An Interactive Method for Tracking & Geocoding

Tracking has been used for many years commercially. Some important applications are RFID tracking on animals and marine beings, military applications etc. tracking and navigation is done by using a wireless sensor having some transmission power. In Geocoding, the local names of the location are matched to their respective longitudes and latitudes so here after tracking we have to place its location on the map so for that the process of geocoding will be used. In this paper we are performing a survey on the various methods being used for geocoding and tracking

Effects of first-line diabetes therapy with biguanides, sulphonylurea and thiazolidinediones on the differentiation, proliferation and apoptosis of islet cell populations

AIMS: Metformin, rosiglitazone and sulfonylureas enhance either insulin action or secretion and thus have been used extensively as early stage anti-diabetic medication, independently of the aetiology of the disease. When administered to newly diagnosed diabetes patients, these drugs produce variable results. Here, we examined the effects of the three early stage oral hypoglycaemic agents in mice with diabetes induced by multiple low doses of streptozotocin, focusing specifically on the developmental biology of pancreatic islets. METHODS: Streptozotocin-treated diabetic mice expressing a fluorescent reporter specifically in pancreatic islet α-cells were administered the biguanide metformin (100 mg/kg), thiazolidinedione rosiglitazone (10 mg/kg), or sulfonylurea tolbutamide (20 mg/kg) for 10 days. We assessed the impact of the treatment on metabolic status of the animals as well as on the morphology, proliferative potential and transdifferentiation of pancreatic islet cells, using immunofluorescence. RESULTS: The effect of the therapy on the islet cells varied depending on the drug and included enhanced pancreatic islet β-cell proliferation, in case of metformin and rosiglitazone; de-differentiation of α-cells and β-cell apoptosis with tolbutamide; increased relative number of β-cells and bi-hormonal insulin + glucagon + cells with metformin. These effects were accompanied by normalisation of food and fluid intake with only minor effects on glycaemia at the low doses of the agents employed. CONCLUSIONS: Our data suggest that metformin and rosiglitazone attenuate the depletion of the β-cell pool in the streptozotocin-induced diabetes, whereas tolbutamide exacerbates the β-cell apoptosis, but is likely to protect β-cells from chronic hyperglycaemia by directly elevating insulin secretion. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40618-021-01620-6

A rotating three component perfect fluid source and its junction with empty space-time

The Kerr solution for empty space-time is presented in an ellipsoidally symmetric coordinate system and it is used to produce generalised ellipsoidal metrics appropriate for the generation of rotating interior solutions of Einstein's equations. It is shown that these solutions are the familiar static perfect fluid cases commonly derived in curvature coordinates but now endowed with rotation. The resulting solutions are also discussed in the context of T-solutions of Einstein's equations and the vacuum T-solution outside a rotating source is presented. The interior source for these solutions is shown not to be a perfect fluid but rather an anisotropic three component perfect fluid for which the energy momentum tensor is derived. The Schwarzschild interior solution is given as an example of the approach.Comment: 14 page

State of the Art in Supply Chain Management a Comprehensive Review

Supply chain Management (SCM) has assumed a significant role in firm's performance. In last few years Supply Chain Management has attracted serious research attention. The main aim of this paper is to review the literature on Supply Chain Management. A literature review reveals a considerable increase in research in theory and practice of SCM. We have presented a literature review for 20 research papers for the period between 2010 and 2017