249 research outputs found
Sobre la formación del profesorado de Geografia en Bachillerato
Han transcurrido no pocos años desde que me disponÃa a comenzar el quehacer profesional como profesor de Geografia en ((Gaztelueta)), colegio que se inauguraba en Las Arenas (Vizcaya). En ese centro se concibió, desde un principio, esta enseñanza como materia separada de la Historia: con profesorado distinto y horarios independientes. Pero antes de emprender esa labor me dediqué, durante varios meses, a una preparación del material pedagógico. Con este fin conseguà cuantos trabajos se podÃan hallar sobre metodologÃa de nuestra disciplina, tanto españoles como extranjeros. Se trataba, ante todo, de seguir las  huellas de esa tradición didáctica de la GeografÃa española en la que figuran nombres como Beltrán y Rózpide, Pedreira Taibo,  allester y Castell, Santaló Parvorell, Doporto Marchori, Chico y Rello, Reverte Salinas, el mismo Dantin Cereceda, y otros más. Pensé enseguida que continuarla era un deber, y que ello harÃa un camino. De ahà que, a lo largo de los años, me afanara por recoger sus frutos y experiencias. Fue entonces cuando en la biblioteca del Laboratorio de GeomorfologÃa de la Facultad  e Ciencias de Barcelona, con sede en el pequeño pabellón contiguo a la calle de Anbau, di con un breve trabajo publicado el  iio 1934. Su titulo: Atlas escolars i lectures cartografiques. El autor era Luis Solé Sabans, en aquella fecha catedrático de Ciencias Naturales, incorporado como profesor de GeografÃa al Instituto Escuela barcelonés. Su lectura me resultó  reveladora: «Si al enseñar GeografÃa debemos huir de la rigidez memorÃstica, de las estadÃsticas enojosas y de las  descripciones inorgánicas propias de una GeografÃa arcaica, hay que escoger instrumentos de trabajo que reduzcan a lÃmites adecuados la explicación del profesor y la sustituyan, en parte, por el trabajo de investigación del alumno. Estos instrumentos de trabajo pueden ser de muy diversa naturaleza, pero no cabe duda que el instrumento geográfico por excelencia es el mapa en cualquiera de sus aspectos ... Sin embargo, el uso de la carta geográfica no se ha de limitar a la localización de los  fenómenos ... sino que debe servir precisamente para obtener la interpretación de estos hechos ... Con una cierta preparación inicial, y mediante el diálogo socrático hábilmente dirigido por el profesor, puede llegarse a extraer de la carta geográfica de un paÃs totalmente desconocido las principales caracterÃsticas fisiográficas y humanas.. . » En párrafos como los transcritos percibà el latido de una experiencia viva, y de tina admirable vocación por la enseñanza geográfica. Puedo afirmar que esos criterios del Dr. Solé, formulados en 1934, constituyeron siempre referencia clara y segura en medio de una ilusionada actividad docente que habÃan de prolongarse muchos años.
I feel it in my finger: Measurement device affects cardiac interoceptive accuracy
This is the final version. Available on open access from Elsevier via the DOI in this recordIn recent years, measures of cardiac interoceptive accuracy have been heavily scrutinised. The focus has been on potentially confounding physiological and psychological factors; little research has examined whether the device used to record objective heartbeats may influence cardiac interoceptive accuracy. The present studies assessed whether the device employed influences heartbeat counting (HCT) accuracy and the location from which heartbeats are perceived. In Study One, participants completed the HCT using a hard-clip finger pulse oximeter, electrocardiogram (ECG) and a smartphone application. In Study Two, an ECG, hard-clip and soft-clip oximeter were compared. Moderate-strong correlations were observed across devices, however, mean HCT accuracy and confidence varied as a function of device. Increased sensation in the finger when using a hard-clip pulse oximeter was related to increased accuracy relative to ECG. Results suggest that the device employed can influence HCT performance, and argue against comparing, or combining, scores obtained using different devices.Economic and Social Research Council (ESRC)Baily Thomas TrustFonds de Recherche Québec – Sant
Azithromycin to Prevent Pertussis in Household Contacts, Catalonia and Navarre, Spain, 2012-2013
We retrospectively assessed the effectiveness of azithromycin in preventing transmission of pertussis to a patient's household contacts. We also considered the duration between symptom onset in the primary patient and azithromycin administration. We categorized contacts into 4 groups: those treated within 21 days after illness onset in the primary patient. We studied 476 primary index patients and their 1,975 household contacts, of whom 4.5% were later identified as having pertussis. When contacts started chemoprophylaxis within 14 days after primary patient's symptom onset was less effective. We recommend that contacts of persons with pertussis begin chemoprophylaxis within <14 days after primary patient's symptom onset
A Generic Platform for Cellular Screening Against Ubiquitin Ligases
Ubiquitin signalling regulates most aspects of cellular life, thus deregulation of ubiquitylation has been linked with a number of diseases. E3 ubiquitin ligases provide substrate selectivity in ubiquitylation cascades and are therefore considered to be attractive targets for developing therapeutic molecules. In contrast to established drug target classes, such as protein kinases, GPCRs, hormone receptors and ion channels, ubiquitin drug discovery is in its early stages. This is, in part, due to the complexity of the ubiquitylation pathways and the lack of robust quantitative technologies that allow high-throughput screening of inhibitors. Here we report the development of a Ubiquitin Ligase Profiling system, which is a novel and generic cellular technology designed to facilitate identification of selective inhibitors against RING type E3 ubiquitin ligases. Utilization of this system requires a single co-transfection of cells with assay vectors, thereby enabling readout of E3 ubiquitin ligase catalytic activity within the cellular environment. Therefore, our robust high-throughput screening platform offers novel opportunities for the development of inhibitors against this difficult-to-target E3 ligase enzyme class
Dislocations in graphene
We study the stability and evolution of various elastic defects in a flat
graphene sheet and the electronic properties of the most stable configurations.
Two types of dislocations are found to be stable: "glide" dislocations
consisting of heptagon-pentagon pairs, and "shuffle" dislocations, an octagon
with a dangling bond. Unlike the most studied case of carbon nanotubes, Stone
Wales defects are unstable in the planar graphene sheet. Similar defects in
which one of the pentagon-heptagon pairs is displaced vertically with respect
to the other one are found to be dynamically stable. Shuffle dislocations will
give rise to local magnetic moments that can provide an alternative route to
magnetism in graphene
Everyday Diplomacy: UKUSA Intelligence Cooperation and Geopolitical Assemblages
This article offers an alternative to civilizational thinking in geopolitics and international relations predicated on assemblage theory. Building on literature in political geography and elsewhere about everyday practices that produce state effects, this article theorizes the existence of transnational geopolitical assemblages that incorporate foreign policy apparatuses of multiple states. Everyday material and discursive circulations make up these assemblages, serving as conduits of affect that produce an emergent agency. To demonstrate this claim, I outline a genealogy of the UKUSA alliance, an assemblage of intelligence communities in the United States, United Kingdom, Canada, Australia, and New Zealand. I then trace the circulation of materialities and affects—at the scales of individual subjects, technological systems of mediation, and transnational processes of foreign policy formation. In doing so, I offer a bottom-up process of assemblage that produces the emergent phenomena that proponents of civilizational thinking mistakenly attribute to macroscaled factors, such as culture
Nucleotide excision repair–induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response
The epigenetic mark indicative of DNA UV damage or double-strand breaks is achieved via a common pathway regardless of the cause of damage
Expression and Localization of CLC Chloride Transport Proteins in the Avian Retina
Members of the ubiquitously expressed CLC protein family of chloride channels and transporters play important roles in regulating cellular chloride and pH. The CLCs that function as Cl−/H+ antiporters, ClCs 3–7, are essential in particular for the acidification of endosomal compartments and protein degradation. These proteins are broadly expressed in the nervous system, and mutations that disrupt their expression are responsible for several human genetic diseases. Furthermore, knock-out of ClC3 and ClC7 in the mouse result in the degeneration of the hippocampus and the retina. Despite this evidence of their importance in retinal function, the expression patterns of different CLC transporters in different retinal cell types are as yet undescribed. Previous work in our lab has shown that in chicken amacrine cells, internal Cl− can be dynamic. To determine whether CLCs have the potential to participate, we used PCR and immunohistochemical techniques to examine CLC transporter expression in the chicken retina. We observed a high level of variation in the retinal expression levels and patterns among the different CLC proteins examined. These findings, which represent the first systematic investigation of CLC transporter expression in the retina, support diverse functions for the different CLCs in this tissue
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