Vacuum fluctuations and topological Casimir effect in Friedmann-Robertson-Walker cosmologies with compact dimensions

We investigate the Wightman function, the vacuum expectation values of the field squared and the energy-momentum tensor for a massless scalar field with general curvature coupling parameter in spatially flat Friedmann-Robertson-Walker universes with an arbitrary number of toroidally compactified dimensions. The topological parts in the expectation values are explicitly extracted and in this way the renormalization is reduced to that for the model with trivial topology. In the limit when the comoving lengths of the compact dimensions are very short compared to the Hubble length, the topological parts coincide with those for a conformal coupling and they are related to the corresponding quantities in the flat spacetime by standard conformal transformation. In the opposite limit of large comoving lengths of the compact dimensions, in dependence of the curvature coupling parameter, two regimes are realized with monotonic or oscillatory behavior of the vacuum expectation values. In the monotonic regime and for nonconformally and nonminimally coupled fields the vacuum stresses are isotropic and the equation of state for the topological parts in the energy density and pressures is of barotropic type. In the oscillatory regime, the amplitude of the oscillations for the topological part in the expectation value of the field squared can be either decreasing or increasing with time, whereas for the energy-momentum tensor the oscillations are damping.Comment: 20 pages, 2 figure

Concurrent resistance and aerobic exercise stimulates both myofibrillar and mitochondrial protein synthesis in sedentary middle-aged men

We determined myofibrillar and mitochondrial protein fractional synthesis rates (FSR), intramuscular signaling protein phosphorylation, and mRNA expression responses after isolated bouts of resistance exercise (RE), aerobic exercise (AE), or in combination [termed concurrent exercise (CE)] in sedentary middle-aged men. Eight subjects (age = 53.3 ± 1.8 yr; body mass index = 29.4 ± 1.4 kg·m2) randomly completed 8 × 8 leg extension repetitions at 70% of one repetition-maximum, 40 min of cycling at 55% peak aerobic power output (AE), or (consecutively) 50% of the RE and AE trials (CE). Biopsies were obtained (during a primed, constant infusion of l-[ring-13C6]phenylalanine) while fasted, and at 1 and 4 h following postexercise ingestion of 20 g of protein. All trials increased mitochondrial FSR above fasted rates (RE = 1.3-fold; AE = 1.5; CE = 1.4; P 0.05), while rpS6 (Ser235/236) increased only in RE (10.4) (P < 0.05). CE and AE both resulted in increased peroxisome proliferator receptor-γ coactivator 1-α (PGC1α) expression at 1 h (CE = 2.9; AE = 2.8; P < 0.05) and 4 h (CE = 2.6; AE = 2.4) and PGC1β expression at 4 h (CE = 2.1; AE = 2.6; P < 0.05). These data suggest that CE-induced acute stimulation of myofibrillar and mitochondrial FSR, protein signaling, and mRNA expression are equivalent to either isolate mode (RE or AE). These results occurred without an interference effect on muscle protein subfractional synthesis rates, protein signaling, or mRNA expression

Subarcsecond view on the high-redshift blazar GB 1508+5714 by the International LOFAR Telescope

Context. Studies of the most distant active galactic nuclei (AGNs) allow us to test our current understanding of the physics present in radio-jetted AGNs across a range of environments, and probe their interactions with these environments. The decrease in apparent luminosity with distance is the primary difficulty to overcome in the study of these distant AGNs, which requires highly sensitive instruments. Aims. Our goal is to employ new long wavelength radio data to better parametrise the broad-band spectral energy distribution (SED) of GB 1508+5714, a high-redshift (z = 4.30) AGN. Its high redshift, high intrinsic luminosity and classification as a blazar allow us to test emission models that consider the efficient cooling of jet electrons via inverse Compton losses in interactions with the dense cosmic microwave background (CMB) photon field at high redshifts. A significant detection of this effect in GB 1508+5714 may partly explain the apparent sparsity of high-redshift radio galaxies in wide-field surveys, detections of this kind are only becoming possible with the current generation of Square Kilometre Array (SKA) precursors. Methods. We used the LOw-Frequency ARray (LOFAR) to image the long wavelength radio emission around the high-redshift blazar GB 1508+5714 on arcsecond scales at frequencies between 128 and 160 MHz. This allowed us to compare the spatially resolved structure with higher frequency observations, and construct spectral index maps to study the spectral properties of the different components. Results. The LOFAR image shows a compact unresolved core and two resolved emission regions around 2 arcsec to the east and to the west of the radio core. We find structure consistent with previous Very Large Array (VLA) observations, as well as a previously unreported emission region to the east. The region in the west shows a spectral index of −1.2−0.2+0.4 while the region in the east indicates a spectral index of ≲−1.1. The radio core features aflat spectral index of 0.02 ± 0.01. Conclusions. We interpret the arcsecond-scale radio structure of GB 1508+5714 as a FR II-like radio galaxy at a small viewing angle, and the western component as the region containing the approaching jet’s terminal hot spot while the eastern diffuse component near the core can be interpreted as the counter-hot spot region. Our SED modelling shows that a scenario featuring significant quenching effects caused by interaction with the CMB provides a good description of the data, and notably explains the suppressed radio emission

TANAMI radio galaxies I : J/A+A/627/A148

VizieR online Data Catalogue associated with article published in journal Astronomy & Astrophysics with title 'Gamma-ray emission in radio galaxies under the VLBI scope. I. Parsec-scale jet kinematics and high-energy properties of gamma-ray-detected TANAMI radio galaxies.' (bibcode: 2019A&A...627A.148A

Human PABP binds AU-rich RNA via RNA-binding domains 3 and 4

Poly(A) binding protein (PABP) binds mRNA poly(A) tails and affects mRNA stability and translation. We show here that there is little free PABP in NIH3T3 cells, with the vast majority complexed with RNA. We found that PABP in NIH3T3 cytoplasmic lysates and recombinant human PABP can bind to AU-rich RNA with high affinity. Human PABP bound an AU-rich RNA with Kd in the nm range, which was only sixfold weaker than the affinity for oligo(A) RNA. Truncated PABP containing RNA recognition motif domains 3 and 4 retained binding to both AU-rich and oligo(A) RNA, whereas a truncated PABP containing RNA recognition motif domains 1 and 2 was highly selective for oligo(A) RNA. The inducible PABP, iPABP, was found to be even less discriminating than PABP in RNA binding, with affinities for AU-rich and oligo(A) RNAs differing by only twofold. These data suggest that iPABP and PABP may in some situations interact with other RNA regions in addition to the poly(A) tail

Mast cells: the forgotten cells of renal fibrosis

Background/Aims—Mast cells, when activated, secrete a large number of fibrogenic factors and have been implicated in the development of fibrotic conditions of the liver, lung, and skin. There is evidence that renal fibrosis is closely linked with a chronic inflammatory cell infiltrate within the interstitium, but a potential role for mast cells in this process has yet to be defined. Therefore, the numbers of mast cells in normal and fibrotic kidneys with various pathologies were investigated. Methods—Mast cells were quantified in renal transplants showing acute and chronic rejection and cyclosporin toxicity, kidneys removed for chronic pyelonephritis, and renal biopsies from patients with IgA nephropathy, membranous nephropathy, and diabetic nephropathy. Mast cells were stained using two methods: acid toluidine blue detected less than 30% of the mast cells revealed by immunohistochemistry for mast cell tryptase. Results—Mast cells were scarce or absent in normal kidney (median, 1.6 mast cells/mm(2)) but numerous throughout the cortex and medulla in all specimens that showed fibrosis. They were almost entirely confined to the renal interstitium. Mast cells were present in large numbers in biopsies from patients with membranous nephropathy (median, 21.7 mast cells/mm(2)) and diabetic nephropathy (median, 29.2 mast cells/mm(2)), which were selected on the basis of showing chronic injury. In 24 unselected IgA nephropathy biopsies there was a close correlation between numbers of mast cells and the extent of interstitial fibrosis (r = 0.771; p < 0.0001). In renal transplant biopsies, mast cells were associated with allograft fibrosis in chronic rejection (median, 27.1 mast cells/mm(2)) and chronic cyclosporin toxicity (median, 10.6 mast cells/mm(2)) but not acute rejection (median, 2.7 mast cells/mm(2)) or acute cyclosporin toxicity (median, 2.0 mast cells/mm(2)). There was no detectable increase in mast cell numbers during acute rejection in those transplants that subsequently progressed to chronic rejection. In some biopsies the mast cells were largely intact, but in most cases some or all were degranulated. Conclusions—An increased number of mast cells is a consistent feature of renal fibrosis, whatever the underlying pathology, and the number of mast cells correlates with the extent of interstitial fibrosis. This suggests that mast cells might play a pathogenetic role in the fibrotic process. Key Words: mast cells • kidney • fibrosi