Numerical simulation of vortex breakdown by the vortex-filament method

The vortex filament method was applied to the simulation of vortex breakdown. The principal vortex region was represented by multiple filaments, and an axial velocity component was induced by a spiral winding of the filaments. First, an accuracy check was performed for a cylindrical swirling flow with simple analytical expressions for the axial and theta velocities. The result suggests that the flow field is simulated to any accuracy by increasing the number of filaments. Second, an axisymmetric type vortex breakdown was simulated, with experimental data serving as upstream conditions. The calculated axial and theta velocity contours show the breakdown of the vortex, including a rapid change in the vortex core, followed axially by a recovery zone and then a second breakdown. When three dimensional initial data are used the second breakdown appears to be of the spiral type in correspondence with experimental observations. The present method is easily used to simulate other types of vortex breakdown or other vortex flows with axial velocity

Optically Controlled Excitonic Transistor

Optical control of exciton fluxes is realized for indirect excitons in a crossed-ramp excitonic device. The device demonstrates experimental proof of principle for all-optical excitonic transistors with a high ratio between the excitonic signal at the optical drain and the excitonic signal due to the optical gate. The device also demonstrates experimental proof of principle for all-optical excitonic routers

1+1 Dimensional Compactifications of String Theory

We argue that stable, maximally symmetric compactifications of string theory to 1+1 dimensions are in conflict with holography. In particular, the finite horizon entropies of the Rindler wedge in 1+1 dimensional Minkowski and anti de Sitter space, and of the de Sitter horizon in any dimension, are inconsistent with the symmetries of these spaces. The argument parallels one made recently by the same authors, in which we demonstrated the incompatibility of the finiteness of the entropy and the symmetries of de Sitter space in any dimension. If the horizon entropy is either infinite or zero the conflict is resolved.Comment: 11 pages, 2 figures v2: added discussion of AdS_2 and comment

Perancangan Buku Ilustrasi Pengenalan Nama Buah-buahan Dengan Sistem Isyarat Bahasa Indonesia (Sibi) Berbasis Karakter Untuk Anak-anak Tklb-b Karya Mulia Surabaya

Interest illustrated book about the introduction of fruits name with a character-based system SIBI for children TKLB-B Karya Mulia Surabaya is as a learning medium that contains the values of science. The study was conducted with qualitative methods based on interviews, observation, documentation, and literature to support the design of a book about the house\u27s name recognition fruits. Data can be analyzed at several stages of data reduction, data presentation, and conclusion. After analyzing the data found informative design concept, the average informative Indonesian big dictionary into said. This concept aims to be informative book designed to provide insight to the public about the introduction of fruits name. Mechanical reality promoted expected to help draft informative because it is interactive, so people can find out the name of the fruit in the dictionary SIBI. Results of design book is expected that children know more about the fruit in the form of illustrated book based characte

Multiscale Kinetic Monte-Carlo for Simulating Epitaxial Growth

We present a fast Monte-Carlo algorithm for simulating epitaxial surface growth, based on the continuous-time Monte-Carlo algorithm of Bortz, Kalos and Lebowitz. When simulating realistic growth regimes, much computational time is consumed by the relatively fast dynamics of the adatoms. Continuum and continuum-discrete hybrid methods have been developed to approach this issue; however in many situations, the density of adatoms is too low to efficiently and accurately simulate as a continuum. To solve the problem of fast adatom dynamics, we allow adatoms to take larger steps, effectively reducing the number of transitions required. We achieve nearly a factor of ten speed up, for growth at moderate temperatures and large D/F.Comment: 7 pages, 6 figures; revised text, accepted by PR

The Aspherical Properties of the Energetic Type Ic SN 2002ap as Inferred from its Nebular Spectra

The nebular spectra of the broad-lined, SN 1998bw-like Type Ic SN 2002ap are studied by means of synthetic spectra. Two different modelling techniques are employed. In one technique, the SN ejecta are treated as a single zone, while in the other a density and abundance distribution in velocity is used from an explosion model. In both cases, heating caused by gamma-ray and positron deposition is computed (in the latter case using a Monte Carlo technique to describe the propagation of gamma-rays and positrons), as is cooling via forbidden-line emission. The results are compared, and although general agreement is found, the stratified models are shown to reproduce the observed line profiles much more accurately than the single-zone model. The explosion produced ~ 0.1 Msun of 56Ni. The distribution in velocity of the various elements is in agreement with that obtained from the early-time models, which indicated an ejected mass of ~ 2.5 Msun with a kinetic energy of 4 x 10^{51} erg. Nebular spectroscopy confirms that most of the ejected mass (~ 1.2 Msun) was oxygen. The presence of an oxygen-rich inner core, combined with that of 56Ni at high velocities as deduced from early-time models, suggests that the explosion was asymmetric, especially in the inner part.Comment: 24 pages, 6 figures, 2 Tables. Accepted by the Astrophysical Journa

Generation of orthotopic patient-derived xenografts from gastrointestinal stromal tumor.

BackgroundGastrointestinal stromal tumor (GIST) is the most common sarcoma and its treatment with imatinib has served as the paradigm for developing targeted anti-cancer therapies. Despite this success, imatinib-resistance has emerged as a major problem and therefore, the clinical efficacy of other drugs has been investigated. Unfortunately, most clinical trials have failed to identify efficacious drugs despite promising in vitro data and pathological responses in subcutaneous xenografts. We hypothesized that it was feasible to develop orthotopic patient-derived xenografts (PDXs) from resected GIST that could recapitulate the genetic heterogeneity and biology of the human disease.MethodsFresh tumor tissue from three patients with pathologically confirmed GISTs was obtained immediately following tumor resection. Tumor fragments (4.2-mm3) were surgically xenografted into the liver, gastric wall, renal capsule, and pancreas of immunodeficient mice. Tumor growth was serially assessed with ultrasonography (US) every 3-4 weeks. Tumors were also evaluated with positron emission tomography (PET). Animals were sacrificed when they became moribund or their tumors reached a threshold size of 2500-mm3. Tumors were subsequently passaged, as well as immunohistochemically and histologically analyzed.ResultsHerein, we describe the first model for generating orthotopic GIST PDXs. We have successfully xenografted three unique KIT-mutated tumors into a total of 25 mice with an overall success rate of 84% (21/25). We serially followed tumor growth with US to describe the natural history of PDX growth. Successful PDXs resulted in 12 primary xenografts in NOD-scid gamma or NOD-scid mice while subsequent successful passages resulted in 9 tumors. At a median of 7.9 weeks (range 2.9-33.1 weeks), tumor size averaged 473 ± 695-mm³ (median 199-mm3, range 12.6-2682.5-mm³) by US. Furthermore, tumor size on US within 14 days of death correlated with gross tumor size on necropsy. We also demonstrated that these tumors are FDG-avid on PET imaging, while immunohistochemically and histologically the PDXs resembled the primary tumors.ConclusionsWe report the first orthotopic model of human GIST using patient-derived tumor tissue. This novel, reproducible in vivo model of human GIST may enhance the study of GIST biology, biomarkers, personalized cancer treatments, and provide a preclinical platform to evaluate new therapeutic agents for GIST

The Multiple Origin of Blue Straggler Stars: Theory vs. Observations

In this chapter we review the various suggested channels for the formation and evolution of blue straggler stars (BSSs) in different environments and their observational predictions. These include mass transfer during binary stellar evolution - case A/B/C and D (wind Roche-lobe overflow) mass transfer, stellar collisions during single and binary encounters in dense stellar cluster, and coupled dynamical and stellar evolution of triple systems. We also explore the importance of the BSS and binary dynamics in stellar clusters. We review the various observed properties of BSSs in different environments (halo and bulge BSSs, BSSs in globular clusters and BSSs in old open clusters), and compare the current observations with the theoretical predictions for BSS formation. We try to constrain the likely progenitors and processes that play a role in the formation of BSSs and their evolution. We find that multiple channels of BSS formation are likely to take part in producing the observed BSSs, and we point out the strengths and weaknesses of each the formation channel in respect to the observational constraints. Finally we point out directions to further explore the origin of BSS, and highlight eclipsing binary BSSs as important observational tool.Comment: Chapter 11, in Ecology of Blue Straggler Stars, H.M.J. Boffin, G. Carraro & G. Beccari (Eds), Astrophysics and Space Science Library, Springe