Shear induced breaking of large internal solitary waves

The stability properties of 24 experimentally generated internal solitary waves (ISWs) of extremely large amplitude, all with minimum Richardson number less than 1/4, are investigated. The study is supplemented by fully nonlinear calculations in a three-layer fluid. The waves move along a linearly stratified pycnocline (depth h2) sandwiched between a thin upper layer (depth h1) and a deep lower layer (depth h3), both homogeneous. In particular, the wave-induced velocity profile through the pycnocline is measured by particle image velocimetry (PIV) and obtained in computation. Breaking ISWs were found to have amplitudes (a1) in the range a1>2.24 √h1h2(1+h2/h1), while stable waves were on or below this limit. Breaking ISWs were investigated for 0.27 0.86 and stable waves for Lx/λ < 0.86. The results show a sort of threshold-like behaviour in terms of Lx/λ. The results demonstrate that the breaking threshold of Lx/λ = 0.86 was sharper than one based on a minimum Richardson number and reveal that the Richardson number was found to become almost antisymmetric across relatively thick pycnoclines, with the minimum occurring towards the top part of the pycnoclinePostprintPeer reviewe

Strategi Manajemen Konflik Komunikasi Interpersonal antara Ibu Tiri dan Anak Tiri

Penelitian ini dilakukan untuk mengetahui strategi manajemen konflik komunikasi interpersonal antara calon ibu tiri dan anak tiri. Topik ini dipilih karena pada awalnya objek penelitan adalah dua orang yang saling bersahabat. Peneliti menggunakan studi kasus sebagai metode penelitian dan observasi non – partisipan serta wawancara mendalam dengan informan penelitian sebagai teknik pengumpulan data.Hasil penelitian menunjukkan bahwa kedua pihak yang berkonflik menggunakan strategi manajemen konflik dalam menyelesaikan konfliknya. Ada lima strategi dalam menyelesaikan konflik yaitu menang-menang, menghindar, memaksa, menaikkan ego dan agresif secara verbal

Phosphoramidite derivatives of macrocycles

The invention is directed to phosphoramidite derivatives of macrocycles, such as porphyrins and expanded porphyrins, including sapphyrins and texaphyrins. The phosphoramidite derivatives are useful as intermediates in the preparation of macrocycle-oligonucleotide conjugates.Board of Regents, University of Texas Syste

Effects of Estrogen on vascular inflammation: a matter of timing.

Objective: Our study aims to determine the role of time of menopause on vascular inflammation biomarkers and how it affects their modulation by estrogen and raloxifene in postmenopausal women. Methods and results: Uterine arteries from 68 postmenopausal women were divided into 3 segments and cultured for 24 hours in tissue culture media containing 17β-estradiol (100 nmol/L), raloxifene (100 nmol/L), or vehicle. Assessment of arterial concentration of 13 inflammatory biomarkers was performed by multiplex immunobead-based assay. Aging per se has a positive correlation with the generation of several proinflammatory markers. Although short-term estradiol exposure correlates with lower expression of tumor necrosis factor-α, vascular endothelial growth factor, and interleukin-1β in all age groups, for most biomarkers aging was associated with a switch from a beneficial anti-inflammatory action by estrogen, at earlier stages of menopause, to a proinflammatory profile after 5 years past its onset. Raloxifene has no significant effect on the expression of all proinflammatory markers. Western blot analysis of estrogen receptor expression (estrogen receptor-α and estrogen receptor-β) showed that estrogen receptor-β increases with aging, and this increase has a positive correlation with the generation of several proinflammatory markers. Conclusions: Aging alters estrogen-mediated effects on the modulation of inflammatory biomarkers in women. How aging affects estrogen responses on vascular inflammation is not clear, but our data show a positive association between increased estrogen receptor-β expression with aging and proinflammatory effects by estrogen

Coarse-grained meandering distributive fluvial system of the Basal Cedar mountain formation, U.S.A.

Funding Information: We thank the following for reviews of this manuscript: Associate Editor Tobi Payenberg, Matt Joeckel, two anonymous reviewers, and John Southard. This work was funded by the SAFARI group. We are deeply grateful to Joe Phillips, Sean Kelly, James Mullins, Ryan King, and Jostein Myking Kjærefjord for help in the field.Peer reviewedPostprin

Crystal Structure of DIM-1, an Acquired Subclass B1 Metallo-β-Lactamase from Pseudomonas stutzeri

Metallo-β-lactamases (MBLs) hydrolyze almost all classes of β-lactam antibiotic, including carbapenems—currently first choice drugs for opportunistic infections by Gram-negative bacterial pathogens. MBL inhibitor development is complicated by the diversity within this group of enzymes, and by the appearance of new enzymes that continue to be identified both as chromosomal genes and on mobile genetic elements. One such newly discovered MBL is DIM-1, a mobile enzyme originally discovered in the opportunist pathogen Pseudomonas stutzeri but subsequently identified in other species and locations. DIM-1 is a subclass B1 MBL more closely related to the TMB-1, GIM-1 and IMP enzymes than to other clinically encountered MBLs such as VIM and NDM; and possesses Arg, rather than the more usual Lys, at position 224 in the putative substrate binding site. Here we report the crystallization and structure determination of DIM-1. DIM-1 possesses a binuclear metal center with a 5 (rather than the more usual 4) co-ordinate tri-histidine (Zn1) site and both 4- and 5-co-ordinate Cys-His-Asp- (Zn2) sites observed in the two molecules of the crystallographic asymmetric unit. These data indicate a degree of variability in metal co-ordination geometry in the DIM-1 active site, as well as facilitating inclusion of DIM-1 in structure-based MBL inhibitor discovery programmes

Perioperative Medication Teaching Protocol: An Evidence-Based Project in a Perioperative Surgical Home

At the outpatient surgery center, there is a need for a perioperative medication guideline to improve appropriate medication teaching and compliance in the days and weeks leading up to a surgical intervention. It is critical that protocols and evidence-based guidelines are used throughout the management of all patients taking oral anticoagulants during the perioperative window. Currently, there is no standardized teaching protocol for patients preparing for surgery who are on anticoagulants. This lack of standardization could lead to increased surgical complications. Patient education is essential to preoperative optimization and can lead to improved patient compliance. This can be done by streamlining the education given to patients regarding their perioperative anticoagulant management, which increases effectiveness of the education and decrease adverse reactions. One solution, and the focus of this project, will be implementing a standardized medication teaching protocol, via the perioperative surgical home, to improve appropriate adherence in patients taking anticoagulants. The aim of the proposed project is that by May 30, 2021, 100% of perioperative nursing staff will receive the preoperative medication guideline, participate in the educational training, and demonstrate competency in knowledge of the guideline and patient education

Managing Resources by Grazing in Grasslands Dominated by Dominant Shrub Species

The European natural grasslands are attracting new attention because of their environmental value as habitats for threatened fauna and flora species and their contribution to the diversity of landscapes. Those responsible for the implementation of the European agri-environmental policy are hence encouraging livestock farmers to adopt grazing practices that contribute to the conservation of grassland biodiversity especially by limiting encroachment by dominant shrubs. However, current scientific knowledge and technical information are often insufficient to connect flock feeding and the impact of grazing on shrub dynamics and livestock farmers are not very enthusiastic about restoring or conserving “plant mosaics” including shrubs that support biodiversity in their fields. This paper presents results of an interdisciplinary study on interactions between small ruminant feeding strategy and population dynamics of dominant shrub species with the objective of managing by grazing the structure of plant community and thus to provide the renewal of resources on a multi-year scale