385 research outputs found
Charged State of a Spherical Plasma in Vacuum
The stationary state of a spherically symmetric plasma configuration is
investigated in the limit of immobile ions and weak collisions. Configurations
with small radii are positively charged as a significant fraction of the
electron population evaporates during the equilibration process, leaving behind
an electron distribution function with an energy cutoff. Such charged plasma
configurations are of interest for the study of Coulomb explosions and ion
acceleration from small clusters irradiated by ultraintense laser pulses and
for the investigation of ion bunches propagation in a plasma
Harmonic generation by atoms in circularly polarized two-color laser fields with coplanar polarizations and commensurate frequencies
The generation of harmonics by atoms or ions in a two-color, coplanar field
configuration with commensurate frequencies is investigated through both, an
analytical calculation based on the Lewenstein model and the numerical ab
initio solution of the time-dependent Schroedinger equation of a
two-dimensional model ion. Through the analytical model, selection rules for
the harmonic orders in this field configuration, a generalized cut-off for the
harmonic spectra, and an integral expression for the harmonic dipole strength
is provided. The numerical results are employed to test the predictions of the
analytical model. The scaling of the cut-off as a function of both, one of the
laser intensities and frequency ratio , as well as entire spectra for
different and laser intensities are presented and analyzed. The
theoretical cut-off is found to be an upper limit for the numerical results.
Other discrepancies between analytical model and numerical results are
clarified by taking into account the probabilities of the absorption processes
involved.Comment: 8 figure
Shift-Symmetric Configurations in Two-Dimensional Cellular Automata: Irreversibility, Insolvability, and Enumeration
The search for symmetry as an unusual yet profoundly appealing phenomenon,
and the origin of regular, repeating configuration patterns have long been a
central focus of complexity science and physics. To better grasp and understand
symmetry of configurations in decentralized toroidal architectures, we employ
group-theoretic methods, which allow us to identify and enumerate these inputs,
and argue about irreversible system behaviors with undesired effects on many
computational problems. The concept of so-called configuration shift-symmetry
is applied to two-dimensional cellular automata as an ideal model of
computation. Regardless of the transition function, the results show the
universal insolvability of crucial distributed tasks, such as leader election,
pattern recognition, hashing, and encryption. By using compact enumeration
formulas and bounding the number of shift-symmetric configurations for a given
lattice size, we efficiently calculate the probability of a configuration being
shift-symmetric for a uniform or density-uniform distribution. Further, we
devise an algorithm detecting the presence of shift-symmetry in a
configuration.
Given the resource constraints, the enumeration and probability formulas can
directly help to lower the minimal expected error and provide recommendations
for system's size and initialization. Besides cellular automata, the
shift-symmetry analysis can be used to study the non-linear behavior in various
synchronous rule-based systems that include inference engines, Boolean
networks, neural networks, and systolic arrays.Comment: 22 pages, 9 figures, 2 appendice
Using the latest resistance score to predict etravirine (ETV) resistance in naïve and NNRTI-failing patients
Methods A set of 17 mutations (V90I, A98G, L100I, K101E/H/P, V106I, E138A, V179D/F/T, Y181C/I/V, G190A/S, M230L) were found associated with ETV resistance in the Phase III DUET-1 and DUET-2 trials. Recently, a different score was assigned to each mutation (i.e. Y181C/I have the highest score: 3). An overall score of ≤4 was associated with reduced response and a score between 2.5–3.5 with intermediate response (reference). ETV resistance was calculated from a large database of patients undergoing genotypic resistance test
Local Causal States and Discrete Coherent Structures
Coherent structures form spontaneously in nonlinear spatiotemporal systems
and are found at all spatial scales in natural phenomena from laboratory
hydrodynamic flows and chemical reactions to ocean, atmosphere, and planetary
climate dynamics. Phenomenologically, they appear as key components that
organize the macroscopic behaviors in such systems. Despite a century of
effort, they have eluded rigorous analysis and empirical prediction, with
progress being made only recently. As a step in this, we present a formal
theory of coherent structures in fully-discrete dynamical field theories. It
builds on the notion of structure introduced by computational mechanics,
generalizing it to a local spatiotemporal setting. The analysis' main tool
employs the \localstates, which are used to uncover a system's hidden
spatiotemporal symmetries and which identify coherent structures as
spatially-localized deviations from those symmetries. The approach is
behavior-driven in the sense that it does not rely on directly analyzing
spatiotemporal equations of motion, rather it considers only the spatiotemporal
fields a system generates. As such, it offers an unsupervised approach to
discover and describe coherent structures. We illustrate the approach by
analyzing coherent structures generated by elementary cellular automata,
comparing the results with an earlier, dynamic-invariant-set approach that
decomposes fields into domains, particles, and particle interactions.Comment: 27 pages, 10 figures;
http://csc.ucdavis.edu/~cmg/compmech/pubs/dcs.ht
Notions of Infinity in Quantum Physics
In this article we will review some notions of infiniteness that appear in
Hilbert space operators and operator algebras. These include proper
infiniteness, Murray von Neumann's classification into type I and type III
factors and the class of F{/o} lner C*-algebras that capture some aspects of
amenability. We will also mention how these notions reappear in the description
of certain mathematical aspects of quantum mechanics, quantum field theory and
the theory of superselection sectors. We also show that the algebra of the
canonical anti-commutation relations (CAR-algebra) is in the class of F{/o}
lner C*-algebras.Comment: 11 page
Branch Rings, Thinned Rings, Tree Enveloping Rings
We develop the theory of ``branch algebras'', which are infinite-dimensional
associative algebras that are isomorphic, up to taking subrings of finite
codimension, to a matrix ring over themselves. The main examples come from
groups acting on trees.
In particular, for every field k we construct a k-algebra K which (1) is
finitely generated and infinite-dimensional, but has only finite-dimensional
quotients;
(2) has a subalgebra of finite codimension, isomorphic to ;
(3) is prime;
(4) has quadratic growth, and therefore Gelfand-Kirillov dimension 2;
(5) is recursively presented;
(6) satisfies no identity;
(7) contains a transcendental, invertible element;
(8) is semiprimitive if k has characteristic ;
(9) is graded if k has characteristic 2;
(10) is primitive if k is a non-algebraic extension of GF(2);
(11) is graded nil and Jacobson radical if k is an algebraic extension of
GF(2).Comment: 35 pages; small changes wrt previous versio
C in intense femtosecond laser pulses: nonlinear dipole response and ionization
We study the interaction of strong femtosecond laser pulses with the C
molecule employing time-dependent density functional theory with the ionic
background treated in a jellium approximation. The laser intensities considered
are below the threshold of strong fragmentation but too high for perturbative
treatments such as linear response. The nonlinear response of the model to
excitations by short pulses of frequencies up to 45eV is presented and analyzed
with the help of Kohn-Sham orbital resolved dipole spectra. In femtosecond
laser pulses of 800nm wavelength ionization is found to occur multiphoton-like
rather than via excitation of a ``giant'' resonance.Comment: 14 pages, including 1 table, 5 figure
Different evolution of genotypic resistance profiles to emtricitabine versus lamivudine in tenofovir-containing regimens.
BACKGROUND: To investigate genotypic resistance profiles to emtricitabine +
tenofovir (FTC + TDF) in-vivo and in-vitro, and compare them with lamivudine +
tenofovir (3TC + TDF).
METHODS: Three hundred fifty-two HIV-1 B-subtype pol sequences from 42 FTC +
TDF-treated patients, 40 3TC + TDF-treated patients, and 270 patients treated
with 3TC plus another nucleoside reverse transcriptase inhibitor (but not TDF).
All patients never received FTC, 3TC, and TDF in their previous therapeutic
regimen. 3TC/FTC ± TDF resistance was investigated using in vitro selection
experiments and docking simulations.
RESULTS: The M184V mutation is less prevalent in FTC + TDF-treated patients than
in 3TC + TDF-treated, and 3TC-treated/TDF-naive patients (14.3% versus 40.0%, P =
0.01 and 55.6%, P < 0.001). Multivariable analysis shows that factors correlated
with a lower probability of M184V emergence at failure were the use of FTC
compared with 3TC [odds ratio (OR): 0.32 (95% confidence interval (CI): 0.10 to
0.99), P = 0.04], the use of boosted protease inhibitor, and the use of TDF [OR:
0.20 (95% CI: 0.11 to 0.37), P < 0.001, and OR: 0.47 (95%CI: 0.22 to 1.01), P =
0.05, respectively]. In vitro selection experiments and docking analysis show
that other reverse transcriptase (RT) mutations, even localized in RT connection
domain, can be selected by 3TC + TDF or FTC + TDF in M184V absence and can affect
RT affinity for 3TC/FTC and/or TDF.
CONCLUSIONS: Our study shows lower rates of M184V development in FTC + TDF
regimens versus 3TC + TDF and suggests a potential role of boosted protease
inhibitors and TDF in delaying the M184V emergence. Novel RT mutational patterns,
more complex than currently known, can contribute to 3TC, FTC, and TDF
resistance
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