What has the UK Ocean Acidification research programme told us? An infographic for Defra.

This is an infographic requested by Defra on the findings of the UK Ocean Acidification research programme

Hot, Sour and Breathless – Ocean under Stress.

ISBN 978-0-9519618-6-

Recent progress in understanding climate thresholds: ice sheets, the Atlantic meridional overturning circulation, tropical forests and responses to ocean acidification

This article reviews recent scientific progress, relating to four major systems that could exhibit threshold behaviour: ice sheets, the Atlantic meridional overturning circulation (AMOC), tropical forests and ecosystem responses to ocean acidification. The focus is on advances since the Intergovernmental Panel on Climate Change Fifth Assessment Report (IPCC AR5). The most significant developments in each component are identified by synthesizing input from multiple experts from each field. For ice sheets, some degree of irreversible loss (timescales of millennia) of part of the West Antarctic Ice Sheet (WAIS) may have already begun, but the rate and eventual magnitude of this irreversible loss is uncertain. The observed AMOC overturning has decreased from 2004–2014, but it is unclear at this stage whether this is forced or is internal variability. New evidence from experimental and natural droughts has given greater confidence that tropical forests are adversely affected by drought. The ecological and socio-economic impacts of ocean acidification are expected to greatly increase over the range from today’s annual value of around 400, up to 650 ppm CO2 in the atmosphere (reached around 2070 under RCP8.5), with the rapid development of aragonite undersaturation at high latitudes affecting calcifying organisms. Tropical coral reefs are vulnerable to the interaction of ocean acidification and temperature rise, and the rapidity of those changes, with severe losses and risks to survival at 2 °C warming above pre-industrial levels. Across the four systems studied, however, quantitative evidence for a difference in risk between 1.5 and 2 °C warming above pre-industrial levels is limited

The Royal Society Climate Updates: What have we learnt since the IPCC 5th Assessment Report?

Climate has a huge influence on the way we live. For example, it affects the crops we can grow and the diseases we might encounter in particular locations. It also determines the physical infrastructure we need to build to survive comfortably in the face of extremes of heat, cold, drought and flood. Human emissions of carbon dioxide and other greenhouse gases have changed the composition of the atmosphere over the last two centuries. This is expected to take Earth’s climate out of the relatively stable range that has characterised the last few thousand years, during which human society has emerged. Measurements of ice cores and sea-floor sediments show that the current concentration of carbon dioxide, at just over 400 parts per million, has not been experienced for at least three million years. This causes more of the heat from the Sun to be retained on Earth, warming the atmosphere and ocean. The global average of atmospheric temperature has so far risen by about 1˚C compared to the late 19th century, with further increases expected dependent on the trajectory of carbon dioxide emissions in the next few decades. In 2013 and 2014 the Intergovernmental Panel on Climate Change (IPCC) published its fifth assessment report (AR5) assessing the evidence about climate change and its impacts. This assessment considered data from observations and records of the past. It then assessed future changes and impacts based on various scenarios for emissions of greenhouse gases and other anthropogenic factors. In 2015, almost every nation in the world agreed (in the so-called Paris Agreement) to the challenging goal of keeping global average warming to well below 2°C above pre-industrial temperatures while pursuing efforts to limit it to 1.5°C. With the next assessment report (AR6) not due until 2022, it is timely to consider how evidence presented since the publication of AR5 affects the assessments made then. The Earth’s climate is a complex system. To understand it, and the impact that climate change will have, requires many different kinds of study. Climate science consists of theory, observation and modelling. Theory begins with well-established scientific principles, seeks to understand processes occurring over a range of spatial and temporal scales and provides the basis for models. Observation includes long time series of careful measurements, recent data from satellites, and studies of past climate using archives such as tree rings, ice cores and marine sediments. It also encompasses laboratory and field experiments designed to test and enhance understanding of processes. Computer models of the Earth climate system use theory, calibrated and validated by the observations, to calculate the result of future changes. There are nevertheless uncertainties in estimating future climate. Firstly the course of climate change is dependent on what socioeconomic, political and energy paths society takes. Secondly there remain inevitable uncertainties induced for example by variability in the interactions between different parts of the Earth system and by processes, such as cloud formation, that occur at too small a scale to incorporate precisely in global models. Assessments such as those of the IPCC describe the state of knowledge at a particular time, and also highlight areas where more research is needed. We are still exploring and improving our understanding of many of the processes within the climate system, but, on the whole, new research confirms the main ideas underpinning climate research, while refining knowledge, so as to reduce the uncertainty in the magnitude and extent of crucial impacts

Impact of audiovisual biofeedback on interfraction respiratory motion reproducibility in liver cancer stereotactic body radiotherapy.

INTRODUCTION: Irregular breathing motion exacerbates uncertainties throughout a course of radiation therapy. Breathing guidance has demonstrated to improve breathing motion consistency. This was the first clinical implementation of audiovisual biofeedback (AVB) breathing guidance over a course of liver stereotactic body radiotherapy (SBRT) investigating interfraction reproducibility. METHODS: Five liver cancer patients underwent a screening procedure prior to CT sim during which patients underwent breathing conditions (i) AVB, or (ii) free breathing (FB). Whichever breathing condition was more regular was utilised for the patient's subsequent course of SBRT. Respiratory motion was obtained from the Varian respiratory position monitoring (RPM) system (Varian Medical Systems). Breathing motion reproducibility was assessed by the variance of displacement across 10 phase-based respiratory bins over each patient's course of SBRT. RESULTS: The screening procedure yielded the decision to utilise AVB for three patients and FB for two patients. Over the course of SBRT, AVB significantly improved the relative interfraction motion by 32%, from 22% displacement difference for FB patients to 15% difference for AVB patients. Further to this, AVB facilitated sub-millimetre interfraction reproducibility for two AVB patients. CONCLUSION: There was significantly less interfraction motion with AVB than FB. These findings demonstrate that AVB is potentially a valuable tool in ensuring reproducible interfraction motion

The talar morphology of a hypochondroplasic dwarf: A case study from the Italian Late Antique period

This project aims to test whether geometric morphometric (GM) and trabecular analyses may be useful tools in identifying talar characteristics related to hypochondroplasia. We quantified the external and internal talar morphology of a hypochondroplasic dwarf (T17) from Modena (northern Italy) dated to the sixth century AD. External talar morphology of T17 was compared with a broad sample of modern human tali (n = 159) using GM methods. Additionally, a subsample of these tali (n = 41) was used to investigate whole talar trabecular changes in T17. Our results show that GM and trabecular analyses identify a combination of traits linked to the dwarfing disorder of hypochondroplasia. These traits include decreased scaled talar dimensions compared with normal-sized individuals, presence of an accessory antero-lateral talar facet, high bone volume fraction, and high anisotropy values throughout the entire talus. In our case study, hypochondroplasia does not appear to substantially modify external talar morphology probably due to the fast growth of the talus. We suggest that small talar dimensions are associated with hypochondroplasia. An antero-lateral talar facet may result from the talus and calcaneus coalition (i.e., talocalcaneal abnormal bridging) possibly related to an everted foot posture that was limited by overgrowth of the fibula. We suggest that high talar trabecular density and strut orientation provide insights into pathological development of the trabecular plates in T17. Finally, our study suggests that high talar trabecular density and strut orientation, and small talar dimensions, may be added as possible concomitant talar hallmarks for hypochondroplasia

Establishment of wMel Wolbachia in Aedes aegypti mosquitoes and reduction of local dengue transmission in Cairns and surrounding locations in northern Queensland, Australia.

Background: The wMel strain of Wolbachia has been successfully introduced into Aedes aegypti mosquitoes and subsequently shown in laboratory studies to reduce transmission of a range of viruses including dengue, Zika, chikungunya, yellow fever, and Mayaro viruses that cause human disease. Here we report the entomological and epidemiological outcomes of staged deployment of Wolbachia across nearly all significant dengue transmission risk areas in Australia. Methods: The  wMel strain of  Wolbachia was backcrossed into the local  Aedes aegypti genotype (Cairns and Townsville backgrounds) and mosquitoes were released in the field by staff or via community assisted methods. Mosquito monitoring was undertaken and mosquitoes were screened for the presence of  Wolbachia. Dengue case notifications were used to track dengue incidence in each location before and after releases. Results: Empirical analyses of the Wolbachia mosquito releases, including data on the density, frequency and duration of Wolbachia mosquito releases, indicate that Wolbachia can be readily established in local mosquito populations, using a variety of deployment options and over short release durations (mean release period 11 weeks, range 2-22 weeks). Importantly, Wolbachia frequencies have remained stable in mosquito populations since releases for up to 8 years. Analysis of dengue case notifications data demonstrates near-elimination of local dengue transmission for the past five years in locations where Wolbachia has been established. The regression model estimate of Wolbachia intervention effect from interrupted time series analyses of case notifications data prior to and after releases, indicated a 96% reduction in dengue incidence in Wolbachia treated populations (95% confidence interval: 84 - 99%). Conclusion: Deployment of the wMel strain of Wolbachia into local Ae. aegypti populations across the Australian regional cities of Cairns and most smaller regional communities with a past history of dengue has resulted in the reduction of local dengue transmission across all deployment areas

Fermi liquid to Luttinger liquid transition at the edge of a two-dimensional electron gas

We present experimental results on the tunneling into the edge of a two dimensional electron gas (2DEG) obtained with a GaAs/AlGaAs cleaved edge overgrown structure in a strong perpendicular magnetic field. While the 2DEG exhibits typical fractional quantum Hall features of a very high mobility sample, we observe the onset of a non-linear current-voltage characteristic in the vicinity of nu=1. For filling factor nu<1 the system is consistent with a non-Fermi liquid behavior, such as a Luttinger liquid, whereas for nu>1 we observe an Ohmic tunneling resistance between the edge and a three dimensional contact, typical for a Fermi liquid. Hence, at the edge, there is a transition from a Luttinger liquid to a Fermi liquid. Finally, we show that the Luttinger liquid exponent at a given filling factor is not universal but depends on sample parameters.Comment: 4 pages, 4 figure