A Model for the Lubrication Mechanism in Knee Joint Replacement

Analytical studies are presented for the understanding of the lubrication mechanism occuring in knee joint replacement under restricted motion. The idealised model has been shown to produce results consistent with those in normal situations. Effects of increase in viscoelastic parameter of the lubricant are similar to those of increase in the concentration of hyaluronic acid molecules in synovial fluid. Slip velocity occuring at the poroelastic boundary helps in normal functioning of the joints

Social media users’ online subjective well-being and fatigue: A network heterogeneity perspective

Scholars have drawn increasing attention to the implications of the dark side of social media for users’ online subjective well-being (OSWB). We develop a research framework based on the limited-capacity model to examine the relationship between OSWB and social media fatigue. Moreover, we explore the associations between specific aspects related to network heterogeneity and social media fatigue for social media users in the United States of America (USA). Further, we examine the mediating effect of network heterogeneity on the association between OSWB and social media fatigue. We utilised a cross-sectional research design to collect data from Prolific Academic (N = 320) and analysed the data through structural equation modelling. The results indicate that OSWB is positively correlated with the network heterogeneity aspect of self-disclosure and negatively correlated with social comparison. OSWB, moreover, is negatively correlated with fatigue, while privacy concerns and self-disclosure are positively correlated with fatigue. Further, of the network heterogeneity aspects we considered, only social comparison is a partial mediator for the relationship between OSWB and social media fatigue. The findings provide insights into the pathways through which social media users’ OSWB and network heterogeneity can induce social media fatigue, raising critical implications for theory and practice

Effect of Glycocalyx on Red Blood Cell Motion in Capillary Surrounded by Tissue

The aim of the paper is to develop a simple model for capillary tissue fluid exchange system to study the effect of glycocalyx layer on the single file flow of red cells. We have considered the channel version of an idealized Krogh capillary-tissue exchange system. The glycocalyx and the tissue are represented as porous layers with different property parametric values. Hydrodynamic Lubrication theory is used to compute the squeezing flow of plasma within the small gap between the cell and the glycocalyx layer symmetrically surrounded by the tissue. The system of non linear partial differential equations has been solved using analytical techniques. The model predicts that decrease in glycocalyx thickness reduces the axial velocity of plasma and the resistance to flow increases in presence of glycocalyx

Stability of hard-core pinch with anisotropic plasma pressure

Stability of hard-core pinch device with anisotropic plasma pressur

Immunodiagnostics - unfulfilled promises and needs

This article does not have an abstract

Adrenal Medullary Autografts in Anterior Eye Chamber, Lateral Ventricle and Striatum of Adult Rats: A Long Term Study

The neurobiological basis for the short-term recovery in Parkinson's patients and experimental animals grafted with adrenal medulla is not yet clear. Structural details of the grafted chromaffin cells are also not available. In the present study, autografts of adrenal medulla in the anterior eye chamber, lateral ventricle and striatum of adult rats were studied for 360 days. Though a large number of cells degenerated, a few healthy chromaffin cells survived up to 360 days in the anterior eye chamber. In the ventricular and striatal regions, cells degenerated more rapidly, and a few surviving cells were seen only up to 120 and 150 days, respectively. Degeneration of the cells was evident from the alteration of the cytoplasmic granules, appearance of vacuoles and lysosomes, rapid decline in the number of TH and DBH positive cells and diffusion of enzymes in the intercellular region. Only lymphocytes and connective tissue cells were seen in the ventricle after 120 days, while outlines of a few chromaffin cells and background fluorescence were still evident in the striatum up to 150 days. In some of the intrastriatal transplants, morphologically identifiable Schwann cells were present and, in one transplant, there was evidence of myelination of axons by Schwann cells. These axons were obviously derived from the adjacent host tissue. From the findings it has been concluded that autografts of adrenal medulla survive for only a Limited period of time on transplantation to the central nervous system and anterior eye chamber. Survival seemed to be better in the anterior eye chamber than at the sites preferentially chosen for treating Parkinson's patients or experimental animals

Neural stem cell research: a revolution in the making

Existence of stem cells capable of differentiating in all types of haemopoietic cells, red blood cells, white blood cells, platelets has been known for the last one decade. These have been isolated from bone marrow cultured and made to differentiate into specific cell types. It is, however, only in the last couple of years that totipotent cells isolated from human embryo at the blastocyst stage, have been shown to retain the potentials to differentiate into any type of adult cells including neuronal series. More or less simultaneously it was demonstrated that contrary to the prevailing belief, neurogenesis continues throughout life even in humans, at least in certain regions of the brain. Not surprisingly, this has lead to active research in the field with the hope of exploiting this knowledge for replacement of lost or degenerating neurons. This review is an attempt to summarize the current knowledge and future areas of research

Post-infection changes in ascorbic acid contents of aonla (Phyllanthus emblica L.) fruits caused by Aspergillus niger Van TIegh

This article does not have an abstract