Promoting resilience in occupational therapy rducation, a scoping literature review

Psychological and emotional resilience are important Occupational Therapy (OT) graduate skills. Occupational Therapists often embark on varied careers in highly demanding and challenging work environments. Theoretically, teaching and learning resilience during training affords protective advantages including safeguarding effects, which promote wellness and a sense of “I can do this, I will survive”. However, OT educators face significant challenges knowing how best to promote resilience through self-directed learning (SDL) approaches. In the UK, there is a strong focal shift towards producing resilient, autonomous life-long learners.  This review was undertaken to inform current education practices in the field

The timing of maternal depressive symptoms and child cognitive development: a longitudinal study.

Background: Maternal depression is known to be associated with impairments in child cognitive development, although the effect of timing of exposure to maternal depression is unclear. Methods: Data collected for the Avon Longitudinal Study of Parents and Children, a longitudinal study beginning in pregnancy, included self-report measures of maternal depression the Edinburgh Postnatal Depression Scale, completed on 6 occasions up to 3 years of age, and IQ of the index child (WISC) measured at aged 8 years. We used these data to assign women to 8 groups according to whether depression occurred in the antenatal, postnatal, preschool period, any combination of these times, or not at all. We compared a model comprising all patterns of depression (saturated model) with models nested within this to test whether there is a relationship between depression and child cognitive development and, if so, whether there is a sensitive period. We then investigated the relationship with child IQ for each model, following adjustment for confounders. Results: Six thousand seven hundred and thirty-five of 13,615 children from singleton births (49.5%, of eligible core sample) attended a research clinic at 8 years and completed a WISC with a score ≥ 70. A total of 5,029 mothers of these children had completed mood assessments over the 3 time periods. In unadjusted analyses, all three sensitive period models were as good as the saturated model, as was an accumulation model. Of the sensitive period models, only that for antenatal exposure was a consistently better fit than the accumulation model. After multiple imputation for missing data (to n = 6,735), there was no effect of postnatal depression on child IQ independent of depression at other times [-0.19 IQ points, 95% confidence interval (CI) -1.5 to 1.1 points]. There was an effect of antenatal depression (-3.19 IQ points, 95% CI: -4.33 to -2.06) which attenuated following adjustment (-0.64 IQ points, 95% CI: -1.68 to 0.40). Conclusions: The postnatal period is not a sensitive one for the effect of maternal depression on child cognitive development. © 2011 The Authors. Journal of Child Psychology and Psychiatry

Adjunctive quetiapine for serotonin reuptake inhibitor-resistant obsessive-compulsive disorder: A meta-analysis of randomised controlled treatment trials

Small studies have shown positive effects from adding a variety of antipsychotic agents in patients with obsessive–compulsive disorder who are unresponsive to treatment with serotonin reuptake inhibitors. The evidence, however, is contradictory. This paper reports a meta-analysis of existing double-blind randomized placebo-controlled studies looking at the addition of the second-generation antipsychotic quetiapine in such cases. Three studies fulfilled the inclusion criteria. Altogether 102 individuals were subjected to analysis using Review Manager (4.2.7). The results showed evidence of efficacy for adjunctive quetiapine (< 400 mg/day) on the primary efficacy criterion, measured as changes from baseline in total Yale–Brown Obsessive Compulsive Scale scores (P = 0.008), the clinical significance of which was limited by between-study heterogeneity. The mechanism underlying the effect may involve serotonin and/or dopamine neurotransmission

On the Fourier transform of the characteristic functions of domains with C1C^1 -smooth boundary

We consider domains $D\subseteq\mathbb R^n$ with $C^1$ -smooth boundary and study the following question: when the Fourier transform $\hat{1_D}$ of the characteristic function $1_D$ belongs to $L^p(\mathbb R^n)$?Comment: added two references; added footnotes on pages 6 and 1

The Luminosity Function of Nearby Galaxy Clusters II: Redshifts and Luminosity Function for Galaxies in the Region of the Centaurus Cluster

We acquired spectra for a random sample of galaxies within a 0.83 square degree region centered on the core of the Centaurus cluster. Radial velocities were obtained for 225 galaxies to limiting magnitudes of V < 19.5. Of the galaxies for which velocities were obtained, we find 35% to be member galaxies. Of the 78 member galaxies, magnitudes range from 11.8 < V < 18.5 (-21.6 < M_{V} < -14.9 for H_o = 70 km s^-1 Mpc^-1) with a limiting central surface brightness of \mu_o < 22.5 mag arcsec^-2. We constructed the cluster galaxy luminosity function by using these spectroscopic results to calculate the expected fraction of cluster members in each magnitude bin. The faint-end slope of the luminosity function using this method is shallower than the one obtained using a statistical method to correct for background galaxy contamination. We also use the spectroscopy results to define surface brightness criteria to establish membership for the full sample. Using these criteria, we find a luminosity function very similar to the one constructed with the statistical background correction. For both, we find a faint-end slope alpha ~ -1.4. Adjusting the surface brightness membership criteria we find that the data are consistent with a faint-end slope as shallow as -1.22 or as steep as -1.50. We describe in this paper some of the limitations of using these methods for constructing the galaxy luminosity function.Comment: 16 pages, 12 figures, accepted by A

Research review: young people leaving care

This paper reviews the international research on young people leaving care. Set in the context of a social exclusion framework, it explores young people's accelerated and compressed transitions to adulthood, and discusses the development and classification of leaving care services in responding to their needs. It then considers the evidence from outcome studies and argues that adopting a resilience framework suggests that young people leaving care may fall into three groups: young people 'moving on', 'survivors' and 'victims'. In concluding, it argues that these three pathways are associated with the quality of care young people receive, their transitions from care and the support they receive after care

Red Blood Cells and Turbulence

Measurements were made of the turbulence intensity of blood of various hematocrits (volume percentage of red cells in blood) flowing through an orifice. The maximum relative turbulence intensity was found to occur in the hematocrit range of 20% - 30%

Pregabalin effects on neural response to emotional faces

Pregabalin has shown promise in the treatment of anxiety disorders. Previous functional magnetic resonance imaging (fMRI) studies indicate agents used to treat anxiety, e.g., SSRIs and benzodiazepines, attenuate amygdala, insula, and medial prefrontal cortex (mPFC) activation during emotional processing. Our prior study has shown that during anticipation of an emotional stimulus, pregabalin attenuates amygdala and insula activation but increases medial PFC activation. In this study, we examined whether, similar to SSRIs and benzodiazepines, pregabalin attenuates amygdala, insula, and medial PFC during emotional face processing. Sixteen healthy volunteers underwent a double-blind within-subjects fMRI study investigating effects of placebo, 50 mg, and 200 mg pregabalin on neural activation during an emotional face-matching task. Linear mixed model analysis revealed that pregabalin dose-dependently attenuated left amygdala activation during fearful face-matching and left anterior insula activation during angry face-matching. The 50 mg dose exhibited more robust effects than the 200 mg dose in the right anterior insula and ventral ACC. Thus, pregabalin shares some similarity to SSRIs and benzodiazepines in attenuating anger and fear-related insula and amygdala activation during emotional face processing. However, there is evidence that a subclinical 50 mg dose of pregabalin produced more robust and widespread effects on neural responses in this paradigm than the more clinically relevant 200 mg dose. Taken together, pregabalin has a slightly different effect on brain activation as it relates to anticipation and emotional face processing, which may account for its unique characteristic as an agent for the treatment of anxiety disorders

Interpolation of Hilbert and Sobolev Spaces: Quantitative Estimates and Counterexamples

This paper provides an overview of interpolation of Banach and Hilbert spaces, with a focus on establishing when equivalence of norms is in fact equality of norms in the key results of the theory. (In brief, our conclusion for the Hilbert space case is that, with the right normalisations, all the key results hold with equality of norms.) In the final section we apply the Hilbert space results to the Sobolev spaces $H^s(\Omega)$ and $\widetilde{H}^s(\Omega)$, for $s\in \mathbb{R}$ and an open $\Omega\subset \mathbb{R}^n$. We exhibit examples in one and two dimensions of sets $\Omega$ for which these scales of Sobolev spaces are not interpolation scales. In the cases when they are interpolation scales (in particular, if $\Omega$ is Lipschitz) we exhibit examples that show that, in general, the interpolation norm does not coincide with the intrinsic Sobolev norm and, in fact, the ratio of these two norms can be arbitrarily large

Investigating hair zinc concentrations in children with and without atopic dermatitis

Background. Atopic dermatitis (AD) is a common chronic inflammatory skin condition that disproportionately affects children and is associated with reduced quality of life. Zinc deficiency may contribute to the pathogenesis of AD because zinc plays a role in epidermal barrier integrity and the immune system. Systematic review evidence suggests that low zinc is associated with AD, but limitations of included studies support further investigation.Objectives. To investigate hair zinc concentrations in children with AD v. healthy controls in a low- to middle-income country setting.Methods. One hundred and five children aged 1 - 12 yea­rs participated in a frequency-matched for age case-control study. The outcome variable, AD, was confirmed by a clinician and corroborated using the UK Working Party criteria. The primary predictor, long-term average zinc concentration, was determined by measuring hair zinc using inductively coupled mass spectrometry. Baseline demographic characteristics, anthropometry and measures of socioeconomic status were included in our logistic regression analysis. Subgroup analysis was performed where interaction terms suggested effect modification.Results. Using data from the overall sample, population median hair zinc was not significantly different between children with AD and healthy controls. However, subgroup analysis suggested a clinically and statistically significant difference in median zinc between children with AD (175.35 µg/g) and healthy controls (206.4 µg/g) in the older age group (5 - 12 years) (p=0.01). In this age group, multivariable logistic regression analysis also found significantly decreased hair zinc concentrations in AD (odds ratio 0.83; 95% confidence interval 0.66 - 0.96; p=0.046).Conclusions. The inverse association between zinc status and AD in children aged 5 - 12 years in our setting is consistent with the international literature. The clinical importance of decreased zinc levels in AD is not yet known. Further investigation into relevant underlying mechanisms seems warranted given the global reach of AD, its effect on quality of life, and the low cost of potential zinc-based interventions.