A trapped mercury 199 ion frequency standard

Mercury 199 ions confined in an RF quadrupole trap and optically pumped by mercury 202 ion resonance light are investigated as the basis for a high performance frequency standard with commercial possibilities. Results achieved and estimates of the potential performance of such a standard are given

Regularization of second-order scalar perturbation produced by a point-particle with a nonlinear coupling

Accurate calculation of the motion of a compact object in a background spacetime induced by a supermassive black hole is required for the future detection of such binary systems by the gravitational-wave detector LISA. Reaching the desired accuracy requires calculation of the second-order gravitational perturbations produced by the compact object. At the point particle limit the second-order gravitational perturbation equations turn out to have highly singular source terms, for which the standard retarded solutions diverge. Here we study a simplified scalar toy-model in which a point particle induces a nonlinear scalar field in a given curved spacetime. The corresponding second-order scalar perturbation equation in this model is found to have a similar singular source term, and therefore its standard retarded solutions diverge. We develop a regularization method for constructing well-defined causal solutions for this equation. Notably these solutions differ from the standard retarded solutions, which are ill-defined in this case.Comment: 14 page

Testing Alternative Theories of Gravity using LISA

We investigate the possible bounds which could be placed on alternative theories of gravity using gravitational wave detection from inspiralling compact binaries with the proposed LISA space interferometer. Specifically, we estimate lower bounds on the coupling parameter \omega of scalar-tensor theories of the Brans-Dicke type and on the Compton wavelength of the graviton \lambda_g in hypothetical massive graviton theories. In these theories, modifications of the gravitational radiation damping formulae or of the propagation of the waves translate into a change in the phase evolution of the observed gravitational waveform. We obtain the bounds through the technique of matched filtering, employing the LISA Sensitivity Curve Generator (SCG), available online. For a neutron star inspiralling into a 10^3 M_sun black hole in the Virgo Cluster, in a two-year integration, we find a lower bound \omega > 3 * 10^5. For lower-mass black holes, the bound could be as large as 2 * 10^6. The bound is independent of LISA arm length, but is inversely proportional to the LISA position noise error. Lower bounds on the graviton Compton wavelength ranging from 10^15 km to 5 * 10^16 km can be obtained from one-year observations of massive binary black hole inspirals at cosmological distances (3 Gpc), for masses ranging from 10^4 to 10^7 M_sun. For the highest-mass systems (10^7 M_sun), the bound is proportional to (LISA arm length)^{1/2} and to (LISA acceleration noise)^{-1/2}. For the others, the bound is independent of these parameters because of the dominance of white-dwarf confusion noise in the relevant part of the frequency spectrum. These bounds improve and extend earlier work which used analytic formulae for the noise curves.Comment: 16 pages, 9 figures, submitted to Classical & Quantum Gravit

Changing the Marks Based Culture of Learning through Peer Assisted Tutorials

We describe and evaluate an approach to student learning that aims to instil a culture of formative assessment based on peer-assisted self learning, instead of a marks-based culture in which learning effort is rewarded with marks that contribute to the students degree. The idea is for suitably qualified third- and fourth-year undergraduates to assist in the running of weekly first-year tutorials. They mark submitted work, provide written and verbal feedback on the students performance and lead problem solving discussions during tutorials. However, contrary to normal practice, the marks they award do not contribute to the students year total; all tutorial work becomes essentially voluntary. We report results from a pilot implementation of the scheme over a 12-month period in an engineering department at a leading academic institution. The set-up of the scheme was such that a comparative and triangulated assessment was possible amongst the students and tutor team. There was no discernible degradation in student attendance, submission rates and performance in either the weekly exercises or end of year examinations. Further analysis demonstrates that this type of peer-assisted learning improves some key aspects of student learning, and provides important benefits to the senior peers in terms of their own personal development. We conclude that the scheme provides an excellent alternative to traditional learning methods whilst substantially reducing the investment in academic staff time. © American Society for Engineering Education, 2009

Perspective: tobacco manufacturers are now compensating states for smoking-related costs: how will this affect the economy?

Smoking out the social and economic benefits of the 1998 tobacco settlement for Massachusetts.Tobacco industry ; Medical care, Cost of

Design and implementation of a compliant robot with force feedback and strategy planning software

Force-feedback robotics techniques are being developed for automated precision assembly and servicing of NASA space flight equipment. Design and implementation of a prototype robot which provides compliance and monitors forces is in progress. Computer software to specify assembly steps and makes force feedback adjustments during assembly are coded and tested for three generically different precision mating problems. A model program demonstrates that a suitably autonomous robot can plan its own strategy

Neurocardiovascular deficits in the Q175 mouse model of Huntington's disease.

Cardiovascular dysautonomia as well as the deterioration of circadian rhythms are among the earliest detectable pathophysiological changes in individuals with Huntington's disease (HD). Preclinical research requires mouse models that recapitulate disease symptoms and the Q175 knock-in model offers a number of advantages but potential autonomic dysfunction has not been explored. In this study, we sought to test the dual hypotheses that cardiovascular dysautonomia can be detected early in disease progression in the Q175 model and that this dysfunction varies with the daily cycle. Using radiotelemetry implants, we observed a significant reduction in the diurnal and circadian activity rhythms in the Q175 mutants at the youngest ages. By middle age, the autonomically driven rhythms in core body temperature were highly compromised, and the Q175 mutants exhibited striking episodes of hypothermia that increased in frequency with mutant huntingtin gene dosage. In addition, Q175 mutants showed higher resting heart rate (HR) during sleep and greatly reduced correlation between activity and HR HR variability was reduced in the mutants in both time and frequency domains, providing more evidence of autonomic dysfunction. Measurement of the baroreceptor reflex revealed that the Q175 mutant could not appropriately increase HR in response to a pharmacologically induced decrease in blood pressure. Echocardiograms showed reduced ventricular mass and ejection fraction in mutant hearts. Finally, cardiac histopathology revealed localized points of fibrosis resembling those caused by myocardial infarction. Thus, the Q175 mouse model of HD exhibits cardiovascular dysautonomia similar to that seen in HD patients with prominent sympathetic dysfunction during the resting phase of the activity rhythm

Wide parameter search for isolated pulsars using the Hough transform

We use the Hough transform to analyze data from the second science run of the LIGO interferometers, to look for gravitational waves from isolated pulsars. We search over the whole sky and over a large range of frequencies and spin-down parameters. Our search method is based on the Hough transform, which is a semi-coherent, computationally efficient, and robust pattern recognition technique. We also present a validation of the search pipeline using hardware signal injections.Comment: Presented at GWDAW-9 in Annecy, France (Dec. 2004). 11 pages, 5 Figures. To appear in Classical and Quantum Gravit

Time-frequency detection of Gravitational Waves

We present a time-frequency method to detect gravitational wave signals in interferometric data. This robust method can detect signals from poorly modeled and unmodeled sources. We evaluate the method on simulated data containing noise and signal components. The noise component approximates initial LIGO interferometer noise. The signal components have the time and frequency characteristics postulated by Flanagan and Hughes for binary black hole coalescence. The signals correspond to binaries with total masses between $45 M_\odot$ to $70 M_\odot$ and with (optimal filter) signal-to-noise ratios of 7 to 12. The method is implementable in real time, and achieves a coincident false alarm rate for two detectors $\approx$ 1 per 475 years. At this false alarm rate, the single detector false dismissal rate for our signal model is as low as 5.3% at an SNR of 10. We expect to obtain similar or better detection rates with this method for any signal of similar power that satisfies certain adiabaticity criteria. Because optimal filtering requires knowledge of the signal waveform to high precision, we argue that this method is likely to detect signals that are undetectable by optimal filtering, which is at present the best developed detection method for transient sources of gravitational waves.Comment: 24 pages, 5 figures, uses REVTE

Water Transport and the Functional Dynamics of Aquaporins in Osmoregulatory Organs of Fishes

Aquaporins play distinct roles for water transport in fishes as they do in mammals—both at the cellular, organ, and organismal levels. However, with over 32,000 known species of fishes inhabiting almost every aquatic environment, from tidal pools, small mountain streams, to the oceans and extreme salty desert lakes, the challenge to obtain consensus as well as specific knowledge about aquaporin physiology in these vertebrate clades is overwhelming. Because the integumental surfaces of these animals are in intimate contact with the surrounding milieu, passive water loss and uptake represent two of the major osmoregulatory challenges that need compensation. However, neither obligatory nor regulatory water transport nor their mechanisms have been elucidated to the same degree as, for example, ion transport in fishes. Currently fewer than 60 papers address fish aquaporins. Most of these papers identify “what is present” and describe tissue expression patterns in various teleosts. The agnathans, chondrichthyans, and functionality of fish aquaporins generally have received little attention. This review emphasizes the functional physiology of aquaporins in fishes, focusing on transepithelial water transport in osmoregulatory organs in euryhaline species – primarily teleosts, but covering other taxonomic groups as well. Most current knowledge comes from teleosts, and there is a strong need for related information on older fish clades. Our survey aims to stimulate new, original research in this area and to bring together new collaborations across disciplines