Isolation of subcellular fractions of Nuerospora of mycelio

Isolation of subcellular fraction

New Measurements of Fine-Scale CMB Polarization Power Spectra from CAPMAP at Both 40 and 90 GHz

We present new measurements of the cosmic microwave background (CMB) polarization from the final season of the Cosmic Anisotropy Polarization MAPper (CAPMAP). The data set was obtained in winter 2004-2005 with the 7 m antenna in Crawford Hill, New Jersey, from 12 W-band (84-100 GHz) and 4 Q-band (36-45 GHz) correlation polarimeters with 3.3' and 6.5' beamsizes, respectively. After selection criteria were applied, 956 (939) hours of data survived for analysis of W-band (Q-band) data. Two independent and complementary pipelines produced results in excellent agreement with each other. A broad suite of null tests as well as extensive simulations showed that systematic errors were minimal, and a comparison of the W-band and Q-band sky maps revealed no contamination from galactic foregrounds. We report the E-mode and B-mode power spectra in 7 bands in the range 200 < l < 3000, extending the range of previous measurements to higher l. The E-mode spectrum, which is detected at 11 sigma significance, is in agreement with cosmological predictions and with previous work at other frequencies and angular resolutions. The BB power spectrum provides one of the best limits to date on B-mode power at 4.8 uK^2 (95% confidence).Comment: 19 pages, 17 figures, 2 tables, submitted to Ap

Combustion Modeling in Advanced Gas Turbine Systems

Goal of DOE`s Advanced Turbine Systems program is to develop and commercialize ultra-high efficiency, environmentally superior, cost competitive gas turbine systems for base-load applications in utility, independent power producer, and industrial markets. Primary objective of the program here is to develop a comprehensive combustion model for advanced gas turbine combustion systems using natural gas (coal gasification or biomass fuels). The efforts included code evaluation (PCGC-3), coherent anti-Stokes Raman spectroscopy, laser Doppler anemometry, and laser-induced fluorescence

Assessment of a novel, capsid-modified adenovirus with an improved vascular gene transfer profile

&lt;p&gt;Background: Cardiovascular disorders, including coronary artery bypass graft failure and in-stent restenosis remain significant opportunities for the advancement of novel therapeutics that target neointimal hyperplasia, a characteristic of both pathologies. Gene therapy may provide a successful approach to improve the clinical outcome of these conditions, but would benefit from the development of more efficient vectors for vascular gene delivery. The aim of this study was to assess whether a novel genetically engineered Adenovirus could be utilised to produce enhanced levels of vascular gene expression.&lt;/p&gt; &lt;p&gt;Methods: Vascular transduction capacity was assessed in primary human saphenous vein smooth muscle and endothelial cells using vectors expressing the LacZ reporter gene. The therapeutic capacity of the vectors was compared by measuring smooth muscle cell metabolic activity and migration following infection with vectors that over-express the candidate therapeutic gene tissue inhibitor of matrix metalloproteinase-3 (TIMP-3).&lt;/p&gt; &lt;p&gt;Results: Compared to Adenovirus serotype 5 (Ad5), the novel vector Ad5T*F35++ demonstrated improved binding and transduction of human vascular cells. Ad5T*F35++ mediated expression of TIMP-3 reduced smooth muscle cell metabolic activity and migration in vitro. We also demonstrated that in human serum samples pre-existing neutralising antibodies to Ad5T*F35++ were less prevalent than Ad5 neutralising antibodies.&lt;/p&gt; &lt;p&gt;Conclusions: We have developed a novel vector with improved vascular transduction and improved resistance to human serum neutralisation. This may provide a novel vector platform for human vascular gene transfer.&lt;/p&gt

First measurements of the polarization of the cosmic microwave background radiation at small angular scales from CAPMAP

Polarization results from the Cosmic Anisotropy Polarization MAPper (CAPMAP) experiment are reported. These are based upon 433 hours, after cuts, observing a 2 square degree patch around the North Celestial Pole (NCP) with four 90 GHz correlation polarimeters coupled to optics defining 4\arcmin beams. The E-mode flat bandpower anisotropy within $\ell=940^{+330}_{-300}$ is measured as 66$^{+69}_{-29} \mu$K$^2$; the 95% Confidence level upper limit for B-mode power within $\ell=1050^{+590}_{-520}$ is measured as 38 $\mu$K$^2$.Comment: 4 pages, 2 figures; corrected formatting and comments of second version, identical in substance. In the first version the wrong concordance model was used, results (fit to multiplier to concordance model) and figures have been updated to the proper one. In the first version the central 68% regions were quoted, while now the 68% confidence intervals of highest posterior density are give

OmniDepth: Dense Depth Estimation for Indoors Spherical Panoramas.

Recent work on depth estimation up to now has only focused on projective images ignoring 360o content which is now increasingly and more easily produced. We show that monocular depth estimation models trained on traditional images produce sub-optimal results on omnidirectional images, showcasing the need for training directly on 360o datasets, which however, are hard to acquire. In this work, we circumvent the challenges associated with acquiring high quality 360o datasets with ground truth depth annotations, by re-using recently released large scale 3D datasets and re-purposing them to 360o via rendering. This dataset, which is considerably larger than similar projective datasets, is publicly offered to the community to enable future research in this direction. We use this dataset to learn in an end-to-end fashion the task of depth estimation from 360o images. We show promising results in our synthesized data as well as in unseen realistic images

Origin and Evolution of Saturn's Ring System

The origin and long-term evolution of Saturn's rings is still an unsolved problem in modern planetary science. In this chapter we review the current state of our knowledge on this long-standing question for the main rings (A, Cassini Division, B, C), the F Ring, and the diffuse rings (E and G). During the Voyager era, models of evolutionary processes affecting the rings on long time scales (erosion, viscous spreading, accretion, ballistic transport, etc.) had suggested that Saturn's rings are not older than 100 My. In addition, Saturn's large system of diffuse rings has been thought to be the result of material loss from one or more of Saturn's satellites. In the Cassini era, high spatial and spectral resolution data have allowed progress to be made on some of these questions. Discoveries such as the ''propellers'' in the A ring, the shape of ring-embedded moonlets, the clumps in the F Ring, and Enceladus' plume provide new constraints on evolutionary processes in Saturn's rings. At the same time, advances in numerical simulations over the last 20 years have opened the way to realistic models of the rings's fine scale structure, and progress in our understanding of the formation of the Solar System provides a better-defined historical context in which to understand ring formation. All these elements have important implications for the origin and long-term evolution of Saturn's rings. They strengthen the idea that Saturn's rings are very dynamical and rapidly evolving, while new arguments suggest that the rings could be older than previously believed, provided that they are regularly renewed. Key evolutionary processes, timescales and possible scenarios for the rings's origin are reviewed in the light of tComment: Chapter 17 of the book ''Saturn After Cassini-Huygens'' Saturn from Cassini-Huygens, Dougherty, M.K.; Esposito, L.W.; Krimigis, S.M. (Ed.) (2009) 537-57

CMB Polarimetry using Correlation Receivers with the PIQUE and CAPMAP Experiments

The Princeton IQU Experiment (PIQUE) and the Cosmic Anisotropy Polarization MAPper (CAPMAP) are experiments designed to measure the polarization of the Cosmic Microwave Background (CMB) on sub-degree scales in an area within 1 degree of the North Celestial Pole using heterodyne correlation polarimeters and off-axis telescopes located in central New Jersey. PIQUE produced the tightest limit on the CMB polarization prior to its detection by DASI, while CAPMAP has recently detected polarization at l~1000. The experimental methods and instrumentation for these two projects are described in detail with emphasis on the particular challenges involved in measuring the tiny polarized component of the CMB.Comment: 70 pages, 13 tables, 18 figures. Accepted by ApJS; tentative publication ApJS July 2005, v159

The person-centred approach to an ageing society

Modern care is often based on investigations such as laboratory markers and imaging - for example, X-ray or ultrasound. The results contribute to a diagnosis and, if judged necessary, treatment is initiated. This diseased-oriented approach is the prevailing mode of management in modern medicine. In contrast, person-centered care (PCC) takes the point of departure from each person\ub4s subjective experience of illness and its impact on daily life. A patient is considered as a person with emotions and feelings. PCC is considered present within clinical care according to a definition articulated by the Centre for Person Centred Care at the University of Gothenburg (GPCC) when three core components are present: elicitation of a detailed patient narrative; formulated partnership between caregiver and patient and documentation of the partnership in the patient record. Accordingly, when there is an illness requiring care and the person is attended using these components, PCC is being applied. In most situations today, PCC is not applied in terms of the narrative and is not fully elicited or the partnership and/or the documentation are not included. It is proposed that the challenge to Society arising from changing demographics can be addressed by implementing PCC and creating an alternative to existing healthcare. The importance and benefits of such an approach on a wider scale is not yet clear as research has been limited to date. Studies in selected patient populations (heart failure and hip fractures), however, have shown promising results. As the population ages, there will be a dramatic increase in healthcare consumption. Even with technological developments, there will be a need for tremendous resources to be dedicated to care. A new organization and attitude from healthcare policymakers and providers above and beyond the present model appears required in order to respond to this demand. As part of such change, person-centred care, with the interaction between healthcare providers and the person of the patient, can facilitate, compensate and develop more effective healthcare services for the future