Catecholaminergic and cholinergic neuromodulation in autism spectrum disorder: A comparison to attention-deficit hyperactivity disorder

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder characterized by social impairments and restricted, repetitive behaviors. Treatment of ASD is notoriously difficult and might benefit from identification of underlying mechanisms that overlap with those disturbed in other developmental disorders, for which treatment options are more obvious. One example of the latter is attention-deficit hyperactivity disorder (ADHD), given the efficacy of especially stimulants in treatment of ADHD. Deficiencies in catecholaminergic systems [dopamine (DA), norepinephrine (NE)] in ADHD are obvious targets for stimulant treatment. Recent findings suggest that dysfunction in catecholaminergic systems may also be a factor in at least a subgroup of ASD. In this review we scrutinize the evidence for catecholaminergic mechanisms underlying ASD symptoms, and also include in this analysis a third classic ascending arousing system, the acetylcholinergic (ACh) network. We complement this with a comprehensive review of DA-, NE-, and ACh-targeted interventions in ASD, and an exploratory search for potential treatment-response predictors (biomarkers) in ASD, genetically or otherwise. Based on this review and analysis we propose that (1) stimulant treatment may be a viable option for an ASD subcategory, possibly defined by genetic subtyping; (2) cerebellar dysfunction is pronounced for a relatively small ADHD subgroup but much more common in ASD and in both cases may point toward NE- or ACh-directed intervention; (3) deficiency of the cortical salience network is sizable in subgroups of both disorders, and biomarkers such as eye blink rate and pupillometric data may predict the efficacy of targeting this underlying deficiency via DA, NE, or ACh in both ASD and ADHD

Dynamics of Fluid Vesicles in Oscillatory Shear Flow

The dynamics of fluid vesicles in oscillatory shear flow was studied using differential equations of two variables: the Taylor deformation parameter and inclination angle $\theta$. In a steady shear flow with a low viscosity $\eta_{\rm {in}}$ of internal fluid, the vesicles exhibit steady tank-treading motion with a constant inclination angle $\theta_0$. In the oscillatory flow with a low shear frequency, $\theta$ oscillates between $\pm \theta_0$ or around $\theta_0$ for zero or finite mean shear rate $\dot\gamma_{\rm m}$, respectively. As shear frequency $f_{\gamma}$ increases, the vesicle oscillation becomes delayed with respect to the shear oscillation, and the oscillation amplitude decreases. At high $f_{\gamma}$ with $\dot\gamma_{\rm m}=0$, another limit-cycle oscillation between $\theta_0-\pi$ and $-\theta_0$ is found to appear. In the steady flow, $\theta$ periodically rotates (tumbling) at high $\eta_{\rm {in}}$, and $\theta$ and the vesicle shape oscillate (swinging) at middle $\eta_{\rm {in}}$ and high shear rate. In the oscillatory flow, the coexistence of two or more limit-cycle oscillations can occur for low $f_{\gamma}$ in these phases. For the vesicle with a fixed shape, the angle $\theta$ rotates back to the original position after an oscillation period. However, it is found that a preferred angle can be induced by small thermal fluctuations.Comment: 11 pages, 13 figure

Progress on a spherical TPC for low energy neutrino detection

The new concept of the spherical TPC aims at relatively large target masses with low threshold and background, keeping an extremely simple and robust operation. Such a device would open the way to detect the neutrino-nucleus interaction, which, although a standard process, remains undetected due to the low energy of the neutrino-induced nuclear recoils. The progress in the development of the fist 1 m$^3$ prototype at Saclay is presented. Other physics goals of such a device could include supernova detection, low energy neutrino oscillations and study of non-standard properties of the neutrino, among others.Comment: 3 pages, talk given at the 9th Workshop on Topics in Astroparticle and Underground Physics, Zaragoza, September 10-1

Fast Photon Detection for Particle Identification with COMPASS RICH-1

Particle identification at high rates is an important challenge for many current and future high-energy physics experiments. The upgrade of the COMPASS RICH-1 detector requires a new technique for Cherenkov photon detection at count rates of several $10^6$ per channel in the central detector region, and a read-out system allowing for trigger rates of up to 100 kHz. To cope with these requirements, the photon detectors in the central region have been replaced with the detection system described in this paper. In the peripheral regions, the existing multi-wire proportional chambers with CsI photocathode are now read out via a new system employing APV pre-amplifiers and flash ADC chips. The new detection system consists of multi-anode photomultiplier tubes (MAPMT) and fast read-out electronics based on the MAD4 discriminator and the F1-TDC chip. The RICH-1 is in operation in its upgraded version for the 2006 CERN SPS run. We present the photon detection design, constructive aspects and the first Cherenkov light in the detector.Comment: Proceedings of the Imaging 2006 conference, Stockholm, Sweden, 27-30 June 2006, 5 pages, 6 figures, to appear in NIM A; corrected typo in caption of Fig.

Fast photon detection for the COMPASS RICH detector

The COMPASS experiment at the SPS accelerator at CERN uses a large scale Ring Imaging CHerenkov detector (RICH) to identify pions, kaons and protons in a wide momentum range. For the data taking in 2006, the COMPASS RICH has been upgraded in the central photon detection area (25% of the surface) with a new technology to detect Cherenkov photons at very high count rates of several 10^6 per second and channel and a new dead-time free read-out system, which allows trigger rates up to 100 kHz. The Cherenkov photons are detected by an array of 576 visible and ultra-violet sensitive multi-anode photomultipliers with 16 channels each. The upgraded detector showed an excellent performance during the 2006 data taking.Comment: Proceeding of the IPRD06 conference (Siena, Okt. 06

The Fast Read-out System for the MAPMTs of COMPASS RICH-1

A fast readout system for the upgrade of the COMPASS RICH detector has been developed and successfully used for data taking in 2006 and 2007. The new readout system for the multi-anode PMTs in the central part of the photon detector of the RICH is based on the high-sensitivity MAD4 preamplifier-discriminator and the dead-time free F1-TDC chip characterized by high-resolution. The readout electronics has been designed taking into account the high photon flux in the central part of the detector and the requirement to run at high trigger rates of up to 100 kHz with negligible dead-time. The system is designed as a very compact setup and is mounted directly behind the multi-anode photomultipliers. The data are digitized on the frontend boards and transferred via optical links to the readout system. The read-out electronics system is described in detail together with its measured performances.Comment: Proceeding of RICH2007 Conference, Trieste, Oct. 2007. v2: minor change

Identification of backgrounds in the EDELWEISS-I dark matter search experiment

This paper presents our interpretation and understanding of the different backgrounds in the EDELWEISS-I data sets. We analyze in detail the several populations observed, which include gammas, alphas, neutrons, thermal sensor events and surface events, and try to combine all data sets to provide a coherent picture of the nature and localisation of the background sources. In light of this interpretation, we draw conclusions regarding the background suppression scheme for the EDELWEISS-II phase

EMSO-ANTARES (Western Ligurian Sea) a unique observatory for sea science and particle astrophysics

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Measurement of the response of heat-and-ionization germanium detectors to nuclear recoils

The heat quenching factor Q' (the ratio of the heat signals produced by nuclear and electron recoils of equal energy) of the heat-and-ionization germanium bolometers used by the EDELWEISS collaboration has been measured. It is explained how this factor affects the energy scale and the effective quenching factor observed in calibrations with neutron sources. This effective quenching effect is found to be equal to Q/Q', where Q is the quenching factor of the ionization yield. To measure Q', a precise EDELWEISS measurement of Q/Q' is combined with values of Q obtained from a review of all available measurements of this quantity in tagged neutron beam experiments. The systematic uncertainties associated with this method to evaluate Q' are discussed in detail. For recoil energies between 20 and 100 keV, the resulting heat quenching factor is Q' = 0.91+-0.03+-0.04, where the two errors are the contributions from the Q and Q/Q' measurements, respectively. The present compilation of Q values and evaluation of Q' represent one of the most precise determinations of the absolute energy scale for any detector used in direct searches for dark matter.Comment: 28 pages, 7 figures. Submitted to Phys. Rev.