of the real projective plane P2, given a finite point set S={p1, p2,..., pn} as input. We prove that a triangulation of P2 always exists if at least six points in S are in general position, i.e., no three of them are collinear. We also design an algorithm for triangulating P2 if this necessary condition holds. As far as we know, this is the first computational result on the real projective plane

Sum of squared logarithms - An inequality relating positive definite matrices and their matrix logarithm

Let y1, y2, y3, a1, a2, a3 > 0 be such that y1 y2 y3 = a1 a2 a3 and y1 + y2 + y3 >= a1 + a2 + a3, y1 y2 + y2 y3 + y1 y3 >= a1 a2 + a2 a3 + a1 a3. Then the following inequality holds (log y1)^2 + (log y2)^2 + (log y3)^2 >= (log a1)^2 + (log a2)^2 + (log a3)^2. This can also be stated in terms of real positive definite 3x3-matrices P1, P2: If their determinants are equal det P1 = det P2, then tr P1 >= tr P2 and tr Cof P1 >= tr Cof P2 implies norm(log P1) >= norm(log P2), where log is the principal matrix logarithm and norm(P) denotes the Frobenius matrix norm. Applications in matrix analysis and nonlinear elasticity are indicated

The group of endotrivial modules for the symmetric and alternating groups.

We complete a classification of the groups of endotrivial modules for the modular group algebras of symmetric groups and alternating groups. We show that, for n ≥ p2, the torsion subgroup of the group of endotrivial modules for the symmetric groups is generated by the sign representation. The torsion subgroup is trivial for the alternating groups. The torsion-free part of the group is free abelian of rank 1 if n ≥ p2 + p and has rank 2 if p2 ≤ n < p2 + p. This completes the work begun earlier by Carlson, Mazza and Nakano

Codominance and toxins: A path to drugs of nearly unlimited selectivity

The effectiveness of drugs is often limited by their insufficient selectivity. I propose designs of therapeutic agents that address this problem. The key feature of these reagents, termed comtoxins (codominance-mediated toxins), is their ability to utilize codominance, a property characteristic of many signals in proteins, including degradation signals (degrons) and nuclear localization signals. A comtoxin designed to kill cells that express intracellular proteins P1 and P2 but to spare cells that lack P1 and/or P2 is a multidomain fusion containing a cytotoxic domain and two degrons placed within or near two domains P1* and P2* that bind, respectively, to pi and P2. In a cell containing both P1 and P2, these proteins would bind to the P1* and P2* domains of the comtoxin and sterically mask the nearby (appropriately positioned) degrons, resulting in a long-lived and therefore toxic drug. By contrast, in a cell lacking P1 and/or P2, at least one of the comtoxin's degrons would be active (unobstructed), yielding a short-lived and therefore nontoxic drug. A comtoxin containing both a degron and a nuclear localization signal can be designed to kill exclusively cells that contain P1 but lack P2. Analogous strategies yield comtoxins sensitive to the presence (or absence) of more than two proteins in a cell. Also considered is a class of comtoxins in which a toxic domain is split by a flexible insert containing binding sites for the target proteins. The potentially unlimited, combinatorial selectivity of comtoxins may help solve the problem of side effects that bedevils present-day therapies, for even nonselective delivery of a comtoxin would not affect cells whose protein "signatures" differ from the targeted one

PIP5KIβ Selectively Modulates Apical Endocytosis in Polarized Renal Epithelial Cells

Localized synthesis of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] at clathrin coated pits (CCPs) is crucial for the recruitment of adaptors and other components of the internalization machinery, as well as for regulating actin dynamics during endocytosis. PtdIns(4,5)P2 is synthesized from phosphatidylinositol 4-phosphate by any of three phosphatidylinositol 5-kinase type I (PIP5KI) isoforms (α, β or γ). PIP5KIβ localizes almost exclusively to the apical surface in polarized mouse cortical collecting duct cells, whereas the other isoforms have a less polarized membrane distribution. We therefore investigated the role of PIP5KI isoforms in endocytosis at the apical and basolateral domains. Endocytosis at the apical surface is known to occur more slowly than at the basolateral surface. Apical endocytosis was selectively stimulated by overexpression of PIP5KIβ whereas the other isoforms had no effect on either apical or basolateral internalization. We found no difference in the affinity for PtdIns(4,5)P2-containing liposomes of the PtdIns(4,5)P2 binding domains of epsin and Dab2, consistent with a generic effect of elevated PtdIns(4,5)P2 on apical endocytosis. Additionally, using apical total internal reflection fluorescence imaging and electron microscopy we found that cells overexpressing PIP5KIβ have fewer apical CCPs but more internalized coated structures than control cells, consistent with enhanced maturation of apical CCPs. Together, our results suggest that synthesis of PtdIns(4,5)P2 mediated by PIP5KIβ is rate limiting for apical but not basolateral endocytosis in polarized kidney cells. PtdIns(4,5)P2 may be required to overcome specific structural constraints that limit the efficiency of apical endocytosis. © 2013 Szalinski et al

PENGARUH SUBTITUSI TEPUNG IKAN DENGAN TEPUNG KEONG MAS (Pomaceae canaliculata) PADA PAKAN TERHADAP RASIO KONVERSI PAKAN, RETENSI PROTEIN DAN RASIO EFISIENSI PROTEIN IKAN LELE DUMBO (Clarias gariepinus)

This research executed in laboratory indoor faculty of husbanry - fishery in university muhammadiyah of Malang on 1 - 28 Decembers 2008. Intention of this research to know substitution influence of flour keong fish with flour keong mas ( Pomacea canaliculata) at feed to feed conversion ratio, retention of protein and fish protein efficiency ratio lele dumbo ( Clarias gariepinus). Method applied is experiment method and design of experiments applied is completely randomized design ( RAL) with 5 treatment that is: comparison of substitution of flour keong mas with fish meal is p1 0 % : 100 %, p2 25 % : 75 %, p3 50 % : 50 %, p4 75 % : 25 %, p5 100 : 0 % and each repeated 3 times. Result of research shows flour keong mas as substitution of fish gives result influential very real to feed conversion ratio ( FCR), retention of protein ( RP) and protein efficiency ratio ( REP) fish lele dumbo ( Clarias gariepinus). Test result bnt ( smallest reality difference) feed conversion ratio of fish lele dumbo shows treatment p1, p2 and p3 differs in to treatment of p4 and p5. Treatment of p2 yields ratio value fcr is low by 2,68. Test result bnt for retention of fish protein lele dumbo shows treatment p1, p2 and p3 differs in to treatment of p4 and p5. Treatment of p2 yields retention value of highest protein equal to 43,19%. test result bnt feed efficiency ratio shows treatment p1, p2 and p3 differs in to treatment of p4 and p5. treatment of p2 shows value is highest 1,25 %. Level of survival rate at treatment of p1 equal to 93,33%, treatment of p2 equal to 90%, treatment of p3 and p5 83,33 and treatment of p4 equal to 80%. To obtain maximum result at feed conversion ratio, retention of protein and protein efficiency ratio and can cost effective feed production better apply is feed with substitution of flour keong mas equal to 50%

Searching for the Profit in Pollution Prevention: Case Studies in the Corporate Evaluation of Environmental Opportunities

The concept of pollution prevention, or "P2," signifies a new, proactive environmental mindset that targets the causes, rather than the consequences, of polluting activity. While anecdotal evidence suggests that P2 opportunities exist and that many have been pursued, there is also the perception that the pace of P2 is far too slow. To explore that claim—and to shed light on barriers to P2 innovation—this paper presents case studies of industrial P2 projects that were in some way unsuccessful. While based on a very limited sample, the evidence contradicts the view that firms suffer from organizational weaknesses that make them unable to appreciate the financial benefits of P2 investments. Instead, the projects foundered because of significant unresolved technical difficulties, marketing challenges, and regulatory barriers. Based on evidence from the cases, the paper concludes with a discussion of environmental policy reforms likely to promote P2 innovation..