Analysis of shared heritability in common disorders of the brain

Paroxysmal Cerebral Disorder

A Model for the Propagation of the Westward Traveling Surge

QC 2012041

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Elektroniskā sistēma ir izveidota cilvēkiem, kuriem ir kādas psiholoģiskās problēmas, kuri saprot problēmu esamību, bet nevar atrast palīdzību vai izrunāties pat tuviem cilvēkiem, tāpēc cieš vientulībā. Tā var būt ļoti noderīga cilvēkiem, kuriem finansiālās iespējas neļauj aprunāties ar psihologu, vai ļoti aizņemtiem cilvēkiem, kuriem nav tik daudz laika, lai doties pie profesionāla. Lietotāji var pastāstīt savu problēmu, uzdot jautājumus un uzzināt atbildes, izlasīt padomu gan no parastiem cilvēkiem, gan no profesionāliem. Katrs lietotājs drīkst komentēt cita lietotāja problēmu un, var būt, dalīties ar savu pieredzi līdzīgā situācijā. Moderatori un administratori uzturēs kārtību sistēmas vide. Administratori tajā pašā laikā kontrolēs galveno kopējo psiholoģisko tēmu izvirzīšanu.Electronic system is found for people who have some psychological problems, who understand the existence of problems, but cannot find support or talk to closest ones, so suffer alone. It may be very helpful to people whose financial facilities do not allow to talk to a psychologist or very busy people who do not have so much time to go to a professional. Users can share their problems, ask questions and find answers, read the advice from both ordinary people and the professionals. Each user is allowed to comment on other user's problem and may share his/her experience in a similar situation. Moderators and administrators maintain the order within the system. Administrators at the same time control common psychological main themes emphasizing

Correlation between cortical plasticity, motor learning and BDNF genotype in healthy subjects

There is good evidence that synaptic plasticity in human motor cortex is involved in behavioural motor learning; in addition, it is now possible to probe mechanisms of synaptic plasticity using a variety of transcranial brain-stimulation protocols. Interactions between these protocols suggest that they both utilise common mechanisms. The aim of the present experiments was to test how well responsiveness to brain-stimulation protocols and behavioural motor learning correlate with each other in a sample of 21 healthy volunteers. We also examined whether any of these measures were influenced by the presence of a Val66Met polymorphism in the BDNF gene since this is another factor that has been suggested to be able to predict response to tests of synaptic plasticity. In 3 different experimental sessions, volunteers underwent 5-Hz rTMS, intermittent theta-burst stimulation (iTBS) and a motor learning task. Blood samples were collected from each subject for BDNF genotyping. As expected, both 5-Hz rTMS and iTBS significantly facilitated MEPs. Similarly, as expected, kinematic variables of finger movement significantly improved during the motor learning task. Although there was a significant correlation between the effect of iTBS and 5-Hz rTMS, there was no relationship in each subject between the amount of TMS-induced plasticity and the increase in kinematic variables during motor learning. Val66Val and Val66Met carriers did not differ in their response to any of the protocols. The present results emphasise that although some TMS measures of cortical plasticity may correlate with each other, they may not always relate directly to measures of behavioural learning. Similarly, presence of the Val66Met BDNF polymorphism also does not reliably predict responsiveness in small groups of individuals. Individual success in behavioural learning is unlikely to be closely related to any single measure of synaptic plasticity. © 2011 Springer-Verlag