435 research outputs found
Expression of anion exchanger 2 in human gastric cancer
Anion exchanger 2 (AE2), which mediates exchange of Cl-/HCO3- across the plasma membrane, is widely expressed in body tissues. It is most abundantly expressed in stomach and is responsible for the uptake of Cl- ions that are destined to become HCl molecules. Aim: To determine whether AE2 expression was altered in gastric tumors. Methods: We have studied AE2 expression in normal human gastric tissues (n =16) and in gastric tumors (n = 33) using immunohistochemistry and immunofluorescent labeling. Results: In normal gastric tissue positive staining was observed in gastric fundus gland, suggesting parietal cell-related expression of AE2, and AE2 expression was localized in the nuclear membrane and even in cell nuclei. For assay of cancerous gastric tissues, specimens of human gastric cancer arising from the region of the fundus (2 cases), the body (14 cases) and the antrum (17 cases) were randomly selected. Immunohistochemical staining has showed that AE2 was down-regulated in all 14 cancerous gastric body specimens, whereas staining for AE2 in cancerous antrum was less intense and had a diffuse profile. Conclusions: The data suggest that AE2 might be associated with gastric carcinogenesis and the achlorhydria experienced by gastric cancer patients.ΠΠ½ΠΈΠΎΠ½Π½ΡΠΉ ΠΎΠ±ΠΌΠ΅Π½Π½ΠΈΠΊ 2 (ΠΠ2), ΠΊΠΎΡΠΎΡΡΠΉ ΠΎΠΏΠΎΡΡΠ΅Π΄ΡΠ΅Ρ ΠΏΠ΅ΡΠ΅Π½ΠΎΡ Cl-
/HCO3
-
ΡΠ΅ΡΠ΅Π· ΠΏΠ»Π°Π·ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΡΡ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ, ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡΡΠ΅ΡΡΡ
ΠΊΠ»Π΅ΡΠΊΠ°ΠΌΠΈ ΡΠ°Π·Π½ΡΡ
ΡΠΊΠ°Π½Π΅ΠΉ. Π‘Π°ΠΌΡΠΉ Π²ΡΡΠΎΠΊΠΈΠΉ ΡΡΠΎΠ²Π΅Π½Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΠ2 Π² ΠΆΠ΅Π»ΡΠ΄ΠΊΠ΅, ΠΏΠΎΡΠΊΠΎΠ»ΡΠΊΡ ΡΡΠΎΡ Π±Π΅Π»ΠΎΠΊ ΠΎΡΠ²Π΅ΡΠ°Π΅Ρ Π·Π° ΠΏΠΎΠ³Π»ΠΎΡΠ΅Π½ΠΈΠ΅
ΠΈΠΎΠ½ΠΎΠ² Cl-
, ΠΊΠΎΡΠΎΡΡΠ΅ Π²ΠΏΠΎΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΡΡΡΡ Π΄Π»Ρ ΡΠ΅ΠΊΡΠ΅ΡΠΈΠΈ HCl. Π¦Π΅Π»Ρ: ΠΠ·ΡΡΠΈΡΡ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Π² ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΠ2 ΠΏΡΠΈ ΡΠ°ΠΊΠ΅
ΠΆΠ΅Π»ΡΠ΄ΠΊΠ°. ΠΠ΅ΡΠΎΠ΄Ρ: ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π° ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ ΠΠ2 Π² Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΡΡ
ΡΠΊΠ°Π½ΡΡ
(n = 16) ΠΈ ΠΎΠΏΡΡ
ΠΎΠ»ΡΡ
ΠΆΠ΅Π»ΡΠ΄ΠΊΠ° (n = 33) Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΈΠΌΠΌΡΠ½ΠΎΠ³ΠΈΡΡΠΎΡ
ΠΈΠΌΠΈΠΈ ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠΈΠΈ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ: Π² Π½Π΅ΡΡΠ°Π½ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ ΠΆΠ΅Π»ΡΠ΄ΠΊΠ° Π² ΡΡΠ½Π΄Π°Π»ΡΠ½ΠΎΠΉ
ΠΆΠ΅Π»Π΅Π·Π΅ Π²ΡΡΠ²Π»ΡΠ»ΠΈ ΡΠΈΠ»ΡΠ½ΡΡ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΡ ΡΠ΅Π°ΠΊΡΠΈΡ, ΡΡΠΎ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΠ΅Ρ ΠΎΠ± ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΠ2 ΠΏΠ°ΡΠΈΠ΅ΡΠ°Π»ΡΠ½ΡΠΌΠΈ ΠΊΠ»Π΅ΡΠΊΠ°ΠΌΠΈ,
ΠΏΡΠΈΡΠ΅ΠΌ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ ΠΠ2 Π±ΡΠ»Π° Π»ΠΎΠΊΠ°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π° Π² ΡΠ΄Π΅ΡΠ½ΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π΅ ΠΈ Π² ΡΠ΄ΡΠ΅. Π ΠΎΠΏΡΡ
ΠΎΠ»ΡΡ
ΠΆΠ΅Π»ΡΠ΄ΠΊΠ° (ΡΡΠ½Π΄Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΡΠ΄Π΅Π»Π° (n =
2), ΡΠ΅Π»Π° (n = 14) ΠΈ Π°Π½ΡΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΡΠ΄Π΅Π»Π° (n = 17)), ΠΎΡΠΎΠ±ΡΠ°Π½Π½ΡΡ
ΡΠ»ΡΡΠ°ΠΉΠ½ΡΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, Π±ΡΠ» ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΠ2.
ΠΠΌΠΌΡΠ½ΠΎΠ³ΠΈΡΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΎ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΠ2 Π²ΠΎ Π²ΡΠ΅Ρ
14 ΡΠ»ΡΡΠ°ΡΡ
ΡΠ°ΠΊΠ° ΡΠ΅Π»Π° ΠΆΠ΅Π»ΡΠ΄ΠΊΠ°. ΠΠΊΡΠ°ΡΠΈΠ²Π°Π½ΠΈΠ΅
ΠΠ2 Π² ΠΎΠ±ΡΠ°Π·ΡΠ°Ρ
ΡΠ°ΠΊΠ° Π°Π½ΡΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΡΠ΄Π΅Π»Π° ΠΆΠ΅Π»ΡΠ΄ΠΊΠ° Π±ΡΠ»ΠΎ ΠΌΠ΅Π½Π΅Π΅ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΡΠΌ ΠΈ Π΄ΠΈΡΡΡΠ·Π½ΡΠΌ. ΠΡΠ²ΠΎΠ΄Ρ: ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅
Π΄Π°Π½Π½ΡΠ΅ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»ΠΎΠΆΠΈΡΡ Π½Π°Π»ΠΈΡΠΈΠ΅ ΡΠ²ΡΠ·ΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠ΅ΠΉ ΠΠ2 ΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ ΡΠ°ΠΊΠ° ΠΆΠ΅Π»ΡΠ΄ΠΊΠ°, Π° ΡΠ°ΠΊΠΆΠ΅ Π°Ρ
Π»ΠΎΡΠ³ΠΈΠ΄ΡΠΈΠ΅ΠΉ,
ΠΎΡΠΌΠ΅ΡΠ°Π΅ΠΌΠΎΠΉ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
ΡΠ°ΠΊΠΎΠΌ ΠΆΠ΅Π»ΡΠ΄ΠΊΠ°
Partial wave analysis of J/\psi \to \gamma \phi \phi
Using events collected in the BESII detector, the
radiative decay is
studied. The invariant mass distribution exhibits a near-threshold
enhancement that peaks around 2.24 GeV/.
A partial wave analysis shows that the structure is dominated by a
state () with a mass of
GeV/ and a width of GeV/. The
product branching fraction is: .Comment: 11 pages, 4 figures. corrected proof for journa
Search for the Rare Decays J/Psi --> Ds- e+ nu_e, J/Psi --> D- e+ nu_e, and J/Psi --> D0bar e+ e-
We report on a search for the decays J/Psi --> Ds- e+ nu_e + c.c., J/Psi -->
D- e+ nu_e + c.c., and J/Psi --> D0bar e+ e- + c.c. in a sample of 5.8 * 10^7
J/Psi events collected with the BESII detector at the BEPC. No excess of signal
above background is observed, and 90% confidence level upper limits on the
branching fractions are set: B(J/Psi --> Ds- e+ nu_e + c.c.)<4.8*10^-5, B(J/Psi
--> D- e+ nu_e + c.c.) D0bar e+ e- + c.c.)<1.1*10^-5Comment: 10 pages, 4 figure
Measurements of psi(2S) decays to octet baryon-antibaryon pairs
With a sample of 14 million psi(2S) events collected by the BESII detector at
the Beijing Electron Positron Collider (BEPC), the decay channels psi(2S)->p
p-bar, Lambda Lambda-bar, Sigma0 Sigma0-bar, Xi Xi-bar are measured, and their
branching ratios are determined to be (3.36+-0.09+-0.24)*10E-4,
(3.39+-0.20+-0.32)*10E-4, (2.35+-0.36+-0.32)*10E-4, (3.03+-0.40+-0.32)*10E-4,
respectively. In the decay psi(2S)->p p-bar, the angular distribution parameter
alpha is determined to be 0.82+-0.17+-0.04.Comment: 8 pages, 8 figure
Measurements of the observed cross sections for exclusive light hadrons containing at , 3.650 and 3.6648 GeV
By analyzing the data sets of 17.3, 6.5 and 1.0 pb taken,
respectively, at , 3.650 and 3.6648 GeV with the BES-II
detector at the BEPC collider, we measure the observed cross sections for
, , ,
and at the three energy
points. Based on these cross sections we set the upper limits on the observed
cross sections and the branching fractions for decay into these
final states at 90% C.L..Comment: 7 pages, 2 figure
Direct Measurements of Absolute Branching Fractions for D0 and D+ Inclusive Semimuonic Decays
By analyzing about 33 data sample collected at and around 3.773
GeV with the BES-II detector at the BEPC collider, we directly measure the
branching fractions for the neutral and charged inclusive semimuonic decays
to be and , and determine the ratio of the two branching
fractions to be
Measurements of the observed cross sections for exclusive light hadron production in e^+e^- annihilation at \sqrt{s}= 3.773 and 3.650 GeV
By analyzing the data sets of 17.3 pb taken at GeV
and 6.5 pb taken at GeV with the BESII detector at the
BEPC collider, we have measured the observed cross sections for 12 exclusive
light hadron final states produced in annihilation at the two energy
points. We have also set the upper limits on the observed cross sections and
the branching fractions for decay to these final states at 90%
C.L.Comment: 8 pages, 5 figur
Measurements of the Mass and Full-Width of the Meson
In a sample of 58 million events collected with the BES II detector,
the process J/ is observed in five different decay
channels: , , (with ), (with
) and . From a combined fit of all five
channels, we determine the mass and full-width of to be
MeV/ and
MeV/.Comment: 9 pages, 2 figures and 4 table. Submitted to Phys. Lett.
A Measurement of Psi(2S) Resonance Parameters
Cross sections for e+e- to hadons, pi+pi- J/Psi, and mu+mu- have been
measured in the vicinity of the Psi(2S) resonance using the BESII detector
operated at the BEPC. The Psi(2S) total width; partial widths to hadrons,
pi+pi- J/Psi, muons; and corresponding branching fractions have been determined
to be Gamma(total)= (264+-27) keV; Gamma(hadron)= (258+-26) keV, Gamma(mu)=
(2.44+-0.21) keV, and Gamma(pi+pi- J/Psi)= (85+-8.7) keV; and Br(hadron)=
(97.79+-0.15)%, Br(pi+pi- J/Psi)= (32+-1.4)%, Br(mu)= (0.93+-0.08)%,
respectively.Comment: 8 pages, 6 figure
A study of charged kappa in
Based on events collected by BESII, the decay
is studied. In the invariant mass
spectrum recoiling against the charged , the charged
particle is found as a low mass enhancement. If a Breit-Wigner function of
constant width is used to parameterize the kappa, its pole locates at MeV/. Also in this channel,
the decay is observed for the first time.
Its branching ratio is .Comment: 14 pages, 4 figure
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